CA2008972A1 - Nifedipine-containing pharmaceutical compositions and process for the preparation thereof - Google Patents
Nifedipine-containing pharmaceutical compositions and process for the preparation thereofInfo
- Publication number
- CA2008972A1 CA2008972A1 CA2008972A CA2008972A CA2008972A1 CA 2008972 A1 CA2008972 A1 CA 2008972A1 CA 2008972 A CA2008972 A CA 2008972A CA 2008972 A CA2008972 A CA 2008972A CA 2008972 A1 CA2008972 A1 CA 2008972A1
- Authority
- CA
- Canada
- Prior art keywords
- nifedipine
- amount
- preparation
- pharmaceutical compositions
- polyvinylpyrrolidone
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
- A61K9/1676—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface having a drug-free core with discrete complete coating layer containing drug
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Abstract
A pharmaceutical composition which comprises particles of a finely divided pharmaceutically acceptable water soluble diluent coated with microcrystalline particles of nifedipine, the majority of which have a particle size of 100 micrometres or less in the presence of polyvinyl-pyrrolidone, the polyvinylpyrrolidone being present in an amount of from 10 to 90% by weight based on the weight of the nifedipine.
The incorporation of polyvinylpyrrolidone in an amount of less than the amount of nifedipine significantly slows the dissolution of nifedipine from the finished solid dosage form.
The incorporation of polyvinylpyrrolidone in an amount of less than the amount of nifedipine significantly slows the dissolution of nifedipine from the finished solid dosage form.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB898903328A GB8903328D0 (en) | 1989-02-14 | 1989-02-14 | Nifedipine-containing pharmaceutical compositions and process for the preparation thereof |
GB8903328.6 | 1989-02-14 |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2008972A1 true CA2008972A1 (en) | 1990-08-14 |
CA2008972C CA2008972C (en) | 1996-09-03 |
Family
ID=10651674
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002008972A Expired - Fee Related CA2008972C (en) | 1989-02-14 | 1990-01-31 | Nifedipine-containing pharmaceutical compositions and process for the preparation thereof |
Country Status (17)
Country | Link |
---|---|
US (1) | US5145683A (en) |
EP (1) | EP0385582B1 (en) |
JP (1) | JPH07112974B2 (en) |
AT (1) | ATE79032T1 (en) |
AU (1) | AU626130B2 (en) |
CA (1) | CA2008972C (en) |
DE (1) | DE69000240T2 (en) |
DK (1) | DK0385582T3 (en) |
ES (1) | ES2052168T3 (en) |
FI (1) | FI95347C (en) |
GB (1) | GB8903328D0 (en) |
GR (1) | GR3005477T3 (en) |
IE (1) | IE64682B1 (en) |
NO (1) | NO175925C (en) |
NZ (1) | NZ232287A (en) |
PH (1) | PH26850A (en) |
ZA (1) | ZA90904B (en) |
Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5624683A (en) * | 1986-08-06 | 1997-04-29 | Eisai Co., Ltd. | Sustained-release multi-granule tablet |
GB9200607D0 (en) * | 1992-01-13 | 1992-03-11 | Ethical Pharma Ltd | Pharmaceutical compositions containing nifedipine and process for the preparation thereof |
US6726930B1 (en) * | 1993-09-09 | 2004-04-27 | Penwest Pharmaceuticals Co. | Sustained release heterodisperse hydrogel systems for insoluble drugs |
US5773025A (en) * | 1993-09-09 | 1998-06-30 | Edward Mendell Co., Inc. | Sustained release heterodisperse hydrogel systems--amorphous drugs |
US5662933A (en) * | 1993-09-09 | 1997-09-02 | Edward Mendell Co., Inc. | Controlled release formulation (albuterol) |
US5455046A (en) * | 1993-09-09 | 1995-10-03 | Edward Mendell Co., Inc. | Sustained release heterodisperse hydrogel systems for insoluble drugs |
