CA2075172A1 - Hollow body implants - Google Patents
Hollow body implantsInfo
- Publication number
- CA2075172A1 CA2075172A1 CA002075172A CA2075172A CA2075172A1 CA 2075172 A1 CA2075172 A1 CA 2075172A1 CA 002075172 A CA002075172 A CA 002075172A CA 2075172 A CA2075172 A CA 2075172A CA 2075172 A1 CA2075172 A1 CA 2075172A1
- Authority
- CA
- Canada
- Prior art keywords
- surgical implant
- surgical
- implant according
- region
- core
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
- A61B17/122—Clamps or clips, e.g. for the umbilical cord
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/064—Surgical staples, i.e. penetrating the tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/064—Surgical staples, i.e. penetrating the tissue
- A61B17/0643—Surgical staples, i.e. penetrating the tissue with separate closing member, e.g. for interlocking with staple
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/08—Wound clamps or clips, i.e. not or only partly penetrating the tissue ; Devices for bringing together the edges of a wound
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B2017/00004—(bio)absorbable, (bio)resorbable, resorptive
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B2017/00831—Material properties
- A61B2017/00893—Material properties pharmaceutically effective
Abstract
ABSTRACT The present invention provides a surgical incision or wound closure implant device possessing an interior hollow core region while maintaining the mechanical beam characteristics of the overall structure. In the case of cored biodegradable implant devices the thickness of the cored region can be varied to regulate the speed at which the device is biodegraded. The core region may optionally be filled with a medicinal agent or a stabilizing material.
Description
(1227) HOLLOW BODY IMPLANTS
Backqround of the Invention This invention relates to fastening devices, implants and articles used in surgical procedures.
Surgical fasteners such as staples, clips, clamps, bands, tacks, or other wound or incision closure devices are commonly used in surgical procedures to allow a surgeon to fasten, secure and/or repair body tissue quickly without the need for time consuming suturing. Examples of surgical fasteners are given in U.S. Patent Nos. 4,994,073 or 4,950,284 or 4,934,364, or 4,932,960.
Surgical fasteners are designed to be inserted into and to join tissue or layers of tissue. In so doing, they are adapted to receive a mechanical load or stress without substantial deformation or breakage. The stress may be generated at different points in time and may arise from different stimuli. For example, when the fastener is a two-part device, such as that shown in U.S. Patent No.
4,932,960, a generally U-shaped fastener member i~ ejected from a stapling device, passed through tissue, and lodged into a retainer member. Conse~uently, the backspan of the U-shaped fastener member receives a load when the pusher of the stapling device contacts the bac~span and propels the fastener out of the device. The fastener member also receives loads when its prongs penetrate the tissue, and further, when the prongs contact and mate with the retainer.
In order to function properly, the fastener and retainer should be designed and constructed to withstand operational stress without substantial deformation or breakage. Once in place, the fastener must also withstand the shearing stress :; 35 1 placed upon the tissue, and consequently, on the fastener itself, which is created by the characteristics of tissue interaction in a living creature.
The ability of a fastener to withstand stress is determined by the kind of material, the amount of material, and the shape of the fastener's various structural members.
It is desirable to optimize these variables, generally by providing the greatest strength to mass of material ratio so as to minimize the amount of foreign material in the body.
The structural members of surgical fasteners commonly have a solid circular, ellipsoidal, rectangular or polygonal aspect. The flex and bend strengths of such members are usually more than sufficient to withstand the loads required in surgical applications, e.g., firing the parts into tissue or during the holding period during which healing occurs and tissue strength is increasing.
Surgical fastening devices may be designed with open grooves or channels to guide the fastener component of a two-piece surgical fastening device from the stapler into a retainer component, see, ~or example U.S. Patent No.
4,513,746. The retainer component receives the legs of the fastener component through tubular columns that become substantially completely filled by the legs of the fastener component. Other exteriorly disposed open grooves pertaining to surgical hemostatic clips are disclosed in U~S. Patent Nos. 4,976,722 or 4,702,247. Such exterior grooves are designed to help grab and secure a blood vessel or artery. U.S. Patent No. 3,91~,455 discloses a hollow filament suture designed to receive and secure the shank of a suture needle. The hollow core of the suture is designed to collapse under stress. The collapsable nature of the core ~7~ 72 1 improves knotability through compressibility of the hollow filament under the tension of knotting.
Various materials are used in the manufacture of surgical fasteners and implants. These materials must be biocompatible, i.e., they do not adversely affect the surrounding living environment, and conversely, their performance is not adversely affected by the surrt)unding living environment. The materials may be inert non-absorbable or biodegradable. Inert materials may be fairly indestructible and maintain their form and function for extended periods of time.
Biodegradable materials are intended to break down and dissolve during and after the healing process.
Biodegradation may occur, e.g., by hydrolysis as in the case of certain ester compounds or by enzymatic degradation as in the case of certain proteins. The time it takes for biodegradable fasteners to dissolve depends, inter alla, upon the inherent solubility of the material, the amount of the material present, the density of the material, and the amount of contact with bodily fluids that decompose the material. optimally, a biodegradable fastener maintains its structural integrity in situ long enough for the tissue being fastened to gain sufficient strength to be self-supporting.
In general, a well-designed surgical fastener or implant should minimize the amount of material needed to create optimum structural integrity. Non-efficient use of materials wastes expensive resources and results in implants or fasteners that are heavier than necessary. Creating lighter implants or fasteners is desirable because less stress would be placed on the surrounding tissue system 2 ~ 7 2 than might normally result from fasteners of excess mass.
Moreover, in the case of biodegradable materials, the ability to exert greater control over adjustments in the density and amount of material used would permit greater regulation of the time it takes for the implant or fastener to be dissolved and absorbed into the living system. Indeed, once the fastened tissue is capable of suitable self-support, it is advantageous for the biodegradable material to be dissolved as ~uickly as possible to reduce continuing tissue interaction with the material.
Consequently, the need to optimize the strength to mass ratio of surgical implants and fasteners is clear. The present invention optimizes the mass to strength ratio in the creation of structurally sound surgical implants and fasteners.
OBJECT~ AND E~UMMARY OF THE INVENTION
Accordingly, it is a feature of certain embodiments of the invention to maximize the strength of surgical implants while using a minimum amount of material.
It is another feature of other forms of the invention to provide a light-weight surgical implant.
It is yet another feature of other embodiments of the invention to provide biodegradable surgical implants whose decomposition is regulated to suit particular applications.
A still further feature of another embodiment of the invention is to provide a focal drug delivery device.
Yet another feature of a further embodiment of the invention is to provide a stable surgical implant.
Other features and advantages of this invention will become apparent from the following summary and detailed description of the invention.
A surgical implant according to the present invention possesses a core occupying an interior region of the 2~7~2 device. The cored implant maintains its form and function due to the ability of the structural members surrounding the cored region to function with the mechanical characteristics of a beam. The implant may be formed into a surgical connector, clip, clamp, band or other fastener device that can function to close incisions or wounds or may otherwise be made to contact and exert or receive pressure or stress within a living system.
The cored region of the implant may be continuous or it may be divided into sections throughout the implant. In certain cases the core may extend through the implant and end as an aperture on the implant. The implant may be made from an inert non-absorbable material or from a biodegradable material. The ~ore region of the implant may optionally be filled with a stabilizing material or with a medicinal agent.
A further feature of another embodiment of the present invention is to provide a surgical implant device comprising structural members having one or more hollow compartments disposed therein, the structural members being adapted to receive and support a mechanical load in use.
A still further feature of another embodiment of the invention is to provide a method of controlling the rate of decomposition of a hiodegradable surgical implant comprising:
forming a hollow core region within the implant and contacting the implant with a suitable degradation medium.
~RIEF DE~CRIP~I5N OF T~E DRA~ING~
FIG. 1 is a perspective view of an implant device in the nature of a surgical fastener in accordance with the present inven-tion, further depicting a cored region in phantom.
FIG. 2 is a perspective view of an implant device in the nature of a surgical fastener in accordance with the -6- 1 2~73 ~ 72 1 present invention, further depicting a crenelated cored regi~n in phantom.
FIG. 3 is a perspective vi~w of an implant device in the nature of a surgical fastener in accordance with the present invention further depicting a crenelated cored region in phantom wherein apertures leading to the cored region are covered by plugs.
FIG. 4 is a perspective view of an implant device in the nature of a surgical clip in accordance with the present invention wherein the cored region ends as apertures.
FIG. 5 is a top view of an implant device in the nature of a surgical clip in accordance with the present invention wherein the cored region is shown in phantom and the cored region is sealed at both ends of the clip.
FIGS. 6A - 6H are cross sectional views illustrating various core configurations in accordance with the invention.
FIG. 7 is a perspective view of an implant device in accordance with the invention, illustrating a core of cylindrical cr~ss-section located in an ellipsoidally configured surgical s$aple.
FIG. 8 is a partial cut-away perspective view of an implant device in accordance with the invention, illustrating a core of rectangular cross-section located in a rectangularly configured surgical staple.
FIG~ 8A is a cross sectional plan view of the surgical staple illustrated in ~IG. 8~
- FIG. 9 is a perspective view of an implant device in the nature of a surgical c~ip in accordance with the .
( 2 ~ 2 1 invention, further illustrating, in phantom, a multiplicity of cored regions separated by solid regions.
FIG. 10 is a perspective view of an implant device in the nature of a surgical fastener in accordance with the present invention further depicting a plurality of crenelated cored regions in phantom.
FIG. 11 is a perspective view of an implant device in the nature of a surgical fastener in accordance with the present invention further depicting a plurality of crenelated cored regions in phantom wherein apertures leading to the cored regions are covered by plugs.
D~TAILED DESCRIPTION OF THE INVEN~ION
The implant device illustrated in FIG. 1 is a surgical fastener 10 constructed in accordance with the present invention. A U-shaped fastener member 1 has two prongs 3 attached to one another via a backspan 5. The prongs 3 have barbs 7 at their ends which mate and engage a retainer member 9. A novel core 11 runs the entire length Of the fastener member 1 and the beam-like characteristics of the overall structure are maintained. As used herein, the "core" or "cored region" is an interiorly disposed hollow section which may be completely enclosed, or open at one or more locations on the surface of the implant. As such, the fastener member 1 is capable of carrying concentrated as well as evenly distributed load forces. The load forces normally act transverse to the longitudinal axis of the core. At any point along the fastener member 1 the shear force and bending moment acting on the beam cross section is used to balance the external loads on either side of the cross section.
2~7~3~72 1 When a load is applied to the fastener, such as when the fastener member 1 is propelled from a stapler into tissue, a pusher from the stapler contacts the backspan 5 and forces the fastener member l out of the stapler. The stress from the contact is generally evenly distributed over the backspan 5 and the rest of the fastener member 1.
Notwithstanding the cored region, the fastener me~er 1 acts in a manner mechanically s~milar to, or better than, the backspan of a fastener not possessing a cored region.
When the fastener member l pierces the tissue to be fastened, the barbs 7 initially receive most of the force of entry and transmit the force and consequent stress to the rest of the fastener member 1. As above, the fastener member 1 and its core region ll have the mechanical characteristics of a beam and concentrated forces are distributed over the fastener member 1. External forces to which the fastener member 1 is subjected are balanced over the cross section of the beam and the cored fastener member l performs in a manner mechanically similar to, or better than, fasteners not possessing such a core.
The retainer member 9 has two tubular columns 13 which are adapted to receive and engage the barbs 7 and a portion of prongs 3 of the fastener member 1. The columns 13 are connected ~ia a bridge 15 containing a hollow cored region 11'. The retainer 9 functions in much the same mechanical manner as a retainer that does not have the cored region 11'. The hollow cored regions ll and 11' facilitate construction of a structurally sound implant device with less material than a similar solid device. In mass production, the present invention allows a substantial economic savings with consequent conservation of resources 9 ~7~
1 and reduces the amount of foreign material introduced to the body. Moreover, the hollow nature of the core region permits instillation of various substances which are capable of performing diverse functions.
In one embodiment, the hollow cored region is filled with a medicament or medicinal agent, generally in a pharmaceutically acceptable vehicle. For convenience, the hollow cored region is described as containing a medicinal, but the term "medicinal" is used in its broadest sense and includes any substance or mixture of substances which may have any clinical use. Thus, it is understood that the hollow core may contain a drug, enzyme, peptide or diagnostic agent such as a releasable dye which may have no biological activity per se. Instillation of a medicinal into a surgical wound or incision closure device permits focal application of drug therapy once the device is in place. Focal application can be more desirable than general systemic application in some cases, e.g., chemotherapy for localized tumors, because it produces fewer side effects in distant tissues or organs and also concentrates therapy at intended sites. Focal application of growth factors by a wound or incision closure device is an ideal drug delivery system to speed healing of the wound or incision.
The material which makes up the implant may be porous, and depending on the size of the pores, will allow the medicinal to diffuse out of the cored region at a controlled rate. Methods by which the number and size of pores disposed within polymeric materials may be controlled are well-known to those with skill in the art. When the core is filled with a medicinal, e.g., in a pharmaceutically acceptable fluid vehicle, and the device is placed in 7 ~
1 tissue, the medicinal penetrates the walls of the device and diffuses into the surrounding environment. The rate of diffusion is determined by the size and number of the pores and is governed by first order kinetics, i.e., the rate of diffusion is directly proportional to the concentration of medicinal. In another embodiment, osmotically active particles are placed in the cored region along with the medicinal and its fluid vehicle. When placed in an agueous medium, the osmotically active particles imbibe or absorb water and expand, thereby pressing the medicinal out from the cored region and into the surrounding environment. The rate of diffusion in this case is relatively constant, i.e., governed by zero order kinetics.
In addition to delivery or a medicinal by diffusion through pores disposed in the walls of the implant device, delivery can also be effected when the biodegradable material surrounding the core degrades and disappears. When a biodegradable wall or a portion thereof is degraded, perforations in the wall are formed which allow the medicinal contained in the core to diffuse or leak from the perforations. This characteristic of the invention can be used to great advantage, i.e., the thickness of the walls can be varied to ultimately control the rate of release of the medicinal. ~IG. 2 illustrates a biodegradable U-shaped surgical fastener 20 having a crenelated core region 21 substantially extending through the entire length of the fastener 20. The wall 23 surrounding the core 21 is crenelated to provide relatively thin portions 25 that, when contacted with bodily tissue, degrade faster than the other thicker parts of the fastener 20. The medicinal is delivered to target areas when the thin portions 25 degrade .
1 and perforations are formed which act as conduits for the medicinal. The thin portions 25 are provided toward the interior radius of the fastener 25 to "point" the conduits and, consequently, the medicinal toward the tissue being fastened and treated. It should be understood that conduits can be provided to "point'l in any desired direction. As above, the core region 21 within the fastener 20 helps maintain the fastener's beam-like attributes.
Referring now to ~IG. 3, and in another aspect of th~ invention, a surgical fastener 30 made of inert material is fitted with biodegradable plugs 31 that fit into corresponding apertures 33 in the wall 35 of the fastener 30. As above, a hollow crenelated core 37 is filled with a medicinal. When the fastener 30 is applied to bodily tissue, the plugs 31 degrade and eventually disappear and the medicinal diffuses or leaks from the fastener 30 to the target area.
When the implant is constructed of a relatively inert matexial such as titanium, titanium alloy, chromium-cobalt-molybdenum alloy, stainless steel, polypropylene, or other polymers, the vehicle used for the medicinal can be aqueous. If the material used is a biodegradable or bioresorbable material, such as polyglyolic acid, polylactic ; acid, copolymer blends of polyglycolic acid and polylactic acid, caprolactone, reconstituted collagen, pol~mers of p-dioxanone, polyesters, polyamino acids such as casein, albumen and the like, polyhydric alcohol polymers such as polyvinyl alcohol, trimethylene carbonate and others, a suitable medicinal and medicinial vehicle would optimally have little or no effect on the integrity of the device, `` , 2 ~
1 i.e., the medicinal and/or the vehicle would not degrade the device.
` ~xamples of classes of medicinals that can be used in accordance with the present invention are antimicrobials, analgesics, antipyretics, anesthetics, antiepileptics, antihistamines, anti-inflammatories, cardiovascular drugs, diagnostic agents, sympathomimetics, cholinomimeti~s, anti-muscarinics, antispasmodics, hormones, growth factors, muscle relaxants, adrenergic neuron blockers, anti-neoplastics, immunosuppressants, gastrointestinal drugs,diuretics, steroids and enzymes. It is also intended that combinations of medicinals can be used in accordance with the present invention.
The cored region of a biodegradable implant can also be filled with a stabilizing material such as glycerol, calcium lactate in glycerol, or certain cellulose derivatives. Stabilizing fluids are useful in prolonging the storage capability of biodegradable implants.
A further advantage of biodegradable cored implants according to the present invention is that they have less mass then similarly sized solid implants but have approximately the same or better capacity to bear a m~chanical load~ Consequently, the implant device can hold together any tissue that an equivalent solid device would, but can be degraded at a much faster rate because of l) the increased surface area available for contact with biodegrading fluids and 2) the smaller amount material that needs to be biodegraded. Thus, a device in accordance with the present in~ention can be designed to remain in contact with the tissue for a shorter period of time than a solid implant and is thus less likely to cause contact related 3~
-13- ( 2~
1 tissue reaction. The thickness of the walls surrounding the cored region can be varied to regulate the speed at which decomposition occurs, i.e., the thicker the wall, the longer to decompose.
Referring now to FIG. 4, a U-shaped surgical clip 40 according to the instant invention is illustrated.
Ordinarily, during a surgical procedure~ the clip 40 is formed around a vein, artery or duct so that legs of the clip 40 assume a substantially parallel orientation and fluid flow in the vein, artery or duct is cut off. A
hollow core 41 extends continuously throughout the clip 40 and can remain open at the ends as in FIG. 4.
Alternatively, the ends can be sealed, as is shown in FIG.
5. In FIG. 5, the core 41' is shown as phantom lines. In either case, the core region within the clip provides the basis for beam-like attributes. As above, the core region can be filled with a medicinal o~ a stabilizing agent to similar advantage.
In general, the core region can have a variety of shapes independent of the shape of the implant device itself. The core can have a circular cross section within a rectangular shaped device member as shown in FIG. 6A or the core can have a rectangular cross section within a rectangular shaped device member as shown in FIG. 6B. FIGS.
6C-6H are other illustrative examples of various cross-sectional embodiments according to the present invention.
This invention applies to cored implants generally and it is contemplated that any shaped core may be located in any surgical fastening device and still be within the scope of the appended claims.
3~
-14- ~ ~ 7 ~
1 The present invention is also applicable to surgical staples, examples of which are illustrated in FIGS.
7 and 8. In FIG. 7, a surgical staple 50 is generally U-shaped and has an elliptical cross-section. The core region 31 has a circular cross-section and extends the entire length of the staple 50. It is noted that any shape core (see, e.g., ~IGS. 6A- 6H) would be suitable 21S long as the desired strength is imparted to the overall device. The staple 50' may also have a rectangular aspect as is shown in ~IG. 8. Also shown is a rectangular core 51'. FIG. 8A
depicts the staple 50' in cross-sectionf further depicting the rectangular core 51' stretching nearly the entire length of the staple 50'. Staples constructed in accordance with the instant invention have approximately the same or better mechanical load bearing characteristics than staples withol~t a core region. The core region, 51 or 51' may be open or sealed at the ends.
In some instances, it may be desirable to provide a series of discontinuous core regions within an implant device- An example of such a device is shown in FIG. 9. A
generally U-shaped surgical clip 60 has arms 61 extending outwardly from a crown 63. The apex 65 of the crown 63 is a juncture at which the clip 60 is bent. The core regions 67 of the arm of the clip 60 ~re separated from the core re~ions 69 of the crown by solid sections 71 which are located at bending points. The apex 65 region is a solid section separating the core regions 69 of the crown ~3. The solid sections may be used to impart increased resilience or resistance at strategic junctures. In other cases, the solid regions may be positioned at various places along the arms 67 of crown 63. In any event, the solid regions may be -15~
1 placed in strategic positions between the cored regions of any implant device in a~cordance with the present invention.
The existence of multiple core regions or compartments is useful in certain aspects of the invention relating to delivery of medicinals. The biodegradable U-shaped surgical fastener 80 illustrated in FIG. 10 is composed of three separate hollow core regions or compartments 83, 83a and 83b. Each compartment can bP
filled with a different medicinal agent or combination of medicinal agents. In this manner, medicinals that may be incompatible with each other are kept separate but are still delivered to target sites. Incompatibility may result from, e.g., different solubilities of different medicinals in a vehicle or inactivity of the medicinals due to complex formation, etc. The compartments can be constructed to release their contents at different points in time. Thus, compartment 83 is not crenelated and will take longer to release medicinals than crenelated compartments 83a and 83b.
Similarly, in FIG. 11, an inert or biodegradable U-shaped fastener 90 is composed of two separate compartments 91 and 93 which can be used to separate incompatible medicinals. Biodegradable plugs 95 fit into corresponding holes 97 in the compartments 91 and 93 to prevent any medicinal contained therein from diffusing or leaking out until the fastener 90 is contacted with bodily tissues. When the plugs 95 degrade, the medicinal diffuses or leaks out to the target site. The speed of release of medicinal from compartment 91 can be regulated relative to compartment 93 by varying the thickness of the plugs 95.
