CA2005151A1 - Inhalator device, in particular a pocket inhalator - Google Patents
Inhalator device, in particular a pocket inhalatorInfo
- Publication number
- CA2005151A1 CA2005151A1 CA002005151A CA2005151A CA2005151A1 CA 2005151 A1 CA2005151 A1 CA 2005151A1 CA 002005151 A CA002005151 A CA 002005151A CA 2005151 A CA2005151 A CA 2005151A CA 2005151 A1 CA2005151 A1 CA 2005151A1
- Authority
- CA
- Canada
- Prior art keywords
- ultrasonic atomizer
- disposed
- inhalator
- medication
- wall
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
- B05B17/00—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups
- B05B17/04—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods
- B05B17/06—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods using ultrasonic or other kinds of vibrations
- B05B17/0607—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods using ultrasonic or other kinds of vibrations generated by electrical means, e.g. piezoelectric transducers
- B05B17/0623—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods using ultrasonic or other kinds of vibrations generated by electrical means, e.g. piezoelectric transducers coupled with a vibrating horn
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0085—Inhalators using ultrasonics
Abstract
Abstract of the Disclosure:
An inhalator device includes a housing in which an ultrasonic atomizer is disposed. A device delivers a medication to the ultrasonic atomizer. A mouthpiece is disposed downstream of the ultrasonic atomizer in flow direction of the medication defining a space between the ultrasonic atomizer and the mouthpiece. The housing has an air inlet opening formed therein communicating with the space downstream of the ultrasonic atomizer.
An inhalator device includes a housing in which an ultrasonic atomizer is disposed. A device delivers a medication to the ultrasonic atomizer. A mouthpiece is disposed downstream of the ultrasonic atomizer in flow direction of the medication defining a space between the ultrasonic atomizer and the mouthpiece. The housing has an air inlet opening formed therein communicating with the space downstream of the ultrasonic atomizer.
Description
)5~
GR 88 P 861~
INHALATOR DEVICE, IN PARTICULAR A POCKET INHALATOR
~EæCification:
The invention relates to an inhalator device~ in particular a pocket inhalator, having a) a housing, b) an ultrasonic atomizer disposed in the housing, c) a device for delivering a medication to the ultrasonic atomizer, and d) a mouthpiece, which adjoins a space downstream of the ultrasonic atomizer.
A pocket inhalator of that type is known from Published European Application No. 0 258 637, for example. The known device is intended for atomizing medicines administered by inhalation. It is constructed in such a way as to produce an aerosol with droplets ranging in diameter substantially from 1 to 5 ~m. Thus it is preferentially intended for asthmatics. The preferably plastic housin~ includes a lower part, which accommodates a piezoelectric vibration system with an atomizer disk, an electronic circuit for ultrasonic excitation of the system, a battery for energy supply to the electronic circuit, and a magnetically actuated switch to turn on the ultrasonic excitation. l'he housing also includes an upper part, detachably secured to the lower part, with a ~outhpiece or suction fitting, in the direction of which the medication is atomized, and a holding chamber into which a medication dosing cartridge can be introduced. The dosing cartridge can be displaced into itself counter to a built-in spring by means of an attached trigger or pushbutton. Upon actuation of the trigger, the cartridge is displaced toward the atomizer disk. At the same time, it is displaced into itself. In that process a droplet is stripped off from the dosing opening of the cartridge onto the atomizer disk. A
magnet disposed on the cartridge actuates the switch magneti-cally when the trigger is pressed, whereupon, after a prede-termined period of time, the ultrasonic atomizer with the atomizer disk is excited, after which the stripped-off droplet is atomized. The resultant aerosol can then be inhaled by the user through the mouthpiece. The device can be made small, lightweight and easy to handle and is there-fore easy for the user to carry along on any occasion. It can be filled with the medicine to be atomized simply by changing the dosing carkridge.
A dosing cartridge of the type under consideration is knownr for instance, from German Published, Non-Examined Application DE-OS 33 39 180. That device has a cylindrical front part, which has a centrally located, a continuous dosage tubule in the end wall thereof, with a dosing opening located on the outside, and a spiral spring in the interior thereo~.
Protruding into the back of the front portion is a thinner cylindrical back part containing the medicine ancl having two end walls. When actuated, the back part can slide into the front part. An outlet tubule attached to the end wall located in the interior of the front part is slidingly seated on the back part of the dosiny tubule. The dosing cartridge is thus displaceable into itself. If the back part is pressed into the interior of the front part counter to the force of the spring, then a small droplet of the medicine is released through the dosing opening of the dosing tubule.
In the pocket inhalator known from Published European Appli-cation No. 0 258 637~, it has been found that in the atomiz-ing process some of the aerosol settles on the walls in the aerosol space ahead of the ultrasonic atomizer and/or in the mouthpiece and thus is wasted in terms of the medical treat-ment. Such settling on the walls is undesirable for various reasons, namely because it is difficult to remove, and there is the danger of damage to the atomizer and the atomizer disk.
It is accordingly an object of the invention to provide an inhalator device, in particular a pocket inhalator, which overcomes the hereinafore-mentioned disadvantages of the heretofore-known devices of this general type and to clo so in such a way that the danger of the formation of a film of aerosol on the walls is markedly reduced.
With the foregoing and other objects in view there is provid-ed, in accordance with the invention, an inhalator device, in particular a pocket inhalator, comprising a housing, an ultrasonic atomizer disposed in the housing, a device for i delivering a medication to the ultrasonic atomizer, and a mouthpiece disposed downstream of the ultrasonic atomizer in flow direction of the medication defining a space between the ultrasonic atomizer and the mouthpiece, the housing having an i air inlet opening formed therein communicating with the space downstream of the ultrasonic atomizer.
.
Through the use of this air inlet opening, the user can aspirate air into the aexosol space. This air entrains the aerosol located there, so that the probability of its forming a film on the walls is markedly reduced.
In accordance with another feature of the invention, there are provided means disposed between the air inlet opening and the space, through which the air inlet opening communicates with the space, for developing a laminar flow of aspirated air.
, In accordance with a further feature of the invention, the laminar flow developing means is in the form of a wall having a multiplicity of small holes formed therein.
The aerosol is entrained by the laminar air flow, making it particularly improbable that the aerosol will settle on the walls before the outlet from the device.
5~
In accordance with an added feature of the invention, the wall is disposed in the immediate vicinity of the ultrasonic atomizer.
In accordance with an additional feature of the invention, the multiplicity of holes formed in the wall are relatively small holes, the wall also has a relatively large opening formed therein, and the ultrasonic atomizer has an atomizer surface protruding into the relatively large opening.
In accordance with again another feature of the invention, the wall is inclined relative to the atomizer surface of the ultrasonic atomizer.
In accordance with again a further feature of the invention, the mouthpiece has an axis, and the wall is disposed in a plane being aligned at an angle of approximately 45~ with respect to the axis.
In accordance with again an added feature of the invention, the air inlet opening has the shape of a slit.
In accordance with again an additional feature of the inven-tion, the air inlet opening is disposed above and in the immediate vicinity of the wall.
In accordance with yet another feature of the invention, the wall has an approximately half-ring shape.
