CA1232814A - Guide wire for catheter - Google Patents

Guide wire for catheter

Info

Publication number
CA1232814A
CA1232814A CA000439266A CA439266A CA1232814A CA 1232814 A CA1232814 A CA 1232814A CA 000439266 A CA000439266 A CA 000439266A CA 439266 A CA439266 A CA 439266A CA 1232814 A CA1232814 A CA 1232814A
Authority
CA
Canada
Prior art keywords
distal end
end portion
guide wire
catheter
body portion
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA000439266A
Other languages
French (fr)
Inventor
Hidetoshi Sakamoto
Tatsuo Suzuki
Toshihiko Endo
Kenjirou Uematsu
Masashi Momota
Susumu Tanabe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fuji Terumo Co Ltd
Original Assignee
Fuji Terumo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26492793&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA1232814(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from JP58169467A external-priority patent/JPS6063065A/en
Priority claimed from JP58169468A external-priority patent/JPS6063066A/en
Application filed by Fuji Terumo Co Ltd filed Critical Fuji Terumo Co Ltd
Application granted granted Critical
Publication of CA1232814A publication Critical patent/CA1232814A/en
Expired legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/02Inorganic materials
    • A61L31/022Metals or alloys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00Catheters; Hollow probes
    • A61M25/01Introducing, guiding, advancing, emplacing or holding catheters
    • A61M25/09Guide wires
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00Materials characterised by their function or physical properties
    • A61L2400/16Materials with shape-memory or superelastic properties
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00Catheters; Hollow probes
    • A61M25/01Introducing, guiding, advancing, emplacing or holding catheters
    • A61M25/09Guide wires
    • A61M2025/09058Basic structures of guide wires
    • A61M2025/09075Basic structures of guide wires having a core without a coil possibly combined with a sheath

Abstract

ABSTRACT OF THE DISCLOSURE

A guide wire for a catheter having a body portion comparatively high in rigidity and a distal end portion comparatively flexible.
At least portions of the body portion and the distal end portion are formed of a super-elastic metallic member. At least portions of inner core portions on the body portion's side and on the distal end portion's side, both of which are coated by a plastic , are formed of the super-elastic metallic member, and at least a portion of the inner core portion on the distal end portion's side is made smaller in cross-section than the inner core portion on the body portion's side.
In consequence, the catheter can be reliably and readily introduced to a predetermined position.

Description

:~2328:

SPECIFICATION
TITLE OF THE INYENTIOH
GUIDE WIRE FOR CATHETER
BACKGROUND Ox THE INVENTION
IDEA Of INVENTION
This invention relates to a guide wire for a catheter for waking the catheter guidable, and Gore paticularl~ to a guide wire lot a catheter for making tune catheter for the medical treatment OX
tests introducible to a predetermined position id a blood vessel, digestive duct, trachea, other bong cavities OX the like and retainable thereat.
DESCRIPTION OF THE PRIOR ART
Heretofore as a guide wire for a catheter there has been used a cbil-shaped guide wire formed ox a stainless steel wire, a piano wire or a monofila~ent-shaPed guide wire jade of plastics. Each of the above-~entioned guide wires of the prior art incorporates a general metallic material such as a stainless steel wire or piano wire progressively being reduced in sectional area frond a body portion to a distal end portion thereof in a portion or over the total length of its interior, whereby the guide wire is formed of the body portion co~parati~elg high in rigidity and the distal end portion coDparativély flexible.
As typified in the case of retaining the Angiograpbic Catheter at a predetermined position in a blood vessel, in zany cases, the aforesaid guide Nine is percutaneously inserted into the blood vessel by use of an introducing needle, the distal tip opening portion of the catheter is covered onto a proximal end portion of the guide vine disposed outside of a human body and the catheter is inserted into the blood vessel with the guide wire being utilized as ad arbor. Thoroughfare certain level of rigidity is given to the body portion of the aforesaid catheter so that the guide wire is jade smoothly insertable into tune blood vessel against a resistance generated between the outer surface of the guide wire and the tissues of the human body and the catheter is jade guidable against a resistance generated between the outer surface of the guide wire and the inner surface of the catheter.
However, as described above, since the body portion of the conventional guide wire is ode of the general metallic material and plastic deformation is caused to the body portion when a certain value of displacement is exceeded, the guide wire Jay be buckled depending on the skill in manual operation, whereby the buckled portion Jay be turned into an unrestorable differed portion, and this deformed portion fortes a considerable obstruction against the advance of the catheter, so that difficulties are felt for an operation of soothly introducing the catheter. ~urtheT-ore, in the case of guiding the catheter by previously curving the distal end portion of the catheter so that the catheter can be readily inserted into the predetermined position in the blood vessel, the catheter is covered onto the guide-wire and coxes into the state OX being straightened. Hence, the resistance of the catheter covered onto the guide wire is increased, whereby a Possibility of occurrence of a trouble caused by the aforesaid buckling is increased.

