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Biochemistry

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John Wiley & Sons, Jun 15, 2011 - Science - 1520 pages
Biochemistry provides the most up to date coverage is important in this course with in-depth and accurate coverage of the chemical concepts that underlie classical biochemical theory, as well as providing coverage of the exciting, modern developments in this dynamic field. The fourth edition challenges students to learn the chemical concepts that underlie both classical biochemical theory as well as the latest developments in the field. It follows a more brief and qualitative approach to present biochemistry with chemical rigor, focusing on the structures of biomolecules, chemical mechanisms, and evolutionary relationships.
  

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Contents

INTRODUCTION AND BACKGROUND
1
Life
3
Figure 213 49
7
Aqueous Solutions
40
A Review
52
Chemical Equilibria
58
BIOMOLECULES
65
Amino Acids
67
Glycogen Metabolism
638
647
667
Signal Transduction
671
Transport through Membranes
744
Citric Acid Cycle
789
Citric Acid Cycle
790
1
819
Electron Transport and Oxidative Phosphorylation
823

Figure 46
72
Optical Activity
73
Nucleic Acids Gene Expression and Recombinant DNA Technology
82
Animated Figure UV absorbance spectra of the nucleic acid bases and
92
1
95
Molecular Cloning
104
Regulation of gene expression by the lac repressor system
109
Techniques of Protein and Nucleic Acid Purifications
129
Techniques of Protein and NucleicAcid Purification Animated Figure An enzymelinked immunosorbent assay ELISA Figure 61
132
Chromatographic Separations
135
Covalent Structures of Proteins and Nucleic Acids
163
Nucleic Acid Sequencing
176
Chemical Evolution
185
An Introduction
194
Chemical Synthesis of Polypeptides
205
6
211
ThreeDimensional Structures of Proteins
221
Pleated sheets
229
Fibrous Proteins
232
Globular Proteins
241
Human carbonic anhydrase
246
Protein Stability
259
Quaternary Structure
266
Protein Folding Dynamics and Structural Evolution
278
Folding Accessory Proteins
290
Protein Structure Prediction and Design
302
Structural Evolution
316
Protein Function in Microcosm
323
Structure and Mechanism
331
Abnormal Hemoglobins
341
Allosteric Regulation
347
Derivation of Symmetry Model
354
Sugars and Polysaccharides
359
Polysaccharides
365
Glycoproteins
373
Lipids and Membranes
386
Properties of Lipid Aggregates
393
Kinemage Exercise
403
Membrane Assembly and Protein Targeting
418
Lipoproteins
465
MECHANISMS OF ENZYME ACTION
467
Introduction to Enzymes
469
Rates of Enzymatic Reactions
482
Inhibition
492
Derivations of MichaelisMenten
501
Enzymatic Catalysis
506
Enzymatic Catalysis
508
517
553
METABOLISM
557
Introduction to Metabolism
559
4
571
Glycolysis
593
of Pyruvate
614
5
620
Electron Transport
828
Oxidative Phosphorylation
845
Control of ATP Production
862
Other Pathways of Carbohydrate Metabolism
871
The Glyoxylate Cycle
880
The Pentose Phosphate Pathway
896
Photosynthesis
901
Light Reactions
903
Dark Reactions
926
Lipid Metabolism
940
Regulation of Fatty Acid Metabolism
973
Prostaglandins
993
Phospholipid and Glycolipid Metabolism
1004
Amino Acid Metabolism
1019
The Urea Cycle
1025
Amino Acids as Biosynthetic Precursors
1047
Nitrogen Fixation
1078
Integration and Organ Specialization
1088
Regulation of Appetite
1095
Metabolic Adaptation
1101
Nucleotide Metabolism
1107
1
1140
EXPRESSION AND TRANSMISSION OF GENETIC INFORMATION
1143
Nucleic Acid Structures
1145
Supercoiled DNA
1158
DNA Replication Repair and Recombination
1173
PostTranscriptional Processing
1190
Elements
1225
Transcription 1260 Translation
1338
Paradigms for Cellular Function
W-1
Figure 915
W-9
Figure 115
W-11
Bacteriophage W20
W-21
Influenza Virus W40
W-41
Eukaryotic Gene Expression W53
W-53
Figure 1286
W-86
1
W-121
Molecular Physiology W165
W-165
Molecular Physiology
W-166
Immunity W179
W-179
Muscles Vesicle Transport
W-211
245
W-245
512
W-255
INDEX WI1
WF-9
Chapters 33 34 and 35 are available on our book
I-1
247
I-5
248
I-21
371
I-25
249
I-32
362
I-33
249
I-40
405
I-46
452
I-52
Copyright

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About the author (2011)

Donald Voet received a Ph.D. in chemistry from Harvard University and did postdoctoral research in the Biology Department at MIT. Don took up a faculty position in the department of chemistry at the University of Pennsylvania, upon completing his postdoctoral work. He has been a visiting scholar at Oxford University, the University of California San Diego, and the Weismann Institute of Science in Israel.

Judith Voet received her Ph.D. from Brandeis University and did postdoctoral research at the University of Pennsylvania, Haverford College and the Fox  Chase Cancer Center. She taught at the University of Delaware before moving to Swarthmore College. Together with Don Voet, she is Co-Editor-in-Chief of the journal Biochemistry and Molecular Biology Education.

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