CA2112474A1 - Tubular surgical implant - Google Patents
Tubular surgical implantInfo
- Publication number
- CA2112474A1 CA2112474A1 CA002112474A CA2112474A CA2112474A1 CA 2112474 A1 CA2112474 A1 CA 2112474A1 CA 002112474 A CA002112474 A CA 002112474A CA 2112474 A CA2112474 A CA 2112474A CA 2112474 A1 CA2112474 A1 CA 2112474A1
- Authority
- CA
- Canada
- Prior art keywords
- tube
- flange
- vessel
- organ
- spikes
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/11—Surgical instruments, devices or methods, e.g. tourniquets for performing anastomosis; Buttons for anastomosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
- A61F2/06—Blood vessels
- A61F2/064—Blood vessels with special features to facilitate anastomotic coupling
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/11—Surgical instruments, devices or methods, e.g. tourniquets for performing anastomosis; Buttons for anastomosis
- A61B2017/1135—End-to-side connections, e.g. T- or Y-connections
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Surgery (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- Transplantation (AREA)
- Vascular Medicine (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Cardiology (AREA)
- Pulmonology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Gastroenterology & Hepatology (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Prostheses (AREA)
- Materials For Medical Uses (AREA)
Abstract
2112474 9300868 PCTABS00019 A tubular surgical implant particularly suitable for use in heart bypass surgery comprising a tube (1) having a flange (2) adapted to be folded and inserted into a cut in a vessel (8). The flange has a series of spikes (3) parallel to the tube which pass through the vessel wall and are engaged with holes (5) in a locking ring (4) slidable on the tube (1). The implant is typically connected between an aorta and a distal coronary artery in a heart bypass operation.
Description
WO 93/00868 PCI`/AU92/00328 "'l U~U~AR SURGICAI, IMPI
TECHNICAL FIEIJD
This invention relates to a tubular surgical implant and has been devised particularly though not solely for use as a by-pass device and specifically as a coronary . by-pass device.
i BACKGROUND ART
So-called ~Iheart by-pass n surgery is relatively common and is necessitated by blockage or partial blockage by narrowing of the coronary arteries causing ischaemia or a lack of blood supply to the heart muscle, distally. The pain felt as a result i5 known as angina -and the result can be heart attack, death or recovery with damage to the heart muscle. The present treatment by way of heart by-pass surgery is effective but is expensive to carry out, time consuming, and requires stopping the heart and placing the patient on a life-support artificial heart-lung machine using large quantities of blood. Surgeon~ must then harvest leg veins or chest arteries or both to sew into position as a by-paYs from the aorta to the distal coronary artery.
It i8 desirable to provide a much less complicated procedure for carrying out a by-pas3 operation, which is not only faster and less expensive to perform, but also results in less risk to the patient.
DISCLOSURE OF THE INVENTION
The pre~ent invention therefore provides a tubular surgical implant adapted to be joined to a wall of a vessel or hollow organ such that the implant opens into the interior of the vessel or organ, said implant comprising an open ended tube, a deformable flange at one end of the tube, a plurality of spikes extending from the flange,~alongside and generally parallel to the tube, and a locking ring arranged to slide axially on the tube, the locking ring incorporating a plurality of holes aligned with and adapted to receive the spikes.
Preferably the locking ring is keyed to the tube, preventing rotation of the ring relative to the tube.
W093/008~ PCT/AU92/00328 P ~ erably the spikes and the holes in the locking ring are provided with a locking mechanism arranged to retain the qpikes within the holes when the locking ring is engaged with the spikes.
The flange may be deformable relative to the tube such that the.flange may be `~efonmed to lie against the tube for in~ertion into an opening in the wall of the ~essel or organ.
Alternatively the flange may be deformable across one or more hinge lines in the flange, allowing parts of the flange to bend back against the tube for insertion into an opening in the wall of the vessel or organ.
In one form of the invention the-implant is adapted to connect two ves~els or hollow organs and .is provided with a flange and locking ring at both ends of the tube.