~-~3Z~

n order to haze the catheter reach the predetermined position of the blood Bessel after the catheter together it the guide wire have been inserted into the blood vessel, it is necessary to further advance Jo the blood vessel the distal end portion of the guide wire projected a predetermined length from the distal end opening of the catheter. Therefore, the distal end portion of the conditional guide wire need to have such a flexibility that tube guide vine does not damage the wall of blood vessel, adapts itself to the shape of meandering blood vessel, and is insertable into a complicate vascular branching.
However, as described above, since the distal end portion of the conventional guide wire is jade of a genital metallic material or plastics, plastic deformation is caused to the distal end portion when a certain value of disPIace~ent is exceeded, whereby the I flexible ~ovabilitY of the guide wire for reaching a predetermined position in the blood vessel is endangered. ~`urether-ore, even if the distal end Portion of the guide vine reaches the predeteTnined position in the blood vessel, the distal end portion is lowered in its rebound due to plastic deformation. Hence, bile the fissured end portion of the catheter is being advanced, there is no resistance between the distal end portion of guide Nine and the Hall of blood vessel, which is required for retaining the forward end portion of the guide wire against the flyer stress of the catheter, with the result that the distal end portion of the guide wire is drawn out of the predetermined position of the blood vessel. and. in nay cases, the retention of the guide wire at the predetermined position ends 1~32814 in a failure and such tire is wasted for the manual operation. The rehash been proposed a guide wire, the distal end portion of Nhicb is previously dehorned into aJ-shape so as to prevent the Hall of blood easel from being da-agedand the distal end portion of the guide wire from engaging the wall of blood Bessel during its o~e-ent Jo the blood vessel. owner, the distal end portion of the guide wire of the type described newer fails to be deformed into a rectilinear shape Chile it passes through the introducing needle. Hence, thereafter, the distal end portion of the guide Nine is not restored to a perfect J-shape. an din any cases, such a disadvantage is presented that the initial function is not satisfactorily fulfilled.
urther~ore, it is preferable that the abo~e-described Goodyear has the outer dotter substantially equal to the inner diameter of the catheter, so that the catheter thus guided can expand the Hall of skin and the Nell of blood vessel naturally and soothly. As for the distal end portion of the guide Nine, it is preferable that, to prevent the blood from leaking out through a gap formed between the introducing needle and the guide wire when tube guide wire is inserted into the introducing needle, the distal end portion hag the outer diameter substantially equal to the inter diameter of introducing needle. i. e., the outer diameter of the body portion of the guide Nine. Therefore in the abo~e-described guide vine, it is preferable that the outer diameter of the guide vine is nude substantially equal to the inner diameter of the distal end portion of the catheter to guide the guide wire, whereby, lX3Z814 oven if the outer diameter of the guide wire is increased, both the body portion and the distal end portion be provided with the elastic strain characteristics required therefore respectively.
One object of the resent invention is to provide a guide wire for a catheter waking the catheter reliably and readily introducible to a predetermined position.
More specifically, this object of the present injection is to provide a guide wire capable of avoiding buckling when the bong portion of the guide Hire is inserted and cowered by the manual lo operation.
Another object of the present invention is to prudes a guide wire capable of being restored to the original state, even if the guide wire buckles, and not affecting the insertion and the covering.
A further object of the Present invention is to provide a guide wire having the distal end portion flexible enough to be insertable, even When a complicated vascular system is encountered, and a good restoring force against deformation.
A still further object of the present invention is to provide ZOO a guide wire braving the distal end portion which constantly has a suitable rebound and nay be retained at a predetermined position when it guides the catheter.
A jet further object of the present invention is to provide guide vines of various outer diameters, having the physical I properties substantially identical with one another.

.. .

aye SUMMARY OF THE ~NYENTION
To the above end, the present invention contemplates that, id a guide wire for a catheter hazing the body portion comparatively high in rigidity and the distal end portion cooperatively flexible, at least portions of the body portion and the distal end portion are formed of a super elastic metallic eyebrow.
To the above end, the preset in~eDtion contemplates that the body portion is formed of a super-elastic Metallic eyebrow.
To the above end, the present invention contemplates that the distal end portion is forded of a super-elastic metallic Debra.
To the above end, the present invention contemplates that both the body portion and the distal end portion are formed of a super-elastic metallic eyebrow.
To the above end, the present invention contemplates that at least a portion of the distal end portion is cede staller in cross-section than the body portion, and a portion between the body portion and the distal end portion is progressively reduced id cross-section front the body potion toward the distal end portion.
To the above! end, the present invention contemplates that, Jo a guide wire for a catheter, wherein an inner core is constituted by an inner core portion on the body portion's side a inner core portion on the distal end portion's side. the inner cove as a whole is coated IBM a coating portion jade of a plastics and the guide wire includes the body portion co~paratiYely Howe in rigidity and the distal end portion comparatively flexible, at least portions of the inner core portion on the body portion's side and the inner core 123281.4 ' . ' portion on the distal end portion's side are formed of a super-elastic metallic oecber and a portion of the inner core portion on the distal end portion's side is cede staller in cross-section than the inner core portion on the body portion's side To the above end, the present invention contemplates that at least a portion of the distal end portion including the aforesaid coating portion is Rae staller id cross-section than tune body portion To the above end tune present invention contemplates that the outer diameters of tube coating portion at the distal end portion and the body portion are cede equal to each other To the above end the preset invention contemplates that the inner core portion on tune bong portion's side is formed of a super-elastic metallic nabber To the above end, the present invention contemplates that the inner core portion on the distal end portion's side is formed of a super-elastic metallic e~ber To the above end, tune present invention contemplates that both the inner core portions on tune body portion's side and on the distal end portion's side are formed of a super-elastic metallic e-ber To the above end the present invention contemplates that a portion between the body portion and the distal end portion is progressively reduced in cross-section fro- the body portion toward the distal end portion To the above end, the present invention coDte~plates that the 1~32814 coating pro ratio is forded of a tube.
To the above end, the present invention contemplates that the coating portion is formed of a crating film.
BRIEF DESCRIPTION OF THE ~RAWlNGS
igloo is a plan lieu showing a first embodiment ox the guide wire for a catheter according to the present invention;
Fugue is a cross sectional vie taken along the line in Foggily ;
Fugue is a cross sectional vie taken along the line - in igloo ;
Fugue is a cross sectional vie taken along the Lionel - in Fugue ;
Fox) through ED are plan views showing modifications of the forms of the distal tip portion of the guide wire according to the present invention;
Fox and 6~B~ are plan views change modifications of the forts of the distal end portion of the guide wire according to the present invention;
igs.7 and 8 are graphic charts showing the flexor load-displace~ent value characteristics of the super-elastic metallic member and the general elastic metallic nabber;
j Fugue is a schematic diagram showing the state of use of the guide vine according to the present invention;
Fugue is a plan vie showing a second embodiment of the guide I vine for a catheter according to the present invention;
Foggily is a cross sectional vie taken along the line 1 .

