CA1180365A - Mammalian subject heating unit using radiant heat - Google Patents
Mammalian subject heating unit using radiant heatInfo
- Publication number
- CA1180365A CA1180365A CA000405751A CA405751A CA1180365A CA 1180365 A CA1180365 A CA 1180365A CA 000405751 A CA000405751 A CA 000405751A CA 405751 A CA405751 A CA 405751A CA 1180365 A CA1180365 A CA 1180365A
- Authority
- CA
- Canada
- Prior art keywords
- wall member
- subject
- temperature
- electric heating
- cavity
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000010438 heat treatment Methods 0.000 title claims abstract description 30
- 238000005485 electric heating Methods 0.000 claims abstract description 21
- 230000002977 hyperthermial effect Effects 0.000 claims description 15
- 206010020843 Hyperthermia Diseases 0.000 claims description 6
- 230000036031 hyperthermia Effects 0.000 claims description 6
- 239000000463 material Substances 0.000 claims description 4
- 238000009413 insulation Methods 0.000 claims description 3
- 230000002708 enhancing effect Effects 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 abstract description 6
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- 241001465754 Metazoa Species 0.000 description 8
- 229910052802 copper Inorganic materials 0.000 description 7
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 6
- 239000004020 conductor Substances 0.000 description 6
- 239000010949 copper Substances 0.000 description 6
- 238000000034 method Methods 0.000 description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
- 238000001816 cooling Methods 0.000 description 3
- 239000012530 fluid Substances 0.000 description 3
- 239000002184 metal Substances 0.000 description 3
- 229910052751 metal Inorganic materials 0.000 description 3
- 239000000523 sample Substances 0.000 description 3
- PXHVJJICTQNCMI-UHFFFAOYSA-N Nickel Chemical compound [Ni] PXHVJJICTQNCMI-UHFFFAOYSA-N 0.000 description 2
- 238000013459 approach Methods 0.000 description 2
- 230000033228 biological regulation Effects 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
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- 238000002695 general anesthesia Methods 0.000 description 2
- 230000002503 metabolic effect Effects 0.000 description 2
- 230000005855 radiation Effects 0.000 description 2
- 238000007789 sealing Methods 0.000 description 2
- 231100000075 skin burn Toxicity 0.000 description 2
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- 241000512668 Eunectes Species 0.000 description 1
- 206010037660 Pyrexia Diseases 0.000 description 1
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- 208000028990 Skin injury Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 230000003466 anti-cipated effect Effects 0.000 description 1
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- 230000036760 body temperature Effects 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
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- 229940000425 combination drug Drugs 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
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- 238000003780 insertion Methods 0.000 description 1
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- 210000004185 liver Anatomy 0.000 description 1
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- 229910052759 nickel Inorganic materials 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
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- 230000000241 respiratory effect Effects 0.000 description 1
- 230000029058 respiratory gaseous exchange Effects 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
Abstract
Mammalian Subject Heating Unit Using Radiant Heat Abstract of the Disclosure A heating unit using radiant heat provides core temperature increases in mammalian subjects, including humans, for cancer treatment or other purposes. The unit has a wall member defining a cavity for receiving the subject. An electric heating cable is placed on the exterior of the wall means for heating the wall means and radiating heat to the subject. A circuit is connectable to a source of electric power for energizing and controlling the heating cables.
Description
Mammalian Subject Heating Unit Usiny Radiant Heat The present invention relates to a heating unit ~or live mammalian subjects, including humans.
The uni-t employs radiant heat to increase internal temperatures, including increases to elevated levels considered to have a therapeutic effect on cancer.
Cancer is currently treated by surgery, radiation, chemotherapy, immunotherapy, or combina-tions of the foregoing. However, there is an in-creasing recogni-tion that hyperthermia - a condition of greatly elevated body t~mperature - may provide significant therapeutic effects on cancer, including that not responsive or amenable to conventional ireatment. Hyperthermic treatment of cancer involves raising the temperature of the pa-tient to 41.8-42C
~approximately 107F) and maintaining that temperature for a predetermined period of time. The entire body of the patient is usually heated so that the technique has become known as "whole body hyperthermia." Hyper-thermia is typically used in combination with other treatment such as chermotherapy or radiation.
To date, a variety of techniques have been uxed to produce the hyperthermic condition. These techniques include immersing the patient in hot wax;
placing the patient in a suit or under a blanket con-taining ducts for heated fluid; withdrawing blood from the body, heating it, and returning it to the body;
diathermy in which an R-F coupling is established between the body and a high frequency energy source;
and applying ultrasonic energy to the patient. How-ever, such approaches exhibit one or more limitations or shortcomings. These include the need for general - anesthesia with the attendant medical risk, the need for specialized personnel and/or facilities, the danger of burns to the patient due to heat concen-tration or hot spots in the equipment, the possi-bility of blood damage to the patient, extensive and complex temperature moni-toring and regulation appara-tus, prolonged heating times, and cumbersomeness of the equipment.
Further, inasmuch as hyperthermia is carried out a-t temperatures only slightly below those that can cause death, the operating characteristics o~ the apparatus used to establish and maintain the hyperthermic condition can be extremely critical.
I-t is, therefore, -the object of the present invention to a~oid the shortcomings of -the above techniques and provide improved apparatus for effec-tively and accurately raising the internal or core temperature of live animals, particularly mammalian subjects including humans, to a desired level with a commensurate degree of safety.
By contras-t to the approaches hereto~ore taken, the apparatus of the present invention utilizes radiant heat. Briefly, the present invention con-templates apparatus having a wall member defining a cavity appropriate for receiving the subject. A
stretcher or other means is provided by which the subject may be positioned in the cavity. An electric heating cable on the exterior of the wall member heats the member in a highly uniform manner and efficiently and effectively radiates heat to the subject. Elec-tric circuitry is connectable to a source of electric power for en~rgizing and controlling the electric heati~g cable.