~ ~g~ ~r;~
ln accordance with yet a further feature of the invention, the housing includes a lower part and an upper part detach-ably secured to the lower part, the device for delivering a medication is disposed in the upper part, the mouthpiece is disposed on the upper part, the air inlet opening is formed in the lower part, and the ultrasonic atomizer and the means for developing a laminar flow oE aspirated air are disposed in the lower part.
In accordance with a concomitant feature of the invention, the device for delivering a medication i5 a dosing cartridge being displaceable into itself and having a front parl with a dosing opening formed therein, and preferably there are provided means, such as a stop, for firmly holding the dosing opening in place relative to the ultrasonic atomizer during a dosage operation.
Other features which are considered as characteristic for the invention are set forth in the appended claims.
Although the invention is illustrated and described herein as embodied in an inhalator device, in particular a pocket inhalator, it is nevertheless not intended to be limited to the details shown, since various modifications and structural changes may be made therein without departing from the spirit of the invention and within the scope and range of equiva-lents of the claims.
r3~
The construction and method of operation of the invention, however, together with additional objects and advantages thersof will be best understood from the following descrip-tion of specific embodiments when read in connection with the accompanying drawings.
Fig. 1 is a fragmentary, diagrammatic, longitudinal-sectional view of a pocket inhalator with an inserted dosing cartridge;
Fig. 2 is a fragmentary sectional view of the device of Fig.
1, taken along the line II-II in Fig. 1, in the direction of the arrows;
Fig. 3 is a fragmentary sectional view of the device of Fig.
1, taken along the line III-III in Fig. 1, in the direction of the arrows; and Fig. 4 is a partly broken-away cross-sectional view of the device of Fig. 1 taken along the line IV-IV in Fig. 1, in the direction of the arrows, with ~he dosing cartridge and the tongue omitted and the windows removed.
Referring now in detail to the figures of the drawing as a whole, it is seen that the pocket inhalator shown includes a plastic housing 2 with a lower part 2a and an upper part 2b detachably secured thereto. The detachable fastening is assured by means of at least one resilient side wall 4 and a snap-in or detent closure 6.
~r-a~ r;~, A pie~oelectric vibration system or ultrasonic atomizer 8 with an atomizer disk 10 pointing upward is accommodated on the lower part 2a. The operating frequency of the atomizer 8 is in the range from 1 to 5 MHz. The electrical energy for this is furnished by an electronic circuit 12, which is located in a sealed front chamber. Also accommodated in this chamber is a magnetically actuated switch 14, in particular a reed contact. The reed contact is located on an upper wall 16 or an intermediate wall of the lower part 2a. A replace-able battery 18 is inserted into a rear chamber. The battery supplies electrical energy to the electronic circuit 12. The front and rear chambers are sealed in a fluid-tight manner.
To this end, the ultrasonic atomizer 8 in the front chamber is preferably potted, for example with a potting composition 20.
A screen plate or closure wall 22 provided with small, round holes is located in the region of the ultrasonic atomizer 8, specifically in its immediate vicinity. The wall could instead be provided with slits or rectangular openin~s. The wall 22 is approximately in the form of a half ring. The central portion of the wall 22 has a larger opening 24, into which the atomizer surface of the atomizer disk 10 protrudes.
Thus an approximately annular separating gap is formed between the atomizer disk 10 and the rim of the wall 22 defined by the opening 24. The closure wall 22 has two functions: First, it provides mechanical protection of the atomizer 8 and the atomizer disk 10 from damage, and second, because of the many small openings, it acts as means for ~5~S~.
providing a laminar flow in a space or aerosol space or chamber 26 located above it. As soon as air is aspirated, the laminar flow occurs, through an air inlet opening 2$ that communicates with the aerosol space 26 and is preferably constructed as a slit defining slit edges 28a and 28b of the housing 2, as seen in Fig. 4. Thus the wall 22 can be considered as means for creating a laminar flow or laminarizing the aspirated air. Other such means may also be used in this case. The air inlet opening 28 in this case is disposed directly below the wall 22 in the housing 2.
The surface of the atomizer disk 10 is slightly inclined relative to the wall 22, which may also be referred to as a perforated grid. The inclination of the ultrasonic atomizer 8 toward the mouth of the user contributes to a compact construction of the inhalator. At the same time, i-t provides for atomization in the direction of the outlet opening of the aerosol space 26. Adequate cleaning of the vibrator region is possible because of the holes in the wall 22.
The aerosol space 26 is disposed in the front portion of the top part 2b. The space 26 terminates in a substantially oval mouthpiece 30, the outlet opening of which is closable with a plastic cap 32. The plane of the wall 22 may be aligned at an angle of approximately 45 with respect to the axis 31 of the mouthpiece 30.
The aerosol space 26 communicates through a guide opening 34 with a rear chamber 36, which accommodates a device, _g_ generally identified by reference numeral 40, for supplying a medicine to the ultrasonic atomizer 10. The device 40 includes a dosing cartridge 42 which is displaceable into itself and is known per se. The dosing cartridge 42 has a cylindrical front part 42a, and a cylindrical back part 42b which contains the medicine and is displaceable into the part 42a. A dosing tubule 44 acting as a cartridge point and having shoulders at the rear is attached to the front part 42a. A dosing opening is shown ak reference numeral 46.
When the dosing cartridge 42 is inserted horizQntally, the dosing tubule 44 is located in the guide opening 34, leaving an annular gap. Accordingly, the guide opening 34 serves to provide exact positioning. ~n important feature in this matter is that the point of the dosing cartridge 42 rests with one of the aforementioned shoulders on a stop 48 which, for example, is formed by the wall of the guide opening 34.
The stop 48 is important not only for centering but also for firmly holding the dosing cartridge 42 during the dosing process. Centering and guidance are also assured by ]ongitu-dinal ribs 50, 52 in the chamber 36.
The device 40 for delivering the medication further includes a trigger or plunger 54 attached to the end of the dosing cartridge 42. The trigger 54 is firmly slipped onto the end of the dosing cartridge 42. However, when the dosing car-tridge 42 is replaced, it is also readily removable from that end~ The dimensioning is selected in such a way that in the undepressed normal position, the rear surface of the trigger 54 approximately closes off the back of the housing 2 and it is introduced Eurther into the upper part 2b upon actuation.
The trigger 54 itself thus serves the purpose of exact retention of the cartridge 42.
A comparison of Fig. 1 and Fig. 4 shows that the trigger is constructed as a semicylindrical hollow body. Its lower end wall or lower surface terminates in a tongue 56. In other words the tongue 56 is integral with the trigger 54. The tongue 56 is essentially a rectangular plastic part. It is preferably provided with a longitudinal rib 58 on the upper surface thereof, in order to increase its stability. As will become clear later, the upper edge of the longitudinal rib 58, like the lower surface of the tongue 56, serves as a slide surface, both when the cartridge 42 is inserted and during dosing.
A magnet 60 is secured to the front end of the tongue 56.
When the trigger 54 is slipped into place, the tongue 56, the longitudinal rib 58 and the magnet 60 are located in a chamber 62 between the lower part 2a and the upper part 2~.
The tongue 56 is longitudinally displaceable in the chamber 62 when the trigger 54 is actuated. There need be no fear of contamination. Upon displacement, the magnet 60 is displaced toward the left relative to the switch 14. If it reaches the sphere of magnetic influence of the switch, the switch 14 is actuated. As a result, ultrasonic excitation of the atomizer 8 is tripped with the aid of the electronic circuit 12, after the trigger 54 is released and upon opening of the switch 14.