1~:328~4 in Fugue;
Fugue is a cross sectional view taken along the line I - on in Fugue;
Fugue is a cross sectional view taken along the line em- pa in ~ig.10;
Fox and 14(B) are play issue showing modifications of the forms of the distal tip portion of the guide vine according to the present invention;
Fox and 15(B~ are plan issue showing modifications of the distal end portion of the guide wire according to the present invention;
Fox and 17 are graphic charts shoving the flyer load-displacement value characteristics of the super-elastic metallic member and the general elastic metallic ember Fugue is a graphic chart showing the floral rigidity Moe outer diameter characteristics of the guide vine; add Eig.l9 is a Shattuck diagram showing the state of use of the guide wire according to the present invention.
BEST RODE OF CARRYING OUT THE INVENTION
Foggily is a plan it showing the first eabodineDt of a guide uirelO for a catheter according to the present invention. Fox through 4 are CROSS sectional issue taken along the lodes - Tao - Jo Foggily.
The guide wire 10 haze a body portion 11 comparatively high Jo rigidity and a distal end portion 12 cosparati~ely flexible, and a tapered portion 13 disposed therebet~een.

~32~4 The aforesaid guide wire 10 is generally formed of a super-elastic pseudo elastic metallic enter such as a Tao alloy of await X, a Cut on alloy of 38.5~ 41.5 wit S Zen, a Cu-Zn-X alloy of 1 10 wit % X Abe Six Sun', Al or Go), an Noel alloy of 36~ 38 atom Al, or the like.
In the bong Portion 11 of the guide wire 10, the outer diameter was determined to be 0.89 I, the length 130 co, and tube field stress then in a range between 10 and 80Kg ( Stereograph type produced by Too Seiko OK the abo~e-Dentioned values None obtained under the conditions of a distance between the chucks being 80 my, a speed of 5 main and a tension temperature of 22~G~. The restoring stress the yield stress under no load, indicated by B in Fugue) was determined to be 60 KgJa 2 (22 Go or less.
Additionally, the outerdiaueter of the bong portion 11 Jay be determined to be in a range between 0.1 and 2 ox, and preferably be in a range between 0.45 and 1.15 em. The length of the body potion 11 may be determined in a range between 10 and 300 I As for the distal end portion 12 of the guide wire 10, the outer diameter there of is determined to be 0.2 ox, the length 20 co, the yield stress in a range between 10 and 80Kg/~ 2 add the restoring stress in a range between 0 and 60Kg/~ u 2 or less. Additionally, the outer diameter of the forward end potion 12 may be determined to be in a range between 0.05 and 1.5 I, and preferably be in a tango between 0.1 and 0.5 pa (provided not exceeding the outer diameter of the body portion 11). Further-ore, the length no the distal end portion 12 ma be determined to be in a range between I and 50 I

~23281~

preferably be in a range between 2 and 30 I The yield stress at the distal end portion in the e~bodioent was detrained to be in a range between Andy 24Kg/~ I and the restoring stress in a range between 12 and 18Kg/D 2 .
Lowe distal tip portion 14 of the distal end portion 12 of the guide wire 10 is formed into an Reshape in order to pronto it from piercing the wall of blood vessel. Furthermore, the tapered portion 13 is progredsi~elg reduced in cross-section from tube body portion if toward the distal end portion 12, whereby tube rigidity in a connecting portion between tune bong portion 11 and distal end portion 12 is moderately varied, so that breakage and bending of the guide wire 10 in this connecting portion can be prevented from occurring.
in order to prevent the distal tip portion of the distal end portion 12 of the guide wire 10 from piercing the Hall of blood vessel, the shape of the distal tip Portion need not necessarily be it'd to the R-shape, but, Jay be formed into a spherical shape designated by lo in ~ig.S(A), a J-shape denoted by 16 in Fugue, a coil-shape indicated by 17 in Fugue, a ring-shape designated by ZOO 18 in Figs or the like.
As shown in Fox and 6~8), the distal end portion AYE
and 12B of the guide wire 10 are cursedly formed into predetermined shapes similar to the vascular system or vascular branching, so that the distal end portions can be reliably and readily inserted into predeterniDed positions in top blood vessel.
The connecting portion between the body portion 11 and the distal end portion 12 of the guide wire 10 need not necessarily be formed into the tapered shape, but such a cross-sectional shape Jay be adopted that no considerable change in cross-section occurs between the body portion 11 and the distal end portion 12 or the connecting portion Jay haze an outer diameter intermediate in size between the body portion 11 and the distal end portion 12 ig.7 is a graphic chart in which the flyer load (W)-displacement value (n) characteristics of a Tin alloy forming a cantile~erbea~ of an outer diameter of 0 em and a length of 20~ is indicated by solid lines, and the flexor load-displace~ent value characteristics of a stainless steel wire forcing a cantilever beau of an outerdia~eter of 0 45~- and a length of 20~ is indicated by ;
broken lines Fig 8 is a graphic chart in Which the flyer load-displacement value characteristics of a Tin alloy forming a cantilever beau of an outer diameter of 0 1YD and a length of 20~-is indicated by solid lines, and the flexor load-displace-e~t value characteristics of a stainless steel wire forming a cantilever boa-is indicated by broken lines in jigs 7 and 8, designated at E is a residual plastic strain value of the stainless steel wire Gore specifically, according to jigs 7 and 8, the super-elastic metallic member (1) is high in restorable elastic strain to reach several X
to ten-odd X, and (2) has the characteristics of that, even if the strain is increased, the load is not varied in value In consequence, the body portion 11 of the Goodyear 10 is formed of the super-elastic metallic e-ber hazing the flexor load-displacement value characteristics substantially equal to that indicated by the solid lines in ~ig.7, whereby tube body portion 11 is provided with the elastic strand characteristics having a comparatively high buckling strength. ~urtbereore, tube distal end - portion 12 of the guide it 10 is formed of the super-elastic S metallic enter hazing the flexor load-displace~eent value characteristics substantially equal to that indicated by the solid lines in Fugue, whereby the distal end portion 12 is provided with elastic strain characteristics capable of being displaced to a comparatiqel~ high extent under a given stress and restorable.
Description Jill hereunder be given of operation of the first e~bodineDt.
The guide wire 10 is of the rectilinear type in igloo, or of curds shapes desirably formed near the distal end portions of catheters 20 as shown in ~ig.9. curved portion thereof, for example, and inserted into the body portion 11 co~parativelg high in rigidity, so that the catheter 20 can be soothly advanced in a blood Bessel 21. ~urther~ore, the guide wire 10 causes the distal end portion 12 thereof to proceed ahead of the distal end portion of catheter 20, so that the distal end portion 12 can guide the distal end portion of the catheter to a predetermined position 22 in the blood Bessel.
Here, the guide wire 10 is provided in the body potion 11 thereof with an elastic strain characteristics comparatively high in yield stress. In consequence, even if a comparatively high flexural deformation is caused to the body portion 11 when the guide wire 10 is inserted into the blood Bessel, the guide wire 10 does not reach 123~4 the plastic deformation region and is Dot subjected to buckling, so that the buckling limit of the body portion 11 can be improved. Gore specifically, even if a deforuatioD of a big value is caused to the body portion 11 by the Nina! operation applied to the guide vine S 10, a portion subjected to this deformation can be Steadily straightened again, so that no resistance is caused to the advance of the catheter. ~urtheroore, Ruben the catheter provided at the distal end tbereDf with the curved portion is covered while being straightened, no resistance of a considerable value occurs between the catheter and the body portion 11, so that the catheter can soothly advance.
Furthermore, tube guide vine 10 is provided at the distal wend portion 12 thereof with an elastic strain characteristics capable of being displaced to a conparativel~ high extent under a given stress and restorable. In consequence, Chile the distal end portion 12 goes trough a bent portion of the blood vessel, a flesural deformation of a high value can be obtained under a load of a comparatively low value, a curved deformation and its restoration are repeated, whereby the accooDodation in shape of the guide Hire 10 to the meandering blood vessel is iDpro~ed and the guide wire 10 can be comparatively easily curved according to a vascular branching, Jo that tile guide wire 10 can be suitably advanced to a predetermined position in the blood vessel. Additionally, when the catheter is inserted to a predetermined Position in tube blood ~essel,the guide vine 10 is provided at the distal end portion lo thereof with a rebound enough to generate a resistance against tube 123~8~