The ~all member is typically a cylindrical copper sheet closed at one end and containing sealing doors at the other, through which the body of the patient is received in the caYity. ~he electric heating cable i5 applied in a uniform pattern over the cylindrical sheet and covered with insulation.
The cable is preferably a plurality oE segments energized in parallel to provide low density, uniform radiant heat sufEicient to raise the core temperature to the desired level during an appropriate time period while avoiding burns or other skin injury, as from localized hot spots.
The apparatus provides close control of temperature and a high degree of repeatability.
Temperature sensors are included in the circuitry :Eor controlling the energi~ation of the electric heating cable responsive to wall member temperature and to desired and maximum permissible temperatures in the chamber.
The present invention is low in cost with respect to both apparatus costs and treatment costs.
It is anticipated that the present invention will permit elimination of general anesthesia to the patient. This will reduce the attendant require-men-ts for highly specialized personnel and facilities ana permit carrying out hyperthermic treatment with a smaller number of people trained in hyperthermia.
While the present invention is described herein in the context of hyperthermic treatment o-E
cancer it will be appreciated that other applications may well arise. For example, the apparatus may be used to treat victims of exposure by safely restor-ing their depressed body temperatures to the normal level. The possibility of its use in the treatment of diseases of the joints also comes to mind.
In the drawings:
Fig. 1 is a perspective view of the radiant heat body heating unit of the present invention.
Fig. 2 is a fragmentary perspective view o~
the unit showing additional details thereof.
Fig. 3 is a partially cut-away perspecti~e view of the unit.
Fig. 4 is a cross-sec-tional view taken along the line 4-~ of Fig. 1.
Fig. 5 is a cut-away view of an electric heating coil suitable for use in the present invention.
Fig. 6 is a schematic diagram showing circuitry for energizing the electric he~ting cable.
Fig. 1 shows apparatus 10 of the present invention for raising the internal or core tempera-ture of live animals, particularly mammalian subjects, including humans. Apparatus 10 includes housing 12 mounted on framework 14, shown most clearly in Figs.
3 and 4. Framework 14 includes`coasters 16 lending mobility to the unit.
Wall member 18 is supported by framewor~
14. As shown most clearly in Fig. 3, wall member 18 includes wall 20 sealed by disc 22 at one end to form a tubular chamber 24 in which the subject or a selec-ted portion of the subjec-t, such as his/her body is received, as hereinafter described. The cylindrical configuration of wall 20 assists in even heat distri-
The uni-t employs radiant heat to increase internal temperatures, including increases to elevated levels considered to have a therapeutic effect on cancer.
Cancer is currently treated by surgery, radiation, chemotherapy, immunotherapy, or combina-tions of the foregoing. However, there is an in-creasing recogni-tion that hyperthermia - a condition of greatly elevated body t~mperature - may provide significant therapeutic effects on cancer, including that not responsive or amenable to conventional ireatment. Hyperthermic treatment of cancer involves raising the temperature of the pa-tient to 41.8-42C
~approximately 107F) and maintaining that temperature for a predetermined period of time. The entire body of the patient is usually heated so that the technique has become known as "whole body hyperthermia." Hyper-thermia is typically used in combination with other treatment such as chermotherapy or radiation.
To date, a variety of techniques have been uxed to produce the hyperthermic condition. These techniques include immersing the patient in hot wax;
placing the patient in a suit or under a blanket con-taining ducts for heated fluid; withdrawing blood from the body, heating it, and returning it to the body;
diathermy in which an R-F coupling is established between the body and a high frequency energy source;
and applying ultrasonic energy to the patient. How-ever, such approaches exhibit one or more limitations or shortcomings. These include the need for general - anesthesia with the attendant medical risk, the need for specialized personnel and/or facilities, the danger of burns to the patient due to heat concen-tration or hot spots in the equipment, the possi-bility of blood damage to the patient, extensive and complex temperature moni-toring and regulation appara-tus, prolonged heating times, and cumbersomeness of the equipment.
Further, inasmuch as hyperthermia is carried out a-t temperatures only slightly below those that can cause death, the operating characteristics o~ the apparatus used to establish and maintain the hyperthermic condition can be extremely critical.
I-t is, therefore, -the object of the present invention to a~oid the shortcomings of -the above techniques and provide improved apparatus for effec-tively and accurately raising the internal or core temperature of live animals, particularly mammalian subjects including humans, to a desired level with a commensurate degree of safety.
By contras-t to the approaches hereto~ore taken, the apparatus of the present invention utilizes radiant heat. Briefly, the present invention con-templates apparatus having a wall member defining a cavity appropriate for receiving the subject. A
stretcher or other means is provided by which the subject may be positioned in the cavity. An electric heating cable on the exterior of the wall member heats the member in a highly uniform manner and efficiently and effectively radiates heat to the subject. Elec-tric circuitry is connectable to a source of electric power for en~rgizing and controlling the electric heati~g cable.
The ~all member is typically a cylindrical copper sheet closed at one end and containing sealing doors at the other, through which the body of the patient is received in the caYity. ~he electric heating cable i5 applied in a uniform pattern over the cylindrical sheet and covered with insulation.
The cable is preferably a plurality oE segments energized in parallel to provide low density, uniform radiant heat sufEicient to raise the core temperature to the desired level during an appropriate time period while avoiding burns or other skin injury, as from localized hot spots.
The apparatus provides close control of temperature and a high degree of repeatability.
