CA1249190A - Method and apparatus for pulmonary and cardiovascular conditioning of racehorse and competition animals - Google Patents

Method and apparatus for pulmonary and cardiovascular conditioning of racehorse and competition animals

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Publication number
CA1249190A
CA1249190A CA000492384A CA492384A CA1249190A CA 1249190 A CA1249190 A CA 1249190A CA 000492384 A CA000492384 A CA 000492384A CA 492384 A CA492384 A CA 492384A CA 1249190 A CA1249190 A CA 1249190A
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CA
Canada
Prior art keywords
dew point
point temperature
air stream
humidified air
stream
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA000492384A
Other languages
French (fr)
Inventor
Richard H. Blackmer
Jonathan W. Hedman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
OXYGEN ENRICHMENT COMPANY Ltd
Original Assignee
OXYGEN ENRICHMENT COMPANY Ltd
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Publication date
Application filed by OXYGEN ENRICHMENT COMPANY Ltd filed Critical OXYGEN ENRICHMENT COMPANY Ltd
Priority to CA000571940A priority Critical patent/CA1261215A/en
Application granted granted Critical
Publication of CA1249190A publication Critical patent/CA1249190A/en
Expired legal-status Critical Current

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
    • A61M16/10Preparation of respiratory gases or vapours
    • A61M16/1075Preparation of respiratory gases or vapours by influencing the temperature
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61DVETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
    • A61D7/00Devices or methods for introducing solid, liquid, or gaseous remedies or other materials into or onto the bodies of animals
    • A61D7/04Devices for anaesthetising animals by gases or vapours; Inhaling devices
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
    • A61M16/10Preparation of respiratory gases or vapours
    • A61M16/1075Preparation of respiratory gases or vapours by influencing the temperature
    • A61M16/1085Preparation of respiratory gases or vapours by influencing the temperature after being humidified or mixed with a beneficial agent
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
    • A61M16/10Preparation of respiratory gases or vapours
    • A61M16/1075Preparation of respiratory gases or vapours by influencing the temperature
    • A61M16/1095Preparation of respiratory gases or vapours by influencing the temperature in the connecting tubes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
    • A61M16/10Preparation of respiratory gases or vapours
    • A61M16/105Filters
    • A61M16/106Filters in a path
    • A61M16/107Filters in a path in the inspiratory path
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00General characteristics of the apparatus
    • A61M2205/33Controlling, regulating or measuring
    • A61M2205/3368Temperature

Abstract

ABSTRACT OF THE DISCLOSURE

METHOD AND APPARATUS FOR PULMONARY AND CARDIOVASCULAR
CONDITIONING OF RACEHORSES AND COMPETITION ANIMALS

A high humidity method and an apparatus are described which are useful for conditioning a pulmonary and/or a cardiovascular system in B large animal. The method broadly comprises deliver-ing a humidified air stream at a dew point temperature greater than the environomental ambient dew point temperature to an animal's respiratory tract.

Description

';EP 2~ '~5 1~ F~'ICOH COF~POMTION P.4 -METHO~ A~D A.PPAR~TUS FOR PULMONAELS! AND CA~r)IOVASCULA~
~O~D~TIO~ OF RA~EHOR~ES ANI~ COMPETITION ANI~A~S

~ACK~ROU~ F TH~ I~VENTION

l. ~ield of the In~ention A hi~h-hum$dlty m~l:hof~ 8nd ~n ~pparata~ are d~sc~ib~d which ~re u~eful for condlt~ onln~ ~ pululona~y ~nd/o~ 8 ~rdiova~c.ular , 8y~e~ in ~ large anlmal ~ l'h8 ~thod broadly ~oPlpr~ ~e9 deliv~r-ln~g ~ humidi~ied ~ir ~re~m at a dew point 'cemper~ture ~r~ater than the en~.rironm~ntal amblerlt dew polnt temp~r~ture ~o a~n anl=el~~ r~pi~ator~ tract.

DECRIPTION OF THE PRIOR A~ :
2. D~cript~on Di~ ~h~ Prior Art The tr~atment o~ the re~pirAeory tr~ct of l~rge snl~al~ th hea~ad~ humldl~l~d air la vl~ually unrepor~et in both patent and technleal ~ourna1 lit2r~tu~e. L~ge Ani~ B a term commonly u~ed ln the ~r~ to re~r ~o ~he ~ollowing anlm~l~t equlne, lncl~ldlng HcandArdbred and thorough~red ho3;~P~, ~ovin~ a~d oYirle ~pecl8~ .
Resp~ tory therRp~r inYolv~ng conti~ionin o~ the pulD~on~ry and/or cardlova~cular ~y~tcm~ o~ l~r:ge ~ni~als romprisln~

P
9~

.. , : , :;, . . .
,, :
, "' ' , SEP 26 ' S5 13 ~ I COH C OI~F~u~HT I Ol l P . 5 dellvering ~ s~ura~ed v~porJ~a~ Dtr~m at ~ d~w poi3 t~mper~ur~ ~re~ter ~hnn th~ ~n~lron~en~Al a~bl~.nt d~ poirlt t~mp~ratu~ ha~ not b~on found ln ~ detailed ~earch o~ th~
technical litara~:u~e by the lnv~n~ar~ .
Inh~lation ~herapy in-Jolving inh~latlon by larga snl~ of wa~r-v~po~at~r~ted alr at dew p~lnt t~mperst~rc~ a~ove t to above 1101 F while ad~lnl~t~r~n$ 300 to 4UO li~er~
pa~ minut~ o~ ~uch alr ~o Y~and~rdb~ed an~ ~ho~oughbr~d I~ac~-ho~e~ al~a ha~ no be~n ~ount in a detalied ~a~ch o~ the tech~lcal literatur~ by th~ lnve~or~.
In general~ pri~r pBtent ~nd technlc~l art refer to the ~d~lnlatr~lon of ~ne~icin~ n~eh~ia, druR~, ~M.A.D.), etc., ~o ~mall anlmals ~uch a~ cat~ ~ dog~ ~ chickens and th~ I ike ~or tb~ pu~po~a of enhanclng v~cinatlo~3 etc- W~t~r v~por ~cpo~tedly 1~ been ~ra~s~err~d in~:o the r~plratory ~y~t~m of ~m~ll animal~ a~ temp~r~ture~ eq~al ~o or lower thsn ~ha ~o~mal bod~ t~mpera~ur~ o the anlmals. T~erapy e~e~tm~nt ~i.e., oth~r th~n replace~ t o~ hyp~3~ed naturfll hu~idlfica~ion i~
~ne~the~ia or ct~ procsdll~eH involrin~ ~rseheal intub~ion~ ~f ~he r~3piratory ~ra~ o~ animal~ at dew polnt ~emp~raturPs neaI~
cr ~bov~ normal core body ~emp~s~ur~s is, to th~ b~t of th~
lnv~nt4r~ kno~l~d~e ~ unreported o~ un~ug~qsted 1~ the ~rlo~ art rsture bol:h te~hn~sl and pat~nt wiae ln US ~nd foreign publ~ c~tlon~ .

