CA2046998A1 - Method of producing liposomal products - Google Patents

Method of producing liposomal products

Info

Publication number
CA2046998A1
CA2046998A1 CA2046998A CA2046998A CA2046998A1 CA 2046998 A1 CA2046998 A1 CA 2046998A1 CA 2046998 A CA2046998 A CA 2046998A CA 2046998 A CA2046998 A CA 2046998A CA 2046998 A1 CA2046998 A1 CA 2046998A1
Authority
CA
Canada
Prior art keywords
liposomal products
producing
producing liposomal
products
liposomes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA2046998A
Other languages
French (fr)
Other versions
CA2046998C (en
Inventor
Hiroshi Kikuchi
Kiyoto Yachi
Hiromi Morita
Sadao Hirota
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Daiichi Pharmaceutical Co Ltd
Original Assignee
Daiichi Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Daiichi Pharmaceutical Co Ltd filed Critical Daiichi Pharmaceutical Co Ltd
Publication of CA2046998A1 publication Critical patent/CA2046998A1/en
Application granted granted Critical
Publication of CA2046998C publication Critical patent/CA2046998C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1277—Processes for preparing; Proliposomes

Abstract

A method of producing liposomal products which comprises treating a positively or negatively charged, freeze- or spray-dried liposomal preparation with an aqueous solution of a drug charged oppositely to the charge of the liposomes.
CA002046998A 1990-08-21 1991-07-12 Method of producing liposomal products Expired - Lifetime CA2046998C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2219735A JP2599492B2 (en) 1990-08-21 1990-08-21 Manufacturing method of liposome preparation
JP2-219735 1990-08-21

Publications (2)

Publication Number Publication Date
CA2046998A1 true CA2046998A1 (en) 1992-02-22
CA2046998C CA2046998C (en) 2000-11-07

Family

ID=16740166

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002046998A Expired - Lifetime CA2046998C (en) 1990-08-21 1991-07-12 Method of producing liposomal products

Country Status (3)