Temperature sensors are included in the circuitry :Eor controlling the energi~ation of the electric heating cable responsive to wall member temperature and to desired and maximum permissible temperatures in the chamber.
The present invention is low in cost with respect to both apparatus costs and treatment costs.
It is anticipated that the present invention will permit elimination of general anesthesia to the patient. This will reduce the attendant require-men-ts for highly specialized personnel and facilities ana permit carrying out hyperthermic treatment with a smaller number of people trained in hyperthermia.
While the present invention is described herein in the context of hyperthermic treatment o-E
cancer it will be appreciated that other applications may well arise. For example, the apparatus may be used to treat victims of exposure by safely restor-ing their depressed body temperatures to the normal level. The possibility of its use in the treatment of diseases of the joints also comes to mind.
In the drawings:
Fig. 1 is a perspective view of the radiant heat body heating unit of the present invention.
Fig. 2 is a fragmentary perspective view o~
the unit showing additional details thereof.
Fig. 3 is a partially cut-away perspecti~e view of the unit.
Fig. 4 is a cross-sec-tional view taken along the line 4-~ of Fig. 1.
Fig. 5 is a cut-away view of an electric heating coil suitable for use in the present invention.
Fig. 6 is a schematic diagram showing circuitry for energizing the electric he~ting cable.
Fig. 1 shows apparatus 10 of the present invention for raising the internal or core tempera-ture of live animals, particularly mammalian subjects, including humans. Apparatus 10 includes housing 12 mounted on framework 14, shown most clearly in Figs.
3 and 4. Framework 14 includes`coasters 16 lending mobility to the unit.
Wall member 18 is supported by framewor~
14. As shown most clearly in Fig. 3, wall member 18 includes wall 20 sealed by disc 22 at one end to form a tubular chamber 24 in which the subject or a selec-ted portion of the subjec-t, such as his/her body is received, as hereinafter described. The cylindrical configuration of wall 20 assists in even heat distri-
2~ bution in chamber 24. Wall member 18 is preferably formed from sheet copper material so that the member has an emissivity that enhances its effectiveness as a radiator. Copper is a good uniform conductor of heat helping to avoid localized hot spots and skin burns to the subject. Copper also has good heat retention properties providing consistent temperatures by avoiding sudden temperature changes.
Rails 26 are positioned on wall member 18 for receiving carriage 28 for stretcher 30 on which the --sub~ect is placed. Rails 26 may be mounted on bands 27 that extend around the interior of wall 20 in the middle and rear of chamber 24, as shown in Fig. 3.
Bands 27 may be expanded by toggle mechanisms, not shown to clamp the bands, and hence rails 26, to wall 20. The use of bands 27 avoids the need to punc-ture wall 20 and the need for seals and the like to maintain the integrity o~ chamber 24. The cleaniny of chamber 24 is also facilltated since bands 27 and rails 26 can be removed from chamber 24.
Carriage 28 includes head rest 32 for the ;~ suhject, a panel 22,that assists in closing chamber 24, and a handle 34 by which the carriage, stretcher, and subject are moved into and out of chamber 24.
The open end of wall member 18 is closed by a pair of insulated doors 36 and 38 orming open-ing 40 through which the neck of the patient extends so that his/her head can rest on head rest 32.
Doors 36 and 38 are shaped as an inverted L and have retaining means such as channel 42 for receiving a sealiny collar that goes around the neck of the patient to seal opening 40. The doors are sealed at the bottom by head rest 32. Doors 36 and 38 are provided with hinges 44 and 46 along outer edges and held closed by magnetic latches 48 and 50 at their inner edges. Doors 36 and 38 and head res-t panel 33 may be provided with gaskets tha-t seal these elements to wall member 18 or housing 12 when they are closed.
Because the head rest 32 is coupled to stretcher 30 and because L-shaped doors open in the center, the insertion and, particularly, removal of the subject and associated medical equipment and instrumentation from chamber 24 is facilitated. In emergencies with humans, the patient can be removed from chamber 24 by pulling handle 34 outwardly and allowing the patient's shoulders to swing open doors 36 and 38.
Housing 12 includes control panel 52 for - 35 the electrical circuitry shown in Fig. 6.
Means are provided on wall member 18 to heat the wall member and chamber 24. As shown in the Figures, such means may comprise electric heating cable 54 wrapped about the exterior of wall 20 so that the wall member can assist in diEfusing -the heat from the cable. The cable may be wrapped cir-cumferentially, as shown in Fig. 3 and the turnsspaced along the periphery of the wall member to pro-vide uniform heating to the wall member to avoid establishing localized hot spots on wall member 18 The turns of cable 54 will typically be uniformly spaced along wall 20, possibly with minor variations because of frame 14 or other localized anomalies.
A retaining or spacer means, not shown, may be pro-vided to hold cable 54 in position on wall 20.
Cable 54 is available from several sources including the Continantal Wire and Cable division of Anaconda Copper Co. and the Wire and Cable Division of the General Electric Company. As shown in Fig. 5, cable 54 may comprise an internal metal resistance wire 56; an asbestos, plastic, or rubber sheath 58 surrounding and insulating the wire; and an outer braided metal jacket 60 for armoring and electrically grounding the cable. Electric resistance wire 56 may be a single conductor of 19 or 20 gauge having a resistance of approximately 675 ohms per circular mil foot at 20C. The conductor is surrounded by .045 inch thick silicon rubber sheath 58 and a nickel plated copper shield braid.
The heating of wall member 18 by the heating means, such as cable 54, is subject to two, somewhat divergent, considerations. A sufficient quantity of radiant heat must be provided from wall member 18 to raise the core temperature of the subject in chamber 24 by a physiologically significant amount in a desired period of time. The physiologically significant temperature increase may be that necessary to cause the subject to enter the hyperthermic state.