P~e 2 ~,EP c~ '85 1~ ICOH I~O~POF~HTION P.6 9~ ~0 Is~corpor~t~d h~reln in their ent~ ~ety by ~e~r~nce ar~ the followln~ pllblicatlons which de~eribe exe~cise induo~d pulmona~
he~orrh~ge (~IPH):
Am~r~c~n Journ~l o~ ~,7etsrina~, Volu~ 43, ~ qb~ 7, P~geB 11~3-1127, JU1Y 189~ ent~ d "FXerC1~e IndUCed PU1DI4~rY H~lDOrrhag~ ~ ThOrO~ghbl~ed~ A~ter R~O1ng at~d :~e~71ngn~ COr1n~3 F- ~Pha1~ ~VM ~nd l~aW~en~e RO SOInA~ VM~-~ 9 ~L~9 V~lum~ 7b" Nu~bor ~, July l~B4e~titled ~cerclse-ïndtlo~d Pulmon~ry ~orrh ga ln Ex8rci~in~
Thoroughbred~ s Preliminary Re~llt~ with ~re-Exercl~e M~diCstiOII" by Corinne ~lph~l Sween~y, l~rqnCe R. S~\ma~ Cynthia A. ~uca~ a~d Sucan G. R~Y f rom the D~par~men~ ~f Clinical Studles, New Boltoll ~en~er, S~hool o~ Y~terinary Medicln~, Universlty o~ Penn~yl~2ni~ K~nnet~ Sq~larf~, PA 193 SUM~IA~Y OF TH~ I~V~N'rION

A high humldity ~ethod and an ~ppar~tu~ ar~ d~crl~ed which a~e u~oful ~or ~ondltloni~lg a pul~o~,ry and/or ~ caraloYa~ lar a~r~tem ln ~ lar~ ani3lal. The ~ethod bro~y ~ompris~ deliv~-lng El hu~dlfied ~lr stream at a dew point temp~r~tura gr~ater th~n the envlronmental a~ ent t~w polnt te~p~rature ~o a~
~nimal~ re~plr~tory tract.

p~ge 3 ,...

.:; :

5EP Z6 '~5 l',:C~5 FICCIH ~~ poFl~TIcl~ P.7 A hlgh-humidit~r th~r~py ~nd app~e~ r~ de~crl~ed which ~re u~e~ or clearin~ pul~onary ~ecr~tion~ and hydratlng tlh~
pulmonsry tr~ct and for incre~lng periph~ral blood ~ircula~lon b~ore exercl~e o large competi~on Rnim~16 .
The ~nv~ntlon lg part~cul~rly u~Xu} fRr ~h~ pre~entlon a~d tre~ment o~ exercise-lnduced pul~on~ry h~orrhag~ In ra~ehor3e~ . ~ore ~p~cif i~qlly~ the in~r~ntion rel~te~ to ~pp~at~3 ~nd ~thods wherein th~ humitity level in the re~pir~to~y trPcts o~ lArge an~ lnc~e gc~ by mu~zl~ m~k ~dmi~ rstlon o~ ~ter-vapor ~u~a~ed ~ o produc~ ln~plred dew polnt te~perature~ ~bove a~blent up to about 110' F.
Wherein the re~piratory trsct~ of anl~al~ ~e pre~ondi~ioned nnd/or trented wl~h ~rApor-ph~ee ~a~r, ti~ua damag~ voidet o~ reducet ln one or mor~ of the ~ollowlng sre~: th~ bron~hl bronchlolell, sveolar duc~s,l~3c~, srt~rla~ and ve~ou8 c~plll~rleo, and othe~ ar~a~ of the r~p~ratoxy ~y~t~- The ~he~npy treat~nt de~crl~ed h~ein retluc~ evapo~tiv~ cooll~g in ~h~ resplrntory ~y~tem and thereby promote~ ~o~pen~atoxy pe~lpher~l ~104d cir~ulat~on wl~h a minl~um consumpt~ on of ~nergy re~orv~ .
Th~ p~thophy~iolo~y o~ e~ercl~e-lnduced p~lmon~ry h~morrha~ 1B b~ v~d ~o l~volve ~upture and tR~rin~ of alveolnr blood capillarie~ cau~d by n~gntlv~ ~ir pres~ur~ and png e 4 , . . .

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.. ,. ' - ~ :'"' ' =; 9-26-85, 1:07 PM; é~Ae'rul51~ 841 2692 ~ 416595116; # 8 SEP 26 '85 13:05 ~'ICOH CO~F'OR~TION P.8 ~L2~

by ov~r-~xp~n~ion o unobat~ucted alveoli during ~aximu~
inl~Rir~tOry Rf ~o~ Th~ pre~en~ inv~ntion i~ a m~thod to minl~ize neg~ t.n~pir~o~y p~e9sure ~nd ob~ruction o~
bronchlal co~nactiu~ to the ~lveoli by promoting th~ n~tural muco~ ry s~retio~ and ~ icula~e-~lear~nce ~e~ion of the bronehlal 8y8t~ by the preYention o~ A~U~y wat~r lo~ and hy the hydr~tion o~ ~1rway ~ur~c~ ~h~o~h She ~dmlnl~trat~4n ~o the uppar respi~atsry ~r~c~ o~ l~r~ animels of ~ ~b~tantially g~rlle, ~erosol-~r~e, water-vapor-~atur~ted alrat~e~m. Thl~
method o~ improving pul~onAry hy~ien~ help~ condltl~ t~ nim~l to achlev~ ito maxlmu~ o~ygenation effi~iqncy th~ou~h reduc~ion o~ airw~y ob~tructlon~ ~nt hydra~lon of alrwa~ m~mbrane~ a~d mu~ou~. Th~ method also eliminat~ e~aporati~ cool~n~ ~rom th~
r~ p$ra~ory ~y~te~ ~nd, typlcally, w~ cres~e ~t~olic hest ~e~nction fro~ other body ~ur~ces by ~bou~ lO pern~t~ a~d cona~quqntly~ i~duces i~cre~ed per~p~eral blood clrcul~tlan.
Thu3, the ~hod o~ thi~ i~v~ntl~ not only eondition~ th~
pulmonary ~ys~em bu~ al~o ~erve~ a~ ~ pr~-exerc~e w~r~up ~ethod to redu~e exerci~e warmup and th~reby bave energy re6erv~ ~or t~e rsoe.
Thq v~t~rln~ry r~plr~tory ~herap~ ~par~us of the preH~n~
inv~tion l~ p~rtlcularly ~d~p~d f~r applic~tlon of v~por-phas~
w~.er ln tre~ ng the upper re~piretory tr~ct o~ large ~nim~l~
wlth ~ ~b0XAntially, ~terll~, Aerosol:-f~ee, w~ter-v~por-s~tur~ted ~Ir~tream havln~ ~ ~ubstAnti~lly unlo~m P~ee 5 , ,, :. ; .
,.; ; . ~:
, .- , , :~ .. .

-6- ~ ~ ~9 ~ ~ ~
dew point/dry bulb temperature above ambient temperature and to above 110F and at flow rates between 60 (~r lower) and 500 (or higher~ liters per minute, sufficient to match the normal peak inhalation flow rate of a typical racehorse.
According to an aspect of the inve.ntion, a high humidity method useful ~or conditioning a pulmonary and/or a cardiovascular system in a large veterinary animal comprises:
(i) providing a stream o~ gas;
(ii~ heating water in a container means;
(iii) providing a porous membrane means disposed within said container means, said container means adapted to permit liquid droplets to contact said porous membrane surface to permit a vapor to defuse therethrough;
(iv) mixing said vapor with said stream of gas to humidify said stream of gas;
(v) delivering said humidified stream of gas at a rate from greater khan about 60 to about 500 liters per minute to the animal's respiratory tract at a dew point temperature greater than the environmental ambient dew point temperature, said humidified air stream dew point temperature is within the range of 99F to about 110F.
The apparatus of this invention comprises a portable electric-powered air blower, means for humidifying the air stream, a flexible heated delivery tube, means for conducting the humidified air without excessive condensation to a muzzle mask and means for administering the humidified air to the nasal passages of a large animal such that the dew point temperature of : the inspired air can be controlled from above am~ient to about 110F. The unified apparatus comprises elements that are relatively inexpensive, portable, and can be operated or maintained by individuals not having a high degree of technical expertise or horse-handling skill for pulmonary and cardiova~cular conditioning o~
racehorses and other large animals.

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6a-According to another aspect of the invention, a composition is provided which is useful for conditioning a pulmonary and/or a cardiovascular system in a large animal. The composition comprises humidified air at a dew point temperature greater than the environmental ambient dew temperature.
BRIEF DESCRIPTION OF THE DRAWINGS
Preferred embodiments of the invention are shown in the drawings wherein:
10Fig. 1 i~ a schematic diagram of a presently preferred embodiment of the invention.
Fig. 2 is a schematic diagram of the electrical control circuit ~or the embodiment depicted in Figure 1.

