CA2079777A1 - Oligonucleotide analogs - Google Patents

Oligonucleotide analogs

Info

Publication number
CA2079777A1
CA2079777A1 CA002079777A CA2079777A CA2079777A1 CA 2079777 A1 CA2079777 A1 CA 2079777A1 CA 002079777 A CA002079777 A CA 002079777A CA 2079777 A CA2079777 A CA 2079777A CA 2079777 A1 CA2079777 A1 CA 2079777A1
Authority
CA
Canada
Prior art keywords
oligonucleotide analogs
replaced
relates
therapeutic potential
phosphodiester linkages
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002079777A
Other languages
French (fr)
Other versions
CA2079777C (en
Inventor
Edward M. Huie
George L. Trainor
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Squibb Pharma Co
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2079777A1 publication Critical patent/CA2079777A1/en
Application granted granted Critical
Publication of CA2079777C publication Critical patent/CA2079777C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals

Abstract

This invention relates to novel oligonucleotide analogs in which one or more of the internucleotide phosphodiester linkages have been replaced by a sulfur based linkage focusing on therapeutic potential.
CA002079777A 1990-04-10 1991-02-25 Oligonucleotide analogs Expired - Lifetime CA2079777C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US07/507,693 US5470967A (en) 1990-04-10 1990-04-10 Oligonucleotide analogs with sulfamate linkages
US07/507,693 1990-04-10
PCT/US1991/001066 WO1991015500A1 (en) 1990-04-10 1991-02-25 Oligonucleotide analogs

Publications (2)

Publication Number Publication Date
CA2079777A1 true CA2079777A1 (en) 1991-10-11
CA2079777C CA2079777C (en) 2002-07-30

Family

ID=24019741

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002079777A Expired - Lifetime CA2079777C (en) 1990-04-10 1991-02-25 Oligonucleotide analogs

Country Status (16)

Country Link
US (1) US5470967A (en)
EP (1) EP0517796B1 (en)
JP (1) JP3050595B2 (en)
AT (1) ATE121416T1 (en)
AU (1) AU639770B2 (en)
CA (1) CA2079777C (en)
DE (1) DE69109100T2 (en)
DK (1) DK0517796T3 (en)
ES (1) ES2071989T3 (en)
HK (1) HK109495A (en)
IE (1) IE73244B1 (en)
IL (1) IL97804A (en)
MY (1) MY107440A (en)
NZ (1) NZ237723A (en)
WO (1) WO1991015500A1 (en)
ZA (1) ZA912660B (en)

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DE69109100T2 (en) 1995-08-31
US5470967A (en) 1995-11-28
JP3050595B2 (en) 2000-06-12
AU7458191A (en) 1991-10-30
EP0517796B1 (en) 1995-04-19
WO1991015500A1 (en) 1991-10-17
MY107440A (en) 1995-12-30
DE69109100D1 (en) 1995-05-24
NZ237723A (en) 1992-04-28
DK0517796T3 (en) 1995-07-03
IL97804A0 (en) 1992-06-21
ZA912660B (en) 1991-12-24

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