Hall ox blood vessel, which is required for retaining the guide wire 10 at the predetermined position against the flyer stress Of the catheter As the result, the distal end portion 12 is not drawn out of the predetermined position in the blood vessel and the S catheter is suitably retained Even if the distal end portion 12, which has been preqiouslg curdle defrauds straighteDedlg deformed Chile passing through the introducing needle, the distal end portion 12 is restored to the perfect curved shape, Ben inserted into the blood vessel threraftel, so that the original function can be fully satisfied The guide wire 10 has no irregularities on the surface thereof, differing from the conventional coil-shaped guide wire, whereby the guide sire 10 satisfactorily acts on the blood coagulation add the tensile strength is high as compared it the plastic guide wire, to thereby be safer than the latter The guide wire 10 is satisfactory in the torque transmission performance in either one of torsional directions, differing fro- the conventional coil-shaped guide wire a torque applied to the body portion 11 wakes it possible to reliably and reading direct tube distal end portion 12 toward a predetermined position in the blood vessel, so that controllability in inserting the distal end pushed 12 to a position in a complicated vascular system can be improved In addition, in the above eebodinent, description has been given of the guide wire Id, in which both the body portion 11 and the distal end portion 12 are forded of the super-elastic metallic Siberia Herr, according to the present invention, only the bong lZ328~

portion of the guide vine jag be formed of the super-elastio metallic Qeober,and further, provided with an elastic strand characteristics hazing a gild stress of a co~paratiqels high value Ott Odin the distal end portion of the guide wire is formed of the 3uper-elastic elk eenber, and further,pro~ided with an elastic strain characteristics capable of being displaced to a comparatively high extent under a gibed stress and restorable Fig 10 is a plan it showing the second e~bodioent of the guide wire 30 for a catheter accordions to the present in~eDtioD
Figs if through 13 are cross sectional issue taken the lines -through - in jig 10 Tube guide wire 30 includes an inner core 31 a coating portion 32, and is constituted by a body portion AYE and a distal end .
portion 308 ¦ Thea inner core 31 of the guide wire 30 is constituted by an inner core portion AYE on the body portion's side and an inset core portion 31B on the distal end potion's side, both of which are integrally formed through a tapered portion 31C The idler core 31 is generally formed of a super-elastic (pseudo-elastic) metallic Qenber sun as a Tin alloy of 49 58 atop X, a Cuisine alloy of 38 5 ¦ 41 5 it X, a Cu-Zn-X alloy of I 10 it OX Abe Six Sun, Al or Cowan Howe alloy of 36~ pa atop ZOO, or the like The coating portion 32 of tube guide wire 30 includes a coating portion AYE on the bong portions side and a coating portion 32B on tube distal end portion's side The coating portion 32 is spade of elicitor or a composite arterial of sgntbetic resin materials 12328~4 .