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XEROX TELt:COPIER 2Y~ b--~b; 1 ~ i'M; e .~e ~r~ 41 . b''~ ~ 41b-)Y~ I Ib, ~; IU
SEP 26 'b5 13 Elb I~ICOH COF~F'OI~'hTION P. 10 Pi5s. ~ iB a front obll~ue pQr~pectlv~ v~w of th~ portabla elec~ie powerQd hum~ ier unlt of th~ pr~ nt invention.
Fl~ . 4 i~ ~ rea~r obl~q~e p~pectl~e v~ ew o the porl:a~le eleotrlc power~d humidi~ia~ unit of the pre~ent invetlt:iorl.
Flg. 5 l~ ~ cu~-aw~y ~nt~rnal ~ect~o~al pe~rtiRl vlau of eh~
h~mldlfier unl~ of the the~py ~pp r~u~ of ~ch~ prese~t iuvent on .
Fl~;. 6 is a ~r~gmentary pes~pect~ve ~r~w o~ a ~u~ mask for the ~t~nls~ra~ion of a hi~h~h~idity ~ r atre~m to An ~quln~ .

DESCRIPTIO~ OF T~l~ P~F~RRED ~ ODIMENTg Figure 1 10 a mechanlcal sohe~at~c di~g:~m ~ one of the p~e~ly pref erred appara~u~e~ of ~hii~ i~ven~ion~ A~blent air , 34 erlter~ the cabln~t 1 ~t etmosph~ pre~urq, enters throt gh ~ filter 35 and p~ o through to ga~ blowar 37 vla alr intake llne 3~. The alr p~a~in~ ~ro~ the blo~r 37, erl~er~
h~mIdl~ic~t~o~ pot ln~ke llne 41 und~r po~iti~t~ a~r p~e~ r~.
Ths voitlme of alr pa~sing lnto the hu~l~iic~t$on pot 43 i~
m~sur~d by ga~ 10w m~ter 6, and i~ ~ot ~rolled by ~ir ~low val~le 7. This air impin~,e~ upo~ ~he liquid water 36 corlt~ined withtn humldlflca~ion pot 43 whlch ha~ bs~n ~rmed by he~ter P~ge 7 ., .

' ." `' ~ ~' ; ~

5EP: 1: 5 ~ D~TIOIi F. 11 ~ .

g~

6y~t~m 45 to the deslr~d operative ~emperAt~re which i~ in exc~ of the deslr~d output dewpoint and prei~er~bly ln exc~
of th~ te~npera~urB requlred ~or pa8~eurlz~tion, e.~" 140~ to 180~ F~ The wat~r level in ~he humidi~lc~ion pot i~ ~lntain~d ~t ~ constant lev01 by llquid w~;er ~roDI re6ervoi~ 31 which 10 ~or~nec~ed to por~t 20. Tube ~9 ~ro~D ~e~e~vlr 31 tertDinat~ ~t ~h~ stlrface o~ wat~r 36~ Water 1~ d~per~ ed only when tha lev~l ln hu~ldificstion p~t 43 ~ u~iciently ~o ~dml~ air ~rom the po1; throu~h tube 29 to re~ervolr ~1. To prevant ~reesln~ o~
w~t~r ln re~ervoir 31 during su~free~lng a~ t~, wa~te he~t fso~ he~ter 0y~em 45 i~ d~r~cted pa~ ~eser~ol~ 31. To en~ur~
th~t ~ter di~p~n~ed fr~m re~e~roir ~1 iY ralsed ~nd maint~in~d a~ p~uteur~z t~on ten~perature I'or aufiel~nt time to kl~l ally orgas~ thet ~ight 1~ pre~ent, s~Lit disp~n~ed w~:ter dl~ected in a labyrinth p~th d~f~ by dow~pipe 30 ~nd cup 32.
DOWDP1~ 30 COllt~h8 vents 33 loc~ed wi~hln hu~ldlfi~at io~ pot 43 ~o ~ no~ to in~erf~r with the lower Qnd o~ ~u~e ~9 ~n def ~ ning w~ter l~v~l . Th~ volume of ~aid l~byrinth path 18 ~u~lclene ~o provide re~ld~nce ti~fl of wa~er ln the p~h whlch 1~ gre~ter ths.n required p~teuriz~ion time.
Te~p~a~r~ ~ ths w~e~ 36 ln h~mldl~ic~tlon pot 43 io ~aintained at a te~p~r~ture whi~h 1~ el~ ed ~bo~ the d~sired output ~7 polx~t b~1 h~ater 45 which adml~l~ter~ h~at to th~
hu~idiflc~tion pot ln re~pon~e to cont:rol o~gnal~ from water p~e B

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:' . ' ~;EP Z6 'S5 13:E18 RICOH CO~F'OI~RTI~N P. lZ
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~4~

te~c~a~ure ~en~o~ ~4. I~ ~h~ N mo~e, eh~ ~ t~mper~t~u~ ~An ~e ~d~u6te~ vi~ v~iable re~is~or 127. Sh~uld ~ mperatur~
exee~d a predetex~Ined upper llmit~ ~h~rn~l ~w~tch 81 openo ~h~reby ~urnin~ o~ po~ar to he~tsr 4S, ~ 62 and l~lowez 37 The further functlon of ~id æ~it~h w1ll ~o~e cle~r upon descrlptlon o Figure 2.
Humidif ie~ byp~ v~lve 8 ~ rlor~4~lly m~lnt~i~ed ~n clo~d pos~t~n, con~rol~ fl~w thro~gh ~ ~hunt pa~h ll which ~yp~e~ the hu~ dific~elon pot 43. Wh~n cher~py l~ b~lng adD~inl#t~r~d, ~hi~ valv~ i~ clo~ed~
Heater 4S iTnpArt~ su~fi~l~nt en~gy t~ th~ w~ter 36 ~n humidific~tion pot 43 to htlmidly the ~lr allt~rlng th~ pot vla condu~t 41. I'he veloelty and d~r~ios~ oE thi ~nt~rin~ ~lr such tha~ laxge w~t~r droplet~ ~nay for~ Sai~ ~rop1~t~ ~rs eoa1e~ced ~y the po~ou~ mer~r~ne 47 loca~d ae the hum$d1f~cation p~t exit port 4g BO th~t the humidlfl~d ll1r exl~l~g th~ h~ tlon pot 43 vi~ co~dult 6~ ig ~r~e of ~Rrosol wator p~ticlea ~hat are k~own ~ r~ ts and potentl~l c~rrier~ ~f ~acteria or otheL und~ir~ble spe~ . The h~nidi~iad alr streA~ contucted by eonduit ~9 exlt~ the cabin~t vla ~ flttln~ wh~ch connect~ to a h~e~d deliv~ry tub~ {~DT) 51 whlch ~ncorpora~:es a h~tlng element 57 for malr~ta1ni~8 the t~lap~rature of the H~ and a temp~ra~ure me~sBurin$~n8~n~
~le~n~ 53 for monitorin~ tha ~ pe`ra~ure o~ the Y~p~r~gaa p~ge 9 , , ' ''' ~ ' ~