PT800392E (en) * | 1994-12-29 | 2002-06-28 | Shire Deutschland Gmbh & Co Kg | PHARMACEUTICAL PREPARATIONS CONTAINING NIFEDIPIN AND PROCESSES FOR THEIR PREPARATION |
US5871776A (en) * | 1995-01-31 | 1999-02-16 | Mehta; Atul M. | Controlled-release nifedipine |
CN1049114C (en) * | 1995-12-07 | 2000-02-09 | 上海华联制药公司 | Method for prepn. of slowly-released medicaments preparation |
CA2231195C (en) | 1996-07-08 | 2003-01-21 | Edward Mendell Co., Inc. | Sustained release matrix for high-dose insoluble drugs |
EP0852141A1 (en) | 1996-08-16 | 1998-07-08 | J.B. Chemicals & Pharmaceuticals Ltd. | Nifedipine containing pharmaceutical extended release composition and a process for the preparation thereof |
IT1284604B1 (en) * | 1996-09-27 | 1998-05-21 | Roberto Valducci | CONTROLLED RELEASE PHARMACEUTICAL COMPOSITIONS FOR ORAL ADMINISTRATION CONTAINING NIFEDIPINE AS THE ACTIVE SUBSTANCE |
US5922352A (en) * | 1997-01-31 | 1999-07-13 | Andrx Pharmaceuticals, Inc. | Once daily calcium channel blocker tablet having a delayed release core |
US5837379A (en) * | 1997-01-31 | 1998-11-17 | Andrx Pharmaceuticals, Inc. | Once daily pharmaceutical tablet having a unitary core |
US6056977A (en) * | 1997-10-15 | 2000-05-02 | Edward Mendell Co., Inc. | Once-a-day controlled release sulfonylurea formulation |
US6485748B1 (en) | 1997-12-12 | 2002-11-26 | Andrx Pharmaceuticals, Inc. | Once daily pharmaceutical tablet having a unitary core |
US6168806B1 (en) | 1999-03-05 | 2001-01-02 | Fang-Yu Lee | Orally administrable nifedipine pellet and process for the preparation thereof |
US20040115134A1 (en) * | 1999-06-22 | 2004-06-17 | Elan Pharma International Ltd. | Novel nifedipine compositions |
JP4627825B2 (en) * | 1999-09-27 | 2011-02-09 | 三生医薬株式会社 | Encapsulated granular material and method for producing the same |
ES2304980T3 (en) * | 1999-09-30 | 2008-11-01 | Penwest Pharmaceuticals Co. | SUSTAINED LIBERATION MATRIX SYSTEMS FOR HIGHLY SOLUBLE PHARMACOS. |
DE60028754T2 (en) * | 1999-11-12 | 2007-05-31 | Abbott Laboratories, Abbott Park | SOLID DISPERSION WITH RITONAVIR, FENOFIBRATE OR GRISEOFULVIN |
US7364752B1 (en) | 1999-11-12 | 2008-04-29 | Abbott Laboratories | Solid dispersion pharamaceutical formulations |
DE10026698A1 (en) | 2000-05-30 | 2001-12-06 | Basf Ag | Self-emulsifying active ingredient formulation and use of this formulation |
EP1406630A1 (en) * | 2001-07-06 | 2004-04-14 | Endo Pharmaceuticals Inc. | Parenteral administration of 6-hydroxy-oxymorphone for use as an analgesic |
US8025899B2 (en) | 2003-08-28 | 2011-09-27 | Abbott Laboratories | Solid pharmaceutical dosage form |
US8377952B2 (en) | 2003-08-28 | 2013-02-19 | Abbott Laboratories | Solid pharmaceutical dosage formulation |
EP2112925A4 (en) * | 2006-11-15 | 2013-01-09 | Abbott Lab | Solid pharmaceutical dosage formulations |
GB2460915B (en) | 2008-06-16 | 2011-05-25 | Biovascular Inc | Controlled release compositions of agents that reduce circulating levels of platelets and methods therefor |
RU2629843C1 (en) * | 2016-05-24 | 2017-09-04 | федеральное государственное автономное образовательное учреждение высшего образования Первый Московский государственный медицинский университет имени И.М. Сеченова Министерства здравоохранения Российской Федерации (Сеченовский университет) | Method for production of nifedipine ointment (versions) |
CN109172534B (en) * | 2018-10-23 | 2020-08-07 | 迪沙药业集团有限公司 | Nifedipine sustained-release tablet composition |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1579818A (en) * | 1977-06-07 | 1980-11-26 | Yamanouchi Pharma Co Ltd | Nifedipine-containing solid preparation composition |