Preferably the tube and the flange are made of a plastics mesh which allows for incorporation of human tissue.
In a further aspect the invention provides a method of connecting two vessels or hollow organs by way of a surgical implant, comprising the steps of; providing a tubular Qurgical implant adap_ed to be joined to a wall of a vessel or organ such that the implant opens into the interior of the vessel or organ, said implant comprising an open ended tube, a deformable flange at one end of the tube,: a plurality of spikes extending from the flange, alongside and generally parallel to the tube, and a locking ring arranged to slide axially on the tube, the locking ring incorporating a plurality of holes aligned ~with and adapted to receive the spikes; cutting a hole or :~slit in the tis8ue wall of the first ~e88el or organ, inserting the end of the tube into the hole or slit with the~flange deformed, allowing or causing the flange to ~open behind the tissue wall, engaging the spikes through the tissue wall and sliding the locking ring on the tube until the spikes are engaged with the holes in the locking ring.
W093/00~8 PCT/AU92/00328
TECHNICAL FIEIJD
This invention relates to a tubular surgical implant and has been devised particularly though not solely for use as a by-pass device and specifically as a coronary . by-pass device.
i BACKGROUND ART
So-called ~Iheart by-pass n surgery is relatively common and is necessitated by blockage or partial blockage by narrowing of the coronary arteries causing ischaemia or a lack of blood supply to the heart muscle, distally. The pain felt as a result i5 known as angina -and the result can be heart attack, death or recovery with damage to the heart muscle. The present treatment by way of heart by-pass surgery is effective but is expensive to carry out, time consuming, and requires stopping the heart and placing the patient on a life-support artificial heart-lung machine using large quantities of blood. Surgeon~ must then harvest leg veins or chest arteries or both to sew into position as a by-paYs from the aorta to the distal coronary artery.
It i8 desirable to provide a much less complicated procedure for carrying out a by-pas3 operation, which is not only faster and less expensive to perform, but also results in less risk to the patient.
DISCLOSURE OF THE INVENTION
The pre~ent invention therefore provides a tubular surgical implant adapted to be joined to a wall of a vessel or hollow organ such that the implant opens into the interior of the vessel or organ, said implant comprising an open ended tube, a deformable flange at one end of the tube, a plurality of spikes extending from the flange,~alongside and generally parallel to the tube, and a locking ring arranged to slide axially on the tube, the locking ring incorporating a plurality of holes aligned with and adapted to receive the spikes.
Preferably the locking ring is keyed to the tube, preventing rotation of the ring relative to the tube.
W093/008~ PCT/AU92/00328 P ~ erably the spikes and the holes in the locking ring are provided with a locking mechanism arranged to retain the qpikes within the holes when the locking ring is engaged with the spikes.
The flange may be deformable relative to the tube such that the.flange may be `~efonmed to lie against the tube for in~ertion into an opening in the wall of the ~essel or organ.
Alternatively the flange may be deformable across one or more hinge lines in the flange, allowing parts of the flange to bend back against the tube for insertion into an opening in the wall of the vessel or organ.
In one form of the invention the-implant is adapted to connect two ves~els or hollow organs and .is provided with a flange and locking ring at both ends of the tube.
Preferably the tube and the flange are made of a plastics mesh which allows for incorporation of human tissue.
In a further aspect the invention provides a method of connecting two vessels or hollow organs by way of a surgical implant, comprising the steps of; providing a tubular Qurgical implant adap_ed to be joined to a wall of a vessel or organ such that the implant opens into the interior of the vessel or organ, said implant comprising an open ended tube, a deformable flange at one end of the tube,: a plurality of spikes extending from the flange, alongside and generally parallel to the tube, and a locking ring arranged to slide axially on the tube, the locking ring incorporating a plurality of holes aligned ~with and adapted to receive the spikes; cutting a hole or :~slit in the tis8ue wall of the first ~e88el or organ, inserting the end of the tube into the hole or slit with the~flange deformed, allowing or causing the flange to ~open behind the tissue wall, engaging the spikes through the tissue wall and sliding the locking ring on the tube until the spikes are engaged with the holes in the locking ring.