SEP 26 '65 13:~1S F~ICClH ~uRFuF~HTIOI~I P.13 ~9~

~tream ~e ~he e~lt ulu~zl~-mfL~k end ca~ t~e HDT~ O~l~pUt h~ater contro:L 55 repre~ent~ coll~tively va~lou~ vaporJg~ dellvQry cont~ol ~yotems incl.udlng varlable volt~e tr~n8~0rme~ ~DT
pow~r tran~orm~r, f ixed re~l~tor~, elect~o~c ligh~ ow$tch an~
powcr llght ele~nent~ (~11 not ~l~.own in~l~tid~l~lly) th~t iht~ Ct wi~h he~ting ele~nt 57. An overt~mper~tu~ ~w~teh 53 whlch intcrupt~ powe~ to th~ he~ted dellvery tL~be 51 in the ev6nt of ~xc~sl~a ~emp~r~ure~ ls lo~ed at ~h~ ~uz~le~ sk end of th~
H~'r .
R~gula'cion of the da~point o~ th~ high~humldl~y output 1 ~ccompll~h~d by cont~ollin~ the temp~r~ture of w~t~r ~6 by ~ean~
of ad~ust~nt 1~7 ~nd ~he ou~p11t ~low ra~ by ~ir ~lou coll~ral ~ralve 7 . rh~ dry b~1~ tempera~ura of ~hb hl~h-hl~ldity output i~ controlled ~y outpu~ hea~er control 5~ . A tranBp~rCnt !i~ctSon 5~ ne~r th2 end of the Hl)T allowa on~ to Qbser~7e ~h~:her or ~not: corl~en~at~on i~ oocurin~ with$n ~he ~DT. Tamperature~
~n~ flow r~e~ are ~d~u~ed ~o thAt ~ ~rac~ of conden3atlon la ob~erv~d ~ust ~hort of entry into muæzle ~k Sl in order to e~re thst ~he erltlre ~rolume o~ pl~ed alr 1~ 100 perc~nt tur~ted, ~ondensa~i o~ wlthin the ro.uz~a ~&~k 61 ~nd ~e.~r~tlotl~ fros~ the anlmal dr~ erOm the ~ v~ port 63. Th~
ma~k m~y optionally include a ba~fl~ 12 to preve.nt dlra~t l~plngement of hi~h velocity air on the anim~1 snd a t~lnper~ture ~n~or/~r~dic~tor 65 to continuously monito~ the te~peratura wlthln the mu~zl~ ma~k 61 turlng the administr~tlon o~ therapy.

Pnge lo :
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SEP 26 '~5 13: ~9 F'ICOH CO~PûPHTIûN P. 14 Th~ ~lo~ rate deliv~red to th3 ~ni~al 18 ad~uated by v~lv~ 7 to ~e ~ub~t~ntia:Lly equal ~o or ~r~er th~n th~ ~nin~ or~l ~e~tin~ average p~sk inhalat~on ra~e . Por hor~ tht0 v~lue 1 in the r~ng~ o~ 300 to 400 llter~ par minut~ .
Bypac~ valv~ 8 ~f~ord~ ~ me~hod o~ dry~ng the ~D~r~ Durl norT~l op~ratlon, ehiQ val~e 1~ in ~ ~loaed po~l~io~. By openinl3 byp~ valvs 8, ~ao~ of the outpu~ ~low f~om blower 37 wlll be ~h~nted ~rqund the humidi~ica~.on po~ 43 vl~ ~ondui~ 11 and wlll con~aln a~bi~n~ olute hun~id~ Th~ ~ddi~lonal wate~ ca~ying capec~ ty o~ thl~ ~lr lg u~d ~o dry the hea~ed dellvery ~:ube. During ~u~h procedure~ ~ the T~u~zl~ ~sak i~ not connected to an ~nlm~l .
-- 'rhe appar~tu~ ~8 dls$~cted b~for~ u~e ~r~d be~w~n anim~l~
by introducin~ old (ambient temp~t~r~) d~ qlnfect~n~
~olutlon 13 v~n ~yrlnge 14 lnto ti~in~ nt p~t 15 while oper~t~nES. ~alt ~olut~orl disinf~cts the ~nterior ~rf~ce~ ~f e~it ~ondult 4~, exlt po3~ a~d h~t~d delivery tube 51 ~ lt ~l~shes ~hro~gh them. ~he tu~ing 1~ th~n dried by opaI~ ng byp~ v~lve ~ while continuin,~ to oper~tR ~t norm~l flow rstes . ~luz~le ma~k ~1 may ~ dlsltl~c~d by wa~hin~ d~rectly with d~nfec~nt 13 ~nd all~wl~ to drl3~ dry. ~ check valv~ 17 ln t~ dl~ln~eet~nt ~onduit 18 pre~nt~ lo~ of huDIldl~lqd air flow through di~infectant por~ 15 durlng norr~l opera~lo~
uit drein outlet port 11 and dr~in Y~llVel :L9 a~e incorporhted ~o psovlde a mea~s o~ rem~vlng w~t~ 36 fro~ ~hQ

~nge 11 .:
' . '" ~, SEP 26 '~5 ~ 9 F'ICOH CO~FO~hTION P. 15 . , .

~pparA~us prior ~o ~x~nd~d 6hutd~wrl. To dx~in w~e~ 36, re~ervoir 31 i~ re~o~r~d And por~ 20 plugg~d y dr~ lve l9 i~
opened~ ~nd ~pp~r~tu~ 1~ 8wltch~d on i~ the ~un ~ode~ Uater 36 1~ for~ed throu~h drsin condui~ 21 ~y the ~e~ultl~g po~t~v~
pre~3ure ln hum~dl~lc~ti4~ pot 4~. Addit~v~1 prb~ e ~ay obtalned by tempor~rily p~uggin~ I~e~ed d~ ry tu~e 51~
~onduit ~ r~inate~ ~t A low poi~t in h~idl~ic~t~ o~ pot 43 ~o draiIl a~ much w~ter AE~ po~ible.
Fan ~ draws ~tnblent in~o the c~ine~ 1 to ~rovlde ~e~t ~ir Por Pllter 35 a~d tQ provlde cooling fur blow~r 62 .
Fi~ure 2 i~ ~ prePerr~d c~bodi~n~ of the ~leotri~l By~tem of thc in~e~ti~n. It include~ a two ~r three wir~ powe~ ~upply cord (No~ Shaw~)~ circult bre~ker 86, 3-po~ition power ~wit~h 5~, relay~ 77 a~d 79, f4n 62, ~lower 37, di~lt~l te~p~ture ~ugo 23, ~lsp~d ~lme i~dica~a~ 58, v~ri~ Yol~ e transfor~er 60, h~t~d dellvery tube tr~n~or~er 7S whic~
re~u~at~ pow~r to h~a~in~ ele~ents (~S), ~ h~atad dellvery tub~
fu~ , heaeed tellve~y tube power light 44, Pixed rasi8tor~ 71 ~nd 73~ water heater te~p~r~ture co~trol p~inted ~ir~ule ~o~r~
~P~B~ 125~ wat~r he~ter power co~erol trlBc ~ap w~ter temps~a~r~ ~en~or B~, overte=pera~ur~ ~naor 81, ~tar h~ter pow~r lndicator ligh~ 42, and water h~at~r 45.
El~ctrl~al ~ow~ ent~ he appar~tu~ throll~h ~ircuit bre~kes 86. A 3-po~itlon powar awltch 52 1~ ua~d to set ths P~ge 1~

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~;EP ~6 'E15 1~:10 F~ICUH CORPUI~HTIUl`1 P. 16 ~;~4~L9~1 devlce to CFF~ ~TAN~BY or RUN. In th~ OFF po~tlon, the devi~e i~ not energi&~d. In STA~DBY p~itlon, di~ieal ~empara~re gauge ~3, el~ps~d l:tme indlca~or ~, and ~oll o relay Kl 77 ar~
~irecely ~nerg~ed. ~he cont~cts o~ rel~y ~1 77 clo~ to ~upply volt~gR to prin~ed clrcuit ~2S whleh con~rolg th~ ~ster h~t~r 45 ln respon~e to a con~rol sign~l ~rom ~at~r temper~t~r~ ~en~o~
~4. ~arl~ble re~i~tor 126 1~ u6ed ~o adi~et the wa~er temperatur~ etpoi~t. The water temp~r~ ure it~lf iu re~ om a ~ign~l derlved f rom a te~perature aen or connect~d to dlgit~l temp~ratur8 g~u~a 23. Wster hea~qr l~ht 42 indicates whdn~ver pow~r i~ appll~d to w~te~ heat~r 45 through ~at~r he~ter power co~t~ol triac ~8. ~vertemperatu~e sw1tch 84 i~ ~or~lly clo~ed~
I~ wAe~ ~emper~ture ex~e~d~ ~fe }imit~, ie ope~ ~nd i~terrupts all pow~r, In ~UN posltion, dIg~ ~al tempera~ura ~uge 233 ~lap~d time meter 55 ~nd coll o~ r~lay Kl 77 are ~n~rgl zd ~ e ~a i~ the STAN~BY posltlon. ~owever~ varial~l~ re~i~tor 127 ~ uied to ad~u~t water te~p~ra~ure. ~oreo~er, power 1~ ~upplled to tho coil o~ relay K2 7g C8U~i~g lt8 con~ to ~lo~e. Th~
qupplie~ p~er to fRn 62, blower 37 atld variable vol a$~
t~s~ormer 60 whieh suppli~ power to th~ h~ated ~ell~ry tube (NS) through hea~ed d~llverD tube 57 trans~or~er 75. A ~u~0 prote~t8 ~h~ o~tp~t of thi~ clrcuit again~t o~rcurrent R~81~tors 71 and 73 fo~m a divld~r network ~nd act ln P~ge 13 4 ~ .