including polyethylene, pol~vinpl chloride, polyester, polypropylene polyamide, polyurethane, polystyrene, fluoride plastics and silicone rubber, or an elastoner or a composite material of the above-nentioDed plastics, to thereby iron a soft, sooth surface with DO
irregularities thereon ID addition, the coating portion 32 can obtain an anti-coagulating agent such as beparin and urokinase, or through coatin8-of an anti-thronbus material such as silicone rubber, a block coupler of urethane and silicone (I Avcothane ), a coupler of hydrosyeth~l nethacr~late-stllene and the like, add cad obtain Lou friction properties by use of resin having a Lou frictional surface such as flyer resin and through applying a -Lubricant such as silicone oil Further-ore, an Era contrast Audi cede of a single substance of petal such as Be, W, Bit Pub or the like, or a co-pound therebetueen is wised with a synthetic resin arterial forcing the coating portion 32, so that the position of the guide wire 30 in the blood vessel can be accturatel~
determined As for the body portion AYE of the guide wire 30, the outer diameter of the inter core potion AYE OX the body portion's side is determined to be 0 62 nun, the outer diameter of the coating portion AYE on the body portion's side 0 89 n, the length 130 an, the yield stress in a range between 10 and 80 Kin 2 (22 ) (Yield stress udder load A in jig 17), and tube restoring stress yield stress under no load 8 in jig 17) in a range between 0 and 60 Kg/nn 2 (22 Z5 ) In addition, the outer diameter of the inner core portion AYE
on the body portion's side determined to be in a range between 0 1 lZ3Z8~-~

and 1 9 go and perfereablY be id a range between 0 35 and 1 05 -Tube buckling strength is deteruiDed to be in a range between 10 and 80 Cowan (22 ) and the restoring stress Jo a range between 0 and 60 Kg/oo2 ~22 ) Additionally the outer diameter of the coating portion AYE OX the body portion s side is determined to be Jo a range butted 0 2 and 2 no and preferably be in range between 0 45 and 1 15-- The length of the body portion AYE pa preferab!g be determined to be in a range butted 10 and 300 an As for the distal end portion 30B of the guide wire 30 the outer diameter of the inter core portion 31B OX the distal end portion s side is detrained to be 0 2 no the outer diameter of the ... .... ..
coating portion 32B on the distal end portion s side 0 47 ox tube Edith in a range between 0 and 150 o- and preferably be Jo a range between 2 and 150 pa add ore preferably be 20 on the yield stress in a range between 10 and 80 Kg/o-2 (22 ) In addition toe outer diameter of the inner core portion 318 on the distal end portion s side is determined to be in a range between 0 05 and 1 5 ox and preferably be in a range between 0 1 and 0 5 ox the flyer load in a range between 0 1 and 10 8 and the restoring load in a range between 0 1 and 10 g ~uretheroore the outer diameter of the inner core portion ox the distal end portion s side as a whole need not necessarily be limited to the sbo~e-described dimensions but oat partially adopt suck dimensions ~urtber the restoring stresses of tube body portion and the distal end port on need not haze the values equal to each other but it is preferable that the restoring stresses okay be varied in accordance with conditions of tube heat .

` ~3Z8~4 treatment so as to obtain suitable properties by use of suitable diameters of the wire. In other words, it is preferable to separate the bowl portion and tube distal end portion id heat treatment, so that the restoring stress Jo tube body portion can be high in value and tube distal end portion flexible. when, the diameter of the wire of the inner core on the distal end portion's side is not cede too stall, so that the mechanical strength thereof can be i-proved.
~urther~ore, the outer diameter of the coating portion 328 is determined to be in a range between 0.07 and 2 on, and preferably be in a range between 0.12 and 1.10 09. The outer diameter of the forward end portion including the coating portion as a whole need not necessarily be limited to the above-described dioensioD, but, nag partially adopt suck dimension. Furthermore, the length of tube distal end portion 30B cay preferably be determined to be in a range lo between 1 and 50 I The outer diameter of the coating Portion nay preferably be equal to that of the body portion.
urtheroore, in general, tube coating portion 32 is closely fused to the inner core 31 through the above-described synthetic resin nabber, and a distal tip portion 33 and a rear end portion, i. e., a proudly end portion 36 are solidly secured to each other in the save wanner as described above. However, when the coating portion 32 is formed of a hollow tube, in addition to the specific for of closely coating, the guide wire 30 over tube total length, it is preferable that the guide wire 30 is affixed to the inner core 31 through bonding or fusing at the distal tip portion 33 and the prorinal end portion 36, or at a suitable position of the body ~Z3Z8~4 Jo portion of the guide wire 30. In ibis case, portions of the distal tip portion 33 and the proaloal end portion 36 or a portion at the - suitable position of the body portion are not substantially o'er the total length be bonded or tuxedo to the inner core 31,uhereby, when flexed, the guide wire 30 is not restrained by the inner core 31, freely table relative to the inner core 31, and particularly, fle3iblg deformable id the distal end portion 30B thereof. in addition, the coating portion according to tube present invention may be constructed such that a coating fin made of the above-described synthetic resin number is applied to the surface of tbeinner core 31. on this case also, it is preferable that the coating portion is not solidly secured to at least the inner core portion ' 31B on the distal end portion's side, so that the distal end portion buff the guide wire 30 Jay be fleaiblg deformed. The guide wire according to the preset in~eDtloD does not adopt a spring, here the four of fixing the coating portion to the inner core is not specified.
' The distal tip portion 33 of the distal end portion 30B of tube guide wire 30 is formed into an R-shape in order to prevent it from piercing the Hall of blood Bessel. Furthermore, the tapered portion 31C is progressively reduced in CrOSS-SeCtiOD froze the body portion AYE to~ard'the distal end portion 30B, Barb the rigidity in a connecting portion between the body portion AYE and the forward end portion 30~ is moderately varied, so that breakage and bending by of the guide wire 30 in this connecting portion can be prevented try occurring.