In accordance with this consideration, cable 54 may provide a heat input suf~icien-t -to raise the core temperature of the subject a-t least 4C within a period of 120 minutes by the radiant heat in chamber 24. More particularly the apparatus should be capable o~ raising the core temperature oE the subject 4 to 5C in a period of 60 to 120 minutes.
At the same time, however, the density of heating, or heat output per unit area of wall member ln 18, shoula be sufficiently uniform and low as to minimize the possibility of superfieial injury to the subject, such as burnsr ~rom wall temperature eonditions, and particularly from localized hot spots in the wall membèr.
The weight of the subjeet may serve as a aetor in the seleetion of the heat input from the eleetric heating means. For heating animal subjects baving a weight of 70 kg (154 lks) in an appropriately sized ehamber 24, an eleetric heating cable having a power rating of about 1,000 watts has been employed.
As shown most clearly in Fig. 4, tubular wall member 18 and cable 54 are surrounded by an insulating material 64 such as glass fiber insula-tion, that is held on tubular member 18 by wrapper 66 formed of metal or other material.
Electrical cireuitry for energizing heating eable 54 is shown in Fig. 6. Heating eable 54 is pre-ferably divided into a plurality of segments conneeted in parallel to insure even heating throughout tubular ehamber 24. This may be accomplished by the appro-priate electrical connection of taps along the heating eable~ Fig. 6 shows, for exemplary purposes, heating eable 54 divided into four quarter segments 54a, 54b, 54e, and 54d.
1 3~
Circuitry 70 is connec-table to an a.c. power source 72, such as conventional 120 volt, 60 cycle al-texnating current supply 72 having energized line 74 and neutral line 76. Conduc-tors 7~ and 80 of circuitry 70 are connected to lines 74 and 76 and contain ground fault interrupter 82 requiring manual rese-t. Ground fault interrupter 82 deenergizes circuitry 70 in the e~ent of an electrical failure -to lessen or a~oid shock hazards in apparatus 10. Conductor 78 contains power switch 84 and relay contacts 86a, which when closed, permit parallel energization of heating cable segments 54a through 54d through conductor ~0.
Indicator lamp 88 is connected across lines 78 and 80 to indicate when main power switch ~4 is - L5 closed.
A plurality o~ elements are also connected across lines 78 and 80 to control the operation o~
electric heating cable 54. These include timer 90 by which the time period for energizing cable 54 may be established. Thermostat q2, which may be of the normally closed, bimetallic type is placed on wall 20 of wall member 18 to sense the temperature of the wall for deener~izing electric cable 54 in the event the temperature rises above a desired maximum value.
Typically thermostat 92 will be set to open at 60C (140F) and reclose at 5aC (130F) and is preferably not operator accessible or adjustable.
~imiting the wall temperature to this magnitude lessens or avoids the danger of skin burns from apparatus 10. Thermostat 94 may be mounted in tubu-lar cha~ber 24 at a location appropriate to sense the temperature inside the chamber. Thermostat 94 may be o~ the normally closed, fluid expansion type.
It is not operator adjustable but is preset to open at the maximum temperature desired in the chamber.
This is typically 70C (160F). The thermostat will ~ 3~J~
_g_ close at 68C (155F) and below. Thermos-tat 96 is also placed in t~lbular chamber 24 at a location to sense the temperature in the chamber. Thermostat 96 may also be of the normally closed, ~luid expansion type and is adjustable by the operator to establish a selected temperature in the chamber less -than the maximum temperature established by thermosta-t 94.
The coil 86b of relay 86 is connected in series with timer 90 and thermostats 92, 94, and 96 across lines 78 and 80. Coil 86b operates contacts 86a in line 78.
Indicator lamp 98 indicates when relay contacts are closed and heating cable 54 is energized.
In ~se, the patient may be prepared for hyperthermic treatment in apparatus 10 by light sedation. The temperature indicators necessary to monitor internal temperature will be placed in the patient, as for example, through the use of rectal, esophageal, and/or cardiac probes. Sensors ~or other physiological functions, such as respiration and heart beat rate, are also applied to the patient.
The patient will be placed on stretcher 30 with his/her head resting on headrest 32. The patient is slid into tubular chamber 24 on stretcher 30 with his/her head outside chamber 24. Doors 36 and 38 are closed and a collar placed around the neck OI the patient to tightly seal opening 40 making chamber 24 a closed system. Timer 90 is set for the maximum treatment time. Thermostat 96 is set for the maximum temperature desired in chamber 24. Power switch 84 is closed to energize heating cable 54. The contacts of timer 90, and thermostats 92, 94, and 96 are closed, energizing relay coil 86b of relay 86 and closing relay contacts 86a. This permits energization of electric cable 54. The energization of cable 56 heat copper wall member 18 radiating heat to the patient on the stretcher. The internal or core temperature of the patient is moni-tored through the temperature probes. The temperatures o~tained from the rectal tempera-ture probe are typi-cally considered the core temperature of the patient~or treatment purposes. The sealing of opening ~0 by the collar causes the perspiration of the patient to maintain a condition o~ saturation or near satura-tion in chamber 24 limiting patient heat loss by evaporation. Fluids lost through perspiration are restored intravenously. As the temperature of the patient increases, his/her metabolic heat generation increases substantially to supplement the radian-t heat from wall member 18 in attaining the hyperthermic state.