, ' ', ' SEP Z6 '1~5 l3'~ ICOH C~ 'FOF~HTION P. 17 i~Z~

con ~ tlo~ h t~l~c ~ to turn he~ed deliv~ry ~ube pow~r llght 42 o~ ~henever pow~r bayond ~ ~hreshhold v~lue 1~ spplled to the he~t~a dellv~ry ~ube .
The tharapy appar~ttl~ of the pr~en~ inv~ lor~ hown by s~bllque pers~ective view~ in Figure~ 3 ~rld 4. Th~ c~vlne~
lncludss le~t side pan~l ~, r~ Z~ht ~ide p~nel 3, an~ ~op p~n~l 4, ~r~n~ eontrol pallel 5, s~d r~a~ p~r~el 28. ~io~t of ~he ~ontrols, monitor~ ant swltche~ are locat~d on ~he front control p~
The~e include: a~ r flow valve 7, g~ flow ~ r 6, heated d~liv~ry tube power Pu~e ~, heated delivery tu~e pow~r ll~h~ 10, dl~ al temp~rattlre gauge 239 heated d~llve~y tub~ ~ow~r control 2~, elap~ed tl~e meter 58, cl~cult bre~ke~ ~6, telnp~r~ture ot ~witch ~4, ~uxllliary s~n~os po~t ~5~ ~ater he~ter llght 429 standby temper~tur:e varlabl~ r~sis~or 126, run temper~ture v~rla~l~ re~l~tor 127a snd power ~ ch 52. Th~ t~per~tu~e selec~ ch 24 1~ ~ three positlon rotary ui~ch to #~l~ct th~
~emp~ra~ure 3enso~ connected to ~he tigit~ p~s~kure g~uga.
The t.hre~ poa~tion~ Are: water ~read temperatu~e of w~e~ t~
humidl~i~r pot ~NS)), HDT ~t~p~rs~ure ~t equin~ ~nd ~ h~ated d~livery t~sbe ant auxllliary - t~pcratu~e ~t ge~sor pltl~ged into ~he ~ux~lliary ~enYOr port). Th~ h~mtdifi~r byp~ sl~tQ g i~ loea~ed on t:he cabinet top, ~ t~r r~ervoir 31. Rlght pa~l 3 lnclud~ ~ por~ ~fi ~o ad~i~ coolin$ ~nd feed air to blower ~NS~. A tray 27 on the front of th~ apparatu~ provld .

Pa~e 14 ~ ", ''''' " ' : ' '' . - ' ~' ' ~" , 5EP ~6 !85 ~ F~ICOH C OF F'OF~HTIOI`I , P. 1 e .
~L~4~9~Lg~

convenient pl~ee for the stor~g~ di~lnf~tant aolutior~ (Not Show~). A dl~:lnfect~nt s~rlnge por~: 15 i~ loc~l:ed ~t th~ re~
of the app~rat~. Als~ loca~d on ~hk r~ar panal 28 ~r~ a draln port 71, draln v~l~re l9, he~tad del~very ~ be con~ecto~ 51~
he~tet delivery t~lbe powe~ ~cket 57, ~and heet~d delivery tube ~;npera~ure ~an~or ~ocket S3~ The hested d~livery tub~ 5 ~ouples to the he~ed dellY~!ry ~ub~ connec~o~ to pr~vid~ ~
contlnlaou~ flow paeh fcr huD~idi~ied si~ fros~ ~h~ ~pp~ratu~ to th~ ~ni~al . Po~r to ~he h~ated deliv~ry tube i~ o~tAitled by plu~gll~g into the h~atad dclivery tu~ pow~ ~ockae. The ~emperature se~or ~ocl~et 53 provides a ~a~n~ for a t~perature ~enoo~ loc~ted n~a~ thc anim~l ~nd of the heated dell-~ry tbe ~o be connect to the digl~al t~p~atu~e ~ug~ ~hrou~h ~21~tion Oe ~th~ heat~d del~very tub0 po~itlon o~ t~pcr~tu~e ~ to~
~lt:ch on the f~or.t pane~ he ~pp~rRt~ m~y ~n~l~de integral wbe~l~, or th~y m~y b~ in~orporslted e ~ 8~p~r~te dolly on wl~ich the ~ppar~tu~ rlte~ .

.
Figure 5 is a cut-away ~e~tional view o~ the prototyp~ of ~h~ pr~s~a~t invent~on u~d ln cllnical and per~o~nc~ ~est~
w~th racehor~e. Thi ~ lllu~tratlon Also ~h~ue a cut-~way :; e~tlon~l v~w OI the humldt~ier portio~ uithln th~ ~pparatu~.
bl~t ~r enter~ ~he cab~nee 3 ~a~mo~pheri~ pre~ur~, ent~r~
-~hrou~,h alr ~ lt~r 35 and p~e~ th~ough tD ~a~ blower 37 Yi~

sir lntske line 39,. The ~lr p~Hsln~ ro~ th~ ~lower 37, ;
Pag~ 15 ~
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~""' . ' :., ~' SEP Zb ~85 13: lZ ~ICOH Co~FuF~HTIC/N P. 19 ~24~91~