W093/00~8 PCT/AU92/00328
2~ 7 ~ ~
BRIEF DESCRIPTION OF DRAWINGS
Notwithstanding any other forms that may fall within its scope, one preferred form of the invention will now be described by way of example only with reference to the s accompanying drawin,gs, in which:-Fig. 1 is a diagrammatic perspective view of a tubular surgical implant according to the invention;
Fig. 2 is a detailed view of one end of the implant shown in Fig. 1;
Fig. 3 is a diagrammatic view of a blood vessel clamped and cut preparatory to engagement with the tubular surgical implant shown in Fig. 1;
- - Fig. 4 is a diagrammatic perspective view of the implant being inserted into the inciQion in the vesQel;
Fig. 5 is a similar view to Fig. 4 showing the spikes of the implant being engaged; and Fig. 6 is a similar view to Figs. 4 and 5 showing engagement of the locking ring.
MODES FOR CARRYING OUT THE INVENTION
In the preferred form of the invention a tubular surgical implant is provided for use as a by-pasQ between the aorta and a coronary artery although it will be appreciated that the device may be uQed in many other applications wherever it is neceQsary to join an artificial tube with a veQsel or organ or to provide a by-pass between different vessels and/or organs. The implant is described as a double-ended device although it will be appreciated that in Qome applications the engagement flange and locking ring may be provided on one end of the tube only.
The implant compriseQ a tube (1) having a flange (2) at either end of the tube. The tube and flange may be formed '~'rom any suitable materialQ but are typically of a plastics mesh material such as a grade of Gortex (Registered Trade Mark) material which allows incorporation of human tissue and a long life for the device in the body.
Each flange is provided with a plurality of spikes wo !~3/1)0868 ~ 4~ 4 PCI /AU92/U0328
BRIEF DESCRIPTION OF DRAWINGS
Notwithstanding any other forms that may fall within its scope, one preferred form of the invention will now be described by way of example only with reference to the s accompanying drawin,gs, in which:-Fig. 1 is a diagrammatic perspective view of a tubular surgical implant according to the invention;
Fig. 2 is a detailed view of one end of the implant shown in Fig. 1;
Fig. 3 is a diagrammatic view of a blood vessel clamped and cut preparatory to engagement with the tubular surgical implant shown in Fig. 1;
- - Fig. 4 is a diagrammatic perspective view of the implant being inserted into the inciQion in the vesQel;
Fig. 5 is a similar view to Fig. 4 showing the spikes of the implant being engaged; and Fig. 6 is a similar view to Figs. 4 and 5 showing engagement of the locking ring.
MODES FOR CARRYING OUT THE INVENTION
In the preferred form of the invention a tubular surgical implant is provided for use as a by-pasQ between the aorta and a coronary artery although it will be appreciated that the device may be uQed in many other applications wherever it is neceQsary to join an artificial tube with a veQsel or organ or to provide a by-pass between different vessels and/or organs. The implant is described as a double-ended device although it will be appreciated that in Qome applications the engagement flange and locking ring may be provided on one end of the tube only.
The implant compriseQ a tube (1) having a flange (2) at either end of the tube. The tube and flange may be formed '~'rom any suitable materialQ but are typically of a plastics mesh material such as a grade of Gortex (Registered Trade Mark) material which allows incorporation of human tissue and a long life for the device in the body.
Each flange is provided with a plurality of spikes wo !~3/1)0868 ~ 4~ 4 PCI /AU92/U0328
(3) extending from the flange, alongside and generally parallel to the tube (1~. In this sense the spikes face away from the open end of the tube.
The implant is further provided with locking rings
The implant is further provided with locking rings
(4) of the same general size and configuration of the flanges (2), the locking ~rings being arranged to slide axially on the tube (~). Each locking ring incorporates a plurality of holes ~5) (Fig. 5) aligned with and adapted to receive the spikes (3) protruding from the corresponding flange (2).