The tongue 56, longitudinal rib 58 and trigger 54 may be constructed as a single injection molded part. From Fig. 1 it is clear that the magnet 60 which may, for instance, be cylindrical, is let or formed into the tongue 56 and the longitudinal rib 58, and that it is essentially flush with the surface of the tongue 56 oriented toward the switch 54.
Upon actuation, the magnet 60 is displaced along the wall 16 of the housing 2. When the user's finger releases the trigger, the cartridge 42 (and thus the magnet 60) returns to its initial position as shown, because of the spring force of the cartridge.
Guidance of the tongue 56 in the chamber 62 is effected with the aid of two side walls 64, 66, which are secured in such a way as to be spaced somewhat apart from and parallel to one another on the lower surface of the upper part 2b.
'.~
Two windows 68, 70 are disposed one above the other on two parallel lonyitudinal side walls 2bl, 2b2 of the upper part 2b. The fill level of the cartridge 42, which is made of transparent plastic, can be observed through these windows.
The dosing cartridge 42 as shown is in the inserted state between these two windows 68, 70. Preferably the windows 68, 70 are made of plastic and are eguipped with detent protru-sions 69, 71, so that they can be clipped into suitable openings in the longitudinal side walls of the upper part 2b.
These detent openings 69, 71 are shaped in such a way that they secure the dosing cartridge 42 against accidentally falling out or being unintentionally removed.
, .
.~ . .
., .
3~
An indentation or countersinking 74 is provided at the guide opening 34 in the material in the vicinity of the atomizer disk 10 provided there. This lessens the capillary action in the annular gap of the guide opening 34 for the emerging droplets o~ medication during dosing. In other words, the distance for the emerging dosage droplet is smaller between the outlet opening 46 and the surface of the atomizer disk 10 than between the dosing opening 46 and the bottom of the indentation 74. As a result, the particle adhesion force of the atomizer disk 10 with respect to the droplet is rein-forced, so that upon dosage it is assured that the droplet is placed on the surface of the atomizer disk 10, rather than in the vicinity o~ the annular gap at the opening 24, for example. A possible later return flow of the droplet of medication through a possible capillary action between the outer periphery of the cartridge tip and the guide opening of the upper part 2 is thus attained by means of a correspond-ingly enlarged guide opening diameter.
The lower and upper parts 2a and 2b can each be respectively composed of two halves or shells. This is shown in Fig. 4 for the lower part 2a by means of the seam line 76.
As already explained above, the upper part 2b can be mounted from above orlto the lower part 2a, to which it can be snapped or clamped together with the aid of the detent closure 6. If the user then presses on the trigger 54, the back part 42b is forced into the front part 42a of the dosing cartridge 42, and a droplet of medication is expelled onto the atomizer disk 10. At the same time, the magnet 60 secured to thetongue 56 moves with the tongue toward the switch 14 and closes it. After the trigger 54 is released and the switch 14 opens, the switching process causes the droplet on the atomizer disk 10 to be atomized by ultrasonic vi~ration. It is converted into an aerosol that moves into the space 26.
The aerosol can be inhaled by the user through the mouthpiece 30 (after the cap 32 is removed). During inhalation, air is aspirated through the air inlet opening 28. Due to the laminar flow eEfected by the screen plate 22, only slight settling of the medication onto the inner surfaces of the mouthpiece 30 in space 26 takes place. This is a consider-able advantage in terms of operational reliability and hygiene.
It should also be stressed that in principle, the laminarizing means may instead be disposed in the upper part 2b, for example again in the form of a grid.
The foregoing is a description corresponding in substance to European Application 88 120 823.5, dated December 13, 1988, the International priority of which is being claimed for the instant application, and which is hereby made part of this application. Any material discrepancies between the fore-going specification and the aforementioned corresponding European application are to be resolved in favor of the latter.
GR 88 P 861~
INHALATOR DEVICE, IN PARTICULAR A POCKET INHALATOR
~EæCification:
The invention relates to an inhalator device~ in particular a pocket inhalator, having a) a housing, b) an ultrasonic atomizer disposed in the housing, c) a device for delivering a medication to the ultrasonic atomizer, and d) a mouthpiece, which adjoins a space downstream of the ultrasonic atomizer.
A pocket inhalator of that type is known from Published European Application No. 0 258 637, for example. The known device is intended for atomizing medicines administered by inhalation. It is constructed in such a way as to produce an aerosol with droplets ranging in diameter substantially from 1 to 5 ~m. Thus it is preferentially intended for asthmatics. The preferably plastic housin~ includes a lower part, which accommodates a piezoelectric vibration system with an atomizer disk, an electronic circuit for ultrasonic excitation of the system, a battery for energy supply to the electronic circuit, and a magnetically actuated switch to turn on the ultrasonic excitation. l'he housing also includes an upper part, detachably secured to the lower part, with a ~outhpiece or suction fitting, in the direction of which the medication is atomized, and a holding chamber into which a medication dosing cartridge can be introduced. The dosing cartridge can be displaced into itself counter to a built-in spring by means of an attached trigger or pushbutton. Upon actuation of the trigger, the cartridge is displaced toward the atomizer disk. At the same time, it is displaced into itself. In that process a droplet is stripped off from the dosing opening of the cartridge onto the atomizer disk. A
magnet disposed on the cartridge actuates the switch magneti-cally when the trigger is pressed, whereupon, after a prede-termined period of time, the ultrasonic atomizer with the atomizer disk is excited, after which the stripped-off droplet is atomized. The resultant aerosol can then be inhaled by the user through the mouthpiece. The device can be made small, lightweight and easy to handle and is there-fore easy for the user to carry along on any occasion. It can be filled with the medicine to be atomized simply by changing the dosing carkridge.
A dosing cartridge of the type under consideration is knownr for instance, from German Published, Non-Examined Application DE-OS 33 39 180. That device has a cylindrical front part, which has a centrally located, a continuous dosage tubule in the end wall thereof, with a dosing opening located on the outside, and a spiral spring in the interior thereo~.
Protruding into the back of the front portion is a thinner cylindrical back part containing the medicine ancl having two end walls. When actuated, the back part can slide into the front part. An outlet tubule attached to the end wall located in the interior of the front part is slidingly seated on the back part of the dosiny tubule. The dosing cartridge is thus displaceable into itself. If the back part is pressed into the interior of the front part counter to the force of the spring, then a small droplet of the medicine is released through the dosing opening of the dosing tubule.
In the pocket inhalator known from Published European Appli-cation No. 0 258 637~, it has been found that in the atomiz-ing process some of the aerosol settles on the walls in the aerosol space ahead of the ultrasonic atomizer and/or in the mouthpiece and thus is wasted in terms of the medical treat-ment. Such settling on the walls is undesirable for various reasons, namely because it is difficult to remove, and there is the danger of damage to the atomizer and the atomizer disk.
It is accordingly an object of the invention to provide an inhalator device, in particular a pocket inhalator, which overcomes the hereinafore-mentioned disadvantages of the heretofore-known devices of this general type and to clo so in such a way that the danger of the formation of a film of aerosol on the walls is markedly reduced.
