CA2109960A1 - Thromboresistant coating for defoaming applications - Google Patents
Thromboresistant coating for defoaming applicationsInfo
- Publication number
- CA2109960A1 CA2109960A1 CA 2109960 CA2109960A CA2109960A1 CA 2109960 A1 CA2109960 A1 CA 2109960A1 CA 2109960 CA2109960 CA 2109960 CA 2109960 A CA2109960 A CA 2109960A CA 2109960 A1 CA2109960 A1 CA 2109960A1
- Authority
- CA
- Canada
- Prior art keywords
- mixture
- anticoagulant
- heparin
- coating
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
- A61L33/0005—Use of materials characterised by their function or physical properties
- A61L33/0011—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate
Abstract
ABSTRACT
A composition for coating medical blood contacting surfaces comprises a mixture of an anticoagulant and a defoaming agent. The coating composition is applied by either dipping the device into a solution containing the mixture or by spraying the mixture onto the surface.
Alternatively, the surface can be sequentially dip coated and/or sprayed with the individual components. In a preferred embodiment, the anticoagulant is a quaternary ammonium complex of heparin, preferably stearyldimethylbenzyl ammonium heparin, and the antifoaming agent is a mixture of polydimethylsiloxane and silicone dioxide.
A composition for coating medical blood contacting surfaces comprises a mixture of an anticoagulant and a defoaming agent. The coating composition is applied by either dipping the device into a solution containing the mixture or by spraying the mixture onto the surface.
Alternatively, the surface can be sequentially dip coated and/or sprayed with the individual components. In a preferred embodiment, the anticoagulant is a quaternary ammonium complex of heparin, preferably stearyldimethylbenzyl ammonium heparin, and the antifoaming agent is a mixture of polydimethylsiloxane and silicone dioxide.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US70860391A | 1991-05-31 | 1991-05-31 | |
US708,603 | 1991-05-31 | ||
PCT/US1992/004268 WO1992021387A1 (en) | 1991-05-31 | 1992-05-20 | Thromboresistant coating for defoaming applications |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2109960A1 true CA2109960A1 (en) | 1992-12-10 |
CA2109960C CA2109960C (en) | 2000-07-18 |
Family
ID=24846460
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002109960A Expired - Lifetime CA2109960C (en) | 1991-05-31 | 1992-05-20 | Thromboresistant coating for defoaming applications |
Country Status (6)
Country | Link |
---|---|
US (1) | US5541167A (en) |
EP (1) | EP0588895B1 (en) |
JP (1) | JP2858045B2 (en) |
CA (1) | CA2109960C (en) |
DE (1) | DE69201193T2 (en) |
WO (1) | WO1992021387A1 (en) |
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DE69839077T2 (en) | 1997-06-18 | 2009-01-22 | Boston Scientific Ltd., St. Michael | POLYCARBONATE POLYURETHANE DISPERSION AS A DUST-RESISTANT COATING |
US5900270A (en) * | 1997-09-22 | 1999-05-04 | Cobe Laboratories, Inc. | Technique for testing and coating a microporous membrane |
US5945457A (en) * | 1997-10-01 | 1999-08-31 | A.V. Topchiev Institute Of Petrochemical Synthesis, Russian Academy Of Science | Process for preparing biologically compatible polymers and their use in medical devices |
US5955588A (en) * | 1997-12-22 | 1999-09-21 | Innerdyne, Inc. | Non-thrombogenic coating composition and methods for using same |
US6051146A (en) * | 1998-01-20 | 2000-04-18 | Cobe Laboratories, Inc. | Methods for separation of particles |
US6024918A (en) * | 1998-03-13 | 2000-02-15 | Medtronic, Inc. | Method for attachment of biomolecules to surfaces of medical devices |
US6533766B1 (en) * | 1998-07-24 | 2003-03-18 | Therox, Inc. | Coating medical device surfaces for delivering gas-supersaturated fluids |