ent~B hu~idi~l~atiorl pot l~tsk~ line 41 unde~ pol3itlYe n~ ~
pr~ure. Tha volum~ o~ air ~nta~ing the hu~idlf l~a~ibt~ pot 43 1 ~ me~ur~d by g~ low m~ar (~) and 1~ ~o~l;rollod l~y ~ir ~low v~lve 7, Thl~ ~i r i~plng~ upon the li~ul d w~ite~ ~6 ~ont~ln~t wtthin hl~idifi~tion po~ 43 whlch ha6 b~n war~ned by h3at~
sy~te~ 45 to the de~1red ope~at~ve temp~tur~ which i~ i~
~xces~ of ~he de~i~ed ou~put dewpoint ~n~ pre~erably i;~ exce~
of th~ temperature ~equlred for p~t~url~ation, e,g., 140~ tO
180 ' F . The water level in the humidif lcat~ on pot i~ m~int~ined at ~ con~tcrlt level by }iquld water ~om ~e~e~voi~ ~1 which ls conn~c~ed to por~ tNS). A tuhc 29 ~hown in phanto~ dotted line ~od~ from ra~ervQir 31 termlnate~ at ~he ~u~f~ce of wR~er 36.
W~te~ i~ dlapen~d unly wh~n the l~vel in hu~idif i cat~on pot 43 falls ~u~fici~ntly ~o ~dmi ~ir fro~n th~ pot ~hrau~h the t~be to l~e~erv~ir 31. ~o pr~v~nt r8~zlng of ~ r in re~P~JOir 31 durlng subree~:~ng ambient~, w~ate heat f~o~ hester ~yst~m 45 ~ .
directed p~se ~ r~Joir 31. ~o en~ure th~t ~ater dl~pen~e~ f~o~
rc~et~voir 31 1~ malntained a~ pa~ceurl~ation ~e~Gp~ra~ur~ for au~lclellt tlme to klll ~ny~organi~m~ that ~lght be pre~ent, ~a~d di~pellsed ~ter is directed In a l~byrl~th path define~l by downplpe 30 and cup 3~ . Downplpe 30 contain~ v~nts 33 locatod above the water lev~l ~o ~ ot to lnt~rf~r wi~h the l~wer ~nd of t~lb~ 2g ln deE~rlin3 the wat~!r level. The volume of ~ald labyrlnth p~th 18 auf f ~ clen~c ~o provlde re~ dence ti~e p~Se 16 SEP 26 'S5 13: lZ I~ICûH C(!~POF~HTIûN P. 20 of w~t~r ln the path wh~ch 1~ great~r ~h~n r~qu~ed past~llri~a~lon ti~e .
Temperatur~ of the wate~ ~ n hu~ldl~ tion pot 43 ~
malllt~ d a~ a ~pera~ure whi~h i~ elev~tod ~bove the d~lr~d outpu~ dew pol~t by heat~r 45 which ~dDIinistsr~ h~s~ ~o the humltlflc~tion pot ln raupon~e to oon~rol sign~ls ro~ ~ter t~per~ture sensor ~4 . In the RUN ~o~, thi~ t~mper~eure can be ad ju~ed . Should the t~mp~raeur6 ~xc~&d P predeterm~ ned upp~
llmlt, a th~rmal ~witch 81 open~s th~by turnin~ o~ power to h~ate~ 45~ f~n 62 ~nd blow~r 37- The urther fun~tio~ thl~
swltch 1~ de~cribed ln Fl~ure 2 .
Hu=ldlfier bypa~ ~alY~ 8, norm~lly m~int~ine~ ln ~lo~d po~itlon~ oo~l:rol~ air f low through ~ ~hun~c p~h 11 ~hlch bypa~e~ ~h~ hu211diflc~ion pOt 43- When th~py i~ be$n~
admlni~tercd, thl~ v~lve i~ clo~ed.
H~aeer 45 lmpar~s s~lf~l~ien~ cnsrgy to the w~te~ 36 in hum~dlflcatlon pot 43 to humid~y ~h~ a~r ent~r~ng the pot vla oondul~ ~1. Th~ velocity ~nd direction o~ th~ ~nt~rt~ Air ~r~
such that lar~ wate~ dropl~ts ~ay orm. ~id droplet& ~b ce~l~8cod hy ~he porous mQ~bl~ne 47 lo~at~d ~e ~e hu~idlfica~loll pot exlt port 49 ~o ~hat th~ huDll~~ied al~
e~itln~ the hu~ldl.elca~lon pot 43 vla conduit 49 i~ free o~
aero~ol w~ter particlc~ thst Are kao~n irr~ tants ~nd poten~

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SEP 26 'E35 1~:13 F~ICl~H COF~F'QF~hTIQN P. 21 ' ~rrler~ o~ ~ac~erl~ or o'cher undsslr~a~l~ spacie~, The humidlfl~d ~r atr~ conducted by condu~t 49 ~xlt~ th~ cabl~
via 8 fi~in$ on ~ha b~ck o the c~bine.t (NS~ which conneclts to a h~t~d ~eliv~ry tube .
Flgure ~ i~ a ~rag~e~ta~y ph~ntom vl~w of a dl~po~ble uzzl~ m~5k ~or th~ a~mlnl~ratl~n of B high-humldity air atr~sm to ~ hor~A Th~ hi$h-~mldi~y output 38 of the sy~te~ i~
delivered ~o the anim~l by the he~te~ del~Yery ~ ube as~embly 51 by w~y o~ a J-~haped t~e 40 ~n~lde di~p~ssble buck~t 61 which ~ervea a,B an in~ulated muzzle n~ask. The anlmal''s exhal~tion ~nd ~ny ~xc~s~ flow ~om the HDT 51 ~xl~ ~re~ly froDI the bucket 61 ~round ~he anim~l~0 mu~zl~. Any ~or;den~ate ~om the HDT 51 and b~lck~t 61 os~ ~e~r~tio~s fro~n th~ ~nim~l dr~in throtl~h Yent pOrtB
63. The J-~haped eub~ 40 ~erv~ A~1 a ~lngor to o~perllte ~lth the ~:wo ir~ar~ of ~he U-a~aped ~racks~ 46~ ~o whlch 1~ 1~
~Lt~ch~d~ ~o C~ lp ~hf~ IIDT a~sembly ts) the fl}~ge o~ buck~c 61.
Tha ~.la~ping ~nd relea8e a~tion~ dep~nd 41~ the ~lexi~lllty c~
th~ bucket Sl arld of ~ha IJ-~haped brElckek 46. ThQ mu~zla ~Daak a~mbly attache~ to the ~nilQal by ~an~ of a hook b,8 on th~
U-br~ke~ 46 whlch engaga~ tha: h~lter throst Bt:~pll~ 50~ Furthar ~ecurlty 1~ p~ovid~d by th~ no~e hook S4 wh~ch engag~ ths hale~r no~ rap 56. After ~tt~ch~ent; the hor~e is cont2olled ~y ~ halto~ rope ~Not Shown) a~tflcbe~d to the halter chln ~trap ~4 or ~y cro~6 tie~ attach~d to cheek ringD 66.

Page l~

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-;EP 2~ '85 13:13 RICOH ~ OF~POF~TIC~N P.22 9~

F~gure ~ al~o ahow~ mo~e d~t~il o~ th~ ~lDT ao~eslbly 51~ A
tr~nsp~re~t 3~ctlon of the d~liv~y tub~ 59 ~ne~leo viewing of conden8atiorl to con1rm p~:op~r op~ration o~ the ~y8~ A~
Outer ~ck~t ~7 o~ ~pir~l-&~rrug~tq~ pl~ c ubing pr~vide~
the~m~l in~ulatlon and prev~n~c~ klnkl~g ~ the ~l~xlbla, thln-w~lled dellvery tub~ 59. ~leatin5s wl~e~ 57 provide e~rgy to ~on~rol the ts~p~ ure of the hi~h hu~idlty output 38 a~
~e~sed by ~ thermocou~ 53 in ~he ~ t~e~m ~o ~R 1:0 prevent e~cces~ conden~ation. ~he d~llvery tub~ ~eache~ to J-tub~ 40 by m~8rlfi of tubln~ mp~ 6~ which can be sdJu~ed ~o provide a do~irqd ~af~ty hr~k-~way for~
The bueket 61 can be fabrio~ted or ~8~y di0inf~ction ~nd reu~e or ~ab~l~ated wlth 1 ow-eo~t n~erlals ~e.~ pr~n~ted p~pe~) ~or o~e~time dl~po~able u~e.
Ths ~ollow$ng ex~ple~ lllu~tr~te3 th~ high h~mit~t~ ~h~r~py tteat~en~ of lsrge 8~ cn e~fec~i~e ~e~a of preven~lnR
and~or h~ ng, reducln~, ~ur~g~ r~pairi~ tbe tl~3u~ d~3e ~one to the c~ lv~olip mucou~, no~trll~ cua ~e~br~nes, na~al p~aa8es~ broncholi, etc., a~ocia~e~ wlth ex~rcls~-lnd~ced pul~on~ry hem~hage i~ hor~s, ehr~u~h~reds a~d se~ndardbrad~, aft~r racin~ os bseez~n~.
Th- trBn~p~ato~ app~tu8 ~ illu~erat~d by Fi;uraa 1-6 de~crlbed her~n beore wa~ ~artet ~nd oper~Rd ln ~ccor~anre wlth the ~ollowlng g~neral procedures on ~ 1,000 p~und 5 year P~ge l9 " ' ~EP Z6 '~5 i_,: 14 F~ICOH C~IF~PClF~RTIO~ P. 23 _ ~ld ~t~ndardbred ma~e n~m~d Oil Palnting own~d by S~r~to~
St~nd~lrdbrRd~3 5 In~. h~ving a racln~ history ~pa~ fro~
1~/13l8$ to 7/~/~5. ~he hi8h humidlty equine Tr~nopi~ator d~vice wa~ connected to 115 vol~ ~ower ~ourc~ t Th~ drain ~al~re of th~ d~vice w~e cl~sed ~nd the humidi~ic~tion water r~erYoir wa~ filled wlth wat~r vla ambi~nt temper~ture ws~e~ ~upply ~ourc~. The power ~wit~h w~ tur~d to ~ndby ~nd th~ Nater hes~x light w~ turned Otl. Ths ten~p~raturR ~sle~t on th~ front p~ne~ w~ turned to the w~r b6l~h ~etting ~nt af ter 10 to 1 olinutes, th~ d~gltal ~mperature mete~ indicated a w~t~
temperAtur~ billzation range of 135 ~ to 155 ~ F. The deliver~r ~ube exit ~3a~ ~tr~Am ~ondu~t wa~ di~in~et~ed by p~B13i~S~ at lea~t lSO ~1 Alcld~ LD 10 ~1:1 golution throu~h the deli~ery tu~e ~ ntD
the ~uzzl~ ~8~; whlle ~ha Tran~plra~or op~rQted ~n BY-PA~S mode ~t m~xl~un! ~ir ~law.
~ f~Rr dlsinfectio~ o~ the ey~em, the muzzl~ ms~k wa~
brol~&ht to dew polnt temperatllr~ of 105 ' F ~t the polnt of delivery o~ the ~at~lr~ed Y~pO~ 8~9 to the muzzle ma~k attQched to the horse~ h~lt~r. ~urlng th~ flr~t treat~ent, Oil .
P~inti~g~ pul~e did no~ exce~d: 40 b~ pBr minutas and her rectGl temperature dld llo~ c~ed 100~ ~. The mars~ bre~thin8 rat~ did not ~xceed ~0 inlJplrc~lons p~r minute. The lit~r~ per ~lnut~ dell Yered to the h~r~e ~nd th~ t~L~psr~:ure0 were recorded `
Plg~ ~