With the foregoing and other objects in view there is provid-ed, in accordance with the invention, an inhalator device, in particular a pocket inhalator, comprising a housing, an ultrasonic atomizer disposed in the housing, a device for i delivering a medication to the ultrasonic atomizer, and a mouthpiece disposed downstream of the ultrasonic atomizer in flow direction of the medication defining a space between the ultrasonic atomizer and the mouthpiece, the housing having an i air inlet opening formed therein communicating with the space downstream of the ultrasonic atomizer.
.
Through the use of this air inlet opening, the user can aspirate air into the aexosol space. This air entrains the aerosol located there, so that the probability of its forming a film on the walls is markedly reduced.
In accordance with another feature of the invention, there are provided means disposed between the air inlet opening and the space, through which the air inlet opening communicates with the space, for developing a laminar flow of aspirated air.
, In accordance with a further feature of the invention, the laminar flow developing means is in the form of a wall having a multiplicity of small holes formed therein.
The aerosol is entrained by the laminar air flow, making it particularly improbable that the aerosol will settle on the walls before the outlet from the device.
5~
In accordance with an added feature of the invention, the wall is disposed in the immediate vicinity of the ultrasonic atomizer.
In accordance with an additional feature of the invention, the multiplicity of holes formed in the wall are relatively small holes, the wall also has a relatively large opening formed therein, and the ultrasonic atomizer has an atomizer surface protruding into the relatively large opening.
In accordance with again another feature of the invention, the wall is inclined relative to the atomizer surface of the ultrasonic atomizer.
In accordance with again a further feature of the invention, the mouthpiece has an axis, and the wall is disposed in a plane being aligned at an angle of approximately 45~ with respect to the axis.
In accordance with again an added feature of the invention, the air inlet opening has the shape of a slit.
In accordance with again an additional feature of the inven-tion, the air inlet opening is disposed above and in the immediate vicinity of the wall.
In accordance with yet another feature of the invention, the wall has an approximately half-ring shape.
~ ~g~ ~r;~
ln accordance with yet a further feature of the invention, the housing includes a lower part and an upper part detach-ably secured to the lower part, the device for delivering a medication is disposed in the upper part, the mouthpiece is disposed on the upper part, the air inlet opening is formed in the lower part, and the ultrasonic atomizer and the means for developing a laminar flow oE aspirated air are disposed in the lower part.
In accordance with a concomitant feature of the invention, the device for delivering a medication i5 a dosing cartridge being displaceable into itself and having a front parl with a dosing opening formed therein, and preferably there are provided means, such as a stop, for firmly holding the dosing opening in place relative to the ultrasonic atomizer during a dosage operation.
Other features which are considered as characteristic for the invention are set forth in the appended claims.
Although the invention is illustrated and described herein as embodied in an inhalator device, in particular a pocket inhalator, it is nevertheless not intended to be limited to the details shown, since various modifications and structural changes may be made therein without departing from the spirit of the invention and within the scope and range of equiva-lents of the claims.
r3~
The construction and method of operation of the invention, however, together with additional objects and advantages thersof will be best understood from the following descrip-tion of specific embodiments when read in connection with the accompanying drawings.
Fig. 1 is a fragmentary, diagrammatic, longitudinal-sectional view of a pocket inhalator with an inserted dosing cartridge;
Fig. 2 is a fragmentary sectional view of the device of Fig.
1, taken along the line II-II in Fig. 1, in the direction of the arrows;
Fig. 3 is a fragmentary sectional view of the device of Fig.
1, taken along the line III-III in Fig. 1, in the direction of the arrows; and Fig. 4 is a partly broken-away cross-sectional view of the device of Fig. 1 taken along the line IV-IV in Fig. 1, in the direction of the arrows, with ~he dosing cartridge and the tongue omitted and the windows removed.
Referring now in detail to the figures of the drawing as a whole, it is seen that the pocket inhalator shown includes a plastic housing 2 with a lower part 2a and an upper part 2b detachably secured thereto. The detachable fastening is assured by means of at least one resilient side wall 4 and a snap-in or detent closure 6.
~r-a~ r;~, A pie~oelectric vibration system or ultrasonic atomizer 8 with an atomizer disk 10 pointing upward is accommodated on the lower part 2a. The operating frequency of the atomizer 8 is in the range from 1 to 5 MHz. The electrical energy for this is furnished by an electronic circuit 12, which is located in a sealed front chamber. Also accommodated in this chamber is a magnetically actuated switch 14, in particular a reed contact. The reed contact is located on an upper wall 16 or an intermediate wall of the lower part 2a. A replace-able battery 18 is inserted into a rear chamber. The battery supplies electrical energy to the electronic circuit 12. The front and rear chambers are sealed in a fluid-tight manner.
To this end, the ultrasonic atomizer 8 in the front chamber is preferably potted, for example with a potting composition 20.
A screen plate or closure wall 22 provided with small, round holes is located in the region of the ultrasonic atomizer 8, specifically in its immediate vicinity. The wall could instead be provided with slits or rectangular openin~s. The wall 22 is approximately in the form of a half ring. The central portion of the wall 22 has a larger opening 24, into which the atomizer surface of the atomizer disk 10 protrudes.
Thus an approximately annular separating gap is formed between the atomizer disk 10 and the rim of the wall 22 defined by the opening 24. The closure wall 22 has two functions: First, it provides mechanical protection of the atomizer 8 and the atomizer disk 10 from damage, and second, because of the many small openings, it acts as means for ~5~S~.
providing a laminar flow in a space or aerosol space or chamber 26 located above it. As soon as air is aspirated, the laminar flow occurs, through an air inlet opening 2$ that communicates with the aerosol space 26 and is preferably constructed as a slit defining slit edges 28a and 28b of the housing 2, as seen in Fig. 4. Thus the wall 22 can be considered as means for creating a laminar flow or laminarizing the aspirated air. Other such means may also be used in this case. The air inlet opening 28 in this case is disposed directly below the wall 22 in the housing 2.
The surface of the atomizer disk 10 is slightly inclined relative to the wall 22, which may also be referred to as a perforated grid. The inclination of the ultrasonic atomizer 8 toward the mouth of the user contributes to a compact construction of the inhalator. At the same time, i-t provides for atomization in the direction of the outlet opening of the aerosol space 26. Adequate cleaning of the vibrator region is possible because of the holes in the wall 22.
The aerosol space 26 is disposed in the front portion of the top part 2b. The space 26 terminates in a substantially oval mouthpiece 30, the outlet opening of which is closable with a plastic cap 32. The plane of the wall 22 may be aligned at an angle of approximately 45 with respect to the axis 31 of the mouthpiece 30.
The aerosol space 26 communicates through a guide opening 34 with a rear chamber 36, which accommodates a device, _g_ generally identified by reference numeral 40, for supplying a medicine to the ultrasonic atomizer 10. The device 40 includes a dosing cartridge 42 which is displaceable into itself and is known per se. The dosing cartridge 42 has a cylindrical front part 42a, and a cylindrical back part 42b which contains the medicine and is displaceable into the part 42a. A dosing tubule 44 acting as a cartridge point and having shoulders at the rear is attached to the front part 42a. A dosing opening is shown ak reference numeral 46.