For example, if the plugs 95 sealing compartment 93 are made thicker than those sealing compartment 91, they will take 2 ~ . 7 ~
1 longer to degrade and, consequently, the medicinal will be released from compartment 91 first. Alternatively, the plugs 95 can be made of different biodegradable materials which have different rates of decomposition. In this way, plugs having slower rates of decomposition than other plugs maintain a sealed compartment longer than the other plugs covering other compartments, thus causing different rates of medicament delivery and permitting sequential medicament release.
The principles, preferred embodiments and modes of operation of the invention have been described in the foregoing specification. The invention which is intended to be protected herein, however, is not to be construed as limited to the particular forms disclosed, since they are to be regarded as illustrative rather than restrictive.
Variations and changes may be made by those skilled in this art without departing from the spirit of the present invention.
Backqround of the Invention This invention relates to fastening devices, implants and articles used in surgical procedures.
Surgical fasteners such as staples, clips, clamps, bands, tacks, or other wound or incision closure devices are commonly used in surgical procedures to allow a surgeon to fasten, secure and/or repair body tissue quickly without the need for time consuming suturing. Examples of surgical fasteners are given in U.S. Patent Nos. 4,994,073 or 4,950,284 or 4,934,364, or 4,932,960.
Surgical fasteners are designed to be inserted into and to join tissue or layers of tissue. In so doing, they are adapted to receive a mechanical load or stress without substantial deformation or breakage. The stress may be generated at different points in time and may arise from different stimuli. For example, when the fastener is a two-part device, such as that shown in U.S. Patent No.
4,932,960, a generally U-shaped fastener member i~ ejected from a stapling device, passed through tissue, and lodged into a retainer member. Conse~uently, the backspan of the U-shaped fastener member receives a load when the pusher of the stapling device contacts the bac~span and propels the fastener out of the device. The fastener member also receives loads when its prongs penetrate the tissue, and further, when the prongs contact and mate with the retainer.
In order to function properly, the fastener and retainer should be designed and constructed to withstand operational stress without substantial deformation or breakage. Once in place, the fastener must also withstand the shearing stress :; 35 1 placed upon the tissue, and consequently, on the fastener itself, which is created by the characteristics of tissue interaction in a living creature.
The ability of a fastener to withstand stress is determined by the kind of material, the amount of material, and the shape of the fastener's various structural members.
It is desirable to optimize these variables, generally by providing the greatest strength to mass of material ratio so as to minimize the amount of foreign material in the body.
The structural members of surgical fasteners commonly have a solid circular, ellipsoidal, rectangular or polygonal aspect. The flex and bend strengths of such members are usually more than sufficient to withstand the loads required in surgical applications, e.g., firing the parts into tissue or during the holding period during which healing occurs and tissue strength is increasing.
Surgical fastening devices may be designed with open grooves or channels to guide the fastener component of a two-piece surgical fastening device from the stapler into a retainer component, see, ~or example U.S. Patent No.
4,513,746. The retainer component receives the legs of the fastener component through tubular columns that become substantially completely filled by the legs of the fastener component. Other exteriorly disposed open grooves pertaining to surgical hemostatic clips are disclosed in U~S. Patent Nos. 4,976,722 or 4,702,247. Such exterior grooves are designed to help grab and secure a blood vessel or artery. U.S. Patent No. 3,91~,455 discloses a hollow filament suture designed to receive and secure the shank of a suture needle. The hollow core of the suture is designed to collapse under stress. The collapsable nature of the core ~7~ 72 1 improves knotability through compressibility of the hollow filament under the tension of knotting.
Various materials are used in the manufacture of surgical fasteners and implants. These materials must be biocompatible, i.e., they do not adversely affect the surrounding living environment, and conversely, their performance is not adversely affected by the surrt)unding living environment. The materials may be inert non-absorbable or biodegradable. Inert materials may be fairly indestructible and maintain their form and function for extended periods of time.
Biodegradable materials are intended to break down and dissolve during and after the healing process.
Biodegradation may occur, e.g., by hydrolysis as in the case of certain ester compounds or by enzymatic degradation as in the case of certain proteins. The time it takes for biodegradable fasteners to dissolve depends, inter alla, upon the inherent solubility of the material, the amount of the material present, the density of the material, and the amount of contact with bodily fluids that decompose the material. optimally, a biodegradable fastener maintains its structural integrity in situ long enough for the tissue being fastened to gain sufficient strength to be self-supporting.
In general, a well-designed surgical fastener or implant should minimize the amount of material needed to create optimum structural integrity. Non-efficient use of materials wastes expensive resources and results in implants or fasteners that are heavier than necessary. Creating lighter implants or fasteners is desirable because less stress would be placed on the surrounding tissue system 2 ~ 7 2 than might normally result from fasteners of excess mass.
Moreover, in the case of biodegradable materials, the ability to exert greater control over adjustments in the density and amount of material used would permit greater regulation of the time it takes for the implant or fastener to be dissolved and absorbed into the living system. Indeed, once the fastened tissue is capable of suitable self-support, it is advantageous for the biodegradable material to be dissolved as ~uickly as possible to reduce continuing tissue interaction with the material.
Consequently, the need to optimize the strength to mass ratio of surgical implants and fasteners is clear. The present invention optimizes the mass to strength ratio in the creation of structurally sound surgical implants and fasteners.
OBJECT~ AND E~UMMARY OF THE INVENTION
Accordingly, it is a feature of certain embodiments of the invention to maximize the strength of surgical implants while using a minimum amount of material.
It is another feature of other forms of the invention to provide a light-weight surgical implant.
It is yet another feature of other embodiments of the invention to provide biodegradable surgical implants whose decomposition is regulated to suit particular applications.
A still further feature of another embodiment of the invention is to provide a focal drug delivery device.
Yet another feature of a further embodiment of the invention is to provide a stable surgical implant.
Other features and advantages of this invention will become apparent from the following summary and detailed description of the invention.
A surgical implant according to the present invention possesses a core occupying an interior region of the 2~7~2 device. The cored implant maintains its form and function due to the ability of the structural members surrounding the cored region to function with the mechanical characteristics of a beam. The implant may be formed into a surgical connector, clip, clamp, band or other fastener device that can function to close incisions or wounds or may otherwise be made to contact and exert or receive pressure or stress within a living system.
The cored region of the implant may be continuous or it may be divided into sections throughout the implant. In certain cases the core may extend through the implant and end as an aperture on the implant. The implant may be made from an inert non-absorbable material or from a biodegradable material. The ~ore region of the implant may optionally be filled with a stabilizing material or with a medicinal agent.
A further feature of another embodiment of the present invention is to provide a surgical implant device comprising structural members having one or more hollow compartments disposed therein, the structural members being adapted to receive and support a mechanical load in use.
A still further feature of another embodiment of the invention is to provide a method of controlling the rate of decomposition of a hiodegradable surgical implant comprising:
forming a hollow core region within the implant and contacting the implant with a suitable degradation medium.
~RIEF DE~CRIP~I5N OF T~E DRA~ING~
FIG. 1 is a perspective view of an implant device in the nature of a surgical fastener in accordance with the present inven-tion, further depicting a cored region in phantom.
FIG. 2 is a perspective view of an implant device in the nature of a surgical fastener in accordance with the -6- 1 2~73 ~ 72 1 present invention, further depicting a crenelated cored regi~n in phantom.
FIG. 3 is a perspective vi~w of an implant device in the nature of a surgical fastener in accordance with the present invention further depicting a crenelated cored region in phantom wherein apertures leading to the cored region are covered by plugs.
FIG. 4 is a perspective view of an implant device in the nature of a surgical clip in accordance with the present invention wherein the cored region ends as apertures.
FIG. 5 is a top view of an implant device in the nature of a surgical clip in accordance with the present invention wherein the cored region is shown in phantom and the cored region is sealed at both ends of the clip.
FIGS. 6A - 6H are cross sectional views illustrating various core configurations in accordance with the invention.
FIG. 7 is a perspective view of an implant device in accordance with the invention, illustrating a core of cylindrical cr~ss-section located in an ellipsoidally configured surgical s$aple.
FIG. 8 is a partial cut-away perspective view of an implant device in accordance with the invention, illustrating a core of rectangular cross-section located in a rectangularly configured surgical staple.
FIG~ 8A is a cross sectional plan view of the surgical staple illustrated in ~IG. 8~
- FIG. 9 is a perspective view of an implant device in the nature of a surgical c~ip in accordance with the .
( 2 ~ 2 1 invention, further illustrating, in phantom, a multiplicity of cored regions separated by solid regions.
FIG. 10 is a perspective view of an implant device in the nature of a surgical fastener in accordance with the present invention further depicting a plurality of crenelated cored regions in phantom.
FIG. 11 is a perspective view of an implant device in the nature of a surgical fastener in accordance with the present invention further depicting a plurality of crenelated cored regions in phantom wherein apertures leading to the cored regions are covered by plugs.
D~TAILED DESCRIPTION OF THE INVEN~ION
The implant device illustrated in FIG. 1 is a surgical fastener 10 constructed in accordance with the present invention. A U-shaped fastener member 1 has two prongs 3 attached to one another via a backspan 5. The prongs 3 have barbs 7 at their ends which mate and engage a retainer member 9. A novel core 11 runs the entire length Of the fastener member 1 and the beam-like characteristics of the overall structure are maintained. As used herein, the "core" or "cored region" is an interiorly disposed hollow section which may be completely enclosed, or open at one or more locations on the surface of the implant. As such, the fastener member 1 is capable of carrying concentrated as well as evenly distributed load forces. The load forces normally act transverse to the longitudinal axis of the core. At any point along the fastener member 1 the shear force and bending moment acting on the beam cross section is used to balance the external loads on either side of the cross section.
2~7~3~72 1 When a load is applied to the fastener, such as when the fastener member 1 is propelled from a stapler into tissue, a pusher from the stapler contacts the backspan 5 and forces the fastener member l out of the stapler. The stress from the contact is generally evenly distributed over the backspan 5 and the rest of the fastener member 1.
Notwithstanding the cored region, the fastener me~er 1 acts in a manner mechanically s~milar to, or better than, the backspan of a fastener not possessing a cored region.
When the fastener member l pierces the tissue to be fastened, the barbs 7 initially receive most of the force of entry and transmit the force and consequent stress to the rest of the fastener member 1. As above, the fastener member 1 and its core region ll have the mechanical characteristics of a beam and concentrated forces are distributed over the fastener member 1. External forces to which the fastener member 1 is subjected are balanced over the cross section of the beam and the cored fastener member l performs in a manner mechanically similar to, or better than, fasteners not possessing such a core.
The retainer member 9 has two tubular columns 13 which are adapted to receive and engage the barbs 7 and a portion of prongs 3 of the fastener member 1. The columns 13 are connected ~ia a bridge 15 containing a hollow cored region 11'. The retainer 9 functions in much the same mechanical manner as a retainer that does not have the cored region 11'. The hollow cored regions ll and 11' facilitate construction of a structurally sound implant device with less material than a similar solid device. In mass production, the present invention allows a substantial economic savings with consequent conservation of resources 9 ~7~
1 and reduces the amount of foreign material introduced to the body. Moreover, the hollow nature of the core region permits instillation of various substances which are capable of performing diverse functions.
In one embodiment, the hollow cored region is filled with a medicament or medicinal agent, generally in a pharmaceutically acceptable vehicle. For convenience, the hollow cored region is described as containing a medicinal, but the term "medicinal" is used in its broadest sense and includes any substance or mixture of substances which may have any clinical use. Thus, it is understood that the hollow core may contain a drug, enzyme, peptide or diagnostic agent such as a releasable dye which may have no biological activity per se. Instillation of a medicinal into a surgical wound or incision closure device permits focal application of drug therapy once the device is in place. Focal application can be more desirable than general systemic application in some cases, e.g., chemotherapy for localized tumors, because it produces fewer side effects in distant tissues or organs and also concentrates therapy at intended sites. Focal application of growth factors by a wound or incision closure device is an ideal drug delivery system to speed healing of the wound or incision.
The material which makes up the implant may be porous, and depending on the size of the pores, will allow the medicinal to diffuse out of the cored region at a controlled rate. Methods by which the number and size of pores disposed within polymeric materials may be controlled are well-known to those with skill in the art. When the core is filled with a medicinal, e.g., in a pharmaceutically acceptable fluid vehicle, and the device is placed in 7 ~
1 tissue, the medicinal penetrates the walls of the device and diffuses into the surrounding environment. The rate of diffusion is determined by the size and number of the pores and is governed by first order kinetics, i.e., the rate of diffusion is directly proportional to the concentration of medicinal. In another embodiment, osmotically active particles are placed in the cored region along with the medicinal and its fluid vehicle. When placed in an agueous medium, the osmotically active particles imbibe or absorb water and expand, thereby pressing the medicinal out from the cored region and into the surrounding environment. The rate of diffusion in this case is relatively constant, i.e., governed by zero order kinetics.
In addition to delivery or a medicinal by diffusion through pores disposed in the walls of the implant device, delivery can also be effected when the biodegradable material surrounding the core degrades and disappears. When a biodegradable wall or a portion thereof is degraded, perforations in the wall are formed which allow the medicinal contained in the core to diffuse or leak from the perforations. This characteristic of the invention can be used to great advantage, i.e., the thickness of the walls can be varied to ultimately control the rate of release of the medicinal. ~IG. 2 illustrates a biodegradable U-shaped surgical fastener 20 having a crenelated core region 21 substantially extending through the entire length of the fastener 20. The wall 23 surrounding the core 21 is crenelated to provide relatively thin portions 25 that, when contacted with bodily tissue, degrade faster than the other thicker parts of the fastener 20. The medicinal is delivered to target areas when the thin portions 25 degrade .
1 and perforations are formed which act as conduits for the medicinal. The thin portions 25 are provided toward the interior radius of the fastener 25 to "point" the conduits and, consequently, the medicinal toward the tissue being fastened and treated. It should be understood that conduits can be provided to "point'l in any desired direction. As above, the core region 21 within the fastener 20 helps maintain the fastener's beam-like attributes.
Referring now to ~IG. 3, and in another aspect of th~ invention, a surgical fastener 30 made of inert material is fitted with biodegradable plugs 31 that fit into corresponding apertures 33 in the wall 35 of the fastener 30. As above, a hollow crenelated core 37 is filled with a medicinal. When the fastener 30 is applied to bodily tissue, the plugs 31 degrade and eventually disappear and the medicinal diffuses or leaks from the fastener 30 to the target area.
When the implant is constructed of a relatively inert matexial such as titanium, titanium alloy, chromium-cobalt-molybdenum alloy, stainless steel, polypropylene, or other polymers, the vehicle used for the medicinal can be aqueous. If the material used is a biodegradable or bioresorbable material, such as polyglyolic acid, polylactic ; acid, copolymer blends of polyglycolic acid and polylactic acid, caprolactone, reconstituted collagen, pol~mers of p-dioxanone, polyesters, polyamino acids such as casein, albumen and the like, polyhydric alcohol polymers such as polyvinyl alcohol, trimethylene carbonate and others, a suitable medicinal and medicinial vehicle would optimally have little or no effect on the integrity of the device, `` , 2 ~
1 i.e., the medicinal and/or the vehicle would not degrade the device.
` ~xamples of classes of medicinals that can be used in accordance with the present invention are antimicrobials, analgesics, antipyretics, anesthetics, antiepileptics, antihistamines, anti-inflammatories, cardiovascular drugs, diagnostic agents, sympathomimetics, cholinomimeti~s, anti-muscarinics, antispasmodics, hormones, growth factors, muscle relaxants, adrenergic neuron blockers, anti-neoplastics, immunosuppressants, gastrointestinal drugs,diuretics, steroids and enzymes. It is also intended that combinations of medicinals can be used in accordance with the present invention.
The cored region of a biodegradable implant can also be filled with a stabilizing material such as glycerol, calcium lactate in glycerol, or certain cellulose derivatives. Stabilizing fluids are useful in prolonging the storage capability of biodegradable implants.
A further advantage of biodegradable cored implants according to the present invention is that they have less mass then similarly sized solid implants but have approximately the same or better capacity to bear a m~chanical load~ Consequently, the implant device can hold together any tissue that an equivalent solid device would, but can be degraded at a much faster rate because of l) the increased surface area available for contact with biodegrading fluids and 2) the smaller amount material that needs to be biodegraded. Thus, a device in accordance with the present in~ention can be designed to remain in contact with the tissue for a shorter period of time than a solid implant and is thus less likely to cause contact related 3~
-13- ( 2~
1 tissue reaction. The thickness of the walls surrounding the cored region can be varied to regulate the speed at which decomposition occurs, i.e., the thicker the wall, the longer to decompose.
Referring now to FIG. 4, a U-shaped surgical clip 40 according to the instant invention is illustrated.
Ordinarily, during a surgical procedure~ the clip 40 is formed around a vein, artery or duct so that legs of the clip 40 assume a substantially parallel orientation and fluid flow in the vein, artery or duct is cut off. A
hollow core 41 extends continuously throughout the clip 40 and can remain open at the ends as in FIG. 4.
Alternatively, the ends can be sealed, as is shown in FIG.
5. In FIG. 5, the core 41' is shown as phantom lines. In either case, the core region within the clip provides the basis for beam-like attributes. As above, the core region can be filled with a medicinal o~ a stabilizing agent to similar advantage.
In general, the core region can have a variety of shapes independent of the shape of the implant device itself. The core can have a circular cross section within a rectangular shaped device member as shown in FIG. 6A or the core can have a rectangular cross section within a rectangular shaped device member as shown in FIG. 6B. FIGS.
6C-6H are other illustrative examples of various cross-sectional embodiments according to the present invention.
This invention applies to cored implants generally and it is contemplated that any shaped core may be located in any surgical fastening device and still be within the scope of the appended claims.
3~
-14- ~ ~ 7 ~
1 The present invention is also applicable to surgical staples, examples of which are illustrated in FIGS.
7 and 8. In FIG. 7, a surgical staple 50 is generally U-shaped and has an elliptical cross-section. The core region 31 has a circular cross-section and extends the entire length of the staple 50. It is noted that any shape core (see, e.g., ~IGS. 6A- 6H) would be suitable 21S long as the desired strength is imparted to the overall device. The staple 50' may also have a rectangular aspect as is shown in ~IG. 8. Also shown is a rectangular core 51'. FIG. 8A
depicts the staple 50' in cross-sectionf further depicting the rectangular core 51' stretching nearly the entire length of the staple 50'. Staples constructed in accordance with the instant invention have approximately the same or better mechanical load bearing characteristics than staples withol~t a core region. The core region, 51 or 51' may be open or sealed at the ends.
In some instances, it may be desirable to provide a series of discontinuous core regions within an implant device- An example of such a device is shown in FIG. 9. A
generally U-shaped surgical clip 60 has arms 61 extending outwardly from a crown 63. The apex 65 of the crown 63 is a juncture at which the clip 60 is bent. The core regions 67 of the arm of the clip 60 ~re separated from the core re~ions 69 of the crown by solid sections 71 which are located at bending points. The apex 65 region is a solid section separating the core regions 69 of the crown ~3. The solid sections may be used to impart increased resilience or resistance at strategic junctures. In other cases, the solid regions may be positioned at various places along the arms 67 of crown 63. In any event, the solid regions may be -15~
1 placed in strategic positions between the cored regions of any implant device in a~cordance with the present invention.
The existence of multiple core regions or compartments is useful in certain aspects of the invention relating to delivery of medicinals. The biodegradable U-shaped surgical fastener 80 illustrated in FIG. 10 is composed of three separate hollow core regions or compartments 83, 83a and 83b. Each compartment can bP
filled with a different medicinal agent or combination of medicinal agents. In this manner, medicinals that may be incompatible with each other are kept separate but are still delivered to target sites. Incompatibility may result from, e.g., different solubilities of different medicinals in a vehicle or inactivity of the medicinals due to complex formation, etc. The compartments can be constructed to release their contents at different points in time. Thus, compartment 83 is not crenelated and will take longer to release medicinals than crenelated compartments 83a and 83b.
Similarly, in FIG. 11, an inert or biodegradable U-shaped fastener 90 is composed of two separate compartments 91 and 93 which can be used to separate incompatible medicinals. Biodegradable plugs 95 fit into corresponding holes 97 in the compartments 91 and 93 to prevent any medicinal contained therein from diffusing or leaking out until the fastener 90 is contacted with bodily tissues. When the plugs 95 degrade, the medicinal diffuses or leaks out to the target site. The speed of release of medicinal from compartment 91 can be regulated relative to compartment 93 by varying the thickness of the plugs 95.
For example, if the plugs 95 sealing compartment 93 are made thicker than those sealing compartment 91, they will take 2 ~ . 7 ~
1 longer to degrade and, consequently, the medicinal will be released from compartment 91 first. Alternatively, the plugs 95 can be made of different biodegradable materials which have different rates of decomposition. In this way, plugs having slower rates of decomposition than other plugs maintain a sealed compartment longer than the other plugs covering other compartments, thus causing different rates of medicament delivery and permitting sequential medicament release.
The principles, preferred embodiments and modes of operation of the invention have been described in the foregoing specification. The invention which is intended to be protected herein, however, is not to be construed as limited to the particular forms disclosed, since they are to be regarded as illustrative rather than restrictive.