lX3Z~

In order to preqeDt the distal tip portion of the distal end portion 30B of the guide wire 30 from piercing tube Hall of blood Bessel, the shape of the distal tip portion need not necessarily be limited to the R-shape, but, jag be formed into a spherical shape designated by 34 on Fugue and a J-shape denoted by 35 Jo jig.
14~Bj .
As shown id Figs.15(Aj and 15(B3, the distal end portion 30B
of the guide wire 30 is curdle footed into a predetermined shape similar to the vascular system or vascular branching, so that the distal end portion can be reliably and readily inserted into a predeter~lned portion in the blood vessel.
The distal end portion 30B of the guide vine 30 cay be progressively reduced in dla~eter toward the distal tip portion '33, so that the distal end portion 30~ can be made Gore flexible.
The connecting portion between the body portion AYE an the distal end portion 308 of the guide vine '30 need not necessarily be formed into the tapered shape, but, such a cross-sectional shape nay be adopted that no considerable change in cross-sectloD occurs between the body Portion AYE and the distal end portloD 30B, or the connecting portion okay have an outer diameter intermediate in size between the body portion AYE and the distal end portion 308.
This Inner core need not necessarily be limited to the one towered by a single wire, but, a plurality of wires arranged in parallel to one another or twisted together okay be used, so that i I the abo~e-described function, 1. e., a gradual or progressl~e changeI in the physical properties okay be fulfilled.

;~32~14 ig.16 is a graphic chart in ffbich the flexor load (W)-displacement value Do characteristics ox a Tao alloy fording a cantilever beam coated by a coating ported jade of po!yethtlene of an outer diameter of 0.~9 ox and having an outer diameter of 0.62 on b an a length of 20 my is i3dlcated by solid lines, and the flyer load- displacement value characteristics of a stainless steel Nine forming a cantilever beta coated by a coating potion made of polyethylene of an outer dla~eter of 0.89 I and hazing an outer diameter of Moe and a length of 20 I is indicated by broken lines. ~ig.1'1 lo a graphic chart in vhlch the flyer load-displacement value characteristics of a Toni alloy forming a cantilever beam coated by a coating portion jade of polyethylene of an outer diameter of 0.42 on and having ad outer dla~eter of 0.15 em and a length of 20 mm is indicated by solid fines, and tube flyer load-dlsplaceoent value characteristics of a stainless steel wire forming a cantilever beam coated by a coating portion made of polyethylene of an outer dlaeeter of 0.42 En and hazing an outer diameter of 0.10 ox and a length ox 20 ma Is indicated by broken fines. In ~1gs.16 and I designated at Is a residual plastic strain value of the stainless steel wire. None specifically, according to ~lgs.16 and 1'1, the super-elastlc metallic eaber (It is high In restorable elastic strain, and (2j has the characteristics of that, even It tube strain Is increased, the load is not varied in 2b value. In consequence, the bong portion boa of the guide wire 30 is termed of the inner core portion VIA cane of a super-elastic Metallic member having the tle~ure load-dlsplaceaent~alue characteristics 1~3~81~

I

substantially swallower to that indicated by the solid lines in ~ig.16 and tube coaling portion AYE jade of the synthetic resin material, ~berebg the body portion AYE is provided with the elastic strain characteristics bullying a coaparatl~elg huh buckling strength.
~urther~ore, the distal end portion JOB of the guide vine 30 is formed of the inner core portion 31~ spade of the super-elastic metallic nabber hulling the flogger load-displace-eDt value characteristics substaintlallg equal to that indicated by the solid `
lines in ~i8.17 and the coating portion 32B nude of the ssDthetic resin material, uherebg the distal end portion 30B is provided with an elastic strain characteristics capable of being displaced to a cooparati~elg high extent under a glen stress and restorable. I-ig.18 is a graphic chart in which the flegural rigidltg(B~-maxinus outer diameter iGj characteristics of the guide wire, tube Inner core portion of which is formed of the super-elastic metallic member and coated by the coating portion jade of the plastics, IS indicated by solid lines, and the flegural riglditg-na~iaum outer diameter characteristics of a guide wire formed of only tube super-elastlc metallic enter is indicated by broken lines.
According to this ~ig.18, in the guide wire towered of only the super-elastic metallic nabber, the range of the Moe outer diameter go) satisfying the deterulned flyer rlglditg(BI ~2j Is stall. in contrast thereto, when the inner core 31 is coated by the coating portion 32 as in the aforesaid guide wire 80, the range of the ~agi~um outer diameter ( g2j satisfying the detrained floral uralrigidltg Is enlarged to a Wright egt2nt. and it is recognized that, ~23'~ 814 I

when the Inner diameter of the catheter to be guided becomes large, the body portion AYE Jay be forced to hare an outer dla-eter substantially equal to the inner dentate of the catheter, it the flerural rigidity being bold within a predeter-iDed ridge Description ~11 hereunder be given of operation of the second eDbOdiDellt.
rho guide lye 30 is of various shapes desirably photoed neat the distal end portions of the catheters 20 as shown Jo Fig lye A
curved portion thereof, for e~anple, is straightened add inserted into the bong portion AYE coDparativelg high Jo fig jditJ, SO that the catheter 20 can be soothly advanced in the blood vessel 21 ~`urtheraore, the guide wire 30 causes the distal end portion 30B
thereof to proceed ahead of the distal end portion of the catheter Z0, so that the distal end portion 30B can guide tube distal end portion of the catheter to a predeter~lned position 22 Jo the blood vessel Here, since the inner core 31 of the guide wire 30 is coated by the coaling portion 32, the dlaneter of the lnnet core 31 nag be ode stall even when the catheter to be guided is large in its '10 diameter, and theta sag be obtained an outset dentate of the inner core I cotrespondlng to the inner dla-eter of the catheter to be guided, with the tlesural rlgidits being held`~ithln a predetermined range, so that the catheter can natutallg and soothly dilate the sold and the Hall of blood vessel US In the guide wire 30 the Inner core portion 31~ on tube distal end portion's side and the coaling portion 32B on the distal end ~32~1 4 I