In order to ensure alig~ment of the holes (5) with the spikes (3) the locking ring may be keyed to t~e tube by way of a keyway (6) on the tube and a corresponding projection or aperture (not shown) in the locking ring (4), preventing rotation of the ring relative to the tube. In this manner, the holes (5) can be accurately aligned with the spikes (3) enabling the ring to be engaged with the spikes as will be described further below. -The flange (2) is deformable relative to the tube -~
(1) either by deforming the entire flange relative to the tube so that the flange may lie against the tube for insertion into an opening of a vessel or organ, or alternati~ely the flange maybe deformable across one or more hinge lines (7) (Fig. 2) allowing parts of the flange to bend back against the tube as shown in Fig. 4 for insertion into an opening in the wall of the vessel or organ.
The use of the implant will now be described with reference to a typical coronary by-pass operation where the implant is engaged between the aorta and the distal coronary artery.
Referring to Fig. 3 the aorta (8) is first partially clamped by way of a non-traumatic clamp (9) positioned partially across the aorta to allow the continuing flow of blood through unclamped portion (10). The clamped portion (11) of the aorta (8) may then be cut to form an incision (12) for engagement with the implant.
2112'17~
As shown in Fig. 4, the flange (2) may be deformed as previously described and inserted through the incision (12) until the entire flange is positioned within the aorta. The flange is then allowed or caused to open behind the tissue wall of the aorta to its original ~onfiguration and the tube pulled back in the direction of arrow (13) (Fig. 5) engaging the spikes (3) through ~ the tissue wall tll).
The locki~g ring (4) is then slid down the tube until the spikes (3~ are engaged with the holes (5) in the locking ring as shown in ~ig. 6.
The spikes (3) and the holes (5) in the locking ring (4) are provided with a Qeries of locking mechanisms arranged to retain the spikes within the holes when the locking ring is engaged with the spikes as shown in Fig.
6. This locking mechanism may take any suitable configuration but is typically a series of "click into place n type of mechanism which engages the locking ring at various spacings from the flange to allow for several aortic wall thicknes~es.
The procedure may then be repeated at the other end of the implant to engage the other flange with the coronary artery so effectively and quickly providing a by-pass between the aorta and the coronary artery.
25In the particular application of a heart by-pass operation the flange adapted to be engaged with the coronary artery may be smaller than the flange to be engaged with the aorta to suit the size of the vessel with which it is engaged. A range of different sized and ended devices would be used to cover the range expected in different sized diameters and thickness of aortas and coronary arteries. In situations where there is more than onè blockage in the coronary artery, the tubular surgical implant can be constructed as a manifold with one larger aortic proximal end and se~eral separate coronary distal ends. The tubes may be either parallel sided or tapered (conical) as required for the desired flow rates.
4~ 6 In this manner a surgical implant is provided which enables a coronary by-pass operation to be performed without stopping the heart function or the aorta blood flow to the body and which furthermore does not entail the stripping of veins or arteries from other parts of the body to use as a by-pass conduit.
The implant has application in many other areas presently the province of vascular and microsurgery and may be used wherever it is necessary to join a tube to a vessel or hollow organ or to form a connection between two vessels and/or organs.
,............................................................ .
In order to ensure alig~ment of the holes (5) with the spikes (3) the locking ring may be keyed to t~e tube by way of a keyway (6) on the tube and a corresponding projection or aperture (not shown) in the locking ring (4), preventing rotation of the ring relative to the tube. In this manner, the holes (5) can be accurately aligned with the spikes (3) enabling the ring to be engaged with the spikes as will be described further below. -The flange (2) is deformable relative to the tube -~
(1) either by deforming the entire flange relative to the tube so that the flange may lie against the tube for insertion into an opening of a vessel or organ, or alternati~ely the flange maybe deformable across one or more hinge lines (7) (Fig. 2) allowing parts of the flange to bend back against the tube as shown in Fig. 4 for insertion into an opening in the wall of the vessel or organ.