Variations and changes may be made by those skilled in this art without departing from the spirit of the present invention.
Claims (29)
1. A surgical implant device possessing a core occupying an interior region of the device, the device being adapted to receive and support a mechanical load in use.
2. A surgical implant device according to Claim 1 which is an incision or wound closure device.
3. A surgical implant according to Claim 2, wherein the incision or wound closure device is a surgical connector, clip, clamp, staple, tack, or band.
4. A surgical implant according to Claim 1 wherein the core occupies a portion of the surgical implant, other portions having a solid cross-section.
5. A surgical implant according to Claim 4 wherein one or more core regions abut one or more solid regions.
6. A surgical implant according to Claim 1 wherein the core extends from the interior region to one or more exterior apertures.
7. A surgical implant according to Claim 6, further comprising one or more biodegradable plugs which are capable of mating with and sealing the apertures.
8. A surgical implant according to Claim 7 wherein the one or more plugs are adapted to biodegrade at different rates in relation to other plugs.
9. A surgical implant according to Claim 1 wherein the implant is fabricated from a biodegradable material.
10. A surgical implant according to Claim 9 wherein the biodegradable material is selected from the group consisting of lactide, glycolide, caprolactone, dioxanone and trimethylene carbonate.
11. A surgical implant according to Claim 9, wherein the core is crenelated.
12. A surgical implant according to Claim 1 wherein the implant is fabricated from a material selected from the group consisting of chromium-cobalt-molybdenum alloy, titanium, stainless steel and titanium alloy.
13. A surgical implant according to Claim 1 wherein the mechanical behavior of the cored region of the implant approximates that of the same implant lacking the cored region.
14. A surgical implant according to Claim 1 wherein the mechanical behavior of the cored region of the implant approximates that of a beam.
15. A surgical implant according to Claim 1 wherein the cored region of the implant contains one or more medicinals.
16. A surgical implant according to Claim 15 wherein the medicinal is selected from the group consisting of antimicrobials, analgesics, antipyretics, anesthetics, antiepileptics, antihistamines, anti-inflammatories, cardiovascular drugs, diagnostic agents, sympathomimetics, cholinomimetics, anti-muscarinics, antispasmodics, hormones, growth factors, muscle relaxants, adrenergic neuron blockers, anti-neoplastics, immunosuppressants, gastrointestinal drugs, diuretics, steroids and enzymes.
17. A surgical implant according to Claim 5 wherein one or more medicinals are instilled into different core regions, the individual core regions adapted to release their contents at different rates.
18. A surgical implant according to Claim 15 wherein the cored region of the implant contains osmotically active particles.
19. A surgical implant according to Claim 1 wherein the cored region contains a stabilizing fluid.
20. A surgical implant according to Claim 1 wherein the stabilizing fluid is glycerol or glycerol plus calcium lactate.
21. A surgical connector, clip, clamp, tack band or fastener comprising a core occupying an interior region of the device, the device being adapted to receive and support a mechanical load in use.
22. A surgical implant device comprising structural members having one or more hollow compartments disposed therein, the structural members being adapted to receive and support a mechanical load in use.
23. A surgical implant according to Claim 22 wherein the incision or wound closure device is a surgical connector, clip, clamp, staple, tack, or band.
24. A surgical implant according to Claim 22 wherein the implant is fabricated from a biodegradable material.
25. A surgical implant according to Claim 22 wherein the mechanical behavior of the cored region of the implant approximates that of a beam.
26. A surgical implant according to Claim 22 wherein the cored region of the implant contains one or more medicinals.
27. A surgical implant according to Claim 22 wherein the cored region contains a stabilizing fluid.
28. A method of controlling the rate of decomposition of a biodegradable surgical implant comprising:
forming a hollow core region within the implant and contacting the implant with a suitable degradation medium.
forming a hollow core region within the implant and contacting the implant with a suitable degradation medium.
29. A method according to Claim 28 further comprising a method for delivering medicinals by instilling a medicinal into the hollow core region.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/745,513 | 1991-08-15 | ||
US07/745,513 US5282829A (en) | 1991-08-15 | 1991-08-15 | Hollow body implants |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2075172A1 true CA2075172A1 (en) | 1993-02-16 |
Family
ID=24997004
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002075172A Abandoned CA2075172A1 (en) | 1991-08-15 | 1992-07-31 | Hollow body implants |
Country Status (3)
Country | Link |
---|---|
US (1) | US5282829A (en) |
EP (1) | EP0531742A1 (en) |
CA (1) | CA2075172A1 (en) |
Families Citing this family (747)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5591206A (en) * | 1993-09-30 | 1997-01-07 | Moufarr+E,Gra E+Ee Ge; Richard | Method and device for closing wounds |
GB9512128D0 (en) * | 1995-06-15 | 1995-08-16 | Ethicon Inc | Surgical pins |
US6090063A (en) * | 1995-12-01 | 2000-07-18 | C. R. Bard, Inc. | Device, system and method for implantation of filaments and particles in the body |
US6015417A (en) * | 1996-01-25 | 2000-01-18 | Reynolds, Jr.; Walker | Surgical fastener |
US5919473A (en) * | 1997-05-12 | 1999-07-06 | Elkhoury; George F. | Methods and devices for delivering opioid analgesics to wounds via a subdermal implant |
DE19731834A1 (en) * | 1997-07-24 | 1999-06-17 | Ernst Peter Prof Dr M Strecker | Implantation device |
US6090131A (en) * | 1997-09-25 | 2000-07-18 | Daley; Robert J. | Bioabsorbable staples |
US5902319A (en) * | 1997-09-25 | 1999-05-11 | Daley; Robert J. | Bioabsorbable staples |
US6120526A (en) * | 1999-01-29 | 2000-09-19 | Daley; Robert J. | Delivery devices for bioabsorbable staples |
US20020095157A1 (en) * | 1999-07-23 | 2002-07-18 | Bowman Steven M. | Graft fixation device combination |
US6179840B1 (en) | 1999-07-23 | 2001-01-30 | Ethicon, Inc. | Graft fixation device and method |
US6277130B1 (en) * | 1999-12-14 | 2001-08-21 | John H. Shadduck | Electrical discharge surgical fastener for meniscal repairs |
US20040093024A1 (en) * | 2000-09-01 | 2004-05-13 | James Lousararian | Advanced wound site management systems and methods |
ATE506929T1 (en) | 2001-06-12 | 2011-05-15 | Univ Johns Hopkins Med | RESERVOIR DEVICE FOR INTRAOCULAR MEDICINAL DELIVERY |
US7464847B2 (en) * | 2005-06-03 | 2008-12-16 | Tyco Healthcare Group Lp | Surgical stapler with timer and feedback display |
US10285694B2 (en) | 2001-10-20 | 2019-05-14 | Covidien Lp | Surgical stapler with timer and feedback display |
US10098640B2 (en) | 2001-12-04 | 2018-10-16 | Atricure, Inc. | Left atrial appendage devices and methods |
FR2834444B1 (en) | 2002-01-09 | 2004-10-29 | Sofradim Production | GASTRIC RING OF TREATMENT OF OBESITY |
US6869436B2 (en) * | 2002-02-07 | 2005-03-22 | Scimed Life Systems, Inc. | Surgical clip with a self-releasing fluid reservoir |
US8241308B2 (en) | 2002-04-24 | 2012-08-14 | Boston Scientific Scimed, Inc. | Tissue fastening devices and processes that promote tissue adhesion |
EP1553877A4 (en) * | 2002-05-06 | 2007-04-04 | Univ Drexel | Tissue joining devices capable of delivery of bioactive agents and methods for use thereof |
US20040167572A1 (en) * | 2003-02-20 | 2004-08-26 | Roth Noah M. | Coated medical devices |
US8404269B2 (en) * | 2003-04-11 | 2013-03-26 | Michael Snyder | Sustained release implantable eye device |
US20040220534A1 (en) * | 2003-04-29 | 2004-11-04 | Martens Paul W. | Medical device with antimicrobial layer |
US7497857B2 (en) * | 2003-04-29 | 2009-03-03 | Medtronic, Inc. | Endocardial dispersive electrode for use with a monopolar RF ablation pen |
EP1624811B1 (en) * | 2003-05-09 | 2007-02-21 | Tyco Healthcare Group Lp | Anastomotic staple with fluid dispensing capillary |
US20070084897A1 (en) | 2003-05-20 | 2007-04-19 | Shelton Frederick E Iv | Articulating surgical stapling instrument incorporating a two-piece e-beam firing mechanism |
US9060770B2 (en) | 2003-05-20 | 2015-06-23 | Ethicon Endo-Surgery, Inc. | Robotically-driven surgical instrument with E-beam driver |
US7905902B2 (en) * | 2003-06-16 | 2011-03-15 | Ethicon Endo-Surgery, Inc. | Surgical implant with preferential corrosion zone |
US20060052825A1 (en) * | 2003-06-16 | 2006-03-09 | Ransick Mark H | Surgical implant alloy |
US8821521B2 (en) * | 2003-07-28 | 2014-09-02 | Baronova, Inc. | Gastro-intestinal device and method for treating addiction |
US9498366B2 (en) * | 2003-07-28 | 2016-11-22 | Baronova, Inc. | Devices and methods for pyloric anchoring |
US20090259236A2 (en) * | 2003-07-28 | 2009-10-15 | Baronova, Inc. | Gastric retaining devices and methods |
US9700450B2 (en) * | 2003-07-28 | 2017-07-11 | Baronova, Inc. | Devices and methods for gastrointestinal stimulation |
US8048169B2 (en) * | 2003-07-28 | 2011-11-01 | Baronova, Inc. | Pyloric valve obstructing devices and methods |
US7556647B2 (en) * | 2003-10-08 | 2009-07-07 | Arbor Surgical Technologies, Inc. | Attachment device and methods of using the same |
US7645285B2 (en) * | 2004-05-26 | 2010-01-12 | Idx Medical, Ltd | Apparatus and methods for occluding a hollow anatomical structure |
EP1768575B1 (en) * | 2004-06-18 | 2019-01-16 | Medtronic, Inc. | Devices for occlusion of an atrial appendage |
US8409219B2 (en) | 2004-06-18 | 2013-04-02 | Medtronic, Inc. | Method and system for placement of electrical lead inside heart |
US8215531B2 (en) | 2004-07-28 | 2012-07-10 | Ethicon Endo-Surgery, Inc. | Surgical stapling instrument having a medical substance dispenser |
US11890012B2 (en) | 2004-07-28 | 2024-02-06 | Cilag Gmbh International | Staple cartridge comprising cartridge body and attached support |
US8905977B2 (en) | 2004-07-28 | 2014-12-09 | Ethicon Endo-Surgery, Inc. | Surgical stapling instrument having an electroactive polymer actuated medical substance dispenser |
US7354447B2 (en) * | 2005-11-10 | 2008-04-08 | Ethicon Endo-Surgery, Inc. | Disposable loading unit and surgical instruments including same |
US7455681B2 (en) * | 2004-09-13 | 2008-11-25 | Wound Care Technologies, Llc | Wound closure product |
AU2005295811B2 (en) | 2004-10-18 | 2011-03-03 | Covidien Lp | Adhesive suture structure and methods of using the same |
US7686829B2 (en) | 2004-11-04 | 2010-03-30 | Wound Care Technologies, Inc. | Wound closure product |
US11291443B2 (en) | 2005-06-03 | 2022-04-05 | Covidien Lp | Surgical stapler with timer and feedback display |
CA2609970C (en) * | 2005-06-03 | 2014-08-12 | Tyco Healthcare Group Lp | Battery powered surgical instrument |
EP1906842B1 (en) * | 2005-07-14 | 2016-12-21 | IDX Medical, Ltd. | Apparatus for occluding a hollow anatomical structure |
US7934630B2 (en) | 2005-08-31 | 2011-05-03 | Ethicon Endo-Surgery, Inc. | Staple cartridges for forming staples having differing formed staple heights |
US11484312B2 (en) | 2005-08-31 | 2022-11-01 | Cilag Gmbh International | Staple cartridge comprising a staple driver arrangement |
US11246590B2 (en) | 2005-08-31 | 2022-02-15 | Cilag Gmbh International | Staple cartridge including staple drivers having different unfired heights |
US9237891B2 (en) | 2005-08-31 | 2016-01-19 | Ethicon Endo-Surgery, Inc. | Robotically-controlled surgical stapling devices that produce formed staples having different lengths |
US20070194079A1 (en) * | 2005-08-31 | 2007-08-23 | Hueil Joseph C | Surgical stapling device with staple drivers of different height |
US7669746B2 (en) | 2005-08-31 | 2010-03-02 | Ethicon Endo-Surgery, Inc. | Staple cartridges for forming staples having differing formed staple heights |
US10159482B2 (en) | 2005-08-31 | 2018-12-25 | Ethicon Llc | Fastener cartridge assembly comprising a fixed anvil and different staple heights |
US7500979B2 (en) | 2005-08-31 | 2009-03-10 | Ethicon Endo-Surgery, Inc. | Surgical stapling device with multiple stacked actuator wedge cams for driving staple drivers |
US8800838B2 (en) | 2005-08-31 | 2014-08-12 | Ethicon Endo-Surgery, Inc. | Robotically-controlled cable-based surgical end effectors |
US20070212397A1 (en) * | 2005-09-15 | 2007-09-13 | Roth Daniel B | Pharmaceutical delivery device and method for providing ocular treatment |
US7467740B2 (en) * | 2005-09-21 | 2008-12-23 | Ethicon Endo-Surgery, Inc. | Surgical stapling instruments having flexible channel and anvil features for adjustable staple heights |
US7799039B2 (en) * | 2005-11-09 | 2010-09-21 | Ethicon Endo-Surgery, Inc. | Surgical instrument having a hydraulically actuated end effector |
US20070106317A1 (en) | 2005-11-09 | 2007-05-10 | Shelton Frederick E Iv | Hydraulically and electrically actuated articulation joints for surgical instruments |
US20070162030A1 (en) * | 2006-01-06 | 2007-07-12 | Ernest Aranyi | Multi-pronged compressive absorbable tack |
US7936062B2 (en) * | 2006-01-23 | 2011-05-03 | Tessera Technologies Ireland Limited | Wafer level chip packaging |
US20110290856A1 (en) | 2006-01-31 | 2011-12-01 | Ethicon Endo-Surgery, Inc. | Robotically-controlled surgical instrument with force-feedback capabilities |
US20070175950A1 (en) * | 2006-01-31 | 2007-08-02 | Shelton Frederick E Iv | Disposable staple cartridge having an anvil with tissue locator for use with a surgical cutting and fastening instrument and modular end effector system therefor |
US7753904B2 (en) | 2006-01-31 | 2010-07-13 | Ethicon Endo-Surgery, Inc. | Endoscopic surgical instrument with a handle that can articulate with respect to the shaft |
US8161977B2 (en) | 2006-01-31 | 2012-04-24 | Ethicon Endo-Surgery, Inc. | Accessing data stored in a memory of a surgical instrument |
US11793518B2 (en) | 2006-01-31 | 2023-10-24 | Cilag Gmbh International | Powered surgical instruments with firing system lockout arrangements |
US20120292367A1 (en) | 2006-01-31 | 2012-11-22 | Ethicon Endo-Surgery, Inc. | Robotically-controlled end effector |
US7568603B2 (en) * | 2006-01-31 | 2009-08-04 | Ethicon Endo-Surgery, Inc. | Motor-driven surgical cutting and fastening instrument with articulatable end effector |
US7845537B2 (en) | 2006-01-31 | 2010-12-07 | Ethicon Endo-Surgery, Inc. | Surgical instrument having recording capabilities |
US20070175951A1 (en) * | 2006-01-31 | 2007-08-02 | Shelton Frederick E Iv | Gearing selector for a powered surgical cutting and fastening instrument |
US7766210B2 (en) * | 2006-01-31 | 2010-08-03 | Ethicon Endo-Surgery, Inc. | Motor-driven surgical cutting and fastening instrument with user feedback system |
US8763879B2 (en) * | 2006-01-31 | 2014-07-01 | Ethicon Endo-Surgery, Inc. | Accessing data stored in a memory of surgical instrument |
US20110006101A1 (en) | 2009-02-06 | 2011-01-13 | EthiconEndo-Surgery, Inc. | Motor driven surgical fastener device with cutting member lockout arrangements |
US20110024477A1 (en) | 2009-02-06 | 2011-02-03 | Hall Steven G | Driven Surgical Stapler Improvements |
US11224427B2 (en) | 2006-01-31 | 2022-01-18 | Cilag Gmbh International | Surgical stapling system including a console and retraction assembly |
US7644848B2 (en) * | 2006-01-31 | 2010-01-12 | Ethicon Endo-Surgery, Inc. | Electronic lockouts and surgical instrument including same |
US8708213B2 (en) | 2006-01-31 | 2014-04-29 | Ethicon Endo-Surgery, Inc. | Surgical instrument having a feedback system |
US8820603B2 (en) | 2006-01-31 | 2014-09-02 | Ethicon Endo-Surgery, Inc. | Accessing data stored in a memory of a surgical instrument |
US9861359B2 (en) | 2006-01-31 | 2018-01-09 | Ethicon Llc | Powered surgical instruments with firing system lockout arrangements |
US11278279B2 (en) | 2006-01-31 | 2022-03-22 | Cilag Gmbh International | Surgical instrument assembly |
US7770775B2 (en) * | 2006-01-31 | 2010-08-10 | Ethicon Endo-Surgery, Inc. | Motor-driven surgical cutting and fastening instrument with adaptive user feedback |
US8186555B2 (en) | 2006-01-31 | 2012-05-29 | Ethicon Endo-Surgery, Inc. | Motor-driven surgical cutting and fastening instrument with mechanical closure system |
US20070225562A1 (en) | 2006-03-23 | 2007-09-27 | Ethicon Endo-Surgery, Inc. | Articulating endoscopic accessory channel |
US8992422B2 (en) | 2006-03-23 | 2015-03-31 | Ethicon Endo-Surgery, Inc. | Robotically-controlled endoscopic accessory channel |
US20070224237A1 (en) * | 2006-03-24 | 2007-09-27 | Julia Hwang | Barbed sutures having a therapeutic agent thereon |
US8322455B2 (en) | 2006-06-27 | 2012-12-04 | Ethicon Endo-Surgery, Inc. | Manually driven surgical cutting and fastening instrument |
US7441684B2 (en) * | 2006-08-02 | 2008-10-28 | Ethicon Endo-Surgery, Inc. | Pneumatically powered surgical cutting and fastening instrument with audible and visual feedback features |
US7740159B2 (en) | 2006-08-02 | 2010-06-22 | Ethicon Endo-Surgery, Inc. | Pneumatically powered surgical cutting and fastening instrument with a variable control of the actuating rate of firing with mechanical power assist |
US20080065154A1 (en) * | 2006-09-08 | 2008-03-13 | Warsaw Orthopedic, Inc | Surgical staple |
US10130359B2 (en) | 2006-09-29 | 2018-11-20 | Ethicon Llc | Method for forming a staple |
US20100133317A1 (en) * | 2006-09-29 | 2010-06-03 | Shelton Iv Frederick E | Motor-Driven Surgical Cutting And Fastening Instrument with Tactile Position Feedback |
US20190269402A1 (en) * | 2006-09-29 | 2019-09-05 | Ethicon Llc | Surgical staple having a deformable member with a non-circular cross-sectional geometry |
US10568652B2 (en) | 2006-09-29 | 2020-02-25 | Ethicon Llc | Surgical staples having attached drivers of different heights and stapling instruments for deploying the same |
US7506791B2 (en) | 2006-09-29 | 2009-03-24 | Ethicon Endo-Surgery, Inc. | Surgical stapling instrument with mechanical mechanism for limiting maximum tissue compression |
US20080085296A1 (en) * | 2006-10-06 | 2008-04-10 | Powell Darrel M | Methods for reduction of post operative ileus. |
US20080086078A1 (en) * | 2006-10-06 | 2008-04-10 | Powell Darrel M | Devices for reduction of post operative ileus |