When the dosing cartridge 42 is inserted horizQntally, the dosing tubule 44 is located in the guide opening 34, leaving an annular gap. Accordingly, the guide opening 34 serves to provide exact positioning. ~n important feature in this matter is that the point of the dosing cartridge 42 rests with one of the aforementioned shoulders on a stop 48 which, for example, is formed by the wall of the guide opening 34.
The stop 48 is important not only for centering but also for firmly holding the dosing cartridge 42 during the dosing process. Centering and guidance are also assured by ]ongitu-dinal ribs 50, 52 in the chamber 36.
The device 40 for delivering the medication further includes a trigger or plunger 54 attached to the end of the dosing cartridge 42. The trigger 54 is firmly slipped onto the end of the dosing cartridge 42. However, when the dosing car-tridge 42 is replaced, it is also readily removable from that end~ The dimensioning is selected in such a way that in the undepressed normal position, the rear surface of the trigger 54 approximately closes off the back of the housing 2 and it is introduced Eurther into the upper part 2b upon actuation.
The trigger 54 itself thus serves the purpose of exact retention of the cartridge 42.
A comparison of Fig. 1 and Fig. 4 shows that the trigger is constructed as a semicylindrical hollow body. Its lower end wall or lower surface terminates in a tongue 56. In other words the tongue 56 is integral with the trigger 54. The tongue 56 is essentially a rectangular plastic part. It is preferably provided with a longitudinal rib 58 on the upper surface thereof, in order to increase its stability. As will become clear later, the upper edge of the longitudinal rib 58, like the lower surface of the tongue 56, serves as a slide surface, both when the cartridge 42 is inserted and during dosing.
A magnet 60 is secured to the front end of the tongue 56.
When the trigger 54 is slipped into place, the tongue 56, the longitudinal rib 58 and the magnet 60 are located in a chamber 62 between the lower part 2a and the upper part 2~.
The tongue 56 is longitudinally displaceable in the chamber 62 when the trigger 54 is actuated. There need be no fear of contamination. Upon displacement, the magnet 60 is displaced toward the left relative to the switch 14. If it reaches the sphere of magnetic influence of the switch, the switch 14 is actuated. As a result, ultrasonic excitation of the atomizer 8 is tripped with the aid of the electronic circuit 12, after the trigger 54 is released and upon opening of the switch 14.
The tongue 56, longitudinal rib 58 and trigger 54 may be constructed as a single injection molded part. From Fig. 1 it is clear that the magnet 60 which may, for instance, be cylindrical, is let or formed into the tongue 56 and the longitudinal rib 58, and that it is essentially flush with the surface of the tongue 56 oriented toward the switch 54.
Upon actuation, the magnet 60 is displaced along the wall 16 of the housing 2. When the user's finger releases the trigger, the cartridge 42 (and thus the magnet 60) returns to its initial position as shown, because of the spring force of the cartridge.
Guidance of the tongue 56 in the chamber 62 is effected with the aid of two side walls 64, 66, which are secured in such a way as to be spaced somewhat apart from and parallel to one another on the lower surface of the upper part 2b.
'.~
Two windows 68, 70 are disposed one above the other on two parallel lonyitudinal side walls 2bl, 2b2 of the upper part 2b. The fill level of the cartridge 42, which is made of transparent plastic, can be observed through these windows.
The dosing cartridge 42 as shown is in the inserted state between these two windows 68, 70. Preferably the windows 68, 70 are made of plastic and are eguipped with detent protru-sions 69, 71, so that they can be clipped into suitable openings in the longitudinal side walls of the upper part 2b.
These detent openings 69, 71 are shaped in such a way that they secure the dosing cartridge 42 against accidentally falling out or being unintentionally removed.
, .
.~ . .
., .
3~
An indentation or countersinking 74 is provided at the guide opening 34 in the material in the vicinity of the atomizer disk 10 provided there. This lessens the capillary action in the annular gap of the guide opening 34 for the emerging droplets o~ medication during dosing. In other words, the distance for the emerging dosage droplet is smaller between the outlet opening 46 and the surface of the atomizer disk 10 than between the dosing opening 46 and the bottom of the indentation 74. As a result, the particle adhesion force of the atomizer disk 10 with respect to the droplet is rein-forced, so that upon dosage it is assured that the droplet is placed on the surface of the atomizer disk 10, rather than in the vicinity o~ the annular gap at the opening 24, for example. A possible later return flow of the droplet of medication through a possible capillary action between the outer periphery of the cartridge tip and the guide opening of the upper part 2 is thus attained by means of a correspond-ingly enlarged guide opening diameter.
The lower and upper parts 2a and 2b can each be respectively composed of two halves or shells. This is shown in Fig. 4 for the lower part 2a by means of the seam line 76.
As already explained above, the upper part 2b can be mounted from above orlto the lower part 2a, to which it can be snapped or clamped together with the aid of the detent closure 6. If the user then presses on the trigger 54, the back part 42b is forced into the front part 42a of the dosing cartridge 42, and a droplet of medication is expelled onto the atomizer disk 10. At the same time, the magnet 60 secured to thetongue 56 moves with the tongue toward the switch 14 and closes it. After the trigger 54 is released and the switch 14 opens, the switching process causes the droplet on the atomizer disk 10 to be atomized by ultrasonic vi~ration. It is converted into an aerosol that moves into the space 26.
The aerosol can be inhaled by the user through the mouthpiece 30 (after the cap 32 is removed). During inhalation, air is aspirated through the air inlet opening 28. Due to the laminar flow eEfected by the screen plate 22, only slight settling of the medication onto the inner surfaces of the mouthpiece 30 in space 26 takes place. This is a consider-able advantage in terms of operational reliability and hygiene.
It should also be stressed that in principle, the laminarizing means may instead be disposed in the upper part 2b, for example again in the form of a grid.
The foregoing is a description corresponding in substance to European Application 88 120 823.5, dated December 13, 1988, the International priority of which is being claimed for the instant application, and which is hereby made part of this application. Any material discrepancies between the fore-going specification and the aforementioned corresponding European application are to be resolved in favor of the latter.
Claims (16)
1. Inhalator device, comprising:
a) a housing, b) an ultrasonic atomizer disposed in said housing, c) a device for delivering a medication to said ultrasonic atomizer, and d) a mouthpiece disposed downstream of said ultrasonic atomizer in flow direction of the medication defining a space between said ultrasonic atomizer and said mouthpiece, e) said housing having an air inlet opening formed therein communicating with said space downstream of said ultrasonic atomizer.
a) a housing, b) an ultrasonic atomizer disposed in said housing, c) a device for delivering a medication to said ultrasonic atomizer, and d) a mouthpiece disposed downstream of said ultrasonic atomizer in flow direction of the medication defining a space between said ultrasonic atomizer and said mouthpiece, e) said housing having an air inlet opening formed therein communicating with said space downstream of said ultrasonic atomizer.
2. Inhalator according to claim l, including means disposed between said air inlet opening and said space for developing a laminar flow of aspirated air.
3. Inhalator according to claim 2, wherein said laminar flow developing means is in the form of a wall having a multiplic-ity of holes formed therein.
