CA2046916A1 - Methods and compositions for treatment of cancer using oligonucleotides - Google Patents

Methods and compositions for treatment of cancer using oligonucleotides

Info

Publication number
CA2046916A1
CA2046916A1 CA002046916A CA2046916A CA2046916A1 CA 2046916 A1 CA2046916 A1 CA 2046916A1 CA 002046916 A CA002046916 A CA 002046916A CA 2046916 A CA2046916 A CA 2046916A CA 2046916 A1 CA2046916 A1 CA 2046916A1
Authority
CA
Canada
Prior art keywords
bone marrow
cancer
oligonucleotides
compositions
treatment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002046916A
Other languages
French (fr)
Other versions
CA2046916C (en
Inventor
Larry J. Smith
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Texas System
Original Assignee
Larry J. Smith
Board Of Regents, The University Of Texas System
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Larry J. Smith, Board Of Regents, The University Of Texas System filed Critical Larry J. Smith
Publication of CA2046916A1 publication Critical patent/CA2046916A1/en
Application granted granted Critical
Publication of CA2046916C publication Critical patent/CA2046916C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1135—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against oncogenes or tumor suppressor genes

Abstract

The present invention provides methods useful in autologous bone marrow transplantation and cancer therapy. According to one aspect of the invention, bone marrow cells from a patient having cancer are treated with selected antisense oligonucleotides in order to deplete the bone marrow of malignant cells prior to infusion back into the bone marrow donor. In a separate embodiment, selected antisense oligonucleotides are administered systemically for anticancer therapy.
CA002046916A 1989-02-15 1990-01-24 Methods and compositions for treatment of cancer using oligonucleotides Expired - Lifetime CA2046916C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US311,096 1989-02-15
US07/311,096 US5087617A (en) 1989-02-15 1989-02-15 Methods and compositions for treatment of cancer using oligonucleotides

Publications (2)

Publication Number Publication Date
CA2046916A1 true CA2046916A1 (en) 1990-08-16
CA2046916C CA2046916C (en) 2001-03-27

Family

ID=23205390

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002046916A Expired - Lifetime CA2046916C (en) 1989-02-15 1990-01-24 Methods and compositions for treatment of cancer using oligonucleotides

Country Status (10)

Country Link
US (1) US5087617A (en)
EP (1) EP0458829B1 (en)
JP (1) JPH04505752A (en)
AT (1) ATE143265T1 (en)
AU (1) AU635002B2 (en)
CA (1) CA2046916C (en)
DE (1) DE69028694T2 (en)
DK (1) DK0458829T3 (en)
ES (1) ES2094148T3 (en)
WO (1) WO1990009180A1 (en)

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