When the desired core temperature is reached in the patient, the patient may be removed from tubular chamber 24 and covered with a blanket to minimize evaporative heat losses. Through the loss of -thermo-regulatory capability brought about by the hyperthermiccondition, the desired internal temperature of the patient is maintained by the heat generated by in-creased metabolic activity withou-t the need for ex-ternal heat application. When the patient has re-mained in the hyperthermic condition for the desiredperiod of time, the blanket is removed to allow cooling by evaporation and the restoration of normal temperature regulation. Should the patient require additional cooling to terminate the hyperthermic condition, this may be achieved by a cooling blan~et or an alcohol sponge bath~
A typical test of apparatus 10, utilized a 70 kg (15~ lb) pig as an animal subject. Such an animal subject resembles a human in body weight, fat distribution ancl in cardic, liver and respiratory ~ .a~ t~
physi.ology. It~ however, does not perspire. The animal, appropriately instrumen-ted, was placed in apparatus 10 and heating cable 54 energized. The internal or core temperature of the animal, measured rectally, was raised to 41.8C in about 80 minutes.
Skin temperature rose to 42.5C. Air temperature near the wall did not exceed 65C (149F) while adjacent to the animal, the temperature was 46C (114F).
The pig was then removed from apparatus 10 and hyperthermic conditions maintained for two additional hours at the end of which the internal temperature was 41.6C. The experiment was then terminated by a liberal ethanol bath. In about 90 minutes internal temperature fell to 38C ~100F).
Tests o~ the above described type sugges-t the suitability of the present invention for use with humans.
Rails 26 are positioned on wall member 18 for receiving carriage 28 for stretcher 30 on which the --sub~ect is placed. Rails 26 may be mounted on bands 27 that extend around the interior of wall 20 in the middle and rear of chamber 24, as shown in Fig. 3.
Bands 27 may be expanded by toggle mechanisms, not shown to clamp the bands, and hence rails 26, to wall 20. The use of bands 27 avoids the need to punc-ture wall 20 and the need for seals and the like to maintain the integrity o~ chamber 24. The cleaniny of chamber 24 is also facilltated since bands 27 and rails 26 can be removed from chamber 24.
Carriage 28 includes head rest 32 for the ;~ suhject, a panel 22,that assists in closing chamber 24, and a handle 34 by which the carriage, stretcher, and subject are moved into and out of chamber 24.
The open end of wall member 18 is closed by a pair of insulated doors 36 and 38 orming open-ing 40 through which the neck of the patient extends so that his/her head can rest on head rest 32.
Doors 36 and 38 are shaped as an inverted L and have retaining means such as channel 42 for receiving a sealiny collar that goes around the neck of the patient to seal opening 40. The doors are sealed at the bottom by head rest 32. Doors 36 and 38 are provided with hinges 44 and 46 along outer edges and held closed by magnetic latches 48 and 50 at their inner edges. Doors 36 and 38 and head res-t panel 33 may be provided with gaskets tha-t seal these elements to wall member 18 or housing 12 when they are closed.
Because the head rest 32 is coupled to stretcher 30 and because L-shaped doors open in the center, the insertion and, particularly, removal of the subject and associated medical equipment and instrumentation from chamber 24 is facilitated. In emergencies with humans, the patient can be removed from chamber 24 by pulling handle 34 outwardly and allowing the patient's shoulders to swing open doors 36 and 38.
Housing 12 includes control panel 52 for - 35 the electrical circuitry shown in Fig. 6.
Means are provided on wall member 18 to heat the wall member and chamber 24. As shown in the Figures, such means may comprise electric heating cable 54 wrapped about the exterior of wall 20 so that the wall member can assist in diEfusing -the heat from the cable. The cable may be wrapped cir-cumferentially, as shown in Fig. 3 and the turnsspaced along the periphery of the wall member to pro-vide uniform heating to the wall member to avoid establishing localized hot spots on wall member 18 The turns of cable 54 will typically be uniformly spaced along wall 20, possibly with minor variations because of frame 14 or other localized anomalies.
A retaining or spacer means, not shown, may be pro-vided to hold cable 54 in position on wall 20.
Cable 54 is available from several sources including the Continantal Wire and Cable division of Anaconda Copper Co. and the Wire and Cable Division of the General Electric Company. As shown in Fig. 5, cable 54 may comprise an internal metal resistance wire 56; an asbestos, plastic, or rubber sheath 58 surrounding and insulating the wire; and an outer braided metal jacket 60 for armoring and electrically grounding the cable. Electric resistance wire 56 may be a single conductor of 19 or 20 gauge having a resistance of approximately 675 ohms per circular mil foot at 20C. The conductor is surrounded by .045 inch thick silicon rubber sheath 58 and a nickel plated copper shield braid.
The heating of wall member 18 by the heating means, such as cable 54, is subject to two, somewhat divergent, considerations. A sufficient quantity of radiant heat must be provided from wall member 18 to raise the core temperature of the subject in chamber 24 by a physiologically significant amount in a desired period of time. The physiologically significant temperature increase may be that necessary to cause the subject to enter the hyperthermic state.
In accordance with this consideration, cable 54 may provide a heat input suf~icien-t -to raise the core temperature of the subject a-t least 4C within a period of 120 minutes by the radiant heat in chamber 24. More particularly the apparatus should be capable o~ raising the core temperature oE the subject 4 to 5C in a period of 60 to 120 minutes.
At the same time, however, the density of heating, or heat output per unit area of wall member ln 18, shoula be sufficiently uniform and low as to minimize the possibility of superfieial injury to the subject, such as burnsr ~rom wall temperature eonditions, and particularly from localized hot spots in the wall membèr.
The weight of the subjeet may serve as a aetor in the seleetion of the heat input from the eleetric heating means. For heating animal subjects baving a weight of 70 kg (154 lks) in an appropriately sized ehamber 24, an eleetric heating cable having a power rating of about 1,000 watts has been employed.