US8652120B2 (en) * | 2007-01-10 | 2014-02-18 | Ethicon Endo-Surgery, Inc. | Surgical instrument with wireless communication between control unit and sensor transponders |
US7721936B2 (en) | 2007-01-10 | 2010-05-25 | Ethicon Endo-Surgery, Inc. | Interlock and surgical instrument including same |
US7721931B2 (en) * | 2007-01-10 | 2010-05-25 | Ethicon Endo-Surgery, Inc. | Prevention of cartridge reuse in a surgical instrument |
US7954682B2 (en) | 2007-01-10 | 2011-06-07 | Ethicon Endo-Surgery, Inc. | Surgical instrument with elements to communicate between control unit and end effector |
US7900805B2 (en) | 2007-01-10 | 2011-03-08 | Ethicon Endo-Surgery, Inc. | Surgical instrument with enhanced battery performance |
US11291441B2 (en) | 2007-01-10 | 2022-04-05 | Cilag Gmbh International | Surgical instrument with wireless communication between control unit and remote sensor |
US8459520B2 (en) | 2007-01-10 | 2013-06-11 | Ethicon Endo-Surgery, Inc. | Surgical instrument with wireless communication between control unit and remote sensor |
US7738971B2 (en) | 2007-01-10 | 2010-06-15 | Ethicon Endo-Surgery, Inc. | Post-sterilization programming of surgical instruments |
US8684253B2 (en) | 2007-01-10 | 2014-04-01 | Ethicon Endo-Surgery, Inc. | Surgical instrument with wireless communication between a control unit of a robotic system and remote sensor |
US8540128B2 (en) | 2007-01-11 | 2013-09-24 | Ethicon Endo-Surgery, Inc. | Surgical stapling device with a curved end effector |
US11039836B2 (en) | 2007-01-11 | 2021-06-22 | Cilag Gmbh International | Staple cartridge for use with a surgical stapling instrument |
US20080169328A1 (en) * | 2007-01-11 | 2008-07-17 | Shelton Frederick E | Buttress material for use with a surgical stapler |
US8727197B2 (en) | 2007-03-15 | 2014-05-20 | Ethicon Endo-Surgery, Inc. | Staple cartridge cavity configuration with cooperative surgical staple |
US7431188B1 (en) | 2007-03-15 | 2008-10-07 | Tyco Healthcare Group Lp | Surgical stapling apparatus with powered articulation |
US8205780B2 (en) | 2007-03-22 | 2012-06-26 | Tyco Healthcare Group Lp | Apparatus for forming variable height surgical fasteners |
US7490749B2 (en) * | 2007-03-28 | 2009-02-17 | Ethicon Endo-Surgery, Inc. | Surgical stapling and cutting instrument with manually retractable firing member |
US8056787B2 (en) | 2007-03-28 | 2011-11-15 | Ethicon Endo-Surgery, Inc. | Surgical stapling and cutting instrument with travel-indicating retraction member |
US8893946B2 (en) | 2007-03-28 | 2014-11-25 | Ethicon Endo-Surgery, Inc. | Laparoscopic tissue thickness and clamp load measuring devices |
US20080243141A1 (en) | 2007-04-02 | 2008-10-02 | Salvatore Privitera | Surgical instrument with separate tool head and method of use |
US11259801B2 (en) | 2007-04-13 | 2022-03-01 | Covidien Lp | Powered surgical instrument |
US20080255413A1 (en) | 2007-04-13 | 2008-10-16 | Michael Zemlok | Powered surgical instrument |
US8800837B2 (en) | 2007-04-13 | 2014-08-12 | Covidien Lp | Powered surgical instrument |
US7950560B2 (en) | 2007-04-13 | 2011-05-31 | Tyco Healthcare Group Lp | Powered surgical instrument |
US7823760B2 (en) * | 2007-05-01 | 2010-11-02 | Tyco Healthcare Group Lp | Powered surgical stapling device platform |
US20080277445A1 (en) * | 2007-05-07 | 2008-11-13 | Zergiebel Earl M | Single fire tacker instrument |
US9636111B2 (en) * | 2007-05-07 | 2017-05-02 | Covidien Lp | Method of stapling tissues with a staple assembly |
US7931660B2 (en) * | 2007-05-10 | 2011-04-26 | Tyco Healthcare Group Lp | Powered tacker instrument |
US7549564B2 (en) * | 2007-06-22 | 2009-06-23 | Ethicon Endo-Surgery, Inc. | Surgical stapling instrument with an articulating end effector |
US7810693B2 (en) | 2007-05-30 | 2010-10-12 | Ethicon Endo-Surgery, Inc. | Surgical stapling and cutting instrument with articulatable end effector |
US7798386B2 (en) | 2007-05-30 | 2010-09-21 | Ethicon Endo-Surgery, Inc. | Surgical instrument articulation joint cover |
US8157145B2 (en) | 2007-05-31 | 2012-04-17 | Ethicon Endo-Surgery, Inc. | Pneumatically powered surgical cutting and fastening instrument with electrical feedback |
US8931682B2 (en) | 2007-06-04 | 2015-01-13 | Ethicon Endo-Surgery, Inc. | Robotically-controlled shaft based rotary drive systems for surgical instruments |
US7832408B2 (en) | 2007-06-04 | 2010-11-16 | Ethicon Endo-Surgery, Inc. | Surgical instrument having a directional switching mechanism |
US7905380B2 (en) | 2007-06-04 | 2011-03-15 | Ethicon Endo-Surgery, Inc. | Surgical instrument having a multiple rate directional switching mechanism |
US11857181B2 (en) | 2007-06-04 | 2024-01-02 | Cilag Gmbh International | Robotically-controlled shaft based rotary drive systems for surgical instruments |
US8534528B2 (en) | 2007-06-04 | 2013-09-17 | Ethicon Endo-Surgery, Inc. | Surgical instrument having a multiple rate directional switching mechanism |
US7510107B2 (en) * | 2007-06-18 | 2009-03-31 | Ethicon Endo-Surgery, Inc. | Cable driven surgical stapling and cutting instrument with apparatus for preventing inadvertent cable disengagement |
US7658311B2 (en) * | 2007-06-22 | 2010-02-09 | Ethicon Endo-Surgery, Inc. | Surgical stapling instrument with a geared return mechanism |
US7597229B2 (en) | 2007-06-22 | 2009-10-06 | Ethicon Endo-Surgery, Inc. | End effector closure system for a surgical stapling instrument |
US7753245B2 (en) * | 2007-06-22 | 2010-07-13 | Ethicon Endo-Surgery, Inc. | Surgical stapling instruments |
US8308040B2 (en) | 2007-06-22 | 2012-11-13 | Ethicon Endo-Surgery, Inc. | Surgical stapling instrument with an articulatable end effector |
US7604150B2 (en) * | 2007-06-22 | 2009-10-20 | Ethicon Endo-Surgery, Inc. | Surgical stapling instrument with an anti-back up mechanism |
US11849941B2 (en) | 2007-06-29 | 2023-12-26 | Cilag Gmbh International | Staple cartridge having staple cavities extending at a transverse angle relative to a longitudinal cartridge axis |
US8348972B2 (en) | 2007-07-11 | 2013-01-08 | Covidien Lp | Surgical staple with augmented compression area |
WO2009033049A1 (en) * | 2007-09-07 | 2009-03-12 | Baronova, Inc. | Device for intermittently obstructing a gastric opening and method of use |
US7922063B2 (en) | 2007-10-31 | 2011-04-12 | Tyco Healthcare Group, Lp | Powered surgical instrument |
US20090177201A1 (en) * | 2007-11-14 | 2009-07-09 | Michael Soltz | Staple with Multiple Cross Sectional Shapes |
US8561870B2 (en) | 2008-02-13 | 2013-10-22 | Ethicon Endo-Surgery, Inc. | Surgical stapling instrument |
US7766209B2 (en) * | 2008-02-13 | 2010-08-03 | Ethicon Endo-Surgery, Inc. | Surgical stapling instrument with improved firing trigger arrangement |
US8348129B2 (en) | 2009-10-09 | 2013-01-08 | Ethicon Endo-Surgery, Inc. | Surgical stapler having a closure mechanism |
US8453908B2 (en) * | 2008-02-13 | 2013-06-04 | Ethicon Endo-Surgery, Inc. | Surgical stapling instrument with improved firing trigger arrangement |
US8540133B2 (en) * | 2008-09-19 | 2013-09-24 | Ethicon Endo-Surgery, Inc. | Staple cartridge |
US7819298B2 (en) | 2008-02-14 | 2010-10-26 | Ethicon Endo-Surgery, Inc. | Surgical stapling apparatus with control features operable with one hand |
US8573465B2 (en) | 2008-02-14 | 2013-11-05 | Ethicon Endo-Surgery, Inc. | Robotically-controlled surgical end effector system with rotary actuated closure systems |
BRPI0901282A2 (en) | 2008-02-14 | 2009-11-17 | Ethicon Endo Surgery Inc | surgical cutting and fixation instrument with rf electrodes |
US7793812B2 (en) | 2008-02-14 | 2010-09-14 | Ethicon Endo-Surgery, Inc. | Disposable motor-driven loading unit for use with a surgical cutting and stapling apparatus |
US8758391B2 (en) * | 2008-02-14 | 2014-06-24 | Ethicon Endo-Surgery, Inc. | Interchangeable tools for surgical instruments |
US7810692B2 (en) * | 2008-02-14 | 2010-10-12 | Ethicon Endo-Surgery, Inc. | Disposable loading unit with firing indicator |
US8657174B2 (en) | 2008-02-14 | 2014-02-25 | Ethicon Endo-Surgery, Inc. | Motorized surgical cutting and fastening instrument having handle based power source |
US7866527B2 (en) | 2008-02-14 | 2011-01-11 | Ethicon Endo-Surgery, Inc. | Surgical stapling apparatus with interlockable firing system |
US8584919B2 (en) | 2008-02-14 | 2013-11-19 | Ethicon Endo-Sugery, Inc. | Surgical stapling apparatus with load-sensitive firing mechanism |
US8459525B2 (en) | 2008-02-14 | 2013-06-11 | Ethicon Endo-Sugery, Inc. | Motorized surgical cutting and fastening instrument having a magnetic drive train torque limiting device |
US7857185B2 (en) | 2008-02-14 | 2010-12-28 | Ethicon Endo-Surgery, Inc. | Disposable loading unit for surgical stapling apparatus |
US7819297B2 (en) * | 2008-02-14 | 2010-10-26 | Ethicon Endo-Surgery, Inc. | Surgical stapling apparatus with reprocessible handle assembly |
US7819296B2 (en) * | 2008-02-14 | 2010-10-26 | Ethicon Endo-Surgery, Inc. | Surgical stapling apparatus with retractable firing systems |
US8752749B2 (en) | 2008-02-14 | 2014-06-17 | Ethicon Endo-Surgery, Inc. | Robotically-controlled disposable motor-driven loading unit |
US8622274B2 (en) | 2008-02-14 | 2014-01-07 | Ethicon Endo-Surgery, Inc. | Motorized cutting and fastening instrument having control circuit for optimizing battery usage |
US20090206133A1 (en) * | 2008-02-14 | 2009-08-20 | Ethicon Endo-Surgery, Inc. | Articulatable loading units for surgical stapling and cutting instruments |
US8636736B2 (en) | 2008-02-14 | 2014-01-28 | Ethicon Endo-Surgery, Inc. | Motorized surgical cutting and fastening instrument |
US7861906B2 (en) | 2008-02-14 | 2011-01-04 | Ethicon Endo-Surgery, Inc. | Surgical stapling apparatus with articulatable components |
US7913891B2 (en) * | 2008-02-14 | 2011-03-29 | Ethicon Endo-Surgery, Inc. | Disposable loading unit with user feedback features and surgical instrument for use therewith |
US9179912B2 (en) | 2008-02-14 | 2015-11-10 | Ethicon Endo-Surgery, Inc. | Robotically-controlled motorized surgical cutting and fastening instrument |
US7980443B2 (en) * | 2008-02-15 | 2011-07-19 | Ethicon Endo-Surgery, Inc. | End effectors for a surgical cutting and stapling instrument |
US11272927B2 (en) | 2008-02-15 | 2022-03-15 | Cilag Gmbh International | Layer arrangements for surgical staple cartridges |
US9770245B2 (en) | 2008-02-15 | 2017-09-26 | Ethicon Llc | Layer arrangements for surgical staple cartridges |
US8231041B2 (en) | 2008-04-14 | 2012-07-31 | Tyco Healthcare Group Lp | Variable compression surgical fastener cartridge |
US8231040B2 (en) * | 2008-04-14 | 2012-07-31 | Tyco Healthcare Group Lp | Variable compression surgical fastener cartridge |
US7926691B2 (en) * | 2008-04-14 | 2011-04-19 | Tyco Healthcare Group, L.P. | Variable compression surgical fastener cartridge |
US20090255974A1 (en) * | 2008-04-14 | 2009-10-15 | Tyco Healthcare Group Lp | Single loop surgical fastener apparatus for applying variable compression |
US8100310B2 (en) * | 2008-04-14 | 2012-01-24 | Tyco Healthcare Group Lp | Variable compression surgical fastener apparatus |
US8028884B2 (en) | 2008-04-22 | 2011-10-04 | Tyco Healthcare Group Lp | Cartridge for applying varying amounts of tissue compression |
US8186556B2 (en) * | 2008-05-09 | 2012-05-29 | Tyco Healthcare Group Lp | Variable compression surgical fastener apparatus |
US9016541B2 (en) | 2008-05-09 | 2015-04-28 | Covidien Lp | Varying tissue compression with an anvil configuration |
US8967446B2 (en) * | 2008-05-09 | 2015-03-03 | Covidien Lp | Variable compression surgical fastener cartridge |
US8464922B2 (en) * | 2008-05-09 | 2013-06-18 | Covidien Lp | Variable compression surgical fastener cartridge |
US8091756B2 (en) * | 2008-05-09 | 2012-01-10 | Tyco Healthcare Group Lp | Varying tissue compression using take-up component |
US9242026B2 (en) | 2008-06-27 | 2016-01-26 | Sofradim Production | Biosynthetic implant for soft tissue repair |
US20100023052A1 (en) * | 2008-07-23 | 2010-01-28 | Tyco Healthcare Group Lp | Staple for use in surgical procedures |
PL3476312T3 (en) | 2008-09-19 | 2024-03-11 | Ethicon Llc | Surgical stapler with apparatus for adjusting staple height |
US7857186B2 (en) | 2008-09-19 | 2010-12-28 | Ethicon Endo-Surgery, Inc. | Surgical stapler having an intermediate closing position |
US9050083B2 (en) | 2008-09-23 | 2015-06-09 | Ethicon Endo-Surgery, Inc. | Motorized surgical instrument |
US8210411B2 (en) | 2008-09-23 | 2012-07-03 | Ethicon Endo-Surgery, Inc. | Motor-driven surgical cutting instrument |
US11648005B2 (en) | 2008-09-23 | 2023-05-16 | Cilag Gmbh International | Robotically-controlled motorized surgical instrument with an end effector |
US9386983B2 (en) | 2008-09-23 | 2016-07-12 | Ethicon Endo-Surgery, Llc | Robotically-controlled motorized surgical instrument |
US9005230B2 (en) | 2008-09-23 | 2015-04-14 | Ethicon Endo-Surgery, Inc. | Motorized surgical instrument |
US8608045B2 (en) | 2008-10-10 | 2013-12-17 | Ethicon Endo-Sugery, Inc. | Powered surgical cutting and stapling apparatus with manually retractable firing system |
US8020743B2 (en) * | 2008-10-15 | 2011-09-20 | Ethicon Endo-Surgery, Inc. | Powered articulatable surgical cutting and fastening instrument with flexible drive member |
WO2010081029A1 (en) | 2009-01-08 | 2010-07-15 | Rotation Medical, Inc. | Implantable tendon protection systems and related kits and methods |
US9393023B2 (en) * | 2009-01-13 | 2016-07-19 | Atricure, Inc. | Apparatus and methods for deploying a clip to occlude an anatomical structure |
US8381961B2 (en) * | 2009-01-14 | 2013-02-26 | Covidien Lp | Surgical stapling apparatus including staple with plate |
US8623395B2 (en) | 2010-01-29 | 2014-01-07 | Forsight Vision4, Inc. | Implantable therapeutic device |
CA2757037C (en) | 2009-01-29 | 2019-08-06 | Forsight Vision4, Inc. | Posterior segment drug delivery |
US8517239B2 (en) | 2009-02-05 | 2013-08-27 | Ethicon Endo-Surgery, Inc. | Surgical stapling instrument comprising a magnetic element driver |
US20100193566A1 (en) * | 2009-02-05 | 2010-08-05 | Ethicon Endo-Surgery, Inc. | Surgical stapling instrument |
US8485413B2 (en) * | 2009-02-05 | 2013-07-16 | Ethicon Endo-Surgery, Inc. | Surgical stapling instrument comprising an articulation joint |
US8397971B2 (en) * | 2009-02-05 | 2013-03-19 | Ethicon Endo-Surgery, Inc. | Sterilizable surgical instrument |
US8414577B2 (en) | 2009-02-05 | 2013-04-09 | Ethicon Endo-Surgery, Inc. | Surgical instruments and components for use in sterile environments |
CN102341048A (en) | 2009-02-06 | 2012-02-01 | 伊西康内外科公司 | Driven surgical stapler improvements |
US8444036B2 (en) | 2009-02-06 | 2013-05-21 | Ethicon Endo-Surgery, Inc. | Motor driven surgical fastener device with mechanisms for adjusting a tissue gap within the end effector |
US9179910B2 (en) * | 2009-03-20 | 2015-11-10 | Rotation Medical, Inc. | Medical device delivery system and method |
US8292154B2 (en) * | 2009-04-16 | 2012-10-23 | Tyco Healthcare Group Lp | Surgical apparatus for applying tissue fasteners |
CA2763919C (en) | 2009-06-04 | 2017-05-23 | Rotation Medical, Inc. | Apparatus for fixing sheet-like materials to a target tissue |
EP3308743A1 (en) | 2009-06-04 | 2018-04-18 | Rotation Medical, Inc. | Methods and apparatus for deploying sheet-like materials |
US8821514B2 (en) * | 2009-06-08 | 2014-09-02 | Covidien Lp | Powered tack applier |
US9220503B2 (en) * | 2009-08-13 | 2015-12-29 | The Trustees Of The University Of Pennsylvania | Surgical device for conjuctival tissue closure |
US8641730B2 (en) * | 2009-08-18 | 2014-02-04 | Covidien Lp | Local biomechanical and/or antimicrobial ligation device |
US9265500B2 (en) * | 2009-08-19 | 2016-02-23 | Covidien Lp | Surgical staple |
US8152041B2 (en) | 2009-10-14 | 2012-04-10 | Tyco Healthcare Group Lp | Varying tissue compression aided by elastic members |
US8899466B2 (en) * | 2009-11-19 | 2014-12-02 | Ethicon Endo-Surgery, Inc. | Devices and methods for introducing a surgical circular stapling instrument into a patient |
US8220688B2 (en) | 2009-12-24 | 2012-07-17 | Ethicon Endo-Surgery, Inc. | Motor-driven surgical cutting instrument with electric actuator directional control assembly |
US8851354B2 (en) | 2009-12-24 | 2014-10-07 | Ethicon Endo-Surgery, Inc. | Surgical cutting instrument that analyzes tissue thickness |
US8267300B2 (en) | 2009-12-30 | 2012-09-18 | Ethicon Endo-Surgery, Inc. | Dampening device for endoscopic surgical stapler |
US10166142B2 (en) | 2010-01-29 | 2019-01-01 | Forsight Vision4, Inc. | Small molecule delivery with implantable therapeutic device |
US9198750B2 (en) | 2010-03-11 | 2015-12-01 | Rotation Medical, Inc. | Tendon repair implant and method of arthroscopic implantation |
US10166021B2 (en) | 2010-07-19 | 2019-01-01 | Wound Care Technologies, Inc. | Wound closure system |
US8789740B2 (en) | 2010-07-30 | 2014-07-29 | Ethicon Endo-Surgery, Inc. | Linear cutting and stapling device with selectively disengageable cutting member |
US8783543B2 (en) | 2010-07-30 | 2014-07-22 | Ethicon Endo-Surgery, Inc. | Tissue acquisition arrangements and methods for surgical stapling devices |
US8672207B2 (en) | 2010-07-30 | 2014-03-18 | Ethicon Endo-Surgery, Inc. | Transwall visualization arrangements and methods for surgical circular staplers |
AU2011285548B2 (en) | 2010-08-05 | 2014-02-06 | Forsight Vision4, Inc. | Combined drug delivery methods and apparatus |
RS61601B1 (en) | 2010-08-05 | 2021-04-29 | Forsight Vision4 Inc | Injector apparatus for drug delivery |
RS62540B1 (en) | 2010-08-05 | 2021-12-31 | Forsight Vision4 Inc | Apparatus to treat an eye |
US8360296B2 (en) | 2010-09-09 | 2013-01-29 | Ethicon Endo-Surgery, Inc. | Surgical stapling head assembly with firing lockout for a surgical stapler |
US9877720B2 (en) | 2010-09-24 | 2018-01-30 | Ethicon Llc | Control features for articulating surgical device |
US8733613B2 (en) | 2010-09-29 | 2014-05-27 | Ethicon Endo-Surgery, Inc. | Staple cartridge |
US20120080478A1 (en) | 2010-09-30 | 2012-04-05 | Ethicon Endo-Surgery, Inc. | Surgical staple cartridges with detachable support structures and surgical stapling instruments with systems for preventing actuation motions when a cartridge is not present |
US11298125B2 (en) | 2010-09-30 | 2022-04-12 | Cilag Gmbh International | Tissue stapler having a thickness compensator |
US9314246B2 (en) | 2010-09-30 | 2016-04-19 | Ethicon Endo-Surgery, Llc | Tissue stapler having a thickness compensator incorporating an anti-inflammatory agent |
US9282962B2 (en) | 2010-09-30 | 2016-03-15 | Ethicon Endo-Surgery, Llc | Adhesive film laminate |
