CA2031522A1 - Irradiation of blood products - Google Patents

Irradiation of blood products

Info

Publication number
CA2031522A1
CA2031522A1 CA2031522A CA2031522A CA2031522A1 CA 2031522 A1 CA2031522 A1 CA 2031522A1 CA 2031522 A CA2031522 A CA 2031522A CA 2031522 A CA2031522 A CA 2031522A CA 2031522 A1 CA2031522 A1 CA 2031522A1
Authority
CA
Canada
Prior art keywords
ultraviolet radiation
blood cells
white blood
flat
per square
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA2031522A
Other languages
French (fr)
Other versions
CA2031522C (en
Inventor
Jeffrey E. Miripol
Arnold Bilstad
John Foley
Dean Glash
William R. Bratten
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fenwal Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2031522A1 publication Critical patent/CA2031522A1/en
Application granted granted Critical
Publication of CA2031522C publication Critical patent/CA2031522C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3681—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits by irradiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
    • A61L2/0011—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using physical methods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
    • A61L2/0011—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using physical methods
    • A61L2/0029—Radiation
    • A61L2/0047—Ultraviolet radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3616—Batch-type treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/05—General characteristics of the apparatus combined with other kinds of therapy
    • A61M2205/051—General characteristics of the apparatus combined with other kinds of therapy with radiation therapy
    • A61M2205/053—General characteristics of the apparatus combined with other kinds of therapy with radiation therapy ultraviolet

Abstract

A thin film (10) or layer (10) of white blood cells, such as the contaminating white cells in a platelet concentrate, is irradiated with ultraviolet radiation predominantely of a wavelength of 280 to 320 nanometers, and preferably at an intensity of 4 to 20 milliwatts per square cm. to provide a total energy exposure of typically 800 to 20,000 millijoules per square cm. of ultraviolet radiation. The white blood cells so processed substantially lose their capability to set off an immune reaction in an alloimmunized patient. The white blood cells may preferably be placed into such film in a flat (10), flexible bag (10) made of poly(ethylene-vinyl acetate) plastic, with the flat (10), flexible bag (10) being stretched in a direction normal to the path of ultraviolet radiation. Novel irradiating devices (40) are also disclosed.
CA002031522A 1989-05-02 1990-01-17 Irradiation of blood products Expired - Lifetime CA2031522C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US7/346,202 1989-05-02
US07/346,202 US4952812A (en) 1986-08-26 1989-05-02 Irradiation of blood products

Publications (2)

Publication Number Publication Date
CA2031522A1 true CA2031522A1 (en) 1990-11-03
CA2031522C CA2031522C (en) 1998-08-25

Family

ID=23358385

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002031522A Expired - Lifetime CA2031522C (en) 1989-05-02 1990-01-17 Irradiation of blood products

Country Status (6)

Country Link
US (1) US4952812A (en)
EP (1) EP0425593B1 (en)
JP (1) JP2920327B2 (en)
CA (1) CA2031522C (en)
DE (1) DE69008664T2 (en)
WO (1) WO1990013334A1 (en)

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Also Published As

Publication number Publication date
EP0425593A4 (en) 1991-12-04
WO1990013334A1 (en) 1990-11-15
DE69008664T2 (en) 1994-12-15
US4952812A (en) 1990-08-28
EP0425593A1 (en) 1991-05-08
EP0425593B1 (en) 1994-05-04
JP2920327B2 (en) 1999-07-19
CA2031522C (en) 1998-08-25
DE69008664D1 (en) 1994-06-09
JPH03505833A (en) 1991-12-19

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