As shown most clearly in Fig. 4, tubular wall member 18 and cable 54 are surrounded by an insulating material 64 such as glass fiber insula-tion, that is held on tubular member 18 by wrapper 66 formed of metal or other material.
Electrical cireuitry for energizing heating eable 54 is shown in Fig. 6. Heating eable 54 is pre-ferably divided into a plurality of segments conneeted in parallel to insure even heating throughout tubular ehamber 24. This may be accomplished by the appro-priate electrical connection of taps along the heating eable~ Fig. 6 shows, for exemplary purposes, heating eable 54 divided into four quarter segments 54a, 54b, 54e, and 54d.
1 3~
Circuitry 70 is connec-table to an a.c. power source 72, such as conventional 120 volt, 60 cycle al-texnating current supply 72 having energized line 74 and neutral line 76. Conduc-tors 7~ and 80 of circuitry 70 are connected to lines 74 and 76 and contain ground fault interrupter 82 requiring manual rese-t. Ground fault interrupter 82 deenergizes circuitry 70 in the e~ent of an electrical failure -to lessen or a~oid shock hazards in apparatus 10. Conductor 78 contains power switch 84 and relay contacts 86a, which when closed, permit parallel energization of heating cable segments 54a through 54d through conductor ~0.
Indicator lamp 88 is connected across lines 78 and 80 to indicate when main power switch ~4 is - L5 closed.
A plurality o~ elements are also connected across lines 78 and 80 to control the operation o~
electric heating cable 54. These include timer 90 by which the time period for energizing cable 54 may be established. Thermostat q2, which may be of the normally closed, bimetallic type is placed on wall 20 of wall member 18 to sense the temperature of the wall for deener~izing electric cable 54 in the event the temperature rises above a desired maximum value.
Typically thermostat 92 will be set to open at 60C (140F) and reclose at 5aC (130F) and is preferably not operator accessible or adjustable.
~imiting the wall temperature to this magnitude lessens or avoids the danger of skin burns from apparatus 10. Thermostat 94 may be mounted in tubu-lar cha~ber 24 at a location appropriate to sense the temperature inside the chamber. Thermostat 94 may be o~ the normally closed, fluid expansion type.
It is not operator adjustable but is preset to open at the maximum temperature desired in the chamber.
This is typically 70C (160F). The thermostat will ~ 3~J~
_g_ close at 68C (155F) and below. Thermos-tat 96 is also placed in t~lbular chamber 24 at a location to sense the temperature in the chamber. Thermostat 96 may also be of the normally closed, ~luid expansion type and is adjustable by the operator to establish a selected temperature in the chamber less -than the maximum temperature established by thermosta-t 94.
The coil 86b of relay 86 is connected in series with timer 90 and thermostats 92, 94, and 96 across lines 78 and 80. Coil 86b operates contacts 86a in line 78.
Indicator lamp 98 indicates when relay contacts are closed and heating cable 54 is energized.
In ~se, the patient may be prepared for hyperthermic treatment in apparatus 10 by light sedation. The temperature indicators necessary to monitor internal temperature will be placed in the patient, as for example, through the use of rectal, esophageal, and/or cardiac probes. Sensors ~or other physiological functions, such as respiration and heart beat rate, are also applied to the patient.
The patient will be placed on stretcher 30 with his/her head resting on headrest 32. The patient is slid into tubular chamber 24 on stretcher 30 with his/her head outside chamber 24. Doors 36 and 38 are closed and a collar placed around the neck OI the patient to tightly seal opening 40 making chamber 24 a closed system. Timer 90 is set for the maximum treatment time. Thermostat 96 is set for the maximum temperature desired in chamber 24. Power switch 84 is closed to energize heating cable 54. The contacts of timer 90, and thermostats 92, 94, and 96 are closed, energizing relay coil 86b of relay 86 and closing relay contacts 86a. This permits energization of electric cable 54. The energization of cable 56 heat copper wall member 18 radiating heat to the patient on the stretcher. The internal or core temperature of the patient is moni-tored through the temperature probes. The temperatures o~tained from the rectal tempera-ture probe are typi-cally considered the core temperature of the patient~or treatment purposes. The sealing of opening ~0 by the collar causes the perspiration of the patient to maintain a condition o~ saturation or near satura-tion in chamber 24 limiting patient heat loss by evaporation. Fluids lost through perspiration are restored intravenously. As the temperature of the patient increases, his/her metabolic heat generation increases substantially to supplement the radian-t heat from wall member 18 in attaining the hyperthermic state.
When the desired core temperature is reached in the patient, the patient may be removed from tubular chamber 24 and covered with a blanket to minimize evaporative heat losses. Through the loss of -thermo-regulatory capability brought about by the hyperthermiccondition, the desired internal temperature of the patient is maintained by the heat generated by in-creased metabolic activity withou-t the need for ex-ternal heat application. When the patient has re-mained in the hyperthermic condition for the desiredperiod of time, the blanket is removed to allow cooling by evaporation and the restoration of normal temperature regulation. Should the patient require additional cooling to terminate the hyperthermic condition, this may be achieved by a cooling blan~et or an alcohol sponge bath~
A typical test of apparatus 10, utilized a 70 kg (15~ lb) pig as an animal subject. Such an animal subject resembles a human in body weight, fat distribution ancl in cardic, liver and respiratory ~ .a~ t~
physi.ology. It~ however, does not perspire. The animal, appropriately instrumen-ted, was placed in apparatus 10 and heating cable 54 energized. The internal or core temperature of the animal, measured rectally, was raised to 41.8C in about 80 minutes.