US6248127B1 (en) | 1998-08-21 | 2001-06-19 | Medtronic Ave, Inc. | Thromboresistant coated medical device |
US6596699B2 (en) | 1998-09-22 | 2003-07-22 | Biosurface Engineering Technologies, Inc. | Nucleic acid coating compositions and methods |
US6342591B1 (en) | 1998-09-22 | 2002-01-29 | Biosurface Engineering Technologies, Inc. | Amphipathic coating for modulating cellular adhesion composition and methods |
BE1012536A3 (en) | 1998-11-04 | 2000-12-05 | Baxter Int | Element with a layer fibrin its preparation and use. |
US6254825B1 (en) | 1999-04-01 | 2001-07-03 | Medtronic, Inc. | Antifoam compositions including lecithin and uses thereof |
GB9928071D0 (en) * | 1999-11-29 | 2000-01-26 | Polybiomed Ltd | Blood compatible medical articles |
US6254921B1 (en) | 1999-12-08 | 2001-07-03 | Surmodics, Inc. | Coating process and apparatus |
US6565544B1 (en) * | 2000-07-12 | 2003-05-20 | Rainin Edgar A | Blood removal device |
US6833153B1 (en) | 2000-10-31 | 2004-12-21 | Advanced Cardiovascular Systems, Inc. | Hemocompatible coatings on hydrophobic porous polymers |
US7807210B1 (en) | 2000-10-31 | 2010-10-05 | Advanced Cardiovascular Systems, Inc. | Hemocompatible polymers on hydrophobic porous polymers |
US6630460B2 (en) * | 2001-02-09 | 2003-10-07 | Medtronic, Inc. | Heparin compositions and methods of making and using the same |
US8101196B2 (en) * | 2001-06-26 | 2012-01-24 | Biointeractions, Ltd. | Polysaccharide biomaterials and methods of use thereof |
US6558409B1 (en) | 2001-09-28 | 2003-05-06 | Tyco Healthcare Group Lp | Plasma treated surgical needles and methods for their manufacture |
US7294357B2 (en) * | 2001-09-28 | 2007-11-13 | Tyco Healthcare Group Lp | Plasma coated sutures |
DE10244657A1 (en) * | 2002-09-24 | 2004-04-01 | Reinemann, Peter, Dr. | Improving flowability of body fluids, e.g. lymph or blood, comprises introduction of defoamer such as polydimethyl siloxane, useful, e.g. in promoting removal of bacterial degradation products |
US7135027B2 (en) * | 2002-10-04 | 2006-11-14 | Baxter International, Inc. | Devices and methods for mixing and extruding medically useful compositions |
US8216045B2 (en) * | 2004-01-27 | 2012-07-10 | Integrated Group Assets Inc. | Method and apparatus for providing a lottery |
US7182625B2 (en) * | 2004-12-03 | 2007-02-27 | Antaya Technologies Corporation | Grounding connector |
US20090036841A1 (en) * | 2007-08-01 | 2009-02-05 | Mckale James M | Coatings for blood and bone marrow-contacting devices |
US8245660B2 (en) * | 2007-09-13 | 2012-08-21 | Oakriver Technology, Inc. | Dip coating apparatus with height adjustable coating tubes and method of coating |
AU2009242369A1 (en) * | 2008-04-30 | 2009-11-05 | Gambro Lundia Ab | Hydrophobic deaeration membrane |
EP2113266A1 (en) | 2008-04-30 | 2009-11-04 | Gambro Lundia AB | Degassing device |
US20100316787A1 (en) * | 2009-06-12 | 2010-12-16 | Greatbatch Ltd. | Biomimetic Coating Method |
JP5688791B2 (en) * | 2010-05-11 | 2015-03-25 | グレイトバッチ リミテッドGreatbatch Ltd. | Surface modification for coating |
US11220582B2 (en) | 2017-03-03 | 2022-01-11 | Harland Medical Systems, Inc. | Coating composition comprised of a hydrophilic crosslinker, a hydrophobic crosslinker and optionally a hydrogel and methods of making and using the same |
US10875048B2 (en) | 2017-09-05 | 2020-12-29 | Harland Medical Systems, Inc | Coating apparatus with an automatic fluid level system, and methods of using the same |
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NL126099C (en) * | 1964-11-02 | 1900-01-01 | ||
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US3453194A (en) * | 1966-08-03 | 1969-07-01 | Dow Corning | Anticoagulant surfaces produced by radiation grafting heparin to a silicone substrate |