US11812965B2 (en) | 2010-09-30 | 2023-11-14 | Cilag Gmbh International | Layer of material for a surgical end effector |
US9055941B2 (en) | 2011-09-23 | 2015-06-16 | Ethicon Endo-Surgery, Inc. | Staple cartridge including collapsible deck |
US9220501B2 (en) | 2010-09-30 | 2015-12-29 | Ethicon Endo-Surgery, Inc. | Tissue thickness compensators |
US9016542B2 (en) | 2010-09-30 | 2015-04-28 | Ethicon Endo-Surgery, Inc. | Staple cartridge comprising compressible distortion resistant components |
US11849952B2 (en) | 2010-09-30 | 2023-12-26 | Cilag Gmbh International | Staple cartridge comprising staples positioned within a compressible portion thereof |
US10945731B2 (en) | 2010-09-30 | 2021-03-16 | Ethicon Llc | Tissue thickness compensator comprising controlled release and expansion |
US9517063B2 (en) | 2012-03-28 | 2016-12-13 | Ethicon Endo-Surgery, Llc | Movable member for use with a tissue thickness compensator |
US8893949B2 (en) | 2010-09-30 | 2014-11-25 | Ethicon Endo-Surgery, Inc. | Surgical stapler with floating anvil |
US9204880B2 (en) | 2012-03-28 | 2015-12-08 | Ethicon Endo-Surgery, Inc. | Tissue thickness compensator comprising capsules defining a low pressure environment |
EP2621356B1 (en) | 2010-09-30 | 2018-03-07 | Ethicon LLC | Fastener system comprising a retention matrix and an alignment matrix |
US9364233B2 (en) | 2010-09-30 | 2016-06-14 | Ethicon Endo-Surgery, Llc | Tissue thickness compensators for circular surgical staplers |
US9332974B2 (en) | 2010-09-30 | 2016-05-10 | Ethicon Endo-Surgery, Llc | Layered tissue thickness compensator |
US9433419B2 (en) | 2010-09-30 | 2016-09-06 | Ethicon Endo-Surgery, Inc. | Tissue thickness compensator comprising a plurality of layers |
US9307989B2 (en) | 2012-03-28 | 2016-04-12 | Ethicon Endo-Surgery, Llc | Tissue stapler having a thickness compensator incorportating a hydrophobic agent |
US9386988B2 (en) | 2010-09-30 | 2016-07-12 | Ethicon End-Surgery, LLC | Retainer assembly including a tissue thickness compensator |
US9211120B2 (en) | 2011-04-29 | 2015-12-15 | Ethicon Endo-Surgery, Inc. | Tissue thickness compensator comprising a plurality of medicaments |
US9629814B2 (en) | 2010-09-30 | 2017-04-25 | Ethicon Endo-Surgery, Llc | Tissue thickness compensator configured to redistribute compressive forces |
US9414838B2 (en) | 2012-03-28 | 2016-08-16 | Ethicon Endo-Surgery, Llc | Tissue thickness compensator comprised of a plurality of materials |
US8695866B2 (en) | 2010-10-01 | 2014-04-15 | Ethicon Endo-Surgery, Inc. | Surgical instrument having a power control circuit |
US8900616B2 (en) | 2010-10-22 | 2014-12-02 | Covidien Lp | System and method for satellite drug delivery |
US9017349B2 (en) | 2010-10-27 | 2015-04-28 | Atricure, Inc. | Appendage clamp deployment assist device |
US9066741B2 (en) | 2010-11-01 | 2015-06-30 | Atricure, Inc. | Robotic toolkit |
US8636754B2 (en) | 2010-11-11 | 2014-01-28 | Atricure, Inc. | Clip applicator |
AU2011329656B2 (en) | 2010-11-19 | 2017-01-05 | Forsight Vision4, Inc. | Therapeutic agent formulations for implanted devices |
DE102012100086A1 (en) * | 2011-01-07 | 2012-08-02 | Z-Medical Gmbh & Co. Kg | Surgical instrument |
WO2012112565A2 (en) | 2011-02-15 | 2012-08-23 | Rotation Medical, Inc. | Methods and apparatus for delivering and positioning sheet-like materials |
WO2012145059A1 (en) | 2011-02-15 | 2012-10-26 | Rotation Medical, Inc. | Methods and apparatus for fixing sheet-like materials to a target tissue |
US9314314B2 (en) | 2011-02-15 | 2016-04-19 | Rotation Medical, Inc. | Anatomical location markers and methods of use in positioning sheet-like materials during surgery |
US8632462B2 (en) | 2011-03-14 | 2014-01-21 | Ethicon Endo-Surgery, Inc. | Trans-rectum universal ports |
US8800841B2 (en) | 2011-03-15 | 2014-08-12 | Ethicon Endo-Surgery, Inc. | Surgical staple cartridges |
FR2972626B1 (en) | 2011-03-16 | 2014-04-11 | Sofradim Production | PROSTHETIC COMPRISING A THREE-DIMENSIONAL KNIT AND ADJUSTED |
CA2834649C (en) | 2011-04-29 | 2021-02-16 | Ethicon Endo-Surgery, Inc. | Staple cartridge comprising staples positioned within a compressible portion thereof |
US9072535B2 (en) | 2011-05-27 | 2015-07-07 | Ethicon Endo-Surgery, Inc. | Surgical stapling instruments with rotatable staple deployment arrangements |
US11207064B2 (en) | 2011-05-27 | 2021-12-28 | Cilag Gmbh International | Automated end effector component reloading system for use with a robotic system |
EP2726016B1 (en) | 2011-06-28 | 2023-07-19 | ForSight Vision4, Inc. | An apparatus for collecting a sample of fluid from a reservoir chamber of a therapeutic device for the eye |
FR2977789B1 (en) | 2011-07-13 | 2013-07-19 | Sofradim Production | PROSTHETIC FOR UMBILIC HERNIA |
FR2977790B1 (en) | 2011-07-13 | 2013-07-19 | Sofradim Production | PROSTHETIC FOR UMBILIC HERNIA |
US8998059B2 (en) | 2011-08-01 | 2015-04-07 | Ethicon Endo-Surgery, Inc. | Adjunct therapy device having driver with cavity for hemostatic agent |
US9492170B2 (en) | 2011-08-10 | 2016-11-15 | Ethicon Endo-Surgery, Inc. | Device for applying adjunct in endoscopic procedure |
EP2744426B1 (en) | 2011-08-15 | 2018-10-10 | AtriCure Inc. | Occlusion clip applicator |
US8833632B2 (en) | 2011-09-06 | 2014-09-16 | Ethicon Endo-Surgery, Inc. | Firing member displacement system for a stapling instrument |
US8998060B2 (en) | 2011-09-13 | 2015-04-07 | Ethicon Endo-Surgery, Inc. | Resistive heated surgical staple cartridge with phase change sealant |
US9101359B2 (en) | 2011-09-13 | 2015-08-11 | Ethicon Endo-Surgery, Inc. | Surgical staple cartridge with self-dispensing staple buttress |
US9999408B2 (en) | 2011-09-14 | 2018-06-19 | Ethicon Endo-Surgery, Inc. | Surgical instrument with fluid fillable buttress |
US8814025B2 (en) | 2011-09-15 | 2014-08-26 | Ethicon Endo-Surgery, Inc. | Fibrin pad matrix with suspended heat activated beads of adhesive |
US9125649B2 (en) * | 2011-09-15 | 2015-09-08 | Ethicon Endo-Surgery, Inc. | Surgical instrument with filled staple |
US9254180B2 (en) | 2011-09-15 | 2016-02-09 | Ethicon Endo-Surgery, Inc. | Surgical instrument with staple reinforcement clip |
WO2013040247A2 (en) | 2011-09-16 | 2013-03-21 | Forsight Vision4, Inc. | Fluid exchange apparatus and methods |
US9393018B2 (en) | 2011-09-22 | 2016-07-19 | Ethicon Endo-Surgery, Inc. | Surgical staple assembly with hemostatic feature |
US9198644B2 (en) | 2011-09-22 | 2015-12-01 | Ethicon Endo-Surgery, Inc. | Anvil cartridge for surgical fastening device |
US8985429B2 (en) | 2011-09-23 | 2015-03-24 | Ethicon Endo-Surgery, Inc. | Surgical stapling device with adjunct material application feature |
US9050084B2 (en) | 2011-09-23 | 2015-06-09 | Ethicon Endo-Surgery, Inc. | Staple cartridge including collapsible deck arrangement |
US8899464B2 (en) | 2011-10-03 | 2014-12-02 | Ethicon Endo-Surgery, Inc. | Attachment of surgical staple buttress to cartridge |
US9089326B2 (en) | 2011-10-07 | 2015-07-28 | Ethicon Endo-Surgery, Inc. | Dual staple cartridge for surgical stapler |
CA2859543A1 (en) | 2011-12-19 | 2013-06-27 | Rotation Medical, Inc. | Apparatus and method for forming pilot holes in bone and delivering fasteners therein for retaining an implant |
US9107661B2 (en) | 2011-12-19 | 2015-08-18 | Rotation Medical, Inc. | Fasteners and fastener delivery devices for affixing sheet-like materials to bone or tissue |
WO2013119321A1 (en) | 2011-12-19 | 2013-08-15 | Rotation Medical, Inc. | Fasteners for affixing sheet -like materials to bone or tissue |
WO2013096224A1 (en) | 2011-12-19 | 2013-06-27 | Rotation Medical, Inc. | Fasteners for affixing sheet -like materials to bone or tissue |
FR2985170B1 (en) | 2011-12-29 | 2014-01-24 | Sofradim Production | PROSTHESIS FOR INGUINAL HERNIA |
WO2013101640A1 (en) | 2011-12-29 | 2013-07-04 | Rotation Medical, Inc. | Guidewire having a distal fixation member for delivering and positioning sheet-like materials in surgery |
WO2013101638A1 (en) | 2011-12-29 | 2013-07-04 | Rotation Medical, Inc. | Methods and apparatus for delivering and positioning sheet -like materials in surgery |
US9282973B2 (en) | 2012-01-20 | 2016-03-15 | Atricure, Inc. | Clip deployment tool and associated methods |
WO2013116061A1 (en) | 2012-02-03 | 2013-08-08 | Forsight Vision4, Inc. | Insertion and removal methods and apparatus for therapeutic devices |
US9044230B2 (en) | 2012-02-13 | 2015-06-02 | Ethicon Endo-Surgery, Inc. | Surgical cutting and fastening instrument with apparatus for determining cartridge and firing motion status |
US9078653B2 (en) | 2012-03-26 | 2015-07-14 | Ethicon Endo-Surgery, Inc. | Surgical stapling device with lockout system for preventing actuation in the absence of an installed staple cartridge |
US9198662B2 (en) | 2012-03-28 | 2015-12-01 | Ethicon Endo-Surgery, Inc. | Tissue thickness compensator having improved visibility |
BR112014024102B1 (en) | 2012-03-28 | 2022-03-03 | Ethicon Endo-Surgery, Inc | CLAMP CARTRIDGE ASSEMBLY FOR A SURGICAL INSTRUMENT AND END ACTUATOR ASSEMBLY FOR A SURGICAL INSTRUMENT |
CN104379068B (en) | 2012-03-28 | 2017-09-22 | 伊西康内外科公司 | Holding device assembly including tissue thickness compensation part |
BR112014024098B1 (en) | 2012-03-28 | 2021-05-25 | Ethicon Endo-Surgery, Inc. | staple cartridge |
US9138274B1 (en) * | 2012-05-04 | 2015-09-22 | Xtraverse, LLC | Fasteners with shape changing bellows and methods using same |
US10405903B1 (en) | 2012-05-04 | 2019-09-10 | Xtraverse, LLC | Fasteners with shape changing zigzag structures and methods using same |
US9101358B2 (en) | 2012-06-15 | 2015-08-11 | Ethicon Endo-Surgery, Inc. | Articulatable surgical instrument comprising a firing drive |
US9561038B2 (en) | 2012-06-28 | 2017-02-07 | Ethicon Endo-Surgery, Llc | Interchangeable clip applier |
US20140001231A1 (en) | 2012-06-28 | 2014-01-02 | Ethicon Endo-Surgery, Inc. | Firing system lockout arrangements for surgical instruments |
BR112014032776B1 (en) | 2012-06-28 | 2021-09-08 | Ethicon Endo-Surgery, Inc | SURGICAL INSTRUMENT SYSTEM AND SURGICAL KIT FOR USE WITH A SURGICAL INSTRUMENT SYSTEM |
JP6290201B2 (en) | 2012-06-28 | 2018-03-07 | エシコン・エンド−サージェリィ・インコーポレイテッドEthicon Endo−Surgery,Inc. | Lockout for empty clip cartridge |
US9289256B2 (en) | 2012-06-28 | 2016-03-22 | Ethicon Endo-Surgery, Llc | Surgical end effectors having angled tissue-contacting surfaces |
US9028494B2 (en) | 2012-06-28 | 2015-05-12 | Ethicon Endo-Surgery, Inc. | Interchangeable end effector coupling arrangement |
US9282974B2 (en) | 2012-06-28 | 2016-03-15 | Ethicon Endo-Surgery, Llc | Empty clip cartridge lockout |
US9119657B2 (en) | 2012-06-28 | 2015-09-01 | Ethicon Endo-Surgery, Inc. | Rotary actuatable closure arrangement for surgical end effector |
US9226751B2 (en) | 2012-06-28 | 2016-01-05 | Ethicon Endo-Surgery, Inc. | Surgical instrument system including replaceable end effectors |
US9204879B2 (en) | 2012-06-28 | 2015-12-08 | Ethicon Endo-Surgery, Inc. | Flexible drive member |
US9101385B2 (en) | 2012-06-28 | 2015-08-11 | Ethicon Endo-Surgery, Inc. | Electrode connections for rotary driven surgical tools |
US9072536B2 (en) | 2012-06-28 | 2015-07-07 | Ethicon Endo-Surgery, Inc. | Differential locking arrangements for rotary powered surgical instruments |
US11278284B2 (en) | 2012-06-28 | 2022-03-22 | Cilag Gmbh International | Rotary drive arrangements for surgical instruments |
US8747238B2 (en) | 2012-06-28 | 2014-06-10 | Ethicon Endo-Surgery, Inc. | Rotary drive shaft assemblies for surgical instruments with articulatable end effectors |
US9125662B2 (en) | 2012-06-28 | 2015-09-08 | Ethicon Endo-Surgery, Inc. | Multi-axis articulating and rotating surgical tools |
FR2994185B1 (en) | 2012-08-02 | 2015-07-31 | Sofradim Production | PROCESS FOR THE PREPARATION OF A POROUS CHITOSAN LAYER |
FR2995788B1 (en) | 2012-09-25 | 2014-09-26 | Sofradim Production | HEMOSTATIC PATCH AND PREPARATION METHOD |
FR2995779B1 (en) | 2012-09-25 | 2015-09-25 | Sofradim Production | PROSTHETIC COMPRISING A TREILLIS AND A MEANS OF CONSOLIDATION |
US9386984B2 (en) | 2013-02-08 | 2016-07-12 | Ethicon Endo-Surgery, Llc | Staple cartridge comprising a releasable cover |
US10092292B2 (en) | 2013-02-28 | 2018-10-09 | Ethicon Llc | Staple forming features for surgical stapling instrument |
JP6382235B2 (en) | 2013-03-01 | 2018-08-29 | エシコン・エンド−サージェリィ・インコーポレイテッドEthicon Endo−Surgery,Inc. | Articulatable surgical instrument with a conductive path for signal communication |
US20140246475A1 (en) | 2013-03-01 | 2014-09-04 | Ethicon Endo-Surgery, Inc. | Control methods for surgical instruments with removable implement portions |
JP6345707B2 (en) | 2013-03-01 | 2018-06-20 | エシコン・エンド−サージェリィ・インコーポレイテッドEthicon Endo−Surgery,Inc. | Surgical instrument with soft stop |
US20140263552A1 (en) | 2013-03-13 | 2014-09-18 | Ethicon Endo-Surgery, Inc. | Staple cartridge tissue thickness sensor system |
US9629629B2 (en) | 2013-03-14 | 2017-04-25 | Ethicon Endo-Surgey, LLC | Control systems for surgical instruments |
CA2905496A1 (en) | 2013-03-14 | 2014-09-25 | Forsight Vision4, Inc. | Systems for sustained intraocular delivery of low solubility compounds from a port delivery system implant |
US9332987B2 (en) | 2013-03-14 | 2016-05-10 | Ethicon Endo-Surgery, Llc | Control arrangements for a drive member of a surgical instrument |
CA2905787C (en) | 2013-03-15 | 2019-06-18 | Baronova, Inc. | Locking gastric obstruction device and method of use |
US9795384B2 (en) | 2013-03-27 | 2017-10-24 | Ethicon Llc | Fastener cartridge comprising a tissue thickness compensator and a gap setting element |
US9572577B2 (en) | 2013-03-27 | 2017-02-21 | Ethicon Endo-Surgery, Llc | Fastener cartridge comprising a tissue thickness compensator including openings therein |
US9332984B2 (en) | 2013-03-27 | 2016-05-10 | Ethicon Endo-Surgery, Llc | Fastener cartridge assemblies |
AU2014241163B2 (en) | 2013-03-28 | 2018-09-27 | Forsight Vision4, Inc. | Ophthalmic implant for delivering therapeutic substances |
BR112015026109B1 (en) | 2013-04-16 | 2022-02-22 | Ethicon Endo-Surgery, Inc | surgical instrument |
US9844368B2 (en) | 2013-04-16 | 2017-12-19 | Ethicon Llc | Surgical system comprising first and second drive systems |
US9574644B2 (en) | 2013-05-30 | 2017-02-21 | Ethicon Endo-Surgery, Llc | Power module for use with a surgical instrument |
JP6416260B2 (en) | 2013-08-23 | 2018-10-31 | エシコン エルエルシー | Firing member retractor for a powered surgical instrument |
US20150053746A1 (en) | 2013-08-23 | 2015-02-26 | Ethicon Endo-Surgery, Inc. | Torque optimization for surgical instruments |
US20140171986A1 (en) | 2013-09-13 | 2014-06-19 | Ethicon Endo-Surgery, Inc. | Surgical Clip Having Comliant Portion |
US9681870B2 (en) | 2013-12-23 | 2017-06-20 | Ethicon Llc | Articulatable surgical instruments with separate and distinct closing and firing systems |
US9642620B2 (en) | 2013-12-23 | 2017-05-09 | Ethicon Endo-Surgery, Llc | Surgical cutting and stapling instruments with articulatable end effectors |
USD775336S1 (en) * | 2013-12-23 | 2016-12-27 | Ethicon Endo-Surgery, Llc | Surgical fastener |
US20150173756A1 (en) | 2013-12-23 | 2015-06-25 | Ethicon Endo-Surgery, Inc. | Surgical cutting and stapling methods |
US9968354B2 (en) | 2013-12-23 | 2018-05-15 | Ethicon Llc | Surgical staples and methods for making the same |
US9839428B2 (en) | 2013-12-23 | 2017-12-12 | Ethicon Llc | Surgical cutting and stapling instruments with independent jaw control features |
US9724092B2 (en) | 2013-12-23 | 2017-08-08 | Ethicon Llc | Modular surgical instruments |
US9962161B2 (en) | 2014-02-12 | 2018-05-08 | Ethicon Llc | Deliverable surgical instrument |
CN106232029B (en) | 2014-02-24 | 2019-04-12 | 伊西康内外科有限责任公司 | Fastening system including firing member locking piece |
US9839422B2 (en) | 2014-02-24 | 2017-12-12 | Ethicon Llc | Implantable layers and methods for altering implantable layers for use with surgical fastening instruments |
US10004497B2 (en) | 2014-03-26 | 2018-06-26 | Ethicon Llc | Interface systems for use with surgical instruments |
BR112016021943B1 (en) | 2014-03-26 | 2022-06-14 | Ethicon Endo-Surgery, Llc | SURGICAL INSTRUMENT FOR USE BY AN OPERATOR IN A SURGICAL PROCEDURE |
US9733663B2 (en) | 2014-03-26 | 2017-08-15 | Ethicon Llc | Power management through segmented circuit and variable voltage protection |
US10201364B2 (en) | 2014-03-26 | 2019-02-12 | Ethicon Llc | Surgical instrument comprising a rotatable shaft |
US9913642B2 (en) | 2014-03-26 | 2018-03-13 | Ethicon Llc | Surgical instrument comprising a sensor system |
US20150297223A1 (en) | 2014-04-16 | 2015-10-22 | Ethicon Endo-Surgery, Inc. | Fastener cartridges including extensions having different configurations |
US10327764B2 (en) | 2014-09-26 | 2019-06-25 | Ethicon Llc | Method for creating a flexible staple line |
US10561422B2 (en) | 2014-04-16 | 2020-02-18 | Ethicon Llc | Fastener cartridge comprising deployable tissue engaging members |
JP6532889B2 (en) | 2014-04-16 | 2019-06-19 | エシコン エルエルシーEthicon LLC | Fastener cartridge assembly and staple holder cover arrangement |
BR112016023825B1 (en) | 2014-04-16 | 2022-08-02 | Ethicon Endo-Surgery, Llc | STAPLE CARTRIDGE FOR USE WITH A SURGICAL STAPLER AND STAPLE CARTRIDGE FOR USE WITH A SURGICAL INSTRUMENT |
JP6636452B2 (en) | 2014-04-16 | 2020-01-29 | エシコン エルエルシーEthicon LLC | Fastener cartridge including extension having different configurations |
JP6267365B2 (en) | 2014-05-09 | 2018-01-24 | ローテーション メディカル インコーポレイテッドRotation Medical,Inc. | Medical implant delivery system for sheet implants |
US10045781B2 (en) | 2014-06-13 | 2018-08-14 | Ethicon Llc | Closure lockout systems for surgical instruments |
WO2016011191A1 (en) | 2014-07-15 | 2016-01-21 | Forsight Vision4, Inc. | Ocular implant delivery device and method |
SG11201700943TA (en) | 2014-08-08 | 2017-03-30 | Forsight Vision4 Inc | Stable and soluble formulations of receptor tyrosine kinase inhibitors, and methods of preparation thereof |
US11161642B2 (en) | 2014-08-11 | 2021-11-02 | Avery Dennison Retail Information Services, Llc | Fastener assembly |
US10111679B2 (en) | 2014-09-05 | 2018-10-30 | Ethicon Llc | Circuitry and sensors for powered medical device |
BR112017004361B1 (en) | 2014-09-05 | 2023-04-11 | Ethicon Llc | ELECTRONIC SYSTEM FOR A SURGICAL INSTRUMENT |
US11311294B2 (en) | 2014-09-05 | 2022-04-26 | Cilag Gmbh International | Powered medical device including measurement of closure state of jaws |
US10105142B2 (en) | 2014-09-18 | 2018-10-23 | Ethicon Llc | Surgical stapler with plurality of cutting elements |
JP6648119B2 (en) | 2014-09-26 | 2020-02-14 | エシコン エルエルシーEthicon LLC | Surgical stapling buttress and accessory materials |