portion's side are jade scalier in cross-sectioD than the inner core portion AYE on the body portliness side and the coating portion AYE
on the bong portion's side, respectively, uhereb~ the distal end portion 30B is nude staller in cross-section than the bong portion AYE, so that the body portion AYE pa be provided ulth the elastic strand characteristics hazing a co~paratiYel~ b18h buckling strength and the distal end portion 30B Jay be provided it the elastic strain characteristics capable of being displaced to a conparati~el~ large extent under a given stress and restorable.
More specifically, the body portion AYE of the guide wire 30 is provided with the elastic strain characteristics hazing a compaTati~elg big bucking strength. In consequence, even if a floral deformation of a conparati~ely high value is caused to the body portion AYE when the guide Roy IS inserted into the catheter It and the blood Bessel, the guide eye 30 does not reach the plastic deforaatioD region and is not subjected to buckling, so that tube buckling list of the body portion AYE can be ispro~ed. Gore specifically, oven of a deformation of a high value is caused to the body portion AYE by the manual operation applied to the guide vine 30, a portion subjected to this deformation can be readily straightened again, so that no resistance is caused to the advance of the catheter. ~urtheroore, Ben the catheter prodded at the distal end thereof with the curved portion Is crounedl~ coupled bile being stralghtend , nun resistance of a considerable value 2b occurs between the catheter and the body portion AYE, so that the catheter cad soothly advance.

123;~8~4 I

urther~ore, tube guide Nine 30 is provided at the distal end portion 30B thereof Nit an elastic strain characteristics capable of being displaced to 2 conparati~elg high extent under a given stress add restorable. ID consequence Nil to tube distal end portion 30B goes through a bent portion of the blood Bessel, a floral diforoation Ott a high value can be obtained under a load of a coDparati~elg lo value, a curved deformation and Its restoration are repeated, here tube accoanodiation in shape of tube guide wire 30 to the ceaDdering blood Bessel is i0pro7ed and the guide wire 30 can be conparati~ely easing curved according to a vascular branching, so that the guide Nine 30 can be soothly advanced to a predetermined position in the blood Bessel. AdditioDalll, When tube -catheter Is inserted to a predetermined position Jo the blood Bessel, the guide Nine 30 is provided at the distal end portion 30B
thereof Nit a rebound enough to generate a resistance against the wall of blood Bessel, Which is required for retching the guide wire at the predetermined position against the flyer stress of the catheter. As the result, the distal end portion 30B is not drawn out of the Predeteralned position in the blood Bessel and the I catheter is sultabll retained. Zen if the distal end portion 30B, Shea has been prosily cursedly dehorned, is straightenedly deformed Nubile passing through the introducing needle, tube distal end portion 30B is restored to the perfect curved shape, when inserted into the blood Jesse! thereafter, so that the original I function can be fully satristied. The guide wire 30 has no Irre8UIar;tleS OX the surface thereof, differing fro- the :~L2;~Z~4 coneentiDnal coil-shaped guide wire, whereby the guide wire 30 satisfactorily acts on the blood coagulation and the tensile strength is high as cnnpared it the plastic guide wire, to thereby be safer than the latter he guide wire 30 is satisfactory Jo the torque transmission performance it either one of torsional directions differing from the conventional coll-shaped guide wire A torque applied to tube body portion AYE wakes it possible to reliably and readily direct the distal end portion 30B toward a predetermined position Jo the 13 blood Bessel, so that controllability Jo iDsertiDg the distal end portion BOB to a position in a complicated vascular Steinway can be mpro~ed.
ID addition, in the above e~bodi~ent, description has been glen of the guide wire 30, Jo which both the body portion AYE and IS the distal end portion 30B are formed of the super-elastic metallic member Herr, according to the present invention, only the body portion of the guide wire sag be formed of the super-elastic metallic number, and further, provided with an elastic strain characteristics having a buckling strength of a coaparati~elY high value Or, only the distal end portion of the guide wire is formed of the super-elastic metallic eyebrow, and further, provided with an elastic strain characteristics capable of being displaced to a comparatively high extent under a given stress and restorable As described above, according to the present invention, Jo tube I guide wire ion the catheter, hazing the body portion comparatively high on rlglditY and the distal end portion comparatively flexible, ~3X8~

at least portions of the body portion and the distal end portion are formed of the super-elastic metallic Myra. In consequence, the catheter can be reliably and readily ~ntrDduced to a predetermined position.
According to the present invention, the body portion is formed of the super-elastic metallic member, so that the body portion can be provided with the elastic strain characteristics hazing the Yield stress comparatively high in value According to the present invention, the distal end portion is formed of the super-elastic metallic member, so that the distal end portion can be provided with the elastic strain characteristics capable of being displaced to a co~paTati~ely high extent under a inn stress and restorable.
According to the present invention, both the body portion and the distal end portion are formed of the super-elastic metallic member, so that the body portion can be provided with the elastic strain characteristics having a comparatively high yield stress and the distal end portion can be provided with the elastic strain characteristics capable of being displaced to a comparatively high extent under a given stress and restorable.
According to the present invention, the distal end portion is made staller in cross-section than the body portion, and a portion between the body portion and at least a Portion of the distal end portion is progressively reduced in cross-section frond the body portion toward the distal end portion, whereby a change in rigidity in a connecting portion between the body portion and the distal end ~232814 .