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SEP 26 'R5 1_':15 F~'IC~H CoF~F~o~RTIoN P.24 ~l~4~963 at lea~t OI~C~ ry 30 mLnute~ ~nd tha tr~t~l~n~ wa~ coatlnued for ~t leA~t two hou~ per d~y. Th~ ~r~ wa~ examinet a~ter e~ch r~c~ with a ~lexibl~ f lberoptic enda~cope .
~ h~ mare WB~ rac~d on the dato ~t out ~n ~hc table her~A~t~ which al~o de~crlbe~ h~r po~it~on at 3J4 m~le pointS
fl~d the poel~iot~ oi~ Oil PAlntln~3 ~t the flnlsh o~ th~ e-~ile r~ 2~dS 3rd, 4th~ etc.)" th~ ~lmo the T~e flnlahed,t wh~thar or not the maxe had been tr~ated bef~r~ th~ ~aCcC a~d wh2~her or not ~he experienced EIPL~ ~t6~ he r~ce.

"OI~ PAINTIN~" BLEEDI~G ~ HIGH-~lMIDITY THE~A~Y HISTORY

RAC~ 3/4 FINISH TI2~E H~IT c BI.E~D d DATX MILE _ _B~f l~re R~cqAf ~r Race 12/13 3 2 2:01 NO NO
12/20 4 2 2:02 NO NO
1/2/B~ 1 1 2;03 NO 2~0 ltlO 4 5 2 ~ 01NO , NO
2/1 7 8 2:06 NO YES
2l8 6 ~ 7 2;Q7 ~NO Y~S
2/15 7 ~ 2 ~ 04NO Y~S
2128 BREEZE !:)N F~RM ~0 YES
312 3 3 2; 03 YE~ ~0
3/9 6 4~L 2 t 03YE~ N0 3~23 5 2b 2: 02 YES ~0 3/30 4 1 2: 03 NO NO

Pa~ 21 , .. . . . . .

5EP 26 ' ~5 1~ 15 ~ I CCH COF~F'OF~T I ON P . 25 ~2~ 9~

"OIL PAINTïNG" BL E~N; & HIGH-~IUMIDITY TEl~RApy HISTOaY
COI:T I21~JED

RAC~ 3/4 FXNIS~I rI~ HET c BLl~ED d D~TE MII,E Before ~ ce 4114 4 8-14 ~ t 00 . 4 N0 Y}~S

514 7 ~-4 ~s00.4 YE8 N0 5J11 6 6~? 1;59+~ YES N0 5/1~ 2 5~4 ~;02-4 Y~S ~0 5/Z5 2 3~1 2: 00 . 3 ~S
(a) THR~E~WAY PHOTO EOR 2ND.
(b) BROK~N HARN~89 AT ~IrART.
(c~ 1 TO 3 HOU~ ~R~TMENTS DAILY, IN~LUDING RAC~ DAY.
5~ :BNDOE~COPlS ~XA2I 12~ ~IOUR~ APT~R RACE~

The above cha~t lllu~r~ th~t with~ut hu~ldlty treat~ent~
Oil PalntlDg showed ~l~n~ of ~ercl6ad-i~du¢~d pulmonary hemor~hag~ ~EIPH) whe~ exa~lned with a ~lexible fiberoptic endo~cope ~F~) 12 hour~ a~t~r ra~:ln~ o1S ~ebruar~ 1, 8~ 15 and 28, lg85. It ~urther illll~tra~teY tha~ w~th htgh-humldlty ther~py prior to rQc~n~, Oil P~lntlng ~how~d no a~ of EIPEI in po~-race FF~ ~x~mIne.~lon~ Oil P~lin~cing was treatet ~or two hour~ ~ day f~om 2~arch 1, 1985~ through M~r~h Z3, 1~85, and ~howed no evid~n~ of ~IP~ sf tar thr~o r~c~ ln thi~ perlod .
The~eafter~ hlgh-hu~idity ther8.py w~ di~continu-d until a~t~r Aprll l4" 1985. She ~h~wed no ~evid~n~a ~ EIPH a~tor wlT~ni~g ~
race~ on March 30, but g~ sho~e~ rlous E~IPH follow~ng ~ r~e on April 14. H~gh-humidity eh~rspy t~ea~e~a~ wa~ re~n~ ti~tet after the: Ap~ll 14 r~ce~ and ~8 llluatrat~d~ ~y ths FF result~, EIPH d~ d n~t reoc,cllr I

p~ge 22 :

, ~

. ,, ,~ .

SEP ~ 'E,5 13:16 FIC~DH ~`O~PCIF~HTION P.Z6 :~2~

011 P~lnting has colltinuet tr~3at~ent8 ant racing ~ineQ
S/25/~5 with 8t~dy i~prov~ment ln h~r racis~g t~m~ ~nd ~thou~
EIP~. ~n 7/8/85 Bt Meadowla~d, ~.J., sh~ f~nifihed ~h~rd at 1~56~4 ~ ln~e 56 ant 4l5 ~soond~3,~he f~ t m~l~ o~
h~ ca~ar.
A~ of 7/1~/~S, the ~o~al numbe~ Df hor6e~ rf~caivi~, or h~vi~ re~eived TranGpirator ~r~t~erlt~ are a~ followg~

Typ~ Loc~tion . Di80rd~r Tre~t~d S'rANDARD~RED EIPH B~ONCHITIS PNEUMONIA
TElOROlJGBR~D

X Sara~o&a ?
X M~adowl~nd~ 4 4 X D~laware ~ark 11 3 X X Univ. of PA 2 ~ .
The two hor~q~ tre~d for pneu=onl~ R~: ~ha Uni~rer~i~y o~
Penn~ylv~nia ~ew ~oleon C~nter war~ fo~ Both fo~l~ responded to ~re~tm~llt a~d ~ouRh~ the ~u~zle ma~k voluntarlly wh~n $e ~4 hun~ ~orl the ~all o the BtEIll~ yete~ arlAn~ noted ullexpec~odly rapld recov~ry by Dne 4f tha f o~
The other ;~oal dled of ~epticemls unr~lat~3d to it~
.~ pneu~onla. How~ver~ d~rin~ one day oP Tran~plra~or treatn~nt Page ~3 ; ,., ~ ., . .
,:
-. ' ~ ' " ' " :, ~ ~;EP 2~, '85 13:16 F~'ICOH ~~ùF~P~IF~l~TICIN P.27 12~

w~e~sed by ~Yer~l ve~erin~rlan~, the ~oal sou~ht ~ut ~he mu~zl~ mA~k, volun~arlly pl~ed it~ mu.zle ln the ma0k (~t~ndlng up or lyin~ down) 9 ~nd wo~ld ~leep with it9 hlesd in the ~B8 wlthout requirln~ atrap~ to hold the ~a~k on.