US11523821B2 (en) | 2014-09-26 | 2022-12-13 | Cilag Gmbh International | Method for creating a flexible staple line |
US10076325B2 (en) | 2014-10-13 | 2018-09-18 | Ethicon Llc | Surgical stapling apparatus comprising a tissue stop |
US9924944B2 (en) | 2014-10-16 | 2018-03-27 | Ethicon Llc | Staple cartridge comprising an adjunct material |
US11141153B2 (en) | 2014-10-29 | 2021-10-12 | Cilag Gmbh International | Staple cartridges comprising driver arrangements |
US10517594B2 (en) | 2014-10-29 | 2019-12-31 | Ethicon Llc | Cartridge assemblies for surgical staplers |
EP3215025B1 (en) | 2014-11-04 | 2020-12-23 | Rotation Medical, Inc. | Medical implant delivery system |
EP3215026B1 (en) | 2014-11-04 | 2023-10-25 | Rotation Medical, Inc. | Medical implant delivery system |
US10675019B2 (en) | 2014-11-04 | 2020-06-09 | Rotation Medical, Inc. | Medical implant delivery system and related methods |
US9844376B2 (en) | 2014-11-06 | 2017-12-19 | Ethicon Llc | Staple cartridge comprising a releasable adjunct material |
CA2967330A1 (en) | 2014-11-10 | 2016-05-19 | Forsight Vision4, Inc. | Expandable drug delivery devices and methods of use |
US10736636B2 (en) | 2014-12-10 | 2020-08-11 | Ethicon Llc | Articulatable surgical instrument system |
US9844374B2 (en) | 2014-12-18 | 2017-12-19 | Ethicon Llc | Surgical instrument systems comprising an articulatable end effector and means for adjusting the firing stroke of a firing member |
MX2017008108A (en) | 2014-12-18 | 2018-03-06 | Ethicon Llc | Surgical instrument with an anvil that is selectively movable about a discrete non-movable axis relative to a staple cartridge. |
US10004501B2 (en) | 2014-12-18 | 2018-06-26 | Ethicon Llc | Surgical instruments with improved closure arrangements |
US10085748B2 (en) | 2014-12-18 | 2018-10-02 | Ethicon Llc | Locking arrangements for detachable shaft assemblies with articulatable surgical end effectors |
US9987000B2 (en) | 2014-12-18 | 2018-06-05 | Ethicon Llc | Surgical instrument assembly comprising a flexible articulation system |
US10117649B2 (en) | 2014-12-18 | 2018-11-06 | Ethicon Llc | Surgical instrument assembly comprising a lockable articulation system |
US9844375B2 (en) | 2014-12-18 | 2017-12-19 | Ethicon Llc | Drive arrangements for articulatable surgical instruments |
US10188385B2 (en) | 2014-12-18 | 2019-01-29 | Ethicon Llc | Surgical instrument system comprising lockable systems |
EP3059255B1 (en) | 2015-02-17 | 2020-05-13 | Sofradim Production | Method for preparing a chitosan-based matrix comprising a fiber reinforcement member |
US10321907B2 (en) | 2015-02-27 | 2019-06-18 | Ethicon Llc | System for monitoring whether a surgical instrument needs to be serviced |
US9993258B2 (en) | 2015-02-27 | 2018-06-12 | Ethicon Llc | Adaptable surgical instrument handle |
US11154301B2 (en) | 2015-02-27 | 2021-10-26 | Cilag Gmbh International | Modular stapling assembly |
US10180463B2 (en) | 2015-02-27 | 2019-01-15 | Ethicon Llc | Surgical apparatus configured to assess whether a performance parameter of the surgical apparatus is within an acceptable performance band |
US9993248B2 (en) | 2015-03-06 | 2018-06-12 | Ethicon Endo-Surgery, Llc | Smart sensors with local signal processing |
US10617412B2 (en) | 2015-03-06 | 2020-04-14 | Ethicon Llc | System for detecting the mis-insertion of a staple cartridge into a surgical stapler |
US10441279B2 (en) | 2015-03-06 | 2019-10-15 | Ethicon Llc | Multiple level thresholds to modify operation of powered surgical instruments |
US10548504B2 (en) | 2015-03-06 | 2020-02-04 | Ethicon Llc | Overlaid multi sensor radio frequency (RF) electrode system to measure tissue compression |
US10687806B2 (en) | 2015-03-06 | 2020-06-23 | Ethicon Llc | Adaptive tissue compression techniques to adjust closure rates for multiple tissue types |
US9924961B2 (en) | 2015-03-06 | 2018-03-27 | Ethicon Endo-Surgery, Llc | Interactive feedback system for powered surgical instruments |
US9901342B2 (en) | 2015-03-06 | 2018-02-27 | Ethicon Endo-Surgery, Llc | Signal and power communication system positioned on a rotatable shaft |
US9895148B2 (en) | 2015-03-06 | 2018-02-20 | Ethicon Endo-Surgery, Llc | Monitoring speed control and precision incrementing of motor for powered surgical instruments |
US9808246B2 (en) | 2015-03-06 | 2017-11-07 | Ethicon Endo-Surgery, Llc | Method of operating a powered surgical instrument |
US10045776B2 (en) | 2015-03-06 | 2018-08-14 | Ethicon Llc | Control techniques and sub-processor contained within modular shaft with select control processing from handle |
JP2020121162A (en) | 2015-03-06 | 2020-08-13 | エシコン エルエルシーEthicon LLC | Time dependent evaluation of sensor data to determine stability element, creep element and viscoelastic element of measurement |
US10245033B2 (en) | 2015-03-06 | 2019-04-02 | Ethicon Llc | Surgical instrument comprising a lockable battery housing |
US10213201B2 (en) | 2015-03-31 | 2019-02-26 | Ethicon Llc | Stapling end effector configured to compensate for an uneven gap between a first jaw and a second jaw |
EP3085337B1 (en) | 2015-04-24 | 2022-09-14 | Sofradim Production | Prosthesis for supporting a breast structure |
WO2016179372A1 (en) | 2015-05-06 | 2016-11-10 | Rotation Medical, Inc. | Medical implant delivery system and related methods |
US10349941B2 (en) * | 2015-05-27 | 2019-07-16 | Covidien Lp | Multi-fire lead screw stapling device |
EP3307204B1 (en) | 2015-06-15 | 2021-11-24 | Rotation Medical, Inc. | Tendon repair implant |
US10368861B2 (en) | 2015-06-18 | 2019-08-06 | Ethicon Llc | Dual articulation drive system arrangements for articulatable surgical instruments |
ES2676072T3 (en) | 2015-06-19 | 2018-07-16 | Sofradim Production | Synthetic prosthesis comprising a knitted fabric and a non-porous film and method of forming it |
US11058425B2 (en) | 2015-08-17 | 2021-07-13 | Ethicon Llc | Implantable layers for a surgical instrument |
JP6828018B2 (en) | 2015-08-26 | 2021-02-10 | エシコン エルエルシーEthicon LLC | Surgical staple strips that allow you to change the characteristics of staples and facilitate filling into cartridges |
US10357251B2 (en) | 2015-08-26 | 2019-07-23 | Ethicon Llc | Surgical staples comprising hardness variations for improved fastening of tissue |
US10188389B2 (en) | 2015-08-31 | 2019-01-29 | Ethicon Llc | Adjunct material for delivery to colon tissue |
US11020116B2 (en) | 2015-08-31 | 2021-06-01 | Ethicon Llc | Surgical adjuncts with medicants affected by activators |
US10279086B2 (en) | 2015-08-31 | 2019-05-07 | Ethicon Llc | Composite adjunct materials for delivering medicants |
US10349938B2 (en) | 2015-08-31 | 2019-07-16 | Ethicon Llc | Surgical adjuncts with medicants affected by activator materials |
US9937283B2 (en) | 2015-08-31 | 2018-04-10 | Ethicon Endo-Surgery, Llc | Adjunct material to provide drug elution from vessels |
US10499913B2 (en) | 2015-08-31 | 2019-12-10 | Ethicon Llc | Tubular surgical constructs including adjunct material |
US10086116B2 (en) | 2015-08-31 | 2018-10-02 | Ethicon Llc | Adjunct material to provide controlled drug release |
US10285692B2 (en) | 2015-08-31 | 2019-05-14 | Ethicon Llc | Adjuncts for surgical devices including agonists and antagonists |
US10463366B2 (en) | 2015-08-31 | 2019-11-05 | Ethicon Llc | Adjunct materials for delivery to liver tissue |
US10194936B2 (en) | 2015-08-31 | 2019-02-05 | Ethicon Endo-Surgery, Llc | Adjunct material for delivery to stomach tissue |
US10111661B2 (en) | 2015-08-31 | 2018-10-30 | Ethicon Llc | Matrix metalloproteinase inhibiting adjuncts for surgical devices |
US10245034B2 (en) | 2015-08-31 | 2019-04-02 | Ethicon Llc | Inducing tissue adhesions using surgical adjuncts and medicants |
US10076324B2 (en) | 2015-08-31 | 2018-09-18 | Ethicon Llc | Adjunct material to provide controlled drug elution |
US10076329B2 (en) | 2015-08-31 | 2018-09-18 | Ethicon Llc | Adjunct material to promote tissue growth in a colon |
US10569071B2 (en) | 2015-08-31 | 2020-02-25 | Ethicon Llc | Medicant eluting adjuncts and methods of using medicant eluting adjuncts |
US10188390B2 (en) | 2015-08-31 | 2019-01-29 | Ethicon Llc | Adjunct material to provide heterogeneous drug elution |
US10213520B2 (en) | 2015-08-31 | 2019-02-26 | Ethicon Llc | Surgical adjuncts having medicants controllably releasable therefrom |
US10130738B2 (en) | 2015-08-31 | 2018-11-20 | Ethicon Llc | Adjunct material to promote tissue growth |
US10172973B2 (en) | 2015-08-31 | 2019-01-08 | Ethicon Llc | Surgical adjuncts and medicants for promoting lung function |
US10238390B2 (en) | 2015-09-02 | 2019-03-26 | Ethicon Llc | Surgical staple cartridges with driver arrangements for establishing herringbone staple patterns |
MX2022006192A (en) | 2015-09-02 | 2022-06-16 | Ethicon Llc | Surgical staple configurations with camming surfaces located between portions supporting surgical staples. |
US10076326B2 (en) | 2015-09-23 | 2018-09-18 | Ethicon Llc | Surgical stapler having current mirror-based motor control |
US10105139B2 (en) | 2015-09-23 | 2018-10-23 | Ethicon Llc | Surgical stapler having downstream current-based motor control |
US10327769B2 (en) | 2015-09-23 | 2019-06-25 | Ethicon Llc | Surgical stapler having motor control based on a drive system component |
US10085751B2 (en) | 2015-09-23 | 2018-10-02 | Ethicon Llc | Surgical stapler having temperature-based motor control |
US10238386B2 (en) | 2015-09-23 | 2019-03-26 | Ethicon Llc | Surgical stapler having motor control based on an electrical parameter related to a motor current |
US10363036B2 (en) | 2015-09-23 | 2019-07-30 | Ethicon Llc | Surgical stapler having force-based motor control |
US10299878B2 (en) | 2015-09-25 | 2019-05-28 | Ethicon Llc | Implantable adjunct systems for determining adjunct skew |
US10980539B2 (en) | 2015-09-30 | 2021-04-20 | Ethicon Llc | Implantable adjunct comprising bonded layers |
US10327777B2 (en) | 2015-09-30 | 2019-06-25 | Ethicon Llc | Implantable layer comprising plastically deformed fibers |
US10285699B2 (en) | 2015-09-30 | 2019-05-14 | Ethicon Llc | Compressible adjunct |
US11890015B2 (en) | 2015-09-30 | 2024-02-06 | Cilag Gmbh International | Compressible adjunct with crossing spacer fibers |
CN113069681B (en) | 2015-11-20 | 2022-12-23 | 弗赛特影像4股份有限公司 | Method of manufacturing a therapeutic device for sustained drug delivery |
US10368865B2 (en) | 2015-12-30 | 2019-08-06 | Ethicon Llc | Mechanisms for compensating for drivetrain failure in powered surgical instruments |
US10265068B2 (en) | 2015-12-30 | 2019-04-23 | Ethicon Llc | Surgical instruments with separable motors and motor control circuits |
US10292704B2 (en) | 2015-12-30 | 2019-05-21 | Ethicon Llc | Mechanisms for compensating for battery pack failure in powered surgical instruments |
WO2017117437A1 (en) | 2015-12-31 | 2017-07-06 | Rotation Medical, Inc. | Fastener delivery system and related methods |
US10314689B2 (en) | 2015-12-31 | 2019-06-11 | Rotation Medical, Inc. | Medical implant delivery system and related methods |
EP3195830B1 (en) | 2016-01-25 | 2020-11-18 | Sofradim Production | Prosthesis for hernia repair |
US20170224332A1 (en) | 2016-02-09 | 2017-08-10 | Ethicon Endo-Surgery, Llc | Surgical instruments with non-symmetrical articulation arrangements |
US11213293B2 (en) | 2016-02-09 | 2022-01-04 | Cilag Gmbh International | Articulatable surgical instruments with single articulation link arrangements |
BR112018016098B1 (en) | 2016-02-09 | 2023-02-23 | Ethicon Llc | SURGICAL INSTRUMENT |
US11224426B2 (en) | 2016-02-12 | 2022-01-18 | Cilag Gmbh International | Mechanisms for compensating for drivetrain failure in powered surgical instruments |
US10258331B2 (en) | 2016-02-12 | 2019-04-16 | Ethicon Llc | Mechanisms for compensating for drivetrain failure in powered surgical instruments |
US10448948B2 (en) | 2016-02-12 | 2019-10-22 | Ethicon Llc | Mechanisms for compensating for drivetrain failure in powered surgical instruments |
US10617413B2 (en) | 2016-04-01 | 2020-04-14 | Ethicon Llc | Closure system arrangements for surgical cutting and stapling devices with separate and distinct firing shafts |
US11284890B2 (en) | 2016-04-01 | 2022-03-29 | Cilag Gmbh International | Circular stapling system comprising an incisable tissue support |
US10307159B2 (en) | 2016-04-01 | 2019-06-04 | Ethicon Llc | Surgical instrument handle assembly with reconfigurable grip portion |
US11064997B2 (en) | 2016-04-01 | 2021-07-20 | Cilag Gmbh International | Surgical stapling instrument |
US10271851B2 (en) | 2016-04-01 | 2019-04-30 | Ethicon Llc | Modular surgical stapling system comprising a display |
ES2837524T3 (en) | 2016-04-05 | 2021-06-30 | Forsight Vision4 Inc | Implantable ocular drug delivery devices |
US10405859B2 (en) | 2016-04-15 | 2019-09-10 | Ethicon Llc | Surgical instrument with adjustable stop/start control during a firing motion |
US11607239B2 (en) | 2016-04-15 | 2023-03-21 | Cilag Gmbh International | Systems and methods for controlling a surgical stapling and cutting instrument |
US10357247B2 (en) | 2016-04-15 | 2019-07-23 | Ethicon Llc | Surgical instrument with multiple program responses during a firing motion |
US11179150B2 (en) | 2016-04-15 | 2021-11-23 | Cilag Gmbh International | Systems and methods for controlling a surgical stapling and cutting instrument |
US10456137B2 (en) | 2016-04-15 | 2019-10-29 | Ethicon Llc | Staple formation detection mechanisms |
US10426467B2 (en) | 2016-04-15 | 2019-10-01 | Ethicon Llc | Surgical instrument with detection sensors |
US10492783B2 (en) | 2016-04-15 | 2019-12-03 | Ethicon, Llc | Surgical instrument with improved stop/start control during a firing motion |
US10828028B2 (en) | 2016-04-15 | 2020-11-10 | Ethicon Llc | Surgical instrument with multiple program responses during a firing motion |
US10335145B2 (en) | 2016-04-15 | 2019-07-02 | Ethicon Llc | Modular surgical instrument with configurable operating mode |
US20170296173A1 (en) | 2016-04-18 | 2017-10-19 | Ethicon Endo-Surgery, Llc | Method for operating a surgical instrument |
US11317917B2 (en) | 2016-04-18 | 2022-05-03 | Cilag Gmbh International | Surgical stapling system comprising a lockable firing assembly |
US10368867B2 (en) | 2016-04-18 | 2019-08-06 | Ethicon Llc | Surgical instrument comprising a lockout |
US10251645B2 (en) * | 2016-06-14 | 2019-04-09 | Covidien Lp | Surgical fastening with W-shaped surgical fasteners |
US10702270B2 (en) * | 2016-06-24 | 2020-07-07 | Ethicon Llc | Stapling system for use with wire staples and stamped staples |
JP6957532B2 (en) | 2016-06-24 | 2021-11-02 | エシコン エルエルシーEthicon LLC | Staple cartridges including wire staples and punched staples |
USD847989S1 (en) | 2016-06-24 | 2019-05-07 | Ethicon Llc | Surgical fastener cartridge |
USD822206S1 (en) | 2016-06-24 | 2018-07-03 | Ethicon Llc | Surgical fastener |
USD826405S1 (en) | 2016-06-24 | 2018-08-21 | Ethicon Llc | Surgical fastener |
USD850617S1 (en) | 2016-06-24 | 2019-06-04 | Ethicon Llc | Surgical fastener cartridge |
EP3312325B1 (en) | 2016-10-21 | 2021-09-22 | Sofradim Production | Method for forming a mesh having a barbed suture attached thereto and the mesh thus obtained |
US10856868B2 (en) | 2016-12-21 | 2020-12-08 | Ethicon Llc | Firing member pin configurations |
JP7010956B2 (en) | 2016-12-21 | 2022-01-26 | エシコン エルエルシー | How to staple tissue |
US10426471B2 (en) | 2016-12-21 | 2019-10-01 | Ethicon Llc | Surgical instrument with multiple failure response modes |
US10682138B2 (en) | 2016-12-21 | 2020-06-16 | Ethicon Llc | Bilaterally asymmetric staple forming pocket pairs |
US10695055B2 (en) | 2016-12-21 | 2020-06-30 | Ethicon Llc | Firing assembly comprising a lockout |
MX2019007311A (en) | 2016-12-21 | 2019-11-18 | Ethicon Llc | Surgical stapling systems. |
US10945727B2 (en) | 2016-12-21 | 2021-03-16 | Ethicon Llc | Staple cartridge with deformable driver retention features |
US10687810B2 (en) | 2016-12-21 | 2020-06-23 | Ethicon Llc | Stepped staple cartridge with tissue retention and gap setting features |
US10993715B2 (en) | 2016-12-21 | 2021-05-04 | Ethicon Llc | Staple cartridge comprising staples with different clamping breadths |
US20180168615A1 (en) | 2016-12-21 | 2018-06-21 | Ethicon Endo-Surgery, Llc | Method of deforming staples from two different types of staple cartridges with the same surgical stapling instrument |
US10588631B2 (en) | 2016-12-21 | 2020-03-17 | Ethicon Llc | Surgical instruments with positive jaw opening features |
US10888322B2 (en) | 2016-12-21 | 2021-01-12 | Ethicon Llc | Surgical instrument comprising a cutting member |
US10973516B2 (en) | 2016-12-21 | 2021-04-13 | Ethicon Llc | Surgical end effectors and adaptable firing members therefor |
US11419606B2 (en) | 2016-12-21 | 2022-08-23 | Cilag Gmbh International | Shaft assembly comprising a clutch configured to adapt the output of a rotary firing member to two different systems |
US20180168633A1 (en) | 2016-12-21 | 2018-06-21 | Ethicon Endo-Surgery, Llc | Surgical stapling instruments and staple-forming anvils |
US10568624B2 (en) | 2016-12-21 | 2020-02-25 | Ethicon Llc | Surgical instruments with jaws that are pivotable about a fixed axis and include separate and distinct closure and firing systems |
US20180168648A1 (en) | 2016-12-21 | 2018-06-21 | Ethicon Endo-Surgery, Llc | Durability features for end effectors and firing assemblies of surgical stapling instruments |
US10959727B2 (en) | 2016-12-21 | 2021-03-30 | Ethicon Llc | Articulatable surgical end effector with asymmetric shaft arrangement |
US11090048B2 (en) | 2016-12-21 | 2021-08-17 | Cilag Gmbh International | Method for resetting a fuse of a surgical instrument shaft |
US11134942B2 (en) | 2016-12-21 | 2021-10-05 | Cilag Gmbh International | Surgical stapling instruments and staple-forming anvils |
CN110099619B (en) | 2016-12-21 | 2022-07-15 | 爱惜康有限责任公司 | Lockout device for surgical end effector and replaceable tool assembly |
US10918385B2 (en) | 2016-12-21 | 2021-02-16 | Ethicon Llc | Surgical system comprising a firing member rotatable into an articulation state to articulate an end effector of the surgical system |
US20180168625A1 (en) | 2016-12-21 | 2018-06-21 | Ethicon Endo-Surgery, Llc | Surgical stapling instruments with smart staple cartridges |
US11684367B2 (en) | 2016-12-21 | 2023-06-27 | Cilag Gmbh International | Stepped assembly having and end-of-life indicator |
US20180221022A1 (en) * | 2017-02-07 | 2018-08-09 | Regents Of The University Of Minnesota | Retainer assembly |
US11465795B2 (en) * | 2017-04-14 | 2022-10-11 | Avery Dennison Corporation | Automation for plastic disc |