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US3846353A (en) * | 1970-06-08 | 1974-11-05 | Department Of Health Education | Nonthrombogenic plastic material and method for making the same |
US3853804A (en) * | 1970-08-14 | 1974-12-10 | California Inst Of Techn | Ionic block elastomeric polymers |
US3755218A (en) * | 1970-08-14 | 1973-08-28 | California Inst Of Techn | Ionically bonded block elastomeric copolymers of a polyquaternary polyurethane and heparin |
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JPS5250399A (en) * | 1975-10-21 | 1977-04-22 | Agency Of Ind Science & Technol | Process for preparing anticoagulating organosilicon polymers |
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US4367749A (en) * | 1979-09-17 | 1983-01-11 | Becton, Dickinson & Company | Nonthrombogenic articles and method of preparation |
JPS57128165A (en) * | 1981-02-03 | 1982-08-09 | Hanako Medical Kk | Silicon coated lead wire containing anti- clotting agent |
US4529614A (en) * | 1981-12-02 | 1985-07-16 | Becton, Dickinson And Company | One step anticoagulant coating |
JPS58185647A (en) * | 1982-03-17 | 1983-10-29 | Nippon Zeon Co Ltd | Stable polymer emulsion composition giving antithrombotic surface and preparation thereof |
US4654327A (en) * | 1982-04-21 | 1987-03-31 | Research Corp. | Quaternary ammonium complexes of heparin |
CA1215676A (en) * | 1983-04-27 | 1986-12-23 | Terry S. Dunn | Heparinization of plasma treated substrates |
US4572724A (en) * | 1984-04-12 | 1986-02-25 | Pall Corporation | Blood filter |
JPS6145765A (en) * | 1984-08-07 | 1986-03-05 | 宇部興産株式会社 | Blood vessel prosthesis and its production |
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IT1213023B (en) * | 1986-01-16 | 1989-12-07 | Rolando Barbucci | MATERIAL ABLE TO ADSORBE STABLY HIGH QUANTITIES OF HEPARIN, AND ITS PREPARATION PROCEDURE. |
DE3682389D1 (en) * | 1986-01-21 | 1991-12-12 | Baxter Int | IONIC HEPARINE COATING. |
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EP0241838B1 (en) * | 1986-04-07 | 1992-04-15 | Agency Of Industrial Science And Technology | Antithrombogenic material |
US4698207A (en) * | 1986-07-14 | 1987-10-06 | Baxter Travenol Laboratories, Inc. | Integrated membrane oxygenator, heat exchanger and reservoir |
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US5061738A (en) * | 1988-04-18 | 1991-10-29 | Becton, Dickinson And Company | Blood compatible, lubricious article and composition and method therefor |
US5013717A (en) * | 1988-04-18 | 1991-05-07 | Becton, Dickinson And Company | Blood compatible, lubricious article and composition and method therefor |
US4865870A (en) * | 1988-07-07 | 1989-09-12 | Becton, Dickinson And Company | Method for rendering a substrate surface antithrombogenic |
JPH0657252B2 (en) * | 1988-08-26 | 1994-08-03 | テルモ株式会社 | Blood reservoir |
US5049403A (en) * | 1989-10-12 | 1991-09-17 | Horsk Hydro A.S. | Process for the preparation of surface modified solid substrates |
-
1992
- 1992-05-20 DE DE69201193T patent/DE69201193T2/en not_active Expired - Lifetime
- 1992-05-20 JP JP5500462A patent/JP2858045B2/en not_active Expired - Fee Related
- 1992-05-20 CA CA002109960A patent/CA2109960C/en not_active Expired - Lifetime
- 1992-05-20 WO PCT/US1992/004268 patent/WO1992021387A1/en active IP Right Grant
- 1992-05-20 EP EP92912416A patent/EP0588895B1/en not_active Expired - Lifetime
-
1994
- 1994-10-28 US US08/331,292 patent/US5541167A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
JP2858045B2 (en) | 1999-02-17 |
EP0588895B1 (en) | 1995-01-11 |
DE69201193D1 (en) | 1995-02-23 |
WO1992021387A1 (en) | 1992-12-10 |
DE69201193T2 (en) | 1995-09-07 |
EP0588895A1 (en) | 1994-03-30 |
JPH06507808A (en) | 1994-09-08 |
US5541167A (en) | 1996-07-30 |
CA2109960C (en) | 2000-07-18 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKEX | Expiry |