US4285665A (en) * | 1978-05-08 | 1981-08-25 | Johnson, Matthey & Co., Limited | Engines |
DE3033919A1 (en) * | 1980-09-09 | 1982-04-22 | Bayer Ag, 5090 Leverkusen | SOLID PHARMACEUTICAL PREPARATIONS CONTAINING NIFEDIPINE AND METHOD FOR THE PRODUCTION THEREOF |
JPS5846019A (en) * | 1981-09-14 | 1983-03-17 | Kanebo Ltd | Nifedipine preparation with prolonged action |
DE3318649A1 (en) * | 1983-05-21 | 1984-11-22 | Bayer Ag, 5090 Leverkusen | TWO-PHASE FORMULATION |
FR2556964A1 (en) * | 1983-12-23 | 1985-06-28 | Ile De France | NEW GALENIC FORMS OF SULPIRIDE USED ORALALLY |
DE3424553A1 (en) * | 1984-07-04 | 1986-01-09 | Bayer Ag, 5090 Leverkusen | SOLID DRUG PREPARATIONS WITH DIHYDROPYRIDINE AND METHOD FOR THE PRODUCTION THEREOF |
IT1178511B (en) * | 1984-09-14 | 1987-09-09 | Pharmatec Spa | PROCEDURE FOR THE PREPARATION OF A SOLID FORM FOR ORAL USE BASED ON NIFEDIPINE WITH RELEASE |
IT1187751B (en) * | 1985-10-15 | 1987-12-23 | Eurand Spa | PROCEDURE FOR THE PREPARATION OF SOLID FORMULATIONS OF NIFEDIPINE WITH HIGH BIO AVAILABILITY AND WITH PROLONGED EFFECT AND FORMULATIONS SO OBTAINED |
SE457326B (en) * | 1986-02-14 | 1988-12-19 | Lejus Medical Ab | PROCEDURES FOR PREPARING A QUICK SUBSTANTIAL CANDLES CONTAINING BLA MICROCRISTALLIN CELLULOSA |
-
1989
- 1989-02-14 GB GB898903328A patent/GB8903328D0/en active Pending
-
1990
- 1990-01-25 IE IE28690A patent/IE64682B1/en not_active IP Right Cessation
- 1990-01-26 NO NO900370A patent/NO175925C/en unknown
- 1990-01-30 US US07/472,659 patent/US5145683A/en not_active Expired - Lifetime
- 1990-01-30 NZ NZ232287A patent/NZ232287A/en unknown
- 1990-01-31 ES ES90301005T patent/ES2052168T3/en not_active Expired - Lifetime
- 1990-01-31 EP EP90301005A patent/EP0385582B1/en not_active Expired - Lifetime
- 1990-01-31 CA CA002008972A patent/CA2008972C/en not_active Expired - Fee Related
- 1990-01-31 AT AT90301005T patent/ATE79032T1/en not_active IP Right Cessation
- 1990-01-31 DK DK90301005.6T patent/DK0385582T3/en active
- 1990-01-31 DE DE9090301005T patent/DE69000240T2/en not_active Expired - Fee Related
- 1990-01-31 AU AU48937/90A patent/AU626130B2/en not_active Ceased
- 1990-02-07 ZA ZA90904A patent/ZA90904B/en unknown
- 1990-02-08 FI FI900633A patent/FI95347C/en not_active IP Right Cessation
- 1990-02-09 PH PH40039A patent/PH26850A/en unknown
- 1990-02-13 JP JP2032325A patent/JPH07112974B2/en not_active Expired - Lifetime
-
1992
- 1992-08-20 GR GR920401816T patent/GR3005477T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
EP0385582A1 (en) | 1990-09-05 |
US5145683A (en) | 1992-09-08 |
DE69000240D1 (en) | 1992-09-10 |
NO175925C (en) | 1995-01-04 |
FI900633A0 (en) | 1990-02-08 |
GR3005477T3 (en) | 1993-05-24 |
PH26850A (en) | 1992-11-05 |
NO900370L (en) | 1990-08-15 |
IE900286L (en) | 1990-08-14 |
CA2008972C (en) | 1996-09-03 |
NZ232287A (en) | 1992-01-29 |
NO900370D0 (en) | 1990-01-26 |
DE69000240T2 (en) | 1993-02-11 |
ATE79032T1 (en) | 1992-08-15 |
EP0385582B1 (en) | 1992-08-05 |
ZA90904B (en) | 1991-06-26 |
IE64682B1 (en) | 1995-08-23 |
FI95347C (en) | 1996-01-25 |
GB8903328D0 (en) | 1989-04-05 |
DK0385582T3 (en) | 1992-09-14 |
AU626130B2 (en) | 1992-07-23 |
AU4893790A (en) | 1990-08-23 |
JPH02235815A (en) | 1990-09-18 |
FI95347B (en) | 1995-10-13 |
ES2052168T3 (en) | 1994-07-01 |
JPH07112974B2 (en) | 1995-12-06 |
NO175925B (en) | 1994-09-26 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKLA | Lapsed |