EP3398554A1 (en) | 2017-05-02 | 2018-11-07 | Sofradim Production | Prosthesis for inguinal hernia repair |
US11311295B2 (en) | 2017-05-15 | 2022-04-26 | Covidien Lp | Adaptive powered stapling algorithm with calibration factor |
US10390841B2 (en) | 2017-06-20 | 2019-08-27 | Ethicon Llc | Control of motor velocity of a surgical stapling and cutting instrument based on angle of articulation |
US10307170B2 (en) | 2017-06-20 | 2019-06-04 | Ethicon Llc | Method for closed loop control of motor velocity of a surgical stapling and cutting instrument |
US10646220B2 (en) | 2017-06-20 | 2020-05-12 | Ethicon Llc | Systems and methods for controlling displacement member velocity for a surgical instrument |
US10327767B2 (en) | 2017-06-20 | 2019-06-25 | Ethicon Llc | Control of motor velocity of a surgical stapling and cutting instrument based on angle of articulation |
USD890784S1 (en) | 2017-06-20 | 2020-07-21 | Ethicon Llc | Display panel with changeable graphical user interface |
US11090046B2 (en) | 2017-06-20 | 2021-08-17 | Cilag Gmbh International | Systems and methods for controlling displacement member motion of a surgical stapling and cutting instrument |
US10813639B2 (en) | 2017-06-20 | 2020-10-27 | Ethicon Llc | Closed loop feedback control of motor velocity of a surgical stapling and cutting instrument based on system conditions |
US11653914B2 (en) | 2017-06-20 | 2023-05-23 | Cilag Gmbh International | Systems and methods for controlling motor velocity of a surgical stapling and cutting instrument according to articulation angle of end effector |
US10779820B2 (en) | 2017-06-20 | 2020-09-22 | Ethicon Llc | Systems and methods for controlling motor speed according to user input for a surgical instrument |
US10980537B2 (en) | 2017-06-20 | 2021-04-20 | Ethicon Llc | Closed loop feedback control of motor velocity of a surgical stapling and cutting instrument based on measured time over a specified number of shaft rotations |
USD879808S1 (en) | 2017-06-20 | 2020-03-31 | Ethicon Llc | Display panel with graphical user interface |
US10624633B2 (en) | 2017-06-20 | 2020-04-21 | Ethicon Llc | Systems and methods for controlling motor velocity of a surgical stapling and cutting instrument |
US11382638B2 (en) | 2017-06-20 | 2022-07-12 | Cilag Gmbh International | Closed loop feedback control of motor velocity of a surgical stapling and cutting instrument based on measured time over a specified displacement distance |
US11517325B2 (en) | 2017-06-20 | 2022-12-06 | Cilag Gmbh International | Closed loop feedback control of motor velocity of a surgical stapling and cutting instrument based on measured displacement distance traveled over a specified time interval |
US10368864B2 (en) | 2017-06-20 | 2019-08-06 | Ethicon Llc | Systems and methods for controlling displaying motor velocity for a surgical instrument |
USD879809S1 (en) | 2017-06-20 | 2020-03-31 | Ethicon Llc | Display panel with changeable graphical user interface |
US10881399B2 (en) | 2017-06-20 | 2021-01-05 | Ethicon Llc | Techniques for adaptive control of motor velocity of a surgical stapling and cutting instrument |
US10888321B2 (en) | 2017-06-20 | 2021-01-12 | Ethicon Llc | Systems and methods for controlling velocity of a displacement member of a surgical stapling and cutting instrument |
US11071554B2 (en) | 2017-06-20 | 2021-07-27 | Cilag Gmbh International | Closed loop feedback control of motor velocity of a surgical stapling and cutting instrument based on magnitude of velocity error measurements |
US10881396B2 (en) | 2017-06-20 | 2021-01-05 | Ethicon Llc | Surgical instrument with variable duration trigger arrangement |
US10856869B2 (en) | 2017-06-27 | 2020-12-08 | Ethicon Llc | Surgical anvil arrangements |
US11266405B2 (en) | 2017-06-27 | 2022-03-08 | Cilag Gmbh International | Surgical anvil manufacturing methods |
US10772629B2 (en) | 2017-06-27 | 2020-09-15 | Ethicon Llc | Surgical anvil arrangements |
US10993716B2 (en) | 2017-06-27 | 2021-05-04 | Ethicon Llc | Surgical anvil arrangements |
US11324503B2 (en) | 2017-06-27 | 2022-05-10 | Cilag Gmbh International | Surgical firing member arrangements |
US20180368844A1 (en) | 2017-06-27 | 2018-12-27 | Ethicon Llc | Staple forming pocket arrangements |
EP3420947B1 (en) | 2017-06-28 | 2022-05-25 | Cilag GmbH International | Surgical instrument comprising selectively actuatable rotatable couplers |
US11259805B2 (en) | 2017-06-28 | 2022-03-01 | Cilag Gmbh International | Surgical instrument comprising firing member supports |
USD906355S1 (en) | 2017-06-28 | 2020-12-29 | Ethicon Llc | Display screen or portion thereof with a graphical user interface for a surgical instrument |
USD869655S1 (en) | 2017-06-28 | 2019-12-10 | Ethicon Llc | Surgical fastener cartridge |
US11484310B2 (en) | 2017-06-28 | 2022-11-01 | Cilag Gmbh International | Surgical instrument comprising a shaft including a closure tube profile |
USD854151S1 (en) | 2017-06-28 | 2019-07-16 | Ethicon Llc | Surgical instrument shaft |
US10211586B2 (en) | 2017-06-28 | 2019-02-19 | Ethicon Llc | Surgical shaft assemblies with watertight housings |
USD851762S1 (en) | 2017-06-28 | 2019-06-18 | Ethicon Llc | Anvil |
US10903685B2 (en) | 2017-06-28 | 2021-01-26 | Ethicon Llc | Surgical shaft assemblies with slip ring assemblies forming capacitive channels |
US10765427B2 (en) | 2017-06-28 | 2020-09-08 | Ethicon Llc | Method for articulating a surgical instrument |
US10716614B2 (en) | 2017-06-28 | 2020-07-21 | Ethicon Llc | Surgical shaft assemblies with slip ring assemblies with increased contact pressure |
US11564686B2 (en) | 2017-06-28 | 2023-01-31 | Cilag Gmbh International | Surgical shaft assemblies with flexible interfaces |
US11246592B2 (en) | 2017-06-28 | 2022-02-15 | Cilag Gmbh International | Surgical instrument comprising an articulation system lockable to a frame |
US11478242B2 (en) | 2017-06-28 | 2022-10-25 | Cilag Gmbh International | Jaw retainer arrangement for retaining a pivotable surgical instrument jaw in pivotable retaining engagement with a second surgical instrument jaw |
US10258418B2 (en) | 2017-06-29 | 2019-04-16 | Ethicon Llc | System for controlling articulation forces |
US10932772B2 (en) | 2017-06-29 | 2021-03-02 | Ethicon Llc | Methods for closed loop velocity control for robotic surgical instrument |
US10898183B2 (en) | 2017-06-29 | 2021-01-26 | Ethicon Llc | Robotic surgical instrument with closed loop feedback techniques for advancement of closure member during firing |
US10398434B2 (en) | 2017-06-29 | 2019-09-03 | Ethicon Llc | Closed loop velocity control of closure member for robotic surgical instrument |
US11007022B2 (en) | 2017-06-29 | 2021-05-18 | Ethicon Llc | Closed loop velocity control techniques based on sensed tissue parameters for robotic surgical instrument |
US11944300B2 (en) | 2017-08-03 | 2024-04-02 | Cilag Gmbh International | Method for operating a surgical system bailout |
US11304695B2 (en) | 2017-08-03 | 2022-04-19 | Cilag Gmbh International | Surgical system shaft interconnection |
US11471155B2 (en) | 2017-08-03 | 2022-10-18 | Cilag Gmbh International | Surgical system bailout |
USD907648S1 (en) | 2017-09-29 | 2021-01-12 | Ethicon Llc | Display screen or portion thereof with animated graphical user interface |
USD917500S1 (en) | 2017-09-29 | 2021-04-27 | Ethicon Llc | Display screen or portion thereof with graphical user interface |
US10796471B2 (en) | 2017-09-29 | 2020-10-06 | Ethicon Llc | Systems and methods of displaying a knife position for a surgical instrument |
US11399829B2 (en) | 2017-09-29 | 2022-08-02 | Cilag Gmbh International | Systems and methods of initiating a power shutdown mode for a surgical instrument |
USD907647S1 (en) | 2017-09-29 | 2021-01-12 | Ethicon Llc | Display screen or portion thereof with animated graphical user interface |
US10765429B2 (en) | 2017-09-29 | 2020-09-08 | Ethicon Llc | Systems and methods for providing alerts according to the operational state of a surgical instrument |
US10743872B2 (en) | 2017-09-29 | 2020-08-18 | Ethicon Llc | System and methods for controlling a display of a surgical instrument |
US10729501B2 (en) | 2017-09-29 | 2020-08-04 | Ethicon Llc | Systems and methods for language selection of a surgical instrument |
US11207066B2 (en) | 2017-10-30 | 2021-12-28 | Covidien Lp | Apparatus for endoscopic procedures |
US10987104B2 (en) | 2017-10-30 | 2021-04-27 | Covidien Lp | Apparatus for endoscopic procedures |
US11090075B2 (en) | 2017-10-30 | 2021-08-17 | Cilag Gmbh International | Articulation features for surgical end effector |
US11134944B2 (en) | 2017-10-30 | 2021-10-05 | Cilag Gmbh International | Surgical stapler knife motion controls |
US10842490B2 (en) | 2017-10-31 | 2020-11-24 | Ethicon Llc | Cartridge body design with force reduction based on firing completion |
US10779903B2 (en) | 2017-10-31 | 2020-09-22 | Ethicon Llc | Positive shaft rotation lock activated by jaw closure |
CN111655206B (en) | 2017-11-21 | 2022-10-14 | 弗赛特影像4股份有限公司 | Fluid exchange device for expandable port delivery system and method of use |
AU2018380146B2 (en) | 2017-12-07 | 2021-04-01 | Rotation Medical, Inc. | Medical implant delivery system and related methods |
US10687813B2 (en) | 2017-12-15 | 2020-06-23 | Ethicon Llc | Adapters with firing stroke sensing arrangements for use in connection with electromechanical surgical instruments |
US11197670B2 (en) | 2017-12-15 | 2021-12-14 | Cilag Gmbh International | Surgical end effectors with pivotal jaws configured to touch at their respective distal ends when fully closed |
US10869666B2 (en) | 2017-12-15 | 2020-12-22 | Ethicon Llc | Adapters with control systems for controlling multiple motors of an electromechanical surgical instrument |
US11071543B2 (en) | 2017-12-15 | 2021-07-27 | Cilag Gmbh International | Surgical end effectors with clamping assemblies configured to increase jaw aperture ranges |
US11033267B2 (en) | 2017-12-15 | 2021-06-15 | Ethicon Llc | Systems and methods of controlling a clamping member firing rate of a surgical instrument |
US10743875B2 (en) | 2017-12-15 | 2020-08-18 | Ethicon Llc | Surgical end effectors with jaw stiffener arrangements configured to permit monitoring of firing member |
US11006955B2 (en) | 2017-12-15 | 2021-05-18 | Ethicon Llc | End effectors with positive jaw opening features for use with adapters for electromechanical surgical instruments |
US10779825B2 (en) | 2017-12-15 | 2020-09-22 | Ethicon Llc | Adapters with end effector position sensing and control arrangements for use in connection with electromechanical surgical instruments |
US10966718B2 (en) | 2017-12-15 | 2021-04-06 | Ethicon Llc | Dynamic clamping assemblies with improved wear characteristics for use in connection with electromechanical surgical instruments |
US10779826B2 (en) | 2017-12-15 | 2020-09-22 | Ethicon Llc | Methods of operating surgical end effectors |
US10743874B2 (en) | 2017-12-15 | 2020-08-18 | Ethicon Llc | Sealed adapters for use with electromechanical surgical instruments |
US10828033B2 (en) | 2017-12-15 | 2020-11-10 | Ethicon Llc | Handheld electromechanical surgical instruments with improved motor control arrangements for positioning components of an adapter coupled thereto |
USD910847S1 (en) | 2017-12-19 | 2021-02-16 | Ethicon Llc | Surgical instrument assembly |
US11020112B2 (en) | 2017-12-19 | 2021-06-01 | Ethicon Llc | Surgical tools configured for interchangeable use with different controller interfaces |
US10716565B2 (en) | 2017-12-19 | 2020-07-21 | Ethicon Llc | Surgical instruments with dual articulation drivers |
US11045270B2 (en) | 2017-12-19 | 2021-06-29 | Cilag Gmbh International | Robotic attachment comprising exterior drive actuator |
US10729509B2 (en) | 2017-12-19 | 2020-08-04 | Ethicon Llc | Surgical instrument comprising closure and firing locking mechanism |
US10835330B2 (en) | 2017-12-19 | 2020-11-17 | Ethicon Llc | Method for determining the position of a rotatable jaw of a surgical instrument attachment assembly |
US11179152B2 (en) | 2017-12-21 | 2021-11-23 | Cilag Gmbh International | Surgical instrument comprising a tissue grasping system |
US11129680B2 (en) | 2017-12-21 | 2021-09-28 | Cilag Gmbh International | Surgical instrument comprising a projector |
US11076853B2 (en) | 2017-12-21 | 2021-08-03 | Cilag Gmbh International | Systems and methods of displaying a knife position during transection for a surgical instrument |
US11311290B2 (en) | 2017-12-21 | 2022-04-26 | Cilag Gmbh International | Surgical instrument comprising an end effector dampener |
US11497490B2 (en) | 2018-07-09 | 2022-11-15 | Covidien Lp | Powered surgical devices including predictive motor control |
US10912559B2 (en) | 2018-08-20 | 2021-02-09 | Ethicon Llc | Reinforced deformable anvil tip for surgical stapler anvil |
US11291440B2 (en) | 2018-08-20 | 2022-04-05 | Cilag Gmbh International | Method for operating a powered articulatable surgical instrument |
US10842492B2 (en) | 2018-08-20 | 2020-11-24 | Ethicon Llc | Powered articulatable surgical instruments with clutching and locking arrangements for linking an articulation drive system to a firing drive system |
US11207065B2 (en) | 2018-08-20 | 2021-12-28 | Cilag Gmbh International | Method for fabricating surgical stapler anvils |
US11039834B2 (en) | 2018-08-20 | 2021-06-22 | Cilag Gmbh International | Surgical stapler anvils with staple directing protrusions and tissue stability features |
USD914878S1 (en) | 2018-08-20 | 2021-03-30 | Ethicon Llc | Surgical instrument anvil |
US10779821B2 (en) | 2018-08-20 | 2020-09-22 | Ethicon Llc | Surgical stapler anvils with tissue stop features configured to avoid tissue pinch |
US10856870B2 (en) | 2018-08-20 | 2020-12-08 | Ethicon Llc | Switching arrangements for motor powered articulatable surgical instruments |
US11045192B2 (en) | 2018-08-20 | 2021-06-29 | Cilag Gmbh International | Fabricating techniques for surgical stapler anvils |
US11324501B2 (en) | 2018-08-20 | 2022-05-10 | Cilag Gmbh International | Surgical stapling devices with improved closure members |
US11083458B2 (en) | 2018-08-20 | 2021-08-10 | Cilag Gmbh International | Powered surgical instruments with clutching arrangements to convert linear drive motions to rotary drive motions |
US11253256B2 (en) | 2018-08-20 | 2022-02-22 | Cilag Gmbh International | Articulatable motor powered surgical instruments with dedicated articulation motor arrangements |
US11197734B2 (en) | 2018-10-30 | 2021-12-14 | Covidien Lp | Load sensing devices for use in surgical instruments |
US11369372B2 (en) | 2018-11-28 | 2022-06-28 | Covidien Lp | Surgical stapler adapter with flexible cable assembly, flexible fingers, and contact clips |
US11202635B2 (en) | 2019-02-04 | 2021-12-21 | Covidien Lp | Programmable distal tilt position of end effector for powered surgical devices |
US11376006B2 (en) | 2019-02-06 | 2022-07-05 | Covidien Lp | End effector force measurement with digital drive circuit |
US11219461B2 (en) | 2019-03-08 | 2022-01-11 | Covidien Lp | Strain gauge stabilization in a surgical device |
US11147551B2 (en) | 2019-03-25 | 2021-10-19 | Cilag Gmbh International | Firing drive arrangements for surgical systems |
US11147553B2 (en) | 2019-03-25 | 2021-10-19 | Cilag Gmbh International | Firing drive arrangements for surgical systems |
US11696761B2 (en) | 2019-03-25 | 2023-07-11 | Cilag Gmbh International | Firing drive arrangements for surgical systems |
US11172929B2 (en) | 2019-03-25 | 2021-11-16 | Cilag Gmbh International | Articulation drive arrangements for surgical systems |
US11432816B2 (en) | 2019-04-30 | 2022-09-06 | Cilag Gmbh International | Articulation pin for a surgical instrument |
US11452528B2 (en) | 2019-04-30 | 2022-09-27 | Cilag Gmbh International | Articulation actuators for a surgical instrument |
US11471157B2 (en) | 2019-04-30 | 2022-10-18 | Cilag Gmbh International | Articulation control mapping for a surgical instrument |
US11648009B2 (en) | 2019-04-30 | 2023-05-16 | Cilag Gmbh International | Rotatable jaw tip for a surgical instrument |
US11903581B2 (en) | 2019-04-30 | 2024-02-20 | Cilag Gmbh International | Methods for stapling tissue using a surgical instrument |
US11426251B2 (en) | 2019-04-30 | 2022-08-30 | Cilag Gmbh International | Articulation directional lights on a surgical instrument |
US11253254B2 (en) | 2019-04-30 | 2022-02-22 | Cilag Gmbh International | Shaft rotation actuator on a surgical instrument |
US11426167B2 (en) | 2019-06-28 | 2022-08-30 | Cilag Gmbh International | Mechanisms for proper anvil attachment surgical stapling head assembly |
US11553971B2 (en) | 2019-06-28 | 2023-01-17 | Cilag Gmbh International | Surgical RFID assemblies for display and communication |
US11246678B2 (en) | 2019-06-28 | 2022-02-15 | Cilag Gmbh International | Surgical stapling system having a frangible RFID tag |
US11298127B2 (en) | 2019-06-28 | 2022-04-12 | Cilag GmbH Interational | Surgical stapling system having a lockout mechanism for an incompatible cartridge |
US11259803B2 (en) | 2019-06-28 | 2022-03-01 | Cilag Gmbh International | Surgical stapling system having an information encryption protocol |
US11478241B2 (en) | 2019-06-28 | 2022-10-25 | Cilag Gmbh International | Staple cartridge including projections |
US11627959B2 (en) | 2019-06-28 | 2023-04-18 | Cilag Gmbh International | Surgical instruments including manual and powered system lockouts |
US11399837B2 (en) | 2019-06-28 | 2022-08-02 | Cilag Gmbh International | Mechanisms for motor control adjustments of a motorized surgical instrument |
US11523822B2 (en) | 2019-06-28 | 2022-12-13 | Cilag Gmbh International | Battery pack including a circuit interrupter |
US11298132B2 (en) | 2019-06-28 | 2022-04-12 | Cilag GmbH Inlernational | Staple cartridge including a honeycomb extension |
US11684434B2 (en) | 2019-06-28 | 2023-06-27 | Cilag Gmbh International | Surgical RFID assemblies for instrument operational setting control |
US11376098B2 (en) | 2019-06-28 | 2022-07-05 | Cilag Gmbh International | Surgical instrument system comprising an RFID system |
US11219455B2 (en) | 2019-06-28 | 2022-01-11 | Cilag Gmbh International | Surgical instrument including a lockout key |
US11051807B2 (en) | 2019-06-28 | 2021-07-06 | Cilag Gmbh International | Packaging assembly including a particulate trap |
US11291451B2 (en) | 2019-06-28 | 2022-04-05 | Cilag Gmbh International | Surgical instrument with battery compatibility verification functionality |
US11464601B2 (en) | 2019-06-28 | 2022-10-11 | Cilag Gmbh International | Surgical instrument comprising an RFID system for tracking a movable component |