4. Inhalator according to claim 3, wherein said wall is disposed in the immediate vicinity of said ultrasonic atomiz-er.
5. Inhalator according to claim 3, wherein said multiplicity of holes formed in said wall are relatively small holes, said wall also has a relatively large opening formed therein, and said ultrasonic atomizer has an atomizer surface protruding into said relatively large opening.
6. Inhalator according to claim 5, wherein said wall is inclined relative to said atomizer surface of said ultrasonic atomizer.
7. Inhalator according to claim 6, wherein said mouthpiece has an axis, and said wall is disposed in a plane being aligned at an angle of approximately 45° with respect to said axis.
8. Inhalator according to claim 1, wherein said air inlet opening has the shape of a slit.
9. Inhalator according to claim 3, wherein said air inlet opening is disposed above and in the immediate vicinity of said wall.
10. Inhalator according to claim 3, wherein said wall has an approximately half-ring shape.
11. Inhalator according to claim 2, wherein said housing includes a lower part and an upper part detachably secured to said lower part, said device for delivering a medication is disposed in said upper part, said mouthpiece is disposed on said upper part, said air inlet opening is formed in said lower part, and said ultrasonic atomizer and said means for developing a laminar flow of aspirated air are disposed in said lower part.
12. Inhalator according to claim 1, wherein said device for delivering a medication is a dosing cartridge being displace-able into itself and having a front part with a dosing opening formed therein.
13. Inhalator according to claim 12, including means for firmly holding said dosing opening in place relative to said ultrasonic atomizer during a dosage operation.
14. Inhalator according to claim 13, wherein said holding means are in the form of a stop to be engaged by said front part of said dosing cartridge.
15. Pocket inhalator, comprising:
a) a housing, b) an ultrasonic atomizer disposed in said housing, c) a device for delivering a medication to said ultrasonic atomizer, and d) a mouthpiece disposed downstream of said ultrasonic atomizer in flow direction of the medication defining a space between said ultrasonic atomizer and said mouthpiece, e) said housing having an air inlet opening formed therein communicating with said space downstream of said ultrasonic atomizer.
a) a housing, b) an ultrasonic atomizer disposed in said housing, c) a device for delivering a medication to said ultrasonic atomizer, and d) a mouthpiece disposed downstream of said ultrasonic atomizer in flow direction of the medication defining a space between said ultrasonic atomizer and said mouthpiece, e) said housing having an air inlet opening formed therein communicating with said space downstream of said ultrasonic atomizer.
16. Inhalator device, comprising an ultrasonic atomizer, means for delivering a medication to said ultrasonic atomiz-er, outlet means disposed downstream of said ultrasonic atomizer in travel direction of a flow of the medication, and means disposed downstream of said ultrasonic atomizer for delivering air to the flow of the medication.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP88120823-5 | 1988-12-13 | ||
EP88120823A EP0373237A1 (en) | 1988-12-13 | 1988-12-13 | Pocket inhaler device |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2005151A1 true CA2005151A1 (en) | 1990-06-13 |
Family
ID=8199653
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002005151A Abandoned CA2005151A1 (en) | 1988-12-13 | 1989-12-11 | Inhalator device, in particular a pocket inhalator |
Country Status (5)
Country | Link |
---|---|
US (1) | US5134993A (en) |
EP (1) | EP0373237A1 (en) |
JP (1) | JPH02243166A (en) |
CA (1) | CA2005151A1 (en) |
DK (1) | DK617989A (en) |
Families Citing this family (92)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IE62780B1 (en) * | 1988-09-10 | 1995-02-22 | Fisons Plc | Inhalation devices with a reduced risk of blockage |
DE69127826T2 (en) * | 1990-12-17 | 1998-04-09 | Minnesota Mining & Mfg | INHALATION DEVICE |
AU651882B2 (en) * | 1991-05-14 | 1994-08-04 | Visiomed Group Limited | Aerosol inhalation device |
DE4117078A1 (en) * | 1991-05-25 | 1992-11-26 | Boehringer Ingelheim Kg | METHOD FOR PRODUCING THERAPEUTICALLY APPLICABLE AEROSOLS |
DE69333443T2 (en) * | 1992-04-09 | 2005-03-24 | Omron Healthcare Co., Ltd. | ultrasonic nebulizer |
US5452711A (en) * | 1992-12-24 | 1995-09-26 | Exar Corporation | Small form factor atomizer |
US5497763A (en) * | 1993-05-21 | 1996-03-12 | Aradigm Corporation | Disposable package for intrapulmonary delivery of aerosolized formulations |
US5709202A (en) * | 1993-05-21 | 1998-01-20 | Aradigm Corporation | Intrapulmonary delivery of aerosolized formulations |
FR2705911B1 (en) * | 1993-06-02 | 1995-08-11 | Oreal | Piezoelectric nebulization device. |
CH686872A5 (en) * | 1993-08-09 | 1996-07-31 | Disetronic Ag | Medical Inhalationsgeraet. |
GB9324250D0 (en) * | 1993-11-25 | 1994-01-12 | Minnesota Mining & Mfg | Inhaler |
US5505194A (en) * | 1994-03-23 | 1996-04-09 | Abbott Laboratories | Aerosol inhalation device having slideably and rotatably connected elliptical cylinder portions |
US5435282A (en) * | 1994-05-19 | 1995-07-25 | Habley Medical Technology Corporation | Nebulizer |
AU701843B2 (en) * | 1995-03-14 | 1999-02-04 | Siemens Aktiengesellschaft | Removable precision dosating unit for ultrasonic atomizer device |
ATE186222T1 (en) * | 1995-03-14 | 1999-11-15 | Siemens Ag | ULTRASONIC ATOMIZER WITH REMOVABLE PRECISION DOSING UNIT |
US5758637A (en) | 1995-08-31 | 1998-06-02 | Aerogen, Inc. | Liquid dispensing apparatus and methods |
WO1997002856A1 (en) * | 1995-07-10 | 1997-01-30 | A & D Company, Limited | Handy atomizer |
US6234167B1 (en) * | 1998-10-14 | 2001-05-22 | Chrysalis Technologies, Incorporated | Aerosol generator and methods of making and using an aerosol generator |
US6196218B1 (en) * | 1999-02-24 | 2001-03-06 | Ponwell Enterprises Ltd | Piezo inhaler |
US6235177B1 (en) | 1999-09-09 | 2001-05-22 | Aerogen, Inc. | Method for the construction of an aperture plate for dispensing liquid droplets |
US6962151B1 (en) * | 1999-11-05 | 2005-11-08 | Pari GmbH Spezialisten für effektive Inhalation | Inhalation nebulizer |