The use of the implant will now be described with reference to a typical coronary by-pass operation where the implant is engaged between the aorta and the distal coronary artery.
Referring to Fig. 3 the aorta (8) is first partially clamped by way of a non-traumatic clamp (9) positioned partially across the aorta to allow the continuing flow of blood through unclamped portion (10). The clamped portion (11) of the aorta (8) may then be cut to form an incision (12) for engagement with the implant.
2112'17~
As shown in Fig. 4, the flange (2) may be deformed as previously described and inserted through the incision (12) until the entire flange is positioned within the aorta. The flange is then allowed or caused to open behind the tissue wall of the aorta to its original ~onfiguration and the tube pulled back in the direction of arrow (13) (Fig. 5) engaging the spikes (3) through ~ the tissue wall tll).
The locki~g ring (4) is then slid down the tube until the spikes (3~ are engaged with the holes (5) in the locking ring as shown in ~ig. 6.
The spikes (3) and the holes (5) in the locking ring (4) are provided with a Qeries of locking mechanisms arranged to retain the spikes within the holes when the locking ring is engaged with the spikes as shown in Fig.
6. This locking mechanism may take any suitable configuration but is typically a series of "click into place n type of mechanism which engages the locking ring at various spacings from the flange to allow for several aortic wall thicknes~es.
The procedure may then be repeated at the other end of the implant to engage the other flange with the coronary artery so effectively and quickly providing a by-pass between the aorta and the coronary artery.
25In the particular application of a heart by-pass operation the flange adapted to be engaged with the coronary artery may be smaller than the flange to be engaged with the aorta to suit the size of the vessel with which it is engaged. A range of different sized and ended devices would be used to cover the range expected in different sized diameters and thickness of aortas and coronary arteries. In situations where there is more than onè blockage in the coronary artery, the tubular surgical implant can be constructed as a manifold with one larger aortic proximal end and se~eral separate coronary distal ends. The tubes may be either parallel sided or tapered (conical) as required for the desired flow rates.
4~ 6 In this manner a surgical implant is provided which enables a coronary by-pass operation to be performed without stopping the heart function or the aorta blood flow to the body and which furthermore does not entail the stripping of veins or arteries from other parts of the body to use as a by-pass conduit.
The implant has application in many other areas presently the province of vascular and microsurgery and may be used wherever it is necessary to join a tube to a vessel or hollow organ or to form a connection between two vessels and/or organs.
,............................................................ .
Claims (10)
1. A tubular surgical implant adapted to be joined to a wall of a vessel or hollow organ such that the implant opens into the interior of the vessel or organ, said implant comprising an open ended tube, a deformable flange at one end of the tube, a plurality of spikes extending from the flange, alongside and generally parallel to the tube, and a locking ring arranged to slide axially on the tube, the locking ring incorporating a plurality of holes aligned with and adapted to receive the spikes.
2. A tubular surgical implant as claimed in claim 1 wherein the locking ring is keyed to the tube, preventing rotation of the ring relative to the tube.
3. A tubular surgical implant as claimed in either claim 1 or claim 2 wherein the spikes and the holes in the locking ring are provided with a locking mechanism arranged to retain the spikes within the holes when the locking ring is engaged with the spikes.
4. A tubular surgical implant as claimed in any one of the preceding claims wherein the flange is deformable relative to the tube such that the flange may be deformed to lie against the tube for insertion into an opening in the wall of the vessel or organ.
5. A tubular surgical implant as claimed in any one of claims 1 to 3 wherein the flange is deformable across one or more hinge lines in the flange, allowing parts of the flange to bend back against the tube for insertion into an opening in the wall of the vessel or organ.
6. A tubular surgical implant as claimed in any one of the preceding claims wherein the implant is adapted to connect two vessels or hollow organs and is provided with a flange and locking ring at both ends of the tube.