US11497492B2 (en) | 2019-06-28 | 2022-11-15 | Cilag Gmbh International | Surgical instrument including an articulation lock |
US11350938B2 (en) | 2019-06-28 | 2022-06-07 | Cilag Gmbh International | Surgical instrument comprising an aligned rfid sensor |
US11660163B2 (en) | 2019-06-28 | 2023-05-30 | Cilag Gmbh International | Surgical system with RFID tags for updating motor assembly parameters |
US11771419B2 (en) | 2019-06-28 | 2023-10-03 | Cilag Gmbh International | Packaging for a replaceable component of a surgical stapling system |
US11638587B2 (en) | 2019-06-28 | 2023-05-02 | Cilag Gmbh International | RFID identification systems for surgical instruments |
US11224497B2 (en) | 2019-06-28 | 2022-01-18 | Cilag Gmbh International | Surgical systems with multiple RFID tags |
US20230056943A1 (en) * | 2019-12-13 | 2023-02-23 | Dinesh Vyas | Stapler apparatus and methods for use |
US11925347B2 (en) | 2019-12-13 | 2024-03-12 | Dinesh Vyas | Stapler apparatus and methods for use |
US11931033B2 (en) | 2019-12-19 | 2024-03-19 | Cilag Gmbh International | Staple cartridge comprising a latch lockout |
US11529139B2 (en) | 2019-12-19 | 2022-12-20 | Cilag Gmbh International | Motor driven surgical instrument |
US11234698B2 (en) | 2019-12-19 | 2022-02-01 | Cilag Gmbh International | Stapling system comprising a clamp lockout and a firing lockout |
US11559304B2 (en) | 2019-12-19 | 2023-01-24 | Cilag Gmbh International | Surgical instrument comprising a rapid closure mechanism |
US11844520B2 (en) | 2019-12-19 | 2023-12-19 | Cilag Gmbh International | Staple cartridge comprising driver retention members |
US11291447B2 (en) | 2019-12-19 | 2022-04-05 | Cilag Gmbh International | Stapling instrument comprising independent jaw closing and staple firing systems |
US11607219B2 (en) | 2019-12-19 | 2023-03-21 | Cilag Gmbh International | Staple cartridge comprising a detachable tissue cutting knife |
US11464512B2 (en) | 2019-12-19 | 2022-10-11 | Cilag Gmbh International | Staple cartridge comprising a curved deck surface |
US11911032B2 (en) | 2019-12-19 | 2024-02-27 | Cilag Gmbh International | Staple cartridge comprising a seating cam |
US11576672B2 (en) | 2019-12-19 | 2023-02-14 | Cilag Gmbh International | Surgical instrument comprising a closure system including a closure member and an opening member driven by a drive screw |
US11504122B2 (en) | 2019-12-19 | 2022-11-22 | Cilag Gmbh International | Surgical instrument comprising a nested firing member |
US11701111B2 (en) | 2019-12-19 | 2023-07-18 | Cilag Gmbh International | Method for operating a surgical stapling instrument |
US11529137B2 (en) | 2019-12-19 | 2022-12-20 | Cilag Gmbh International | Staple cartridge comprising driver retention members |
US11446029B2 (en) | 2019-12-19 | 2022-09-20 | Cilag Gmbh International | Staple cartridge comprising projections extending from a curved deck surface |
US11304696B2 (en) | 2019-12-19 | 2022-04-19 | Cilag Gmbh International | Surgical instrument comprising a powered articulation system |
US11458244B2 (en) | 2020-02-07 | 2022-10-04 | Covidien Lp | Irrigating surgical apparatus with positive pressure fluid |
US11553913B2 (en) | 2020-02-11 | 2023-01-17 | Covidien Lp | Electrically-determining tissue cut with surgical stapling apparatus |
USD966512S1 (en) | 2020-06-02 | 2022-10-11 | Cilag Gmbh International | Staple cartridge |
USD967421S1 (en) | 2020-06-02 | 2022-10-18 | Cilag Gmbh International | Staple cartridge |
USD975851S1 (en) | 2020-06-02 | 2023-01-17 | Cilag Gmbh International | Staple cartridge |
USD975278S1 (en) | 2020-06-02 | 2023-01-10 | Cilag Gmbh International | Staple cartridge |
USD976401S1 (en) | 2020-06-02 | 2023-01-24 | Cilag Gmbh International | Staple cartridge |
USD975850S1 (en) | 2020-06-02 | 2023-01-17 | Cilag Gmbh International | Staple cartridge |
USD974560S1 (en) | 2020-06-02 | 2023-01-03 | Cilag Gmbh International | Staple cartridge |
US11622768B2 (en) | 2020-07-13 | 2023-04-11 | Covidien Lp | Methods and structure for confirming proper assembly of powered surgical stapling systems |
US20220031320A1 (en) | 2020-07-28 | 2022-02-03 | Cilag Gmbh International | Surgical instruments with flexible firing member actuator constraint arrangements |
USD980425S1 (en) | 2020-10-29 | 2023-03-07 | Cilag Gmbh International | Surgical instrument assembly |
US11717289B2 (en) | 2020-10-29 | 2023-08-08 | Cilag Gmbh International | Surgical instrument comprising an indicator which indicates that an articulation drive is actuatable |
US11517390B2 (en) | 2020-10-29 | 2022-12-06 | Cilag Gmbh International | Surgical instrument comprising a limited travel switch |
US11534259B2 (en) | 2020-10-29 | 2022-12-27 | Cilag Gmbh International | Surgical instrument comprising an articulation indicator |
USD1013170S1 (en) | 2020-10-29 | 2024-01-30 | Cilag Gmbh International | Surgical instrument assembly |
US11617577B2 (en) | 2020-10-29 | 2023-04-04 | Cilag Gmbh International | Surgical instrument comprising a sensor configured to sense whether an articulation drive of the surgical instrument is actuatable |
US11452526B2 (en) | 2020-10-29 | 2022-09-27 | Cilag Gmbh International | Surgical instrument comprising a staged voltage regulation start-up system |
US11931025B2 (en) | 2020-10-29 | 2024-03-19 | Cilag Gmbh International | Surgical instrument comprising a releasable closure drive lock |
US11896217B2 (en) | 2020-10-29 | 2024-02-13 | Cilag Gmbh International | Surgical instrument comprising an articulation lock |
US11844518B2 (en) | 2020-10-29 | 2023-12-19 | Cilag Gmbh International | Method for operating a surgical instrument |
US11779330B2 (en) | 2020-10-29 | 2023-10-10 | Cilag Gmbh International | Surgical instrument comprising a jaw alignment system |
US11744580B2 (en) | 2020-11-24 | 2023-09-05 | Covidien Lp | Long stapler reloads with continuous cartridge |
US11653919B2 (en) | 2020-11-24 | 2023-05-23 | Covidien Lp | Stapler line reinforcement continuity |
US11849943B2 (en) | 2020-12-02 | 2023-12-26 | Cilag Gmbh International | Surgical instrument with cartridge release mechanisms |
US11737751B2 (en) | 2020-12-02 | 2023-08-29 | Cilag Gmbh International | Devices and methods of managing energy dissipated within sterile barriers of surgical instrument housings |
US11653920B2 (en) | 2020-12-02 | 2023-05-23 | Cilag Gmbh International | Powered surgical instruments with communication interfaces through sterile barrier |
US11890010B2 (en) | 2020-12-02 | 2024-02-06 | Cllag GmbH International | Dual-sided reinforced reload for surgical instruments |
US11944296B2 (en) | 2020-12-02 | 2024-04-02 | Cilag Gmbh International | Powered surgical instruments with external connectors |
US11744581B2 (en) | 2020-12-02 | 2023-09-05 | Cilag Gmbh International | Powered surgical instruments with multi-phase tissue treatment |
US11653915B2 (en) | 2020-12-02 | 2023-05-23 | Cilag Gmbh International | Surgical instruments with sled location detection and adjustment features |
US11678882B2 (en) | 2020-12-02 | 2023-06-20 | Cilag Gmbh International | Surgical instruments with interactive features to remedy incidental sled movements |
US11627960B2 (en) | 2020-12-02 | 2023-04-18 | Cilag Gmbh International | Powered surgical instruments with smart reload with separately attachable exteriorly mounted wiring connections |
US11701113B2 (en) | 2021-02-26 | 2023-07-18 | Cilag Gmbh International | Stapling instrument comprising a separate power antenna and a data transfer antenna |
US11950777B2 (en) | 2021-02-26 | 2024-04-09 | Cilag Gmbh International | Staple cartridge comprising an information access control system |
US11812964B2 (en) | 2021-02-26 | 2023-11-14 | Cilag Gmbh International | Staple cartridge comprising a power management circuit |
US11723657B2 (en) | 2021-02-26 | 2023-08-15 | Cilag Gmbh International | Adjustable communication based on available bandwidth and power capacity |
US11744583B2 (en) | 2021-02-26 | 2023-09-05 | Cilag Gmbh International | Distal communication array to tune frequency of RF systems |
US11696757B2 (en) | 2021-02-26 | 2023-07-11 | Cilag Gmbh International | Monitoring of internal systems to detect and track cartridge motion status |
US11751869B2 (en) | 2021-02-26 | 2023-09-12 | Cilag Gmbh International | Monitoring of multiple sensors over time to detect moving characteristics of tissue |
US11730473B2 (en) | 2021-02-26 | 2023-08-22 | Cilag Gmbh International | Monitoring of manufacturing life-cycle |
US11925349B2 (en) | 2021-02-26 | 2024-03-12 | Cilag Gmbh International | Adjustment to transfer parameters to improve available power |
US11950779B2 (en) | 2021-02-26 | 2024-04-09 | Cilag Gmbh International | Method of powering and communicating with a staple cartridge |
US11749877B2 (en) | 2021-02-26 | 2023-09-05 | Cilag Gmbh International | Stapling instrument comprising a signal antenna |
US11793514B2 (en) | 2021-02-26 | 2023-10-24 | Cilag Gmbh International | Staple cartridge comprising sensor array which may be embedded in cartridge body |
US11806011B2 (en) | 2021-03-22 | 2023-11-07 | Cilag Gmbh International | Stapling instrument comprising tissue compression systems |
US11737749B2 (en) | 2021-03-22 | 2023-08-29 | Cilag Gmbh International | Surgical stapling instrument comprising a retraction system |
US11826012B2 (en) | 2021-03-22 | 2023-11-28 | Cilag Gmbh International | Stapling instrument comprising a pulsed motor-driven firing rack |
US11723658B2 (en) | 2021-03-22 | 2023-08-15 | Cilag Gmbh International | Staple cartridge comprising a firing lockout |
US11826042B2 (en) | 2021-03-22 | 2023-11-28 | Cilag Gmbh International | Surgical instrument comprising a firing drive including a selectable leverage mechanism |
US11717291B2 (en) | 2021-03-22 | 2023-08-08 | Cilag Gmbh International | Staple cartridge comprising staples configured to apply different tissue compression |
US11759202B2 (en) | 2021-03-22 | 2023-09-19 | Cilag Gmbh International | Staple cartridge comprising an implantable layer |
US11786239B2 (en) | 2021-03-24 | 2023-10-17 | Cilag Gmbh International | Surgical instrument articulation joint arrangements comprising multiple moving linkage features |
US11849944B2 (en) | 2021-03-24 | 2023-12-26 | Cilag Gmbh International | Drivers for fastener cartridge assemblies having rotary drive screws |
US11793516B2 (en) | 2021-03-24 | 2023-10-24 | Cilag Gmbh International | Surgical staple cartridge comprising longitudinal support beam |
US11896219B2 (en) | 2021-03-24 | 2024-02-13 | Cilag Gmbh International | Mating features between drivers and underside of a cartridge deck |
US11849945B2 (en) | 2021-03-24 | 2023-12-26 | Cilag Gmbh International | Rotary-driven surgical stapling assembly comprising eccentrically driven firing member |
US11903582B2 (en) | 2021-03-24 | 2024-02-20 | Cilag Gmbh International | Leveraging surfaces for cartridge installation |
US11896218B2 (en) | 2021-03-24 | 2024-02-13 | Cilag Gmbh International | Method of using a powered stapling device |
US11857183B2 (en) | 2021-03-24 | 2024-01-02 | Cilag Gmbh International | Stapling assembly components having metal substrates and plastic bodies |
US11744603B2 (en) | 2021-03-24 | 2023-09-05 | Cilag Gmbh International | Multi-axis pivot joints for surgical instruments and methods for manufacturing same |
US11944336B2 (en) | 2021-03-24 | 2024-04-02 | Cilag Gmbh International | Joint arrangements for multi-planar alignment and support of operational drive shafts in articulatable surgical instruments |
US11832816B2 (en) | 2021-03-24 | 2023-12-05 | Cilag Gmbh International | Surgical stapling assembly comprising nonplanar staples and planar staples |
US11786243B2 (en) | 2021-03-24 | 2023-10-17 | Cilag Gmbh International | Firing members having flexible portions for adapting to a load during a surgical firing stroke |
US11826047B2 (en) | 2021-05-28 | 2023-11-28 | Cilag Gmbh International | Stapling instrument comprising jaw mounts |
US11684362B2 (en) | 2021-06-07 | 2023-06-27 | Covidien Lp | Handheld electromechanical surgical system |
US11771432B2 (en) | 2021-06-29 | 2023-10-03 | Covidien Lp | Stapling and cutting to default values in the event of strain gauge data integrity loss |
US11877745B2 (en) | 2021-10-18 | 2024-01-23 | Cilag Gmbh International | Surgical stapling assembly having longitudinally-repeating staple leg clusters |
US11937816B2 (en) | 2021-10-28 | 2024-03-26 | Cilag Gmbh International | Electrical lead arrangements for surgical instruments |
US11832823B2 (en) | 2022-02-08 | 2023-12-05 | Covidien Lp | Determination of anvil release during anastomosis |
Family Cites Families (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3739773A (en) * | 1963-10-31 | 1973-06-19 | American Cyanamid Co | Polyglycolic acid prosthetic devices |
US3363628A (en) * | 1964-09-28 | 1968-01-16 | Peter B Samuels | Hemostatic clip |
US4069307A (en) * | 1970-10-01 | 1978-01-17 | Alza Corporation | Drug-delivery device comprising certain polymeric materials for controlled release of drug |
US4351337A (en) * | 1973-05-17 | 1982-09-28 | Arthur D. Little, Inc. | Biodegradable, implantable drug delivery device, and process for preparing and using the same |
US3991766A (en) * | 1973-05-31 | 1976-11-16 | American Cyanamid Company | Controlled release of medicaments using polymers from glycolic acid |
US3918455A (en) * | 1974-04-29 | 1975-11-11 | Albany Int Corp | Combined surgical suture and needle |
US3946734A (en) * | 1975-02-19 | 1976-03-30 | The United States Of America As Represented By The Secretary Of State | Apparatus for controlling the release of a drug |
US4144317A (en) * | 1975-05-30 | 1979-03-13 | Alza Corporation | Device consisting of copolymer having acetoxy groups for delivering drugs |
US4024871A (en) * | 1975-07-23 | 1977-05-24 | Ethicon, Inc. | Antimicrobial sutures |
US4175326A (en) * | 1977-10-26 | 1979-11-27 | Forsyth Dental Infirmary For Children | Hollow-fiber devices for and a method of the treament and diagnosis of oral diseases |
SU982676A1 (en) * | 1981-04-07 | 1982-12-23 | Всесоюзный научно-исследовательский и испытательный институт медицинской техники | Surgical cramp |
AU548370B2 (en) * | 1981-10-08 | 1985-12-05 | United States Surgical Corporation | Surgical fastener |
US4513746A (en) * | 1981-10-09 | 1985-04-30 | United States Surgical Corp. | Instrument for applying plastic-like surgical fastening devices |
DE3214667C2 (en) * | 1982-04-21 | 1985-07-18 | Akzo Gmbh, 5600 Wuppertal | Composite body for the long-term delivery of active ingredients |
US4961931A (en) * | 1982-07-29 | 1990-10-09 | Alza Corporation | Method for the management of hyperplasia |
DE3337592A1 (en) * | 1983-10-15 | 1985-04-25 | Gesellschaft für Strahlen- und Umweltforschung mbH, 8000 München | ORGANIC MATERIAL CARRIER WITH INTEGRATED ACTIVE SUBSTANCES |
DE3445738A1 (en) * | 1984-12-14 | 1986-06-19 | Draenert Klaus | IMPLANT FOR BONE REINFORCEMENT AND ANCHORING OF BONE SCREWS, IMPLANTS OR IMPLANT PARTS |
US4736746A (en) * | 1985-04-11 | 1988-04-12 | Dennison Manufacturing Company | Method of fastening tissues |
US4696300A (en) * | 1985-04-11 | 1987-09-29 | Dennison Manufacturing Company | Fastener for joining materials |
US4673565A (en) * | 1985-05-03 | 1987-06-16 | E. I. Du Pont De Nemours And Company | Pharmaceutical compositions containing hollow fine tubular drug delivery systems |
US4720384A (en) * | 1985-05-03 | 1988-01-19 | E. I. Du Pont De Nemours And Company | Manufacture of hollow fine tubular drug delivery systems |
US4702247A (en) * | 1985-08-20 | 1987-10-27 | American Hospital Supply Corporation | Ligating clip |
US4884572A (en) * | 1986-05-20 | 1989-12-05 | Concept, Inc. | Tack and applicator for treating torn bodily material in vivo |
US4840626A (en) * | 1986-09-29 | 1989-06-20 | Johnson & Johnson Patient Care, Inc. | Heparin-containing adhesion prevention barrier and process |
US4719917A (en) * | 1987-02-17 | 1988-01-19 | Minnesota Mining And Manufacturing Company | Surgical staple |
FR2612392A1 (en) * | 1987-03-19 | 1988-09-23 | Audion Michel | Interrupted biodegradable composites of variable strength |
US4871542A (en) * | 1987-04-30 | 1989-10-03 | Ferring Service Center, N.V. | Method and apparatus useful for delivering medicinal compositions into the bladder and urinary tract |
US5051272A (en) * | 1988-07-19 | 1991-09-24 | United States Surgical Corporation | Method for improving the storage stability of a polymeric article susceptible to hydrolytic degradation and resulting article |
DK50588D0 (en) * | 1988-02-01 | 1988-02-01 | Einar Skeie | SURGICAL PROCESS |
US4932962A (en) * | 1989-05-16 | 1990-06-12 | Inbae Yoon | Suture devices particularly useful in endoscopic surgery and methods of suturing |
US4976722A (en) * | 1989-05-22 | 1990-12-11 | Ethicon, Inc. | Surgical hemostatic clips |
US4983177A (en) * | 1990-01-03 | 1991-01-08 | Wolf Gerald L | Method and apparatus for reversibly occluding a biological tube |
JPH05503934A (en) * | 1990-01-30 | 1993-06-24 | アクゾ・エヌ・ヴエー | Article for controlled delivery of active substances, consisting of a hollow space completely surrounded by walls and filled in whole or in part with one or more active substances |
-
1991
- 1991-08-15 US US07/745,513 patent/US5282829A/en not_active Expired - Lifetime
-
1992
- 1992-07-31 CA CA002075172A patent/CA2075172A1/en not_active Abandoned
- 1992-08-14 EP EP92113879A patent/EP0531742A1/en not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
US5282829A (en) | 1994-02-01 |
EP0531742A1 (en) | 1993-03-17 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US5282829A (en) | Hollow body implants | |
JP6470359B2 (en) | Improved suture | |
JP5570046B2 (en) | Mooring device | |
US8932327B2 (en) | Anchoring device | |
JP5619726B2 (en) | Self-retaining suture with bidirectional retainer or unidirectional retainer | |
JP5562546B2 (en) | Composite fiber reinforced with filament | |
JP6153997B2 (en) | Tissue thickness compensator composed of multiple materials | |
US20090228021A1 (en) | Matrix material | |
US7497864B2 (en) | Tissue fastener and methods for using same | |
JP2008538300A (en) | Bioactive widely woven mesh | |
US20180000480A1 (en) | Mesh suture with anti-roping characteristics | |
JP2011240134A (en) | Anchoring device | |
JP2011240133A (en) | Anchoring device | |
JP6802909B2 (en) | Indirect attachment of the needle to the mesh suture | |
JP3568756B2 (en) | Vascular prosthesis fitting |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
FZDE | Discontinued | ||
FZDE | Discontinued |
Effective date: 19960131 |