AU3400501A (en) | 2000-02-28 | 2001-09-12 | Vectura Ltd | Improvements in or relating to the delivery of oral drugs |
MY136453A (en) | 2000-04-27 | 2008-10-31 | Philip Morris Usa Inc | "improved method and apparatus for generating an aerosol" |
US6883516B2 (en) | 2000-04-27 | 2005-04-26 | Chrysalis Technologies Incorporated | Method for generating an aerosol with a predetermined and/or substantially monodispersed particle size distribution |
US6748944B1 (en) * | 2000-05-03 | 2004-06-15 | Dellavecchia Michael Anthony | Ultrasonic dosage device and method |
US7971588B2 (en) | 2000-05-05 | 2011-07-05 | Novartis Ag | Methods and systems for operating an aerosol generator |
MXPA02010884A (en) * | 2000-05-05 | 2003-03-27 | Aerogen Ireland Ltd | Apparatus and methods for the delivery of medicaments to the respiratory system. |
US8336545B2 (en) | 2000-05-05 | 2012-12-25 | Novartis Pharma Ag | Methods and systems for operating an aerosol generator |
US6543443B1 (en) * | 2000-07-12 | 2003-04-08 | Aerogen, Inc. | Methods and devices for nebulizing fluids |
US6629524B1 (en) | 2000-07-12 | 2003-10-07 | Ponwell Enterprises Limited | Inhaler |
CA2418613C (en) * | 2000-08-18 | 2009-02-24 | Norton Healthcare Limited | Spray device |
US6435175B1 (en) | 2000-08-29 | 2002-08-20 | Sensormedics Corporation | Pulmonary drug delivery device |
US6964647B1 (en) | 2000-10-06 | 2005-11-15 | Ellaz Babaev | Nozzle for ultrasound wound treatment |
US6601581B1 (en) * | 2000-11-01 | 2003-08-05 | Advanced Medical Applications, Inc. | Method and device for ultrasound drug delivery |
US6681998B2 (en) | 2000-12-22 | 2004-01-27 | Chrysalis Technologies Incorporated | Aerosol generator having inductive heater and method of use thereof |
US7077130B2 (en) | 2000-12-22 | 2006-07-18 | Chrysalis Technologies Incorporated | Disposable inhaler system |
US6701921B2 (en) | 2000-12-22 | 2004-03-09 | Chrysalis Technologies Incorporated | Aerosol generator having heater in multilayered composite and method of use thereof |
US6761729B2 (en) | 2000-12-22 | 2004-07-13 | Advanced Medicalapplications, Inc. | Wound treatment method and device with combination of ultrasound and laser energy |
US6799572B2 (en) | 2000-12-22 | 2004-10-05 | Chrysalis Technologies Incorporated | Disposable aerosol generator system and methods for administering the aerosol |
US6533803B2 (en) | 2000-12-22 | 2003-03-18 | Advanced Medical Applications, Inc. | Wound treatment method and device with combination of ultrasound and laser energy |
US6501052B2 (en) | 2000-12-22 | 2002-12-31 | Chrysalis Technologies Incorporated | Aerosol generator having multiple heating zones and methods of use thereof |
US6491233B2 (en) | 2000-12-22 | 2002-12-10 | Chrysalis Technologies Incorporated | Vapor driven aerosol generator and method of use thereof |
US6569099B1 (en) | 2001-01-12 | 2003-05-27 | Eilaz Babaev | Ultrasonic method and device for wound treatment |
US7914470B2 (en) | 2001-01-12 | 2011-03-29 | Celleration, Inc. | Ultrasonic method and device for wound treatment |
US8235919B2 (en) | 2001-01-12 | 2012-08-07 | Celleration, Inc. | Ultrasonic method and device for wound treatment |
US6960173B2 (en) * | 2001-01-30 | 2005-11-01 | Eilaz Babaev | Ultrasound wound treatment method and device using standing waves |
US6550472B2 (en) * | 2001-03-16 | 2003-04-22 | Aerogen, Inc. | Devices and methods for nebulizing fluids using flow directors |
US6623444B2 (en) | 2001-03-21 | 2003-09-23 | Advanced Medical Applications, Inc. | Ultrasonic catheter drug delivery method and device |
US6478754B1 (en) | 2001-04-23 | 2002-11-12 | Advanced Medical Applications, Inc. | Ultrasonic method and device for wound treatment |
US6568390B2 (en) | 2001-09-21 | 2003-05-27 | Chrysalis Technologies Incorporated | Dual capillary fluid vaporizing device |
US6640050B2 (en) | 2001-09-21 | 2003-10-28 | Chrysalis Technologies Incorporated | Fluid vaporizing device having controlled temperature profile heater/capillary tube |
US6804458B2 (en) | 2001-12-06 | 2004-10-12 | Chrysalis Technologies Incorporated | Aerosol generator having heater arranged to vaporize fluid in fluid passage between bonded layers of laminate |
US6681769B2 (en) | 2001-12-06 | 2004-01-27 | Crysalis Technologies Incorporated | Aerosol generator having a multiple path heater arrangement and method of use thereof |
US6701922B2 (en) | 2001-12-20 | 2004-03-09 | Chrysalis Technologies Incorporated | Mouthpiece entrainment airflow control for aerosol generators |
US7677467B2 (en) | 2002-01-07 | 2010-03-16 | Novartis Pharma Ag | Methods and devices for aerosolizing medicament |
EP1471960B1 (en) | 2002-01-07 | 2019-03-13 | Novartis AG | Devices for nebulizing fluids for inhalation |
AU2003203043A1 (en) | 2002-01-15 | 2003-07-30 | Aerogen, Inc. | Methods and systems for operating an aerosol generator |
ES2572770T3 (en) | 2002-05-20 | 2016-06-02 | Novartis Ag | Apparatus for providing spray for medical treatment and methods |
US20040039755A1 (en) * | 2002-06-05 | 2004-02-26 | Matthew Kunze | Metadata relationships |
JP4243499B2 (en) * | 2002-06-11 | 2009-03-25 | 富士通株式会社 | Bonded substrate manufacturing apparatus and bonded substrate manufacturing method |
US8545463B2 (en) | 2003-05-20 | 2013-10-01 | Optimyst Systems Inc. | Ophthalmic fluid reservoir assembly for use with an ophthalmic fluid delivery device |
EP1624938B1 (en) | 2003-05-20 | 2011-03-16 | James F. Collins | Ophthalmic drug delivery system |
US8616195B2 (en) | 2003-07-18 | 2013-12-31 | Novartis Ag | Nebuliser for the production of aerosolized medication |
US7367334B2 (en) | 2003-08-27 | 2008-05-06 | Philip Morris Usa Inc. | Fluid vaporizing device having controlled temperature profile heater/capillary tube |
DE102004006450B4 (en) | 2004-02-05 | 2012-09-27 | Ing. Erich Pfeiffer Gmbh | metering |
US7946291B2 (en) | 2004-04-20 | 2011-05-24 | Novartis Ag | Ventilation systems and methods employing aerosol generators |
WO2006127181A2 (en) | 2005-05-25 | 2006-11-30 | Aerogen, Inc. | Vibration systems and methods |
US7785277B2 (en) | 2005-06-23 | 2010-08-31 | Celleration, Inc. | Removable applicator nozzle for ultrasound wound therapy device |
US7713218B2 (en) | 2005-06-23 | 2010-05-11 | Celleration, Inc. | Removable applicator nozzle for ultrasound wound therapy device |