Skin temperature rose to 42.5C. Air temperature near the wall did not exceed 65C (149F) while adjacent to the animal, the temperature was 46C (114F).
The pig was then removed from apparatus 10 and hyperthermic conditions maintained for two additional hours at the end of which the internal temperature was 41.6C. The experiment was then terminated by a liberal ethanol bath. In about 90 minutes internal temperature fell to 38C ~100F).
Tests o~ the above described type sugges-t the suitability of the present invention for use with humans.
Claims (22)
- Claim 1 continued....
temperature of said wall member at approximately 65°C
and the skin temperature of the subject at approximately 42.5°C while achieving a hyperthermic condition in the subject; and circuit means connected to a source of electrical power for energizing said electric heating means. - 2. The apparatus according to Claim 1 wherein said apparatus is further defined as one for obtaining core temperature increases to hyperthermic conditions in the subject wherein said electric heating means is further defined as providing a heat input to the wall member sufficient to attain hyperthermic conditions in the subject.
- 3. The apparatus according to Claim 1 wherein said electric heating means is further defined as generating a heat input sufficient to raise the core temperature of the subject at least 4°C within a period of 120 min.
- 4. The apparatus according to Claim 3 wherein said electric heating means is further defined as generating a heat input sufficient to raise the core temperature of the subject 4° to 5°C in a period of 60 to 120 min.
- 5. The apparatus according to Claim 1 or 2 wherein said wall member is formed of a cupreous material.
- 6. The apparatus according to Claim 1 wherein said heating means is applied in a generally uniform manner to said wall member.
- 7. The apparatus according to Claim 1 wherein said electric heating means comprises an electric heating cable applied in a generally uniform pattern to at least a selected portion of said wall member.
- 8. The apparatus according to Claim 6 wherein said electric heating means comprises an electric heating cable applied in a uniform pattern to the wall member.
- 9. The apparatus according to Claim 7 or 8 wherein said electric heating cable comprises a plurality of cable segments electrically connected in parallel.
- 10. The apparatus according to Claim 1 wherein said electric heating means comprises an electric heating cable having a power rating of approximately 1000 watts.
- 11. The apparatus according to Claim 1 including insulation means on the exterior of said wall member and electric heating means for assisting in the uniform heating.
- 12. The apparatus according to Claim 1 wherein said electric circuit means includes control means responsive to the temperature in said cavity for establishing that temperature at a desired level.
- 13. The apparatus according to Claim 12 wherein said electric circuit means includes further control means responsive to the temperature in said cavity for establishing the maximum temperature in said cavity.
- 14. The apparatus according to Claim 1 wherein said electric circuit means includes control means responsive to the temperature in said space for establishing the maximum temperature in said cavity.
- 15. The apparatus according to Claim 1 wherein said electric circuit means includes control means responsive to the temperature of said wall member for establishing the maximum temperature of said wall member.
- 16. The apparatus according to Claim 12 wherein said electric circuit means includes additional control means responsive to the temperature of said wall member for establishing the maximum temperature of said wall member.
- 17. The apparatus according to Claim 13 wherein said electric circuit means includes additional control means responsive to the temperature of said wall member for establishing the maximum temperature of said wall member.
- 18. The apparatus according to Claim 1 wherein said electric circuit means includes means for establishing the period of energization of said electric heating means.
- 19. The apparatus according to Claim 1 wherein said wall member has a generally cylindrical wall.
- 20. The apparatus according to Claim 1 wherein said closure means includes a pair of doors positioned across an end of said cavity and having abutting edges located generally centrally of said wall member and wherein said doors are openable along said abutting edges.
- 21. The apparatus according to Claim 1 wherein said positioning means comprises a stretcher for receiving the head and body of the subject, said stretcher having means extending from said cavity by which the subject may be inserted and removed from said cavity.
- 22. The apparatus according to Claim 21 wherein said stretcher forms a portion of said closure means.
1. Whole body hyperthermia apparatus capable of providing hyperthermic core temperature conditions in live mammalian subjects while minimizing risk to the subject comprising:
a wall member and a pair of end walls defining a closed cavity suitable for receiving the body of the subject with the head and neck of the subject extending through an opening in one of said end walls outside the closed cavity, said one end wall having closure means at said opening for providing a substantially air tight seal at said opening about the neck of the subject to prevent air circulation to and from said cavity, said wall member extending completely around the body of the subject when received therein, said wall member being formed of a material capable of radiating heat and having a radiant heat enhancing emissivity;
means for positioning the body of the subject in a generally central position in the cavity as defined by said wall member;