portion is made moderate, so that breakage and bending of the guide wire in the connecting portion can be prevented from occurring.
According to the present in~eDtion~ Jo the guide wire for the catheter, wherein the inner core is constituted by the inner core portion on top body portion's side and the inner core portion on the distal end portion's side inner core as a whole is coated by the coating portion made of the plastics, and the guide wire has the bong portion comparatively high in rigidity and the distal end portion comparatively flexible, at least portion of the inner core Portion on the bong portion's side and the inner core portion on the distal end portion's side are formed of the super- elastic Metallic member, and at least a portion of the inner core portion on the distal end portion's side is jade staller in cross-section than the inner core portion on the body portion's side. In consequence, the It catheter can be reliably and reading introduced to a predetermined position.
According to the present invention, the outer diameter of at least a portion of the distal end portion including the coating portion is made smaller in cross-section than that of the body Portion, so that the catheter can be reliably and readily introduced to a predetermined position.
According tooth present invention. the outer diameters of the coating portion at the distal end portion and the body portion are made equal to each other, so that blood can be prevented from leaking out when the introducing needle is inserted, and the catheter can naturally and smoothly expand the Hall of skin and the 123X~14 wall of blood Bessel.
According to the present invention, the inner core portion on the body portion s side is formed of the super-elastic metallic member, so that the body portion can be provided with the elastic strain characteristics hazing the bulling strength comparatively high in value.
According to the present Invention, the inner core portion on the distal end portion s side is formed of the super-elastic metallic member, so that the distal end portion can be provided with the elastic strain characteristics capable of being displaced to a comparati~elg high extent under a given stress and restorable.
According to the present in~entioD, both tube inner core portion on the body portion s side and the inner core potion on the distal end portion s side are formed of the super-elastic metallic 16 member, so that the body portion can be provided with the elastic strain characteristics hazing the buckling strength co-paratiYely high in value and the distal end portion can be provided with the elastic strain characteristics capable of being displaced to a comparatively high extent under a given stress and restorable.
According to the present invention, at least a Portion between the inner core portion on the body portion s side and the inner core portion on the distal end portion s side is progressively reduced in Cross-sectiOD from the body portion toward the distal end portion, whereby rigidity in a connecting portion between the body portion and the distal end Portion is varied moderately, so that breakage and bending of the guide wire in the connecting portion can ~232814 be prevented from occurring.
According to the present invention, the coated portion is formed into the hollow pipe, so that the distal end portion can secure a high flexibility.
According to the present invention, the coating portion is formed of a coating film. so that the coating portion can be readily formed on the outer surface of the inner cove.

Claims (14)

THE EMBODIMENTS OF THE INVENTION IN WHICH AN EXCLUSIVE
PROPERTY OR PRIVILEGE IS CLAIMED ARE DEFINED AS FOLLOWS:
1. A guide wire for a catheter comprising a body portion comparatively high in rigidity and a distal end portion comparatively flexible, wherein at least portions of said body portion and said distal end portion are formed of a super-elastic metallic member.
2. The guide wire for a catheter as set forth in claim 1 wherein at least a portion of said distal end portion is made smaller in cross-section than said body portion, and a portion between said body portion and said distal end portion is progressively reduced in cross-section from said body portion toward said distal end portion.
3. The guide wire for a catheter as set forth in claim 1, wherein said body portion is formed of the super-elastic metallic member.
4. The guide wire for a catheter as set forth in claim 1 or claim 2 wherein said distal end portion is formed of the super-elastic metallic member.
5. The guide wire for a catheter as set forth in claim 1 or claim 2 wherein both the body portion and the distal end portion are formed of the super-elastic metallic member.
6. A guide wire for a catheter, wherein an inner core is constituted by an inner core portion on a body portion's side and an inner core portion on a distal end portion's side, said inner core as a whole is coated by a coating portion made of a plastic and said guide wire comprises said body portion com-paratively high in rigidity and said distal end portion comparatively flexible, characterized in that at least portions of said inner core portions on the body portion's side and on the distal end portion's side are formed of a super-elastic metallic member and at least a portion of said inner core portion on the distal end portion's side is made smaller in cross-section than said inner core portion on the body portion's side.
7. The guide wire for a catheter as set forth in claim 6 wherein a portion between the inner core portion on the body portion's side and the inner core portion on the distal end portion's side is progressively reduced in cross-section from the body portion toward the distal end portion.
8. The guide wire for a catheter as set forth in claim 6 or claim 7 wherein at least a portion of said distal end portion is smaller in cross-section than said body portion.
9. The guide wire for a catheter as set forth in claim 6 or claim 7, wherein said coating portion has substantially equal outer diameters at the distal end portion and at the body portion.
10. The guide wire for a catheter as set forth in claim 6 or claim 7 wherein said inner core portion on the body portion's side is formed of the super-elastic metallic member.
11. The guide wire for a catheter as set forth in claim 6 or claim 7 wherein said inner core portion on the distal end portion's side is formed of the super-elastic metallic member.
12. The guide wire for a catheter as set forth in claim 6 or claim 7 wherein both the inner core portions on the body portion's side and on the distal end portion's side are formed of the super-elastic metallic member.
13. The guide wire for a catheter as set forth in claim 6 or claim 7, wherein said coating portion is formed of a hollow pipe.
14. The guide wire for a catheter as set forth in claim 6 or claim 7, wherein said coating portion is formed of a coating film.
CA000439266A 1983-09-16 1983-10-19 Guide wire for catheter Expired CA1232814A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP58-169468 1983-09-16
JP58169467A JPS6063065A (en) 1983-09-16 1983-09-16 Guide wire for catheter
JP58-169467 1983-09-16
JP58169468A JPS6063066A (en) 1983-09-16 1983-09-16 Guide wire for catheter

Publications (1)

Publication Number Publication Date
CA1232814A true CA1232814A (en) 1988-02-16

Family

ID=26492793

Family Applications (1)

Application Number Title Priority Date Filing Date
CA000439266A Expired CA1232814A (en) 1983-09-16 1983-10-19 Guide wire for catheter

Country Status (5)

Country Link
US (1) US4925445A (en)
EP (1) EP0141006B2 (en)
AU (1) AU562843B2 (en)
CA (1) CA1232814A (en)
DE (1) DE3477737D1 (en)

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US4925445A (en) 1990-05-15
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EP0141006B1 (en) 1989-04-19
AU3249884A (en) 1985-03-21

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