US20070012316A1 (en) * | 2005-07-14 | 2007-01-18 | Joann Truza | Disposable compact rescue inhaler |
US9101949B2 (en) | 2005-08-04 | 2015-08-11 | Eilaz Babaev | Ultrasonic atomization and/or seperation system |
US7896539B2 (en) | 2005-08-16 | 2011-03-01 | Bacoustics, Llc | Ultrasound apparatus and methods for mixing liquids and coating stents |
US7431704B2 (en) | 2006-06-07 | 2008-10-07 | Bacoustics, Llc | Apparatus and method for the treatment of tissue with ultrasound energy by direct contact |
US20080183200A1 (en) * | 2006-06-07 | 2008-07-31 | Bacoustics Llc | Method of selective and contained ultrasound debridement |
US8562547B2 (en) * | 2006-06-07 | 2013-10-22 | Eliaz Babaev | Method for debriding wounds |
US8156933B2 (en) | 2006-06-21 | 2012-04-17 | Puthalath Koroth Raghuprasad | Cloud nebulizer |
JP2010501287A (en) * | 2006-08-25 | 2010-01-21 | ババエヴ,エイラズ | Portable ultrasound device for wound treatment |
FR2908329B1 (en) | 2006-11-14 | 2011-01-07 | Telemaq | DEVICE AND METHOD FOR ULTRASOUND FLUID DELIVERY |
US8491521B2 (en) | 2007-01-04 | 2013-07-23 | Celleration, Inc. | Removable multi-channel applicator nozzle |
US7780095B2 (en) | 2007-07-13 | 2010-08-24 | Bacoustics, Llc | Ultrasound pumping apparatus |
US7753285B2 (en) | 2007-07-13 | 2010-07-13 | Bacoustics, Llc | Echoing ultrasound atomization and/or mixing system |
CN103118642B (en) | 2010-07-15 | 2015-09-09 | 艾诺维亚股份有限公司 | Drop formation device |
US10154923B2 (en) | 2010-07-15 | 2018-12-18 | Eyenovia, Inc. | Drop generating device |
WO2012009696A2 (en) | 2010-07-15 | 2012-01-19 | Corinthian Ophthalmic, Inc. | Ophthalmic drug delivery |
WO2012009702A1 (en) | 2010-07-15 | 2012-01-19 | Corinthian Ophthalmic, Inc. | Method and system for performing remote treatment and monitoring |
WO2013090468A1 (en) | 2011-12-12 | 2013-06-20 | Corinthian Ophthalmic, Inc. | High modulus polymeric ejector mechanism, ejector device, and methods of use |
EP3074089A4 (en) | 2013-11-26 | 2017-07-26 | Alliqua Biomedical, Inc. | Systems and methods for producing and delivering ultrasonic therapies for wound treatment and healing |
US10471222B2 (en) * | 2014-07-01 | 2019-11-12 | Dance Biopharm Inc. | Aerosolization system with flow restrictor and feedback device |
US11273271B2 (en) | 2014-07-01 | 2022-03-15 | Aerami Therapeutics, Inc. | Aerosolization system with flow restrictor and feedback device |
CN107735135B (en) | 2015-04-02 | 2020-06-26 | 希尔-罗姆服务私人有限公司 | Manifold for a respiratory device |
WO2018146738A1 (en) * | 2017-02-08 | 2018-08-16 | 日本たばこ産業株式会社 | Cartridge and inhaler |
EP3634550A4 (en) | 2017-06-10 | 2021-03-03 | Eyenovia, Inc. | Methods and devices for handling a fluid and delivering the fluid to the eye |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE531640A (en) * | ||||
DE1103522B (en) * | 1957-10-24 | 1961-03-30 | Transform Roentgen Matern Veb | Exhalation device for aerosols generated by means of ultrasound |
US3989042A (en) * | 1974-06-06 | 1976-11-02 | Tdk Electronics Company, Limited | Oscillator-exciting system for ultrasonic liquid nebulizer |
DE2445791C2 (en) * | 1974-09-25 | 1984-04-19 | Siemens AG, 1000 Berlin und 8000 München | Ultrasonic liquid atomizer |
US4094317A (en) * | 1976-06-11 | 1978-06-13 | Wasnich Richard D | Nebulization system |
US4113809A (en) * | 1977-04-04 | 1978-09-12 | Champion Spark Plug Company | Hand held ultrasonic nebulizer |
US4109863A (en) * | 1977-08-17 | 1978-08-29 | The United States Of America As Represented By The United States Department Of Energy | Apparatus for ultrasonic nebulization |
DE2854841C2 (en) * | 1978-12-19 | 1981-03-26 | Bosch-Siemens Hausgeräte GmbH, 7000 Stuttgart | Liquid atomizer, preferably inhalation device |
DE3339180C2 (en) * | 1983-10-28 | 1993-10-14 | Pfeiffer Erich Gmbh & Co Kg | Discharge device for media |
DE3627222A1 (en) * | 1986-08-11 | 1988-02-18 | Siemens Ag | ULTRASONIC POCKET SPRAYER |
US4976259A (en) * | 1986-12-22 | 1990-12-11 | Mountain Medical Equipment, Inc. | Ultrasonic nebulizer |
-
1988
- 1988-12-13 EP EP88120823A patent/EP0373237A1/en not_active Withdrawn
-
1989
- 1989-12-07 DK DK617989A patent/DK617989A/en unknown
- 1989-12-11 US US07/449,705 patent/US5134993A/en not_active Expired - Fee Related
- 1989-12-11 CA CA002005151A patent/CA2005151A1/en not_active Abandoned
- 1989-12-12 JP JP1322441A patent/JPH02243166A/en active Pending
Also Published As
Publication number | Publication date |
---|---|
JPH02243166A (en) | 1990-09-27 |
EP0373237A1 (en) | 1990-06-20 |
DK617989A (en) | 1990-06-14 |
DK617989D0 (en) | 1989-12-07 |
US5134993A (en) | 1992-08-04 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US5134993A (en) | Inhalator device, in particular a pocket inhalator | |
US4877989A (en) | Ultrasonic pocket atomizer | |
US4294407A (en) | Atomizer for fluids, preferably an inhalation device | |
US4793339A (en) | Ultrasonic atomizer and storage bottle and nozzle therefor | |
US7025057B2 (en) | Medicament delivery and packaging | |
US4334531A (en) | Inhalator | |
US3001524A (en) | Aerosol dispensing apparatus | |
US5487378A (en) | Inhaler | |
RU2270701C2 (en) | Dozer (versions) | |
CA2497680C (en) | Apparatus for the dispensing of liquids, container cartridge suitable for this, and system comprising the apparatus for the dispensing of liquids and the container cartridge | |
EP1471960B1 (en) | Devices for nebulizing fluids for inhalation | |
US20130319404A1 (en) | Liquid Droplet Spray Device | |
US20040094146A1 (en) | Apparatus for the dispensing of liquids, container cartridge suitable for this, and system comprising the apparatus for the dispensing of liquids and the container cartridge | |
JPH09508845A (en) | Dose metering inhaler | |
EP1471961A1 (en) | Methods and devices for nebulizing fluids | |
ES2119417T3 (en) | AUTONOMOUS COUNTER FOR DISPENSER INHALER. | |
JP3709790B2 (en) | Liquid spray device | |
EP0782867B1 (en) | Powdery medicine dosing device | |
JP2002510225A (en) | Nasal applicator and dispenser device using the same | |
EP0862921B1 (en) | Improved inhalation apparatus | |
FI72879B (en) | DISPENSERINGSANORDNING FOER EN MEDICINAEROSOL. | |
US20220203053A1 (en) | Warning system, inhaler, and method for generating warning | |
JPH0510146B2 (en) | ||
JPH0510147B2 (en) | ||
SU1697837A1 (en) | Inhaler |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FZDE | Discontinued |