7. A tubular surgical implant as claimed in any one of the preceding claims wherein the tube and the flange are made of a plastics mesh which allows for incorporation of human tissue.
8. A method of connecting two vessels or hollow organs by way of a surgical implant, comprising the steps of:
providing a tubular surgical implant adapted to be joined to a wall of a vessel or organ such that the implant opens into the interior of the vessel or organ, said implant comprising an open ended tube, a deformable flange at one end of the tube, a plurality of spikes extending from the flange, alongside and generally parallel to the tube, and a locking ring arranged to slide axially on the tube, the locking ring incorporating a plurality of holes aligned with and adapted to receive the spikes; cutting a hole or slit in the tissue wall of the first vessel or organ, inserting the end of the tube into the hole or slit with the flange deformed, allowing or causing the flange to open behind the tissue wall, engaging the spikes through the tissue wall and sliding the locking ring on the tube until the spikes are engaged with the holes in the locking ring.
providing a tubular surgical implant adapted to be joined to a wall of a vessel or organ such that the implant opens into the interior of the vessel or organ, said implant comprising an open ended tube, a deformable flange at one end of the tube, a plurality of spikes extending from the flange, alongside and generally parallel to the tube, and a locking ring arranged to slide axially on the tube, the locking ring incorporating a plurality of holes aligned with and adapted to receive the spikes; cutting a hole or slit in the tissue wall of the first vessel or organ, inserting the end of the tube into the hole or slit with the flange deformed, allowing or causing the flange to open behind the tissue wall, engaging the spikes through the tissue wall and sliding the locking ring on the tube until the spikes are engaged with the holes in the locking ring.
9. A method as claimed in claim 8 wherein the area of the first vessel or organ surrounding the hole or slit is isolated from the remainder of the first vessel or organ by way of a clamp before making the hole or slit, in a manner allowing fluid to continue to flow through the remainder of the vessel or organ.
10. A method as claimed in either claim 8 or claim 9 wherein the first vessel or organ comprises an aorta and the second vessel or organ comprises a distal coronary artery.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AUPK705791 | 1991-07-04 | ||
AUPK7057 | 1991-07-04 |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2112474A1 true CA2112474A1 (en) | 1993-01-21 |
Family
ID=3775524
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002112474A Abandoned CA2112474A1 (en) | 1991-07-04 | 1992-07-03 | Tubular surgical implant |
Country Status (7)
Country | Link |
---|---|
US (1) | US5456714A (en) |
EP (1) | EP0593600B1 (en) |
JP (1) | JPH07500023A (en) |
AT (1) | ATE175568T1 (en) |
CA (1) | CA2112474A1 (en) |
DE (1) | DE69228184T2 (en) |
WO (1) | WO1993000868A1 (en) |
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-
1992
- 1992-07-03 WO PCT/AU1992/000328 patent/WO1993000868A1/en active IP Right Grant
- 1992-07-03 EP EP92914819A patent/EP0593600B1/en not_active Expired - Lifetime
- 1992-07-03 AT AT92914819T patent/ATE175568T1/en not_active IP Right Cessation
- 1992-07-03 DE DE69228184T patent/DE69228184T2/en not_active Expired - Fee Related
- 1992-07-03 US US08/170,312 patent/US5456714A/en not_active Expired - Fee Related
- 1992-07-03 JP JP5501840A patent/JPH07500023A/en active Pending
- 1992-07-03 CA CA002112474A patent/CA2112474A1/en not_active Abandoned
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WO1993000868A1 (en) | 1993-01-21 |
US5456714A (en) | 1995-10-10 |
EP0593600B1 (en) | 1999-01-13 |
EP0593600A4 (en) | 1995-02-22 |
EP0593600A1 (en) | 1994-04-27 |
DE69228184T2 (en) | 1999-09-16 |
DE69228184D1 (en) | 1999-02-25 |
ATE175568T1 (en) | 1999-01-15 |
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FZDE | Discontinued |