electric heating means mounted on the exterior of said wall member generating a heat input to the wall member for providing a sufficient quantity of radiant heat from the wall member directly to the body of the subject to increase the core temperature of the subject by radiant heating by a physiologically significant amount in a desired period of time, said wall member and heating means providing such radiant heat generally uniformly over the entire area of the wall member to minimize convection air currents in said cavity and at a power density low enough to limit the
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/280,999 US4501275A (en) | 1981-07-06 | 1981-07-06 | Mammalian subject heating unit using radiant heat |
US280,999 | 1981-07-06 |
Publications (1)
Publication Number | Publication Date |
---|---|
CA1180365A true CA1180365A (en) | 1985-01-02 |
Family
ID=23075538
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA000405751A Expired CA1180365A (en) | 1981-07-06 | 1982-06-22 | Mammalian subject heating unit using radiant heat |
Country Status (6)
Country | Link |
---|---|
US (1) | US4501275A (en) |
JP (1) | JPS5815858A (en) |
CA (1) | CA1180365A (en) |
DE (1) | DE3224947A1 (en) |
FR (1) | FR2508794B1 (en) |
GB (1) | GB2104360B (en) |
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US4628931A (en) * | 1982-03-03 | 1986-12-16 | Barrett Harold F | Medical treatment method |
JPS59157952A (en) * | 1983-02-25 | 1984-09-07 | Shin Kobe Electric Mach Co Ltd | Separator for lead-acid battery |
US4657004A (en) * | 1986-08-29 | 1987-04-14 | Coffey Robert T | Mobile livestock intensive care unit |
DE3700019C1 (en) * | 1987-01-02 | 1988-06-30 | Helmut Dallinga | Pressure vessel for hyperbaric application of living things |
JPH0649298Y2 (en) * | 1988-11-24 | 1994-12-14 | 晴夫 高瀬 | Electronic therapy equipment |
CA2061654A1 (en) * | 1991-03-07 | 1992-09-08 | William J. Hansen | Thermal recovery heating unit |
US5413587A (en) * | 1993-11-22 | 1995-05-09 | Hochstein; Peter A. | Infrared heating apparatus and methods |
PT2255800E (en) * | 1997-11-10 | 2012-12-17 | Sloan Kettering Inst Cancer | Arsenic trioxide for use in the treatment of leukaemia |
US6107611A (en) * | 1998-01-19 | 2000-08-22 | Msx, Inc. | Method and apparatus for detecting ground faults in a shielded heater wire by sensing electrical arcing |
DE19932580C2 (en) * | 1998-11-30 | 2003-07-03 | Forsch Innovative Medizinische | Hyperthermia device |
AU4523301A (en) * | 1999-12-14 | 2001-06-25 | Radiant Medical, Inc. | Method for reducing myocardial infarct by applicaton of intravascular hypothermia |
GB2360922A (en) | 2000-03-31 | 2001-10-03 | Http Hypothermia Therapy | A heating device for surface heating of a patient's body |
US6891136B2 (en) | 2002-06-18 | 2005-05-10 | Http-Hypothermia Therapy Ltd. | Electrical heating device |
AU2003231916A1 (en) | 2002-06-18 | 2003-12-31 | Http-Hypothermia Therapy Ltd. | Electrical heating device, particularly for heating a patient body |
AU2002338021A1 (en) * | 2002-09-11 | 2004-04-30 | Thermedix Co., Ltd. | Thermotherapy method |
WO2004026097A2 (en) * | 2002-09-19 | 2004-04-01 | First Circle Medical, Inc. | Treatment of steatosis using hyperthermia |
CA2450633C (en) * | 2003-12-23 | 2008-06-17 | Michel Dussault | Therapeutic device |
WO2014168832A1 (en) * | 2013-04-08 | 2014-10-16 | Farhan Taghizadeh | System and method for providing treatment feedback for a thermal treatment device |
EP3125837A4 (en) * | 2014-04-04 | 2017-11-08 | Aesthetics Biomedical, Inc. | System and method for providing treatment feedback for a thermal treatment device |
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US558394A (en) * | 1896-04-14 | Radiant-heat bath | ||
US670668A (en) * | 1899-02-01 | 1901-03-26 | William S Hadaway Jr | Apparatus for baking. |
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US1875261A (en) * | 1928-02-10 | 1932-08-30 | William S Jennings | Apparatus for applying heat for therapeutic and other purposes |
US2012221A (en) * | 1932-08-30 | 1935-08-20 | Gordon H Clark | Hyperpyrexator |
US2086827A (en) * | 1932-11-03 | 1937-07-13 | Knapp Monarch Co | Biscuit baker or oven |
US2098295A (en) * | 1933-03-17 | 1937-11-09 | Gen Motors Corp | Method of and apparatus for creating an artificial fever |
US1968015A (en) * | 1933-03-20 | 1934-07-31 | Cooke | Therapeutic treatment device |
US2098316A (en) * | 1933-07-22 | 1937-11-09 | Gen Motors Corp | Method of and apparatus for creating an artificial fever |
US2096128A (en) * | 1936-04-18 | 1937-10-19 | Jr William E Mortrude | Electrophysical cabinet |
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US4055863A (en) * | 1975-12-22 | 1977-11-01 | Lawrence Edward Duval | Apparatus for bathing persons |
US4100415A (en) * | 1976-06-04 | 1978-07-11 | Gte Sylvania Incorporated | Modular photochemotherapy chamber |
FR2476482A1 (en) * | 1979-09-11 | 1981-08-28 | Milly Lucien | Hyper-thermal or artificial fever appts. for cancer treatment - provides controlled application of microwave radiation to destroy selectively cancer cells and uses cross-shaped waveguides |
JPS5681726U (en) * | 1979-11-29 | 1981-07-02 | ||
JPH0319858Y2 (en) * | 1988-06-30 | 1991-04-26 |
-
1981
- 1981-07-06 US US06/280,999 patent/US4501275A/en not_active Expired - Lifetime
-
1982
- 1982-06-22 CA CA000405751A patent/CA1180365A/en not_active Expired
- 1982-07-02 GB GB08219114A patent/GB2104360B/en not_active Expired
- 1982-07-03 DE DE19823224947 patent/DE3224947A1/en not_active Ceased
- 1982-07-06 FR FR828211894A patent/FR2508794B1/en not_active Expired - Lifetime
- 1982-07-06 JP JP57117628A patent/JPS5815858A/en active Granted
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DE3224947A1 (en) | 1983-01-20 |
FR2508794B1 (en) | 1990-02-02 |
JPS5815858A (en) | 1983-01-29 |
US4501275A (en) | 1985-02-26 |
GB2104360B (en) | 1985-07-31 |
FR2508794A1 (en) | 1983-01-07 |
JPH0456623B2 (en) | 1992-09-09 |
GB2104360A (en) | 1983-03-02 |
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