Country Link
US (1) US5376380A (en)
JP (1) JP2599492B2 (en)
CA (1) CA2046998C (en)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU694135B2 (en) 1993-07-30 1998-07-16 Imcor Pharmaceutical Company Stabilized microbubble compositions for ultrasound
US5798091A (en) 1993-07-30 1998-08-25 Alliance Pharmaceutical Corp. Stabilized gas emulsion containing phospholipid for ultrasound contrast enhancement
US5540909A (en) * 1994-09-28 1996-07-30 Alliance Pharmaceutical Corp. Harmonic ultrasound imaging with microbubbles
US5804162A (en) 1995-06-07 1998-09-08 Alliance Pharmaceutical Corp. Gas emulsions stabilized with fluorinated ethers having low Ostwald coefficients
AU6366599A (en) * 1998-10-29 2000-05-22 Sankyo Company Limited Liposome with lowered toxicity
JPWO2002038128A1 (en) * 2000-11-10 2004-03-11 科学技術振興事業団 Method for producing ER dispersion
US20060193905A1 (en) * 2002-05-14 2006-08-31 University Of Louisville Research Foundation, Inc. Direct cellular energy delivery system
JP2004261885A (en) * 2003-02-18 2004-09-24 Japan Science & Technology Agency Method of leading functional material to organic nanotube
JP2005162702A (en) * 2003-12-04 2005-06-23 Konica Minolta Medical & Graphic Inc Method for producing liposome preparation, liposome preparation and apparatus for producing the same
EP1750673B1 (en) * 2004-05-17 2009-12-02 Tekmira Pharmaceuticals Corporation Liposomal formulations comprising dihydrosphingomyelin and methods of use thereof
US20110135725A1 (en) * 2005-05-23 2011-06-09 Sdg, Inc. Lipid Construct for Delivery of Insulin to a Mammal
EP3357490A1 (en) * 2006-04-28 2018-08-08 Children's Hospital Medical Center Fusogenic properties of saposin c and related proteins and polypeptides for application to transmembrane drug delivery systems
EP1920765A1 (en) * 2006-11-07 2008-05-14 Medigene AG Liposome preparation by single-pass process
US7964580B2 (en) 2007-03-30 2011-06-21 Pharmasset, Inc. Nucleoside phosphoramidate prodrugs
US8962015B2 (en) 2007-09-28 2015-02-24 Sdg, Inc. Orally bioavailable lipid-based constructs
JP2011503188A (en) * 2007-11-14 2011-01-27 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア Sterol-modified amphiphilic lipids
US8173621B2 (en) 2008-06-11 2012-05-08 Gilead Pharmasset Llc Nucleoside cyclicphosphates
CL2008002730A1 (en) * 2008-09-12 2008-10-24 Roberto Figueroa Liza Patricio DERMATOLOGICAL PHARMACEUTICAL COMPOSITION, OF TOPICAL APPLICATION, IN THE FORM OF A CREAM, GEL, Ointment, SOLUTION, EMULSION THAT INCLUDES 1A 99% OF PENTOXYPHILINE, 0.1 TO 80% OF BASE CREAM AND 0.1 to 75% OF LIPOSOMES, USEFUL FOR ROSACEA , DISORDERS WITH PHOTOSENSIBILE
US8716263B2 (en) 2008-12-23 2014-05-06 Gilead Pharmasset Llc Synthesis of purine nucleosides
US8551973B2 (en) 2008-12-23 2013-10-08 Gilead Pharmasset Llc Nucleoside analogs
SG172359A1 (en) 2008-12-23 2011-07-28 Pharmasset Inc Nucleoside phosphoramidates
US8618076B2 (en) 2009-05-20 2013-12-31 Gilead Pharmasset Llc Nucleoside phosphoramidates
TWI598358B (en) 2009-05-20 2017-09-11 基利法瑪席特有限責任公司 Nucleoside phosphoramidates
PL3290428T3 (en) 2010-03-31 2022-02-07 Gilead Pharmasset Llc Tablet comprising crystalline (s)-isopropyl 2-(((s)-(((2r,3r,4r,5r)-5-(2,4-dioxo-3,4-dihydropyrimidin-1 (2h)-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)amino)propanoate
SI2609923T1 (en) 2010-03-31 2017-10-30 Gilead Pharmasset Llc Process for the crystallisation of (s)-isopropyl 2-(((s)-(perfluorophenoxy)(phenoxy)phosphoryl)amino)propanoate
PE20130183A1 (en) 2010-03-31 2013-02-21 Gilead Pharmasset Llc NUCLEOSIDE PHOSPHORAMIDATES
US8841275B2 (en) 2010-11-30 2014-09-23 Gilead Pharmasset Llc 2′-spiro-nucleosides and derivatives thereof useful for treating hepatitis C virus and dengue virus infections
WO2012088414A1 (en) * 2010-12-23 2012-06-28 Ludwig Institute For Cancer Research Ltd. Liposomal formulation of nonglycosidic ceramides and uses thereof
US8889159B2 (en) 2011-11-29 2014-11-18 Gilead Pharmasset Llc Compositions and methods for treating hepatitis C virus
SI3038601T1 (en) 2013-08-27 2020-07-31 Gilead Pharmasset Llc Combination formulation of two antiviral compounds
US11077173B2 (en) 2017-03-13 2021-08-03 Sdg, Inc. Lipid-based nanoparticles and methods using same
JP7306718B2 (en) 2017-03-13 2023-07-11 エスディージー インコーポレイテッド Lipid-based nanoparticles with improved stability

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6150912A (en) * 1984-08-16 1986-03-13 Shionogi & Co Ltd Production of liposome preparation
US5059421A (en) * 1985-07-26 1991-10-22 The Liposome Company, Inc. Preparation of targeted liposome systems of a defined size distribution
IE58981B1 (en) * 1985-10-15 1993-12-15 Vestar Inc Anthracycline antineoplastic agents encapsulated in phospholipid micellular particles
US4946683A (en) * 1987-11-18 1990-08-07 Vestar, Inc. Multiple step entrapment/loading procedure for preparing lipophilic drug-containing liposomes

Also Published As

Publication number Publication date
US5376380A (en) 1994-12-27
JP2599492B2 (en) 1997-04-09
CA2046998C (en) 2000-11-07
JPH04103527A (en) 1992-04-06

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