Fou~ ~t~nd~rdbr~d and three th~rou~hbre~ hor6~ wlth ~verQ
to ~c~te bronchitiu and/or sll0r~1c polyp~ we~e gl~e~
Tr~plrstor conditlonl~g tre~tment~. Alr ~tur~ted fro~ 100~ F
to 110' ~ W~9 admini~ter~t by muzzle m~sk fo~ ~bout a 2-ho~r pe~iot ~ 300 to 400 liter~ p~r minutR~ Thi~ tr~atm~nt wa~
~lven once A d~y ~or three to flve d~y6 ln conjunotion with antibiotic drug ~he~apy. Bef ore-~nd-~fte~ broncho~cop~
exa~inAtlon~ revealed vi~ible improvam~nt~ hree o the hors~ ~hat ~ay be s~eribu~able to ~h~ Tr~n~plrator therapy, ~hree of tbe~e ho~ r~ed eft4r tr&~t~en~. T~o o~ theln posted nlflc~nt i~p~ov~mcnt~ ov~r the~ recent ra~ng time~.
Exerci~e-ind~ce~ p~ ona7:~ heDIorrh~ge ~IPH): h~ been the pri ary ocus of ~r~n~p$~tor trestment~ thu~ P~r. Some 22 hor~e6 wi th docu~a~ted or ~uspec ted EIPH h~ve been 8iven daily treatment~ ~or up to fiv~ days pre~edin~ ~ r~ce. Each day air saturAted from 1007 to 1107 ~ wa~ admlnl~ered by muz~le ~ask for ~bout a 2~hour per~od at 300 to 400 ~ rf~ per minute-Sixteen ho~se~ rac~d aftar the tr~a~me!nt~: none of the~e show~d wor~enlng o~ ~IPH or racin,g p~rfor~ance four ~houed le~seni~g o~ EIPa w~th rl~ ehfln~e irl performance; BiX that :~arB not P~13e 24 , - , ;

SEP 26 '~5 13: 17 ~'IC:OH l ~JI~F'ClF~HTIOI~ P.Z8 ~ ~ 4~ ~ 9 bro~cho~eoped ~howed improved performanc~; four showed no ~IP~
~fter r~clng; a~d thr~e ran th~ be~t ~c~ tlme~ of th~
car~erR. Cont~olled ~tudie~ under the ~uperv~slon of Univer~ity of P~nn~ylvanl~ ~eterina~an conault~nta ar~ now ln progre~0 at ~he Delaw~r~ Par~ Thorou~h~red ~r~ck ln N~werk~ Delawar~1 Other appllcation~ of T~ansp~rator trealm~n~ th~t ~re planno~ ~or ~tudy ~n the near future ~nclude: fos~ and cal~
pn~monl~ bronehlti~ th~a, ~lnusltis, allargic rhinlsia, and vlr~l rhlni~ S~voral half-hour tr~at~ent~ ~t or 61i htly ~bove llO' F ~re expectet to prod~ce ai~ni~i4an~ aymp~oml4 r~lle~ ~or the latter three diacrd~rs ~nd to speed their cure.

N~al ~flnnula ~dm~n~atr~tion foflelbllisy hae ~e~ dflmon~tra~d with ~rly prototype~ o~ ~he rr~n~pl~ator ~or the tre~tm~nt of foal~ snd a~ule r~ce hor~a~ al cannul~ ad~inistratio~

perml~ ~lon~-eer~ treatme~t~ without costly aupervi8iO~ ~nd, siDce hor~es are obligate n~l brea~herQ, proyld~s a ~can~ ror c~tan~ posltl~e ~lrway prssRure ~CPAP) th~rapy~ Lon~-te~

naaal cannula ad~ini~trat~on permit~ nn anlmal to ~uckle, drlnk, and e~t while f~aR-roaming on a heated telivery tube ~ther from t~e Tr~D~pir~eo~ CPAP therap~ oy~n~ rollap~ed or ob~tructed ~lrw~ys fo~ sdmin$stration of aero~ollzed medlcations and ~or promotion of pulmona~y hyg~ne. ~est~ Are planned wh~r~in nasal prong~ with inflatable cuffed ~aals wlll be u~ed to administer Tr~nsplrator output 90 as ~ produ~e CPAP or var~ble airway pre~ure to 8~8i~t ven~ tion.

pJlge 25 ':

SEP ~6 ~85 13:17 F~ICOH ~F~PO~ITION P.23 ~2~9~9~

Wbile ~ prim~ry fc~tura~ o~ ~he ~ran~pir~.tor i~ d21ivery hi~h hu~dlty ~lthout water ~eroM~ls which might ind~ ca b~nc~o~pa~m~ or c~ry p~thogen~ l~to the lur3~ ~ a~r~ol~ of water and mP~icAe~on sre t~lr~ble fox many vet~rlnAr~all ~rea~ent~.
Th~
Tran~pirRt~r outpu~ n ideal Yehicle for nero~ol mediC~'CiOnB~
expeci~ y ln ~on~nctlon w$th n~al eannula 2dmini~tr~tloll.
Te~g are pl~nned where~n n~ullzad ~etieatlons ~ e a~plrated into the Tr~ pirator output ~or admini~tr~tion by mu~ ma~k and na~l ce~nn-~la.

pnge 26 ': ' ` :~
' ;, , "' "' ~` :
.

Claims (7)

THE EMBODIMENTS OF THE INVENTION IN WHICH AN EXCLUSIVE
PROPERTY OR PRIVILEGE IS CLAIMED ARE DEFINED AS FOLLOWS:
1. A high humidity method useful for conditioning a pulmonary and/or a cardiovascular system in a large animal veterinary comprising:
(i) providing a stream of gas;
(ii) heating water in a container means;
(iii) providing a porous membrane means disposed within said container means, said container means adapted to permit liquid droplets to contact said porous membrane surface to permit a vapor to defuse therethrough;
(iv) mixing said vapor with said stream of gas to humidify said stream of gas;
(v) delivering said humidified stream of gas at a rate from greater than about 60 to about 500 liters per minute to the animal's respiratory tract at a dew point temperature greater than the environmental ambient dew point temperature, said humidified air stream dew point temperature is within the range of 99°F to about 110°F.
2. A high humidity method of claim 1 wherein:
(i) a humidified air stream at a dew point temperature greater than the environmental ambient dew point temperature;
(ii) said humidified stream of gas is delivered in the substantial absence of nebulized water aerosol.
3. A high humidity method of claim 2 wherein:
(i) said humidified air stream is delivered at a dew point temperature greater than 93°F (33.9°C).
4. A method of claim 1, wherein (i) the humidified air stream is delivered continuously.
5. A method of claim 4 wherein (i) the humidified air stream is delivered continuously for a time period of less than about 24 hours.
6. A method of claim 5 wherein (i) the humidified air stream is delivered continuously for a time period of less than about 8 hours.
7. A high humidity veterinary therapy method useful for conditioning pulmonary and/or cardiovascular system in veterinary animals comprising delivering a humidified air stream at a dew point temperature within the range of about 99°F to about 110°F temperature and less than a permanent tissue damage temperature of an animal's central nervous system, said humidified air stream is delivered at a rate from greater than about 60 to about 500 liters per minute.
CA000492384A 1985-07-16 1985-10-07 Method and apparatus for pulmonary and cardiovascular conditioning of racehorse and competition animals Expired CA1249190A (en)

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US755,562 1985-07-16

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EP (1) EP0228374A1 (en)
AU (2) AU4960585A (en)
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WO (1) WO1987000423A1 (en)

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AU5757390A (en) 1990-10-11
US4722334A (en) 1988-02-02
NZ213826A (en) 1988-07-28
EP0228374A1 (en) 1987-07-15
AU4960585A (en) 1987-02-10
WO1987000423A1 (en) 1987-01-29

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