CA2020958A1 - Nucleic acid sequence amplification methods - Google Patents

Nucleic acid sequence amplification methods

Info

Publication number
CA2020958A1
CA2020958A1 CA002020958A CA2020958A CA2020958A1 CA 2020958 A1 CA2020958 A1 CA 2020958A1 CA 002020958 A CA002020958 A CA 002020958A CA 2020958 A CA2020958 A CA 2020958A CA 2020958 A1 CA2020958 A1 CA 2020958A1
Authority
CA
Canada
Prior art keywords
nucleic acid
copies
acid sequence
amplification methods
methods
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002020958A
Other languages
French (fr)
Other versions
CA2020958C (en
Inventor
Daniel L. Kacian
Timothy J. Fultz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gen Probe Inc
Original Assignee
Gen Probe Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/550,837 external-priority patent/US5480784A/en
Application filed by Gen Probe Inc filed Critical Gen Probe Inc
Publication of CA2020958A1 publication Critical patent/CA2020958A1/en
Application granted granted Critical
Publication of CA2020958C publication Critical patent/CA2020958C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/6853—Nucleic acid amplification reactions using modified primers or templates
    • C12Q1/6855—Ligating adaptors
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/975—Kit

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Methods of synthesizing multiple copies of a target nucleic acid sequence autocatalytically under conditions of substantially constant temperature, ionic strength, and pH are provided in which multiple RNA copies of the target sequence autocatalytically generate additional copies.
These methods are useful for generating copies of a nucleic acid target sequence for purposes which include assays to quantitate specific nucleic acid sequences in clinical, environmental, forensic and similar samples, cloning and generating probes.
CA002020958A 1989-07-11 1990-07-11 Nucleic acid sequence amplification methods Expired - Lifetime CA2020958C (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US37950189A 1989-07-11 1989-07-11
US379,501 1989-07-11
US07/550,837 US5480784A (en) 1989-07-11 1990-07-10 Nucleic acid sequence amplification methods
US550,837 1990-07-10

Publications (2)

Publication Number Publication Date
CA2020958A1 true CA2020958A1 (en) 1991-01-12
CA2020958C CA2020958C (en) 2005-01-11

Family

ID=27008641

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002020958A Expired - Lifetime CA2020958C (en) 1989-07-11 1990-07-11 Nucleic acid sequence amplification methods

Country Status (2)

Country Link
US (3) US5399491A (en)
CA (1) CA2020958C (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6489097B2 (en) 1996-06-28 2002-12-03 Chugai Seiyaku Kabushiki Kaisha Method for the